GSK2556286 Is a Novel Antitubercular Drug Candidate Effective In Vivo with the Potential To Shorten Tuberculosis Treatment von Nuermberger, Eric L, Martínez-Martínez, Maria Santos, Sanz, Olalla, Urones, Beatriz, Esquivias, Jorge, Soni, Heena, Tasneen, Rokeya, Tyagi, Sandeep, Li, Si-Yang, Converse, Paul J, Boshoff, Helena I, Robertson, Gregory T, Besra, Gurdyal S, Abrahams, Katherine A, Upton, Anna M, Mdluli, Khisimuzi, Boyle, Gary W, Turner, Sam, Fotouhi, Nader, Cammack, Nicholas C, Siles, Juan Miguel, Alonso, Marta, Escribano, Jaime, Lelievre, Joel, Rullas-Trincado, Joaquin, Pérez-Herrán, Esther, Bates, Robert H, Maher-Edwards, Gareth, Barros, David, Ballell, Lluís, Jiménez, Elena

Volltext

Identification of KasA as the cellular target of an anti-tubercular scaffold von Abrahams, Katherine A., Chung, Chun-wa, Ghidelli-Disse, Sonja, Rullas, Joaquín, Rebollo-López, María José, Gurcha, Sudagar S., Cox, Jonathan A. G., Mendoza, Alfonso, Jiménez-Navarro, Elena, Martínez-Martínez, María Santos, Neu, Margarete, Shillings, Anthony, Homes, Paul, Argyrou, Argyrides, Casanueva, Ruth, Loman, Nicholas J., Moynihan, Patrick J., Lelièvre, Joël, Selenski, Carolyn, Axtman, Matthew, Kremer, Laurent, Bantscheff, Marcus, Angulo-Barturen, Iñigo, Izquierdo, Mónica Cacho, Cammack, Nicholas C., Drewes, Gerard, Ballell, Lluis, Barros, David, Besra, Gurdyal S., Bates, Robert H.

Volltext

Tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide and N-benzyl-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran] analogues with bactericidal efficacy against Mycobacterium tub... von Remuiñán, Modesto J, Pérez-Herrán, Esther, Rullás, Joaquín, Alemparte, Carlos, Martínez-Hoyos, María, Dow, David J, Afari, Johnson, Mehta, Nalini, Esquivias, Jorge, Jiménez, Elena, Ortega-Muro, Fátima, Fraile-Gabaldón, María Teresa, Spivey, Vickey L, Loman, Nicholas J, Pallen, Mark J, Constantinidou, Chrystala, Minick, Douglas J, Cacho, Mónica, Rebollo-López, María José, González, Carolina, Sousa, Verónica, Angulo-Barturen, Iñigo, Mendoza-Losana, Alfonso, Barros, David, Besra, Gurdyal S, Ballell, Lluís, Cammack, Nicholas

Volltext

Tres Cantos Open Lab: celebrating a decade of innovation in collaboration to combat endemic infectious diseases COMMENT von Calderon, Felix, Ballell, Lluis, Barros, David, Bilbe, Graeme, Cammack, Nicholas, Gabarro, Raquel, Halsey, Audra, Heaton, Penny M., Kang, Gagandeep, Mizrahi, Valerie, Nathan, Carl, Strange, Mike E., Williams, Pauline M., Winzeler, Elizabeth A., Fairlamb, Alan H.

Volltext

Open Lab as a source of hits and leads against tuberculosis, malaria and kinetoplastid diseases von Ballell, Lluís, Strange, Mike, Cammack, Nicholas, Fairlamb, Alan H., Borysiewicz, Leszek

Volltext

Fueling Open-Source Drug Discovery: 177 Small-Molecule Leads against Tuberculosis von Ballell, Lluís, Bates, Robert H., Young, Rob J., Alvarez-Gomez, Daniel, Alvarez-Ruiz, Emilio, Barroso, Vanessa, Blanco, Delia, Crespo, Benigno, Escribano, Jaime, González, Rubén, Lozano, Sonia, Huss, Sophie, Santos-Villarejo, Angel, Martín-Plaza, José Julio, Mendoza, Alfonso, Rebollo-Lopez, María José, Remuiñan-Blanco, Modesto, Lavandera, José Luis, Pérez-Herran, Esther, Gamo-Benito, Francisco Javier, García-Bustos, José Francisco, Barros, David, Castro, Julia P., Cammack, Nicholas

