Genomic profile of advanced breast cancer in circulating tumour DNA von Kingston, Belinda, Cutts, Rosalind J., Bye, Hannah, Beaney, Matthew, Walsh-Crestani, Giselle, Hrebien, Sarah, Swift, Claire, Kilburn, Lucy S., Kernaghan, Sarah, Moretti, Laura, Wilkinson, Katie, Wardley, Andrew M., Macpherson, Iain R., Baird, Richard D., Roylance, Rebecca, Reis-Filho, Jorge S., Hubank, Michael, Faull, Iris, Banks, Kimberly C., Lanman, Richard B., Garcia-Murillas, Isaac, Bliss, Judith M., Ring, Alistair, Turner, Nicholas C.

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Inactivating NF1 Mutations Are Enriched in Advanced Breast Cancer and Contribute to Endocrine Therapy Resistance von Pearson, Alex, Proszek, Paula, Pascual, Javier, Fribbens, Charlotte, Shamsher, Monee K, Kingston, Belinda, O'Leary, Ben, Herrera-Abreu, Maria T, Cutts, Rosalind J, Garcia-Murillas, Isaac, Bye, Hannah, Walker, Brian A, Gonzalez De Castro, David, Yuan, Lina, Jamal, Sabri, Hubank, Mike, Lopez-Knowles, Elena, Schuster, Eugene F, Dowsett, Mitch, Osin, Peter, Nerurkar, Ashutosh, Parton, Marina, Okines, Alicia F C, Johnston, Stephen R D, Ring, Alistair, Turner, Nicholas C

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MicroRNA-223 controls the expression of histone deacetylase 2: a novel axis in COPD von Leuenberger, Caroline, Schuoler, Claudio, Bye, Hannah, Mignan, Célia, Rechsteiner, Thomas, Hillinger, Sven, Opitz, Isabelle, Marsland, Benjamin, Faiz, Alen, Hiemstra, Pieter S., Timens, Wim, Camici, Giovanni G., Kohler, Malcolm, Huber, Lars C., Brock, Matthias

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The pathogenesis of pulmonary hypertension--an update von Huber, Lars C, Bye, Hannah, Brock, Matthias

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Pooled sequencing of 531 genes in inflammatory bowel disease identifies an associated rare variant in BTNL2 and implicates other immune related genes von Prescott, Natalie J, Lehne, Benjamin, Stone, Kristina, Lee, James C, Taylor, Kirstin, Knight, Jo, Papouli, Efterpi, Mirza, Muddassar M, Simpson, Michael A, Spain, Sarah L, Lu, Grace, Fraternali, Franca, Bumpstead, Suzannah J, Gray, Emma, Amar, Ariella, Bye, Hannah, Green, Peter, Chung-Faye, Guy, Hayee, Bu'Hussain, Pollok, Richard, Satsangi, Jack, Parkes, Miles, Barrett, Jeffrey C, Mansfield, John C, Sanderson, Jeremy, Lewis, Cathryn M, Weale, Michael E, Schlitt, Thomas, Mathew, Christopher G

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Author Correction: Genomic profile of advanced breast cancer in circulating tumor DNA von Kingston, Belinda, Cutts, Rosalind J., Bye, Hannah, Beaney, Matthew, Walsh-Crestani, Giselle, Hrebien, Sarah, Swift, Claire, Kilburn, Lucy S., Kernaghan, Sarah, Moretti, Laura, Wilkinson, Katie, Wardley, Andrew M., Macpherson, Iain R., Baird, Richard D., Roylance, Rebecca, Reis-Filho, Jorge S., Hubank, Michael, Faull, Iris, Banks, Kimberly C., Lanman, Richard B., Garcia-Murillas, Isaac, Bliss, Judith M., Ring, Alistair, Turner, Nicholas C.

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Differential and longitudinal immune gene patterns associated with reprogrammed microenvironment and viral mimicry in response to neoadjuvant radiotherapy in rectal cancer von Wilkins, Anna, Fontana, Elisa, Nyamundanda, Gift, Ragulan, Chanthirika, Patil, Yatish, Mansfield, David, Kingston, Jennifer, Errington-Mais, Fiona, Bottomley, Daniel, von Loga, Katharina, Bye, Hannah, Carter, Paul, Tinkler-Hundal, Emma, Noshirwani, Arish, Downs, Jessica, Dillon, Magnus, Demaria, Sandra, Sebag-Montefiore, David, Harrington, Kevin, West, Nick, Melcher, Alan, Sadanandam, Anguraj

