Targeted resequencing analysis of 31 genes commonly mutated in myeloid disorders in serial samples from myelodysplastic syndrome patients showing disease progression von Pellagatti, A, Roy, S, Di Genua, C, Burns, A, McGraw, K, Valletta, S, Larrayoz, M J, Fernandez-Mercado, M, Mason, J, Killick, S, Mecucci, C, Calasanz, M J, List, A, Schuh, A, Boultwood, J

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NUP98-fusion transcripts characterize different biological entities within acute myeloid leukemia: a report from the AIEOP-AML group von Bisio, V, Zampini, M, Tregnago, C, Manara, E, Salsi, V, Di Meglio, A, Masetti, R, Togni, M, Di Giacomo, D, Minuzzo, S, Leszl, A, Zappavigna, V, Rondelli, R, Mecucci, C, Pession, A, Locatelli, F, Basso, G, Pigazzi, M

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Blastic plasmacytoid dendritic cell neoplasm and chronic myelomonocytic leukemia: a shared clonal origin von Brunetti, L, Di Battista, V, Venanzi, A, Schiavoni, G, Martelli, M P, Ascani, S, Mecucci, C, Tiacci, E, Falini, B

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Translocations and mutations involving the nucleophosmin (NPM1) gene in lymphomas and leukemias von Falini, Brunangelo, Nicoletti, Ildo, Bolli, Niccolo, Martelli, Maria Paola, Liso, Arcangelo, Gorello, Paolo, Mandelli, Franco, Mecucci, Cristina, Martelli, Massimo Fabrizio

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Quantitative assessment of minimal residual disease in acute myeloid leukemia carrying nucleophosmin (NPM1) gene mutations von GORELLO, P, CAZZANIGA, G, LO COCO, F, BIONDI, A, SAGLIO, G, MECUCCI, C, FALINI, B, ALBERTI, F, DELL'ORO, M. G, GOTTARDI, E, SPECCHIA, G, ROTI, G, ROSATI, R, MARTELLI, M. F, DIVERIO, D

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Molecular analysis of Fanconi anemia: the experience of the Bone Marrow Failure Study Group of the Italian Association of Pediatric Onco-Hematology von De Rocco, Daniela, Bottega, Roberta, Cappelli, Enrico, Cavani, Simona, Criscuolo, Maria, Nicchia, Elena, Corsolini, Fabio, Greco, Chiara, Borriello, Adriana, Svahn, Johanna, Pillon, Marta, Mecucci, Cristina, Casazza, Gabriella, Verzegnassi, Federico, Cugno, Chiara, Locasciulli, Anna, Farruggia, Piero, Longoni, Daniela, Ramenghi, Ugo, Barberi, Walter, Tucci, Fabio, Perrotta, Silverio, Grammatico, Paola, Hanenberg, Helmut, Della Ragione, Fulvio, Dufour, Carlo, Savoia, Anna

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CALM/AF10-positive leukemias show upregulation of genes involved in chromatin assembly and DNA repair processes and of genes adjacent to the breakpoint at 10p12 von Mulaw, M A, Krause, A J, Deshpande, A J, Krause, L F, Rouhi, A, La Starza, R, Borkhardt, A, Buske, C, Mecucci, C, Ludwig, W-D, Lottaz, C, Bohlander, S K

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A novel germline mutation in CDK4 codon 24 associated to familial melanoma von Bottillo, I., La Starza, R., Radio, F. C., Molica, C., Pedace, L., Pierini, T., De Bernardo, C., Stingeni, L., Bargiacchi, S., Paiardini, A., Janson, G., Mecucci, C., Grammatico, P.

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Simultaneous detection of NPM1 and FLT3-ITD mutations by capillary electrophoresis in acute myeloid leukemia von NOGUERA, N. I, AMMATUNA, E, ZANGRILLI, D, LAVORGNA, S, DIVONA, M, BUCCISANO, F, AMADORI, S, MECUCCI, C, FALINI, B, LO-COCO, F

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C-kit mutations in core binding factor leukemias von Beghini, A, Peterlongo, P, Ripamonti, C B, Larizza, L, Cairoli, R, Morra, E, Mecucci, C

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Role of BCL2L10 methylation and TET2 mutations in higher risk myelodysplastic syndromes treated with 5-Azacytidine von Voso, M T, Fabiani, E, Piciocchi, A, Matteucci, C, Brandimarte, L, Finelli, C, Pogliani, E, Angelucci, E, Fioritoni, G, Musto, P, Greco, M, Criscuolo, M, Fianchi, L, Vignetti, M, Santini, V, Hohaus, S, Mecucci, C, Leone, G

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P739: THE EPI‐GENOMIC LANDSCAPE OF MONOSOMY 7 IN ADULT MDS/AML von Lema Fernandez, A. G., Nardelli, C., Di Battista, V., Quintini, M., Pellanera, F., Matteucci, C., Pierini, V., Crescenzi, B., Moretti, M., Bardelli, V., Gorello, P., Mecucci, C.