Volltext

Tres Cantos Open Lab: celebrating a decade of innovation in collaboration to combat endemic infectious diseases von Calderón, Felix, Ballell, Lluis, Barros, David, Bilbe, Graeme, Cammack, Nicholas, Gabarró, Raquel, Halsey, Audra, Heaton, Penny M., Kang, Gagandeep, Mizrahi, Valerie, Nathan, Carl, Strange, Mike E., Williams, Pauline M., Winzeler, Elizabeth A., Fairlamb, Alan H.

Volltext

Release of 50 new, drug-like compounds and their computational target predictions for open source anti-tubercular drug discovery von Rebollo-Lopez, María Jose, Lelièvre, Joël, Alvarez-Gomez, Daniel, Castro-Pichel, Julia, Martínez-Jiménez, Francisco, Papadatos, George, Kumar, Vinod, Colmenarejo, Gonzalo, Mugumbate, Grace, Hurle, Mark, Barroso, Vanessa, Young, Rob J, Martinez-Hoyos, María, González del Río, Rubén, Bates, Robert H, Lopez-Roman, Eva Maria, Mendoza-Losana, Alfonso, Brown, James R, Alvarez-Ruiz, Emilio, Marti-Renom, Marc A, Overington, John P, Cammack, Nicholas, Ballell, Lluís, Barros-Aguire, David

Volltext

The Discovery of Novel Antimalarial Aminoxadiazoles as a Promising Nonendoperoxide Scaffold von Sandoval, Elena, Lafuente-Monasterio, María José, Almela, María J, Castañeda, Pablo, Jiménez Díaz, María Belén, Martínez-Martínez, María S, Vidal, Jaume, Angulo-Barturen, Íñigo, Bamborough, Paul, Burrows, Jeremy, Cammack, Nicholas, Chaparro, María J, Coterón, José M, de Cozar, Cristina, Crespo, Benigno, Díaz, Beatriz, Drewes, Gerard, Fernández, Esther, Ferrer-Bazaga, Santiago, Fraile, María Teresa, Gamo, Francisco J, Ghidelli-Disse, Sonja, Gómez, Rubén, Haselden, John, Huss, Sophie, León, María Luisa, de Mercado, Jaime, Macdonald, Simon J. F, Martín Hernando, José Ignacio, Prats, Sara, Puente, Margarita, Rodríguez, Anne, de la Rosa, Juan C, Rueda, Lourdes, Selenski, Carolyn, Willis, Paul, Wilson, David M, Witty, Michael, Calderón, Félix

Volltext

Correction to The Discovery of Novel Antimalarial Aminoxadiazoles as a Promising Nonendoperoxide Scaffold von Sandoval, Elena, Lafuente-Monasterio, María José, Almela, María J., Castañeda, Pablo, Jiménez Díaz, María Belén, Martínez-Martínez, María S., Vidal, Jaume, Angulo-Barturen, Íñigo, Bamborough, Paul, Burrows, Jeremy, Cammack, Nicholas, Chaparro, María J., Coterón, José M., de Cozar, Cristina, Crespo, Benigno, Díaz, Beatriz, Drewes, Gerard, Fernández, Esther, Ferrer-Bazaga, Santiago, Fraile, María Teresa, Gamo, Francisco J., Ghidelli-Disse, Sonja, Gómez, Rubén, Haselden, John, Huss, Sophie, León, María Luisa, de Mercado, Jaime, Macdonald, Simon J. F., Martín Hernando, José Ignacio, Prats, Sara, Puente, Margarita, Rodríguez, Anne, de la Rosa, Juan C., Rueda, Lourdes, Selenski, Carolyn, Willis, Paul, Wilson, David M., Witty, Michael, Calderón, Félix

