A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity von Compte, Marta, Harwood, Seandean Lykke, Muñoz, Ines G., Navarro, Rocio, Zonca, Manuela, Perez-Chacon, Gema, Erce-Llamazares, Ainhoa, Merino, Nekane, Tapia-Galisteo, Antonio, Cuesta, Angel M., Mikkelsen, Kasper, Caleiras, Eduardo, Nuñez-Prado, Natalia, Aznar, M. Angela, Lykkemark, Simon, Martínez-Torrecuadrada, Jorge, Melero, Ignacio, Blanco, Francisco J., Bernardino de la Serna, Jorge, Zapata, Juan M., Sanz, Laura, Alvarez-Vallina, Luis

Volltext

Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling von de la Calle Arregui, Celia, Plata-Gómez, Ana Belén, Deleyto-Seldas, Nerea, García, Fernando, Ortega-Molina, Ana, Abril-Garrido, Julio, Rodriguez, Elena, Nemazanyy, Ivan, Tribouillard, Laura, de Martino, Alba, Caleiras, Eduardo, Campos-Olivas, Ramón, Mulero, Francisca, Laplante, Mathieu, Muñoz, Javier, Pende, Mario, Sabio, Guadalupe, Sabatini, David M., Efeyan, Alejo

Volltext

FGFR1 amplification or overexpression and hormonal resistance in luminal breast cancer: rationale for a triple blockade of ER, CDK4/6, and FGFR1 von Mouron, Silvana, Manso, Luis, Caleiras, Eduardo, Rodriguez-Peralto, Jose L, Rueda, Oscar M, Caldas, Carlos, Colomer, Ramon, Quintela-Fandino, Miguel, Bueno, Maria J

Volltext

Molecular characterization of chromophobe renal cell carcinoma reveals mTOR pathway alterations in patients with poor outcome von Roldan-Romero, Juan María, Santos, María, Lanillos, Javier, Caleiras, Eduardo, Anguera, Georgia, Maroto, Pablo, García-Donas, Jesús, de Velasco, Guillermo, Martinez-Montes, Ángel Mario, Calsina, Bruna, Monteagudo, María, Letón, Rocío, Leandro-García, Luis Javier, Montero-Conde, Cristina, Cascón, Alberto, Robledo, Mercedes, Rodriguez-Antona, Cristina

Volltext

Hepatic nutrient and hormone signaling to mTORC1 instructs the postnatal metabolic zonation of the liver von Plata-Gómez, Ana Belén, de Prado-Rivas, Lucía, Sanz, Alba, Deleyto-Seldas, Nerea, García, Fernando, de la Calle Arregui, Celia, Silva, Camila, Caleiras, Eduardo, Graña-Castro, Osvaldo, Piñeiro-Yáñez, Elena, Krebs, Joseph, Leiva-Vega, Luis, Muñoz, Javier, Jain, Ajay, Sabio, Guadalupe, Efeyan, Alejo

Volltext

Immuno-priming durvalumab with bevacizumab in HER2-negative advanced breast cancer: a pilot clinical trial von Quintela-Fandino, Miguel, Holgado, Esther, Manso, Luis, Morales, Serafin, Bermejo, Begoña, Colomer, Ramon, Apala, Juan V, Blanco, Raquel, Muñoz, Manuel, Caleiras, Eduardo, Iranzo, Vega, Martinez, Mario, Dominguez, Orlando, Hornedo, Javier, Gonzalez-Cortijo, Lucia, Cortes, Javier, Gasol Cudos, Ariadna, Malon, Diego, Lopez-Alonso, Antonio, Moreno-Ortíz, María C, Mouron, Silvana, Mañes, Santos

Volltext

Prevalence of pathogenic germline variants in patients with metastatic renal cell carcinoma von Santos, María, Lanillos, Javier, Roldan-Romero, Juan María, Caleiras, Eduardo, Montero-Conde, Cristina, Cascón, Alberto, Climent, Miguel Angel, Anguera, Georgia, Hernando, Susana, Laínez, Nuria, Robledo, Mercedes, Robles, Luis, de Velasco, Guillermo, García-Donas, Jesús, Rodriguez-Antona, Cristina

Volltext

NGFR regulates stromal cell activation in germinal centers von Hernández-Barranco, Alberto, Santos, Vanesa, Mazariegos, Marina S., Caleiras, Eduardo, Nogués, Laura, Mourcin, Frédéric, Léonard, Simon, Oblet, Christelle, Genebrier, Steve, Rossille, Delphine, Benguría, Alberto, Sanz, Alba, Vázquez, Enrique, Dopazo, Ana, Efeyan, Alejo, Ortega-Molina, Ana, Cogne, Michel, Tarte, Karin, Peinado, Héctor

Volltext

miR-203 drives breast cancer cell differentiation von Martínez-Illescas, Nuria G, Leal, Silvia, González, Patricia, Graña-Castro, Osvaldo, Muñoz-Oliveira, Juan José, Cortés-Peña, Alfonso, Gómez-Gil, María, Vega, Zaira, Neva, Verónica, Romero, Andrea, Quintela-Fandino, Miguel, Ciruelos, Eva, Sanz, Consuelo, Aragón, Sofía, Sotolongo, Leisy, Jiménez, Sara, Caleiras, Eduardo, Mulero, Francisca, Sánchez, Cristina, Malumbres, Marcos, Salazar-Roa, María

