Current directions in tau research: Highlights from Tau 2020 von Sexton, Claire, Snyder, Heather, Beher, Dirk, Boxer, Adam L., Brannelly, Pat, Brion, Jean‐Pierre, Buée, Luc, Cacace, Angela M., Chételat, Gaël, Citron, Martin, DeVos, Sarah L., Diaz, Kristophe, Feldman, Howard H., Frost, Bess, Goate, Alison M., Gold, Michael, Hyman, Bradley, Johnson, Keith, Karch, Celeste M., Kerwin, Diana R., Koroshetz, Walter J., Litvan, Irene, Morris, Huw R., Mummery, Catherine J., Mutamba, James, Patterson, Marc C., Quiroz, Yakeel T., Rabinovici, Gil D., Rommel, Amy, Shulman, Melanie B., Toledo‐Sherman, Leticia M., Weninger, Stacie, Wildsmith, Kristin R., Worley, Susan L., Carrillo, Maria C.

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Tau overexpression impacts a neuroinflammation gene expression network perturbed in Alzheimer's disease von Wes, Paul D, Easton, Amy, Corradi, John, Barten, Donna M, Devidze, Nino, DeCarr, Lynn B, Truong, Amy, He, Aiqing, Barrezueta, Nestor X, Polson, Craig, Bourin, Clotilde, Flynn, Marianne E, Keenan, Stefanie, Lidge, Regina, Meredith, Jere, Natale, Joanne, Sankaranarayanan, Sethu, Cadelina, Greg W, Albright, Charlie F, Cacace, Angela M

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The NMDA receptor co-agonists, d -serine and glycine, regulate neuronal dendritic architecture in the somatosensory cortex von Balu, Darrick T, Basu, Alo C, Corradi, John P, Cacace, Angela M, Coyle, Joseph T

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Identification and characterization of a MAPT-targeting locked nucleic acid antisense oligonucleotide therapeutic for tauopathies von Easton, Amy, Jensen, Marianne L., Wang, Congwei, Hagedorn, Peter H., Li, Yuwen, Weed, Michael, Meredith, Jere E., Guss, Valerie, Jones, Kelli, Gill, Martin, Krause, Carol, Brown, Jeffrey M., Hunihan, Lisa, Natale, Joanne, Fernandes, Alda, Lu, Yifeng, Polino, Joe, Bookbinder, Mark, Cadelina, Greg, Benitex, Yulia, Sane, Ramola, Morrison, John, Drexler, Dieter, Mercer, Stephen E., Bon, Charlotte, Pandya, Nikhil J., Jagasia, Ravi, Ou Yang, Tai-Hsien, Distler, Tania, Grüninger, Fiona, Meldgaard, Michael, Terrigno, Marco, Macor, John E., Albright, Charles F., Loy, James, Hoeg, Anja M., Olson, Richard E., Cacace, Angela M.

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New therapies on the horizon: Targeted protein degradation in neuroscience von Gregory, James A., Hickey, Christopher M., Chavez, Juan, Cacace, Angela M.

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p38α Regulates Expression of DUX4 in a Model of Facioscapulohumeral Muscular Dystrophy von Rojas, L. Alejandro, Valentine, Erin, Accorsi, Anthony, Maglio, Joseph, Shen, Ning, Robertson, Alan, Kazmirski, Steven, Rahl, Peter, Tawil, Rabi, Cadavid, Diego, Thompson, Lorin A., Ronco, Lucienne, Chang, Aaron N., Cacace, Angela M., Wallace, Owen

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Acute Neurotoxicity of Antisense Oligonucleotides After Intracerebroventricular Injection Into Mouse Brain Can Be Predicted from Sequence Features von Hagedorn, Peter H, Brown, Jeffrey M, Easton, Amy, Pierdomenico, Maria, Jones, Kelli, Olson, Richard E, Mercer, Stephen E, Li, Dong, Loy, James, Høg, Anja M, Jensen, Marianne L, Gill, Martin, Cacace, Angela M