Volltext

Identification of Novel Anti-mycobacterial Compounds by Screening a Pharmaceutical Small-Molecule Library against Nonreplicating Mycobacterium tuberculosis von Warrier, Thulasi, Martinez-Hoyos, Maria, Marin-Amieva, Manuel, Colmenarejo, Gonzalo, Porras-De Francisco, Esther, Alvarez-Pedraglio, Ana Isabel, Fraile-Gabaldon, Maria Teresa, Torres-Gomez, Pedro Alfonso, Lopez-Quezada, Landys, Gold, Ben, Roberts, Julia, Ling, Yan, Somersan-Karakaya, Selin, Little, David, Cammack, Nicholas, Nathan, Carl, Mendoza-Losana, Alfonso

Volltext

Case Study of Small Molecules As Antimalarials: 2‑Amino-1-phenylethanol (APE) Derivatives von Chaparro, María J, Vidal, Jaume, Angulo-Barturen, Íñigo, Bueno, José M, Burrows, Jeremy, Cammack, Nicholas, Castañeda, Pablo, Colmenarejo, Gonzalo, Coterón, José M, de las Heras, Laura, Fernández, Esther, Ferrer, Santiago, Gabarró, Raquel, Gamo, Francisco J, García, Mercedes, Jiménez-Díaz, María B, Lafuente, María J, León, María L, Martínez, María S, Minick, Douglas, Prats, Sara, Puente, Margarita, Rueda, Lourdes, Sandoval, Elena, Santos-Villarejo, Ángel, Witty, Michael, Calderón, Félix

Volltext

Cellular metabolism of (−) enantiomeric 2′-deoxy-3′-thiacytidine von Cammack, Nicholas, Rouse, Philippa, Marr, Clara L.P., Reid, Paula J., Boehme, Richard E., Coates, Jonathan A.V., Penn, Charles R., Cameron, Janet M.

Volltext

Benzophenone Derivatives: A Novel Series of Potent and Selective Inhibitors of Human Immunodeficiency Virus Type 1 Reverse Transcriptase von Wyatt, Paul G, Bethell, Richard C, Cammack, Nicholas, Charon, Daniel, Dodic, Nerina, Dumaitre, Bernard, Evans, Derek N, Green, Darren V. S, Hopewell, Philippa L

Volltext

Synthesis and anti-HIV-1 activity of a series of imidazo[1,5-b]pyridazines von Livermore, David G. H, Bethell, Richard C, Cammack, Nicholas, Hancock, Ashley P, Hann, Michael M, Green, Darren V. S, Lamont, R. Brian, Noble, Stewart A, Orr, David C

Volltext

Virus excretion and mutation by infants following primary vaccination with live oral poliovaccine from two sources von Dunn, Glynis, Begg, Norman T., Cammack, Nicholas, Minor, Philip D.

Volltext

Penicillin derived C2-symmetric dimers as novel inhibitors of HIV-1 proteinase von Humber, David C, Cammack, Nicholas, Coates, Jonathan A. V, Cobley, Kevin N, Orr, David C, Storer, Richard, Weingarten, Gordon G, Weir, Malcolm P

Volltext

Synthesis and Structure-Activity Relationships of a Series of Penicillin-Derived HIV Proteinase Inhibitors: Heterocyclic Ring Systems Containing P1' and P2' Substituents von Kitchin, John, Bethell, Richard C, Cammack, Nicholas, Dolan, Simon, Evans, Derek N, Holman, Stuart, Holmes, Duncan S, McMeekin, Peter, Mo, Chi L

Volltext

A series of penicillin-derived C2-symmetric inhibitors of HIV-1 proteinase: synthesis, mode of interaction, and structure-activity relationships von Humber, David C, Bamford, Mark J, Bethell, Richard C, Cammack, Nicholas, Cobley, Kevin, Evans, Derek N, Gray, Norman M, Hann, Michael M, Orr, David C

Volltext

Synthesis and structure-activity relationships of a series of penicillin-derived HIV proteinase inhibitors containing a stereochemically unique peptide isostere von Holmes, Duncan S, Bethell, Richard C, Cammack, Nicholas, Clemens, Ian R, Kitchin, John, McMeekin, Peter, Mo, Chi L, Orr, David C, Patel, Binakumari

Volltext