HIV-1 Integrase Pharmacophore:  Discovery of Inhibitors through Three-Dimensional Database Searching von Nicklaus, Marc C, Neamati, Nouri, Hong, Huixiao, Mazumder, Abhijit, Sunder, Sanjay, Chen, Julie, Milne, George W. A, Pommier, Yves

Volltext

Discovery of HIV-1 Integrase Inhibitors by Pharmacophore Searching von Hong, Huixiao, Neamati, Nouri, Wang, Shaomeng, Nicklaus, Marc C, Mazumder, Abhijit, Zhao, He, Burke, Terrence R, Pommier, Yves, Milne, George W. A

Volltext

Discovery of Novel, Non-Peptide HIV-1 Protease Inhibitors by Pharmacophore Searching von Wang, Shaomeng, Milne, G. W. A, Yan, Xinjian, Posey, Isadora J, Nicklaus, Marc C, Graham, Lisa, Rice, William G

Volltext

Experimental and Structural Evidence that Herpes 1 Kinase and Cellular DNA Polymerase(s) Discriminate on the Basis of Sugar Pucker von Marquez, Victor E, Ben-Kasus, Tsipi, Barchi, Joseph J, Green, Karen M, Nicklaus, Marc C, Agbaria, Riad

Volltext

Depsides and Depsidones as Inhibitors of HIV-1 Integrase:  Discovery of Novel Inhibitors through 3D Database Searching von Neamati, Nouri, Hong, Huixiao, Mazumder, Abhijit, Wang, Shaomeng, Sunder, Sanjay, Nicklaus, Marc C, Milne, George W. A, Proksa, Bohumil, Pommier, Yves

Volltext

Conformationally Locked Nucleoside Analogs. Synthesis of Dideoxycarbocyclic Nucleoside Analogs Structurally Related to Neplanocin C von Rodriguez, Juan B, Marquez, Victor E, Nicklaus, Marc C, Mitsuya, Hiroaki, Barchi, Joseph J

Volltext

An Optimized Protein Kinase C Activating Diacylglycerol Combining High Binding Affinity (K i) with Reduced Lipophilicity (log P) von Nacro, Kassoum, Sigano, Dina M, Yan, Shunqi, Nicklaus, Marc C, Pearce, Larry L, Lewin, Nancy E, Garfield, Susan H, Blumberg, Peter M, Marquez, Victor E

Volltext

Interactions of Conformationally Biased North and South 2‘-Fluoro-2‘,3‘-dideoxynucleoside 5‘-Triphosphates with the Active Site of HIV-1 Reverse Transcriptase von Mu, Lan, Sarafianos, Stefan G, Nicklaus, Marc C, Russ, Pamela, Siddiqui, Maqbool A, Ford, Harry, Mitsuya, Hiroaki, Le, Richard, Kodama, Eiichi, Meier, Chris, Knispel, Tina, Anderson, Lynne, Barchi, Joseph J, Marquez, Victor E

Volltext

Conformationally Constrained Analogues of Diacylglycerol. 18. The Incorporation of a Hydroxamate Moiety into Diacylglycerol-Lactones Reduces Lipophilicity and Helps Discriminate be... von Lee, Jeewoo, Han, Kee-Chung, Kang, Ji-Hye, Pearce, Larry L, Lewin, Nancy E, Yan, Shunqi, Benzaria, Samira, Nicklaus, Marc C, Blumberg, Peter M, Marquez, Victor E

Volltext

Metal-Dependent Inhibition of HIV-1 Integrase von Neamati, Nouri, Lin, Zhaiwei, Karki, Rajeshri G, Orr, Ann, Cowansage, Kiriana, Strumberg, Dirk, Pais, Godwin C. G, Voigt, Johannes H, Nicklaus, Marc C, Winslow, Heather E, Zhao, He, Turpin, Jim A, Yi, Jizu, Skalka, Anna Marie, Burke, Terrence R, Pommier, Yves

Volltext

Comparison of the NCI Open Database with Seven Large Chemical Structural Databases von Voigt, Johannes H, Bienfait, Bruno, Wang, Shaomeng, Nicklaus, Marc C

Volltext

Adenosine Deaminase Prefers a Distinct Sugar Ring Conformation for Binding and Catalysis:  Kinetic and Structural Studies von Ford, Harry, Dai, Fang, Mu, Lan, Siddiqui, Maqbool A, Nicklaus, Marc C, Anderson, Lynne, Marquez, Victor E, Barchi, Joseph J

Volltext

Conformational changes of small molecules binding to proteins von Nicklaus, Marc C., Wang, Shaomeng, Driscoll, John S., Milne, George W.A.

Volltext

Pharmacophores in Drug Design and Discovery von Milne, G. W. A., Nicklaus, M. C., Wang, S.

Volltext

Design and Synthesis of Conformationally Constrained Grb2 SH2 Domain Binding Peptides Employing α-Methylphenylalanyl Based Phosphotyrosyl Mimetics von Oishi, Shinya, Karki, Rajeshri G, Kang, Sang-Uk, Wang, Xiangzhu, Worthy, Karen M, Bindu, Lakshman K, Nicklaus, Marc C, Fisher, Robert J, Burke, Terrence R

Volltext

Protein Kinase C. Modeling of the Binding Site and Prediction of Binding Constants von Wang, Shaomeng, Milne, George W. A, Nicklaus, Marc C, Marquez, Victor E, Lee, Jeewoo, Blumberg, Peter M

Volltext

Use of Oligodeoxyribonucleotides with Conformationally Constrained Abasic Sugar Targets To Probe the Mechanism of Base Flipping by HhaI DNA (Cytosine C5)-methyltransferase von Wang, Peiyuan, Brank, Adam S, Banavali, Nilesh K, Nicklaus, Marc C, Marquez, Victor E, Christman, Judith K, MacKerell, Alexander D

Volltext

Identification of HIV-1 integrase inhibitors via three-dimensional database searching using ASV and HIV-1 integrases as targets von Chen, I-Jen, Neamati, Nouri, Nicklaus, Marc C., Orr, Ann, Anderson, Lynne, Barchi, Joseph J., Kelley, James A., Pommier, Yves, MacKerell, Alexander D.

Volltext

Importance of the Fourth Alpha-Helix within the CAP Homology Domain of Type II Topoisomerase for DNA Cleavage Site Recognition and Quinolone Action von Strumberg, Dirk, Nitiss, John L, Dong, Jiaowang, Walker, Jerrylaine, Nicklaus, Marc C, Kohn, Kurt W, Heddle, Jonathan G, Maxwell, Anthony, Seeber, Siegfried, Pommier, Yves

Volltext

Mutation of a Conserved Serine Residue in a Quinolone-resistant Type II Topoisomerase Alters the Enzyme-DNA and Drug Interactions von Strumberg, Dirk, Nitiss, John L., Rose, Angela, Nicklaus, Marc C., Pommier, Yves

Volltext