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266 Tumour mutation burden (TMB) and efficacy outcomes in the phase III DANUBE study of advanced urothelial carcinoma (UC) von Wildsmith, Sophie, Walker, Jill, L’Hernault, Anne, Li, Weimin, Bye, Hannah, He, Philip, Xiao, Feng, Zhang, Qu, Stewart, Ross, Reyes, Melissa de los, Raja, Rajiv, Levin, Wendy, Gupta, Ashok, Powles, Thomas, Bellmunt, Joaquim, Galsky, Matthew, Drakaki, Alexandra, Heijden, Michiel van der

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Circulating tumour DNA analysis to direct therapy in advanced breast cancer (plasmaMATCH): a multicentre, multicohort, phase 2a, platform trial von Turner, Nicholas C, Kingston, Belinda, Kilburn, Lucy S, Kernaghan, Sarah, Wardley, Andrew M, Macpherson, Iain R, Baird, Richard D, Roylance, Rebecca, Stephens, Peter, Oikonomidou, Olga, Braybrooke, Jeremy P, Tuthill, Mark, Abraham, Jacinta, Winter, Matthew C, Bye, Hannah, Hubank, Michael, Gevensleben, Heidrun, Cutts, Ros, Snowdon, Claire, Rea, Daniel, Cameron, David, Shaaban, Abeer, Randle, Katrina, Martin, Sue, Wilkinson, Katie, Moretti, Laura, Bliss, Judith M, Ring, Alistair

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Mutation detection in saliva from oral cancer patients von Ahmed, Ahmed A., Sborchia, Mateja, Bye, Hannah, Roman-Escorza, Maria, Amar, Ariella, Henley-Smith, Rhonda, Odell, Edward, McGurk, Mark, Simpson, Michael, Ng, Tony, Sawyer, Elinor J., Mathew, Christopher G.

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Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism von Reynolds, John J, Bicknell, Louise S, Carroll, Paula, Higgs, Martin R, Shaheen, Ranad, Murray, Jennie E, Papadopoulos, Dimitrios K, Leitch, Andrea, Murina, Olga, Tarnauskaitė, Žygimantė, Wessel, Sarah R, Zlatanou, Anastasia, Vernet, Audrey, von Kriegsheim, Alex, Mottram, Rachel M A, Logan, Clare V, Bye, Hannah, Li, Yun, Brean, Alexander, Maddirevula, Sateesh, Challis, Rachel C, Skouloudaki, Kassiani, Almoisheer, Agaadir, Alsaif, Hessa S, Amar, Ariella, Prescott, Natalie J, Bober, Michael B, Duker, Angela, Faqeih, Eissa, Seidahmed, Mohammed Zain, Al Tala, Saeed, Alswaid, Abdulrahman, Ahmed, Saleem, Al-Aama, Jumana Yousuf, Altmüller, Janine, Al Balwi, Mohammed, Brady, Angela F, Chessa, Luciana, Cox, Helen, Fischetto, Rita, Heller, Raoul, Henderson, Bertram D, Hobson, Emma, Nürnberg, Peter, Percin, E Ferda, Peron, Angela, Spaccini, Luigina, Quigley, Alan J, Thakur, Seema, Wise, Carol A, Yoon, Grace, Alnemer, Maha, Tomancak, Pavel, Yigit, Gökhan, Taylor, A Malcolm R, Reijns, Martin A M, Simpson, Michael A, Cortez, David, Alkuraya, Fowzan S, Mathew, Christopher G, Jackson, Andrew P, Stewart, Grant S

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Abstract GS3-07: The genomic landscape of breast cancer based on ctDNA analysis: Data from the plasmaMATCH trial von Kingston, Belinda, Bye, Hannah, Hubank, Michael, Walsh, Giselle, Swift, Claire, Beaney, Matthew, Kilburn, Lucy, Kernaghan, Sarah, Wardley, Andrew M, Macpherson, Iain, Baird, Richard D, Roylance, Rebecca, Wilkinson, Katie, Garcia-Murillas, Isaac, Bliss, Judith M, Turner, Nicholas, Ring, Alistair

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Abstract 237: The genetic architecture of African esophageal cancer von Mathew, Christopher G., Chen, Wenlong C., Bye, Hannah, Prescott, Natalie J., Matejcic, Marco, Kerr, Robyn, Singh, Elvira, Lewis, Cathryn M., Villiers, Chantal Babb de, Parker, Mohamed I.

