AMG 479, a fully human anti–insulin-like growth factor receptor type I monoclonal antibody, inhibits the growth and survival of pancreatic carcinoma cells von Beltran, Pedro J, Mitchell, Petia, Chung, Young-A, Cajulis, Elaina, Lu, John, Belmontes, Brian, Ho, Joanne, Tsai, Mei Mei, Zhu, Min, Vonderfecht, Steven, Baserga, Renato, Kendall, Richard, Radinsky, Robert, Calzone, Frank J

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Epitope-specific mechanisms of IGF1R inhibition by ganitumab von Calzone, Frank J, Cajulis, Elaina, Chung, Young-Ah, Tsai, Mei-Mei, Mitchell, Petia, Lu, John, Chen, Ching, Sun, Jilin, Radinsky, Robert, Kendall, Richard, Beltran, Pedro J

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HER2 and HLA-A02 dual CAR-T cells utilize LOH in a NOT logic gate to address on-target off-tumor toxicity von Bassan, David, Weinberger, Leehee, Yi, Jason, Kim, Tanya, Weist, Michael R, Adams, Gregor B, Foord, Orit, Chaim, Neta, Tabak, Sarit, Bujanover, Nir, Lopesco, Yael, Vucci, Kristina, Schnair, Caitlin, Levy-Knafo, Limor, Kendall, Richard L, Calzone, Frank J, Sharbi-Yunger, Adi

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Ganitumab (AMG 479) Inhibits IGF-II-Dependent Ovarian Cancer Growth and Potentiates Platinum-Based Chemotherapy von BELTRAN, Pedro J, CALZONE, Frank J, GUORONG YANG, JINGWEI QI, SLAMON, Dennis J, KONECNY, Gottfried E, MITCHELL, Petia, CHUNG, Young-Ah, CAJULIS, Elaina, MOODY, Gordon, BELMONTES, Brian, LI, Chi-Ming, VONDERFECHT, Steven, VELCULESCU, Victor E

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Efficacy of Ganitumab (AMG 479), Alone and in Combination with Rapamycin, in Ewing’s and Osteogenic Sarcoma Models von Beltran, Pedro J., Chung, Young-Ah, Moody, Gordon, Mitchell, Petia, Cajulis, Elaina, Vonderfecht, Steven, Kendall, Richard, Radinsky, Robert, Calzone, Frank J.

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IGF1R blockade with ganitumab results in systemic effects on the GH–IGF axis in mice von Moody, Gordon, Beltran, Pedro J, Mitchell, Petia, Cajulis, Elaina, Chung, Young-Ah, Hwang, David, Kendall, Richard, Radinsky, Robert, Cohen, Pinchas, Calzone, Frank J

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Effect of a low-fat diet combined with IGF-1 receptor blockade on 22Rv1 prostate cancer xenografts von Konijeti, Ramdev, Koyama, Satomi, Gray, Ashley, Barnard, R James, Said, Jonathan W, Castor, Brandon, Elashoff, David, Wan, Junxiang, Beltran, Pedro J, Calzone, Frank J, Cohen, Pinchas, Galet, Colette, Aronson, William J

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HER-2 overexpression differentially alters transforming growth factor-beta responses in luminal versus mesenchymal human breast cancer cells von Wilson, Cindy A, Cajulis, Elaina E, Green, Jennifer L, Olsen, Taylor M, Chung, Young Ah, Damore, Michael A, Dering, Judy, Calzone, Frank J, Slamon, Dennis J

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Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas von Wilson, Cindy A., Ramos, Lillian, Villaseñor, Maria R., Anders, Karl H., Press, Michael F., Clarke, Kathy, Karlan, Beth, Chen, Jun-Jie, Scully, Ralph, Livingston, David, Zuch, Robert H., Kanter, Michael H., Cohen, Sylvan, Calzone, Frank J., Slamon, Dennis J.