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P307: DEL(17)(Q11) IS TYPICAL MARKER OF IMMATURE T‐ALL OF ADULTS, WITH NF1, UTP6, AND SUZ12 HAPLOINSUFFICIENCY, GENOME INSTABILITY, AND GENE DOWNREGULATION von Bardelli, V., Pierini, V., Arniani, S., Mvridou, E., Matteucci, C., Lema Fernandez, A. G., Moretti, M., Elia, L., Giglio, F., Forghieri, F., Cerrano, M., Fracchiolla, N., Delia, M., Sica, S., Mecucci, C., La Starza, R.

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186 AZACITIDINE IS EFFICACIOUS IN CHRONIC MYELOMONOCYTIC LEUKEMIA INVOLVING SKIN AND MUCOSA von Di Battista, V, Matteucci, C, Quintini, M, Ballanti, S, Falini, B, Mecucci, C

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P574: CPX‐351 COMBINED WITH HEMATOPOIETIC CELL TRANSPLANTATION WITH REGULATORY AND CONVENTIONAL T CELL IMMUNOTHERAPY FOR HIGH‐RISK ACUTE MYELOID LEUKEMIA von Sciabolacci, S., Ruggeri, L., Cardinali, V., Brunetti, L., Tricarico, S., Saldi, S., Marzuttini, F., Griselli, M., Perta, G., Viglione, V., Cimino, G., Osmani, A., Caridi, M., Sembenico, R., Terenzi, A., Zei, T., Iacucci Ostini, R., Martelli, M. F., Falini, B., Velardi, A., Aristei, C., Mecucci, C., Carotti, A., Martelli, M. P., Pierini, A.

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P1000: INCREASED PLASMA LEVELS OF LNCRNAS ARE POTENTIAL PROGNOSTIC BIOMARKERS IN MYELOFIBROSIS von Sartini, S., Fantini, S., Rontauroli, S., Mirabile, M., Bianchi, E., Badii, F., Maccaferri, M., Guglielmelli, P., Ottone, T., Palmieri, R., Genovese, E., Carretta, C., Parenti, S., Mallia, S., Tavernari, L., Salvadori, C., Gesullo, F., Maccari, C., Zizza, M., Grande, A., Salmoiraghi, S., Mora, B., Potenza, L., Rosti, V., Passamonti, F., Rambaldi, A., Voso, M. T., Mecucci, C., Tagliafico, E., Luppi, M., Vannucchi, A. M., Manfredini, R.

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Activation of the mTOR signaling pathway by L-leucine in 5q- syndrome and other RPS14-deficient erythroblasts von Yip, B H, Vuppusetty, C, Attwood, M, Giagounidis, A, Germing, U, Lamikanra, A A, Roberts, D J, Maciejewski, J P, Vandenberghe, P, Mecucci, C, Wainscoat, J S, Pellagatti, A, Boultwood, J

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52 TARGETED RE-SEQUENCING ANALYSIS OF 31 GENES COMMONLY MUTATED IN MYELOID DISORDERS IN SERIAL SAMPLES FROM MYELODYSPLASTIC SYNDROME PATIENTS WITH DISEASE PROGRESSION von Pellagatti, A, Roy, S, Di Genua, C, Burns, A, McGraw, K, Larrayoz, M.J, Fernandez-Mercado, M, Valletta, S, Mason, J, Killick, S, Mecucci, C, Calasanz, M.J, List, A, Schuh, A, Boultwood, J

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Targeted sequencing identifies associations between IL7R-JAK mutations and epigenetic modulators in T-cell acute lymphoblastic leukemia von Vicente, Carmen, Schwab, Claire, Broux, Michaël, Geerdens, Ellen, Degryse, Sandrine, Demeyer, Sofie, Lahortiga, Idoya, Elliott, Alannah, Chilton, Lucy, La Starza, Roberta, Mecucci, Cristina, Vandenberghe, Peter, Goulden, Nicholas, Vora, Ajay, Moorman, Anthony V, Soulier, Jean, Harrison, Christine J, Clappier, Emmanuelle, Cools, Jan

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CALM/AF10-positive leukemias show upregulation of genes involved in chromatin assembly and DNA repair processes and of genes adjacent to the breakpoint at 10p12 von Mulaw, M.A, Krause, A, Deshpande, A.J, Krause, L.F, Rouhi, A, La Starza, R, Borkhardt, A, Buske, C, Mecucci, C, Ludwig, W.-D, Lottaz, C, Bohlander, S.K

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