Volltext

Inhibition of Rag GTPase signaling in mice suppresses B cell responses and lymphomagenesis with minimal detrimental trade-offs von Ortega-Molina, Ana, Lebrero-Fernández, Cristina, Sanz, Alba, Deleyto-Seldas, Nerea, Plata-Gómez, Ana Belén, Menéndez, Camino, Graña-Castro, Osvaldo, Caleiras, Eduardo, Efeyan, Alejo

Volltext

High-mobility group box (TOX) antibody a useful tool for the identification of B and T cell subpopulations von Maestre, Lorena, García-García, Juan Fernando, Jiménez, Scherezade, Reyes-García, Ana Isabel, García-González, Álvaro, Montes-Moreno, Santiago, Arribas, Alberto J, González-García, Patricia, Caleiras, Eduardo, Banham, Alison H, Piris, Miguel Ángel, Roncador, Giovanna

Volltext

Genetic deletion of HVEM in a leukemia B cell line promotes a preferential increase of PD-1 - stem cell-like T cells over PD-1 + T cells curbing tumor progression von Del Rio, Maria-Luisa, de Juan, Carla Yago-Diez, Roncador, Giovanna, Caleiras, Eduardo, Álvarez-Esteban, Ramón, Pérez-Simón, José Antonio, Rodriguez-Barbosa, Jose-Ignacio

Volltext

Ly9 (CD229) Antibody Targeting Depletes Marginal Zone and Germinal Center B Cells in Lymphoid Tissues and Reduces Salivary Gland Inflammation in a Mouse Model of Sjögren's Syndrome... von Puñet-Ortiz, Joan, Sáez Moya, Manuel, Cuenca, Marta, Caleiras, Eduardo, Lazaro, Adriana, Engel, Pablo

Volltext

S179: HNRNPK OVEREXPRESSION DRIVES NUCLEOLAR ABERRANCIES CAUSING RIBOSOMPATHIES von Garrido, Pedro Aguilar, Estevez, Maria Velasco, Ángel Navarro Aguadero, Miguel, Hernández Sánchez, María, Malaney, Prerna, Hornbaker, Marisa, Zhang, Xiaorui, Ibañez Navarro, Marta, Ortiz‐Ruiz, Alejandra, Otero‐Sobrino, Álvaro, Megías, Diego, Pérez, Manuel, Gómez, Jesús, Mata, Gadea, Dominguez, Orlando, Grana, Osvaldo, Caleiras, Eduardo, Isasa, Marta, Andrés, Paloma Jimena, Rodriguez, Sandra, Torres, Raúl, Sirozh, Oleksandra, Lafarga, Vanesa, Martínez‐Lopez, Joaquín, Post, Sean, Gallardo, Miguel

Volltext

RAF1 kinase activity is dispensable for KRAS/p53 mutant lung tumor progression von Sanclemente, Manuel, Nieto, Patricia, Garcia-Alonso, Sara, Fernández-García, Fernando, Esteban-Burgos, Laura, Guerra, Carmen, Drosten, Matthias, Caleiras, Eduardo, Martinez-Torrecuadrada, Jorge, Santamaría, David, Musteanu, Monica, Barbacid, Mariano

Volltext

Distribution of PD-L1, TROP2 and HER2- “lowness” in early triple-negative breast cancer: an opportunity for treatment de-escalation von Bueno, Maria Jose, Mouron, Silvana, Caleiras, Eduardo, Martínez, Mario, Manso, Luis, Colomer, Ramón, Quintela-Fandino, Miguel

Volltext

Genetic interaction between PLK1 and downstream MCPH proteins in the control of centrosome asymmetry and cell fate during neural progenitor division von González-Martínez, José, Cwetsch, Andrzej W., Gilabert-Juan, Javier, Gómez, Jesús, Garaulet, Guillermo, Schneider, Paulina, de Cárcer, Guillermo, Mulero, Francisca, Caleiras, Eduardo, Megías, Diego, Porlan, Eva, Malumbres, Marcos

Volltext

KRAS4A induces metastatic lung adenocarcinomas in vivo in the absence of the KRAS4B isoform von Salmón, Marina, Paniagua, Guillem, Lechuga, Carmen G., Fernández-García, Fernando, Zarzuela, Eduardo, Álvarez-Díaz, Ruth, Musteanu, Monica, Guerra, Carmen, Caleiras, Eduardo, Muñoz, Javier, Ortega, Sagrario, Drosten, Matthias, Barbacid, Mariano

Volltext

Abstract OT2-20-01: Rogaratinib, palbociclib and fulvestrant in advanced hormone receptor-positive (HR+), FGFR1/2-positive breast cancer: Phase I trial plus an expansion cohort von Pernas, Sonia, Hernando, Cristina, Bermejo, Begoña, Martinez-Jañez, Noelia, Saenz, Jose A García, Morales, Serafin, Manso, Luis, Silva, Jorge, Guerra, Juan A, Malon, Diego, Mouron, Silvana, Caleiras, Eduardo, Quintela-Fandino, Miguel

Volltext

Abstract OT2-19-08: Phase IB/II trial of palbociclib and binimetinib in advanced triple-negative breast cancer with hyperactivation of ERK and/or CDK4/6 von Manso, Luis, Cortes, Alfonso, Cejalvo, Juan M, Morales, Serafin, Saenz, Jose A García, Colomer, Ramon, Sanchez-Bayona, Rodrigo, Silva, Jorge, Guerra, Juan A, Malon, Diego, Mouron, Silvana, Caleiras, Eduardo, Quintela-Fandino, Miguel

Volltext