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Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules von Hickey, Christopher M., Digianantonio, Katherine M., Zimmermann, Kurt, Harbin, Alicia, Quinn, Connor, Patel, Avani, Gareiss, Peter, Chapman, Amanda, Tiberi, Bernadette, Dobrodziej, Jennifer, Corradi, John, Cacace, Angela M., Langley, David R., Békés, Miklós

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Targeted Protein Degradation: Methods and Protocols von Cacace, Angela M, Hickey, Christopher M, Bekes, Miklos

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Neuronal calcineurin transcriptional targets parallel changes observed in Alzheimer disease brain von Hopp, Sarah C., Bihlmeyer, Nathan A., Corradi, John P., Vanderburg, Charles, Cacace, Angela M., Das, Sudeshna, Clark, Timothy W., Betensky, Rebecca A., Hyman, Bradley T., Hudry, Eloise

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Discovery of D1 Dopamine Receptor Positive Allosteric Modulators: Characterization of Pharmacology and Identification of Residues that Regulate Species Selectivity von Lewis, Martin A, Hunihan, Lisa, Watson, John, Gentles, Robert G, Hu, Shuanghua, Huang, Yazhong, Bronson, Joanne, Macor, John E, Beno, Brett R, Ferrante, Meredith, Hendricson, Adam, Knox, Ronald J, Molski, Thaddeus F, Kong, Yan, Cvijic, Mary Ellen, Rockwell, Kristin L, Weed, Michael R, Cacace, Angela M, Westphal, Ryan S, Alt, Andrew, Brown, Jeffrey M

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Mechanistic and Structural Features of PROTAC Ternary Complexes von Casement, Ryan, Bond, Adam, Craigon, Conner, Ciulli, Alessio

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Distinctive transcriptome alterations of prefrontal pyramidal neurons in schizophrenia and schizoaffective disorder von Arion, D, Corradi, J P, Tang, S, Datta, D, Boothe, F, He, A, Cacace, A M, Zaczek, R, Albright, C F, Tseng, G, Lewis, D A

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Identification of Constitutive and Ras-Inducible Phosphorylation Sites of KSR: Implications for 14-3-3 Binding, Mitogen-Activated Protein Kinase Binding, and KSR Overexpression von Cacace, Angela M., Michaud, Neil R., Therrien, Marc, Mathes, Karen, Copeland, Terry, Rubin, Gerald M., Morrison, Deborah K.

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The structure of human tau-tubulin kinase 1 both in the apo form and in complex with an inhibitor von Kiefer, Susan E., Chang, ChiehYing J., Kimura, S. Roy, Gao, Mian, Xie, Dianlin, Zhang, Yaqun, Zhang, Guifen, Gill, Martin B., Mastalerz, Harold, Thompson, Lorin A., Cacace, Angela M., Sheriff, Steven

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Evaluating Ligands for Ubiquitin Ligases Using Affinity Beads von Dobrodziej, Jennifer, Dong, Hanqing, Zimmermann, Kurt, Hickey, Christopher M.

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Protein Ligand Interactions Using Surface Plasmon Resonance von O’Connell, Nichole

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Identification of B-KSR1, a Novel Brain-Specific Isoform of KSR1 That Functions in Neuronal Signaling von Müller, Jürgen, Cacace, Angela M., Lyons, W. Ernest, McGill, Carolyn B., Morrison, Deborah K.

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Human neural progenitor cells as an in vitro model system to study mitochondrial dysfunction in Alzheimer's disease von Cacace, Angela M, Wes, Paul, Flynn, Marianne, Kieras, Cathy, Sankaranaryanan, Sethu, Toyn, Jeremy, Poundstone, Patricia, Chen, Lin, Fennell, Myles, Charles, F

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O5‐04‐05: A NEW THERAPEUTIC STRATEGY FOR TAUOPATHIES: DISCOVERY OF HIGHLY POTENT BRAIN PENETRANT PROTAC TM DEGRADER MOLECULES THAT TARGET PATHOLOGIC TAU PROTEIN SPECIES von Cacace, Angela M., Chandler, J., Flanagan, J.J., Berlin, M., Cadelina, G., Pizzano, J., Bookbinder, M., Crews, C.M., Crew, A.P., Taylor, I., Houston, J.

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