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Differential subcellular localization, expression and biological toxicity of BRCA1 and the splice variant BRCA1-Δ11b von Wilson, Cindy A, Payton, Marc N, Elliott, Gary S, Buaas, F William, Cajulis, Elaina E, Grosshans, David, Ramos, Lillian, Reese, David M, Slamon, Dennis J, Calzone, Frank J

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Targeting the Glucagon Receptor Signaling Pathway As a Novel Strategy to Counteract PI3K Inhibitor Induced Hyperglycemia While Sustaining Tumor PI3K Inhibition von Wang, Jie, Morse, Michael, Calzone, Frank, Yan, Hai, Thai, Zung, Osada, Takuya, Lyerly, Herbert

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Novel consensus DNA-binding sequence for BRCA1 protein complexes von Cable, P. LouAnn, Wilson, Cindy A., Calzone, Frank J., Rauscher III, Frank J., Scully, Ralph, Livingston, David M., Li, Leping, Blackwell, Courtney B., Futreal, P. Andrew, Afshari, Cynthia A.

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316 Next generation CAR-T incorporating an inhibitory CAR (iCAR) for increased safety in solid tumors von Bassan, David, Weist, Michael, Weinberger, Leehee, Yi, Jason, Adams, Gregor, Kim, Tanya, Schnair, Caitlin, Vucci, Kristina, Tabak, Sarit, Neta Chaim, Bujanover, Nir, Lopesco, Yael, Levy-Kanfo, Limor, Foord, Orit, Johnston, Jim, Calzone, Frank, Kendell, Rick, Sharbi-Yunger, Adi

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Abstract 1206: Preclinical evaluation of targeting Notch-3 in breast cancer von Hurvitz, Sara A., von Euw, Erika, O’Brien, Neil, Conklin, Dylan, Hu, Chuhong, Zhuo, Jiaying, Zhao, Alice, Calzone, Frank, Chen, Hsiao-Wang, Dering, Judy, Geles, Ken, Sapra, Puja, Slamon, Dennis J.

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Abstract 2826: Rewiring CAR T-cells for absolute solid tumor specificity and safety von Weist, Michael R., Sharbi-Yunger, Adi, Yi, Jason, Schnair, Caitlin, Bassan, David, Kim, Tanya, Tabak, Sarit, Lopesco, Yael, Weinberger, Leehee, Bujanover, Nir, Chaim, Neta, Vucci, Kristina, Foord, Orit, Calzone, Frank J., Kendall, Rick, Adams, Gregor B.

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Abstract 2848: Incorporation of inhibitory signaling domains into chimeric antigen receptors (iCAR) designed for self-regulation of canonical CAR-T to treat solid tumors von Bassan, David, Yi, Jason, Chaim, Neta, Bujanover, Nir, Tabak, Sarit, Kim, Tanya, Lopesco, Yael, Weinberger, Leehee, Vucci, Kristina, Weist, Michael, Schnair, Caitlin, Adams, Gregor B., Foord, Orit, Calzone, Frank J., Kendall, Rick, Sharbi-Yunger, Adi

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Abstract C55: Ganitumab (AMG 479) inhibits the development and progression of castration-resistant VCaP human prostate cancer xenografts von Fahrenholtz, Cale D., Beltran, Pedro J., Calzone, Frank J., Burnstein, Kerry L.

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Abstract LB-257: Ganitumab (AMG 479), an anti IGF-1R antibody, inhibits the proliferation of melanoma cells von Von Euw, Erika M., Konkankit, Veerauo V., Gong, Ke-Wei, Calzone, Frank, Finn, Richard S., Chmielowski, Bartosz, Slamon, Dennis J.

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Combination of glucagon receptor antagonists and PI3K pathway inhibitors for the treatment of cancer von Calzone, Frank J

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Combination of glucagon receptor antagonists and PI3K pathway inhibitors for the treatment of cancer von Calzone, Frank J

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