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Association of genetic variants in CHEK2 with oesophageal squamous cell carcinoma in the South African Black population von Chen, Wenlong C, Bye, Hannah, Matejcic, Marco, Amar, Ariella, Govender, Dhiren, Khew, Yee Wen, Beynon, Victoria, Kerr, Robyn, Singh, Elvira, Prescott, Natalie J, Lewis, Cathryn M, Babb de Villiers, Chantal, Parker, M Iqbal, Mathew, Christopher G

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Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA von Abbosh, Christopher, Frankell, Alexander, Harrison, Thomas, Kisistok, Judit, Garnett, Aaron, Johnson, Laura, Veeriah, Selvaraju, Moreau, Mike, Chesh, Adrian, Chaunzwa, Tafadzwa, Weiss, Jakob, Schroeder, Morgan, Ward, Sophia, Grigoriadis, Kristiana, Shahpurwalla, Aamir, Litchfield, Kevin, Puttick, Clare, Biswas, Dhruva, Karasaki, Takahiro, Black, James R.M, Martinez-Ruiz, Carlos, Al Bakir, Maise, Pich, Oriol, Watkins, Thomas B.K, Lim, Emilia, Huebner, Ariana, Moore, David I, Godin-Heymann, Nadia, L'Hernault, Anne, Bye, Hannah, Odell, Aaron G, Roberts, Paula, Gomes, Fabio, Patel, Akshay, Manzano, Elizabeth, Hiley, Crispin, Carey, Nicolas J, Riley, Joan, Cook, Daniel, Hodgson, Darren G, Stetson, Daniel, Barrett, J. Carl, Kortlever, Roderik, Evan, Gerard, Hackshaw, Allan, Daber, Robert, Shaw, Jacqui, Aerts, Hugo J.W.L.J, Licon, Abel, Stahl, Josh, Jamal-Hanjani, Mariam, TRACERx Consortium, Birkbak, Nicolai J, McGranahan, Nicholas, Swanton, Charles

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Abstract A34: The genetic etiology of esophageal cancer in South African Black populations von Chen, Wenlong Carl, Bye, Hannah, Matejcic, Marco, Kerr, Robyn, Singh, Elvira, Prescott, Natalie J., Lewis, Cathryn M., Villers, Chantal Babb de, Parker, Iqbal, Mathew, Christopher G.

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Abstract GS3-06: Results from the plasmaMATCH trial: A multiple parallel cohort, multi-centre clinical trial of circulating tumour DNA testing to direct targeted therapies in patie... von Turner, Nicholas, Kingston, Belinda, Kilburn, Lucy, Kernaghan, Sarah, Wardley, Andrew M, Macpherson, Iain, Baird, Richard D, Roylance, Rebecca, Stephens, Peter, Oikonomidou, Olga, Braybrooke, Jeremy P, Tuthill, Mark, Abraham, Jacinta, Winter, Matthew C, Bye, Hannah, Hubank, Michael, Snowdon, Claire, Rea, Daniel, Cameron, David, Shaaban, Abeer, Randle, Katrina, Wilkinson, Katie, Moretti, Laura, Bliss, Judith M, Ring, Alistair

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PIPA: A phase Ib study of β-isoform sparing phosphatidylinositol 3-kinase (PI3K) inhibitor taselisib (T) plus palbociclib (P) and fulvestrant (FUL) in PIK3CA -mutant (mt) ER-positi... von Pascual, Javier, MacPherson, Iain R., Armstrong, Anne Caroline, Ward, Sarah Emily, Parmar, Mona, Turner, Alison Joanne, Bye, Hannah, Proszek, Paula, Dodson, Andrew, Garcia-Murillas, Isaac, King, Jenny, Hall, Emma, Finneran, Laura, Lopez, Juanita Suzanne, Okines, Alicia Frances Clare, Ring, Alistair E., Turner, Nicholas C.

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PIPA: A phase Ib study of selective ß-isoform sparing phosphatidylinositol 3-kinase (PI3K) inhibitor taselisib (T) plus palbociclib (P) in patients (pts) with advanced solid cancer... von Lopez, Juanita Suzanne, SelviMiralles, Manuel, Ameratunga, Malaka, Minchom, Anna, Pascual, Javier, Banerji, Udai, Bye, Hannah, Raynaud, Florence I., Swales, Karen E, Malia, Jason, Hubank, Michael, Garcia-Murillas, Isaac, Parmar, Mona, Ward, Sarah Emily, Finneran, Laura, Hall, Emma, Turner, Alison Joanne, De Bono, Johann S., Yap, Timothy A, Turner, Nicholas C.

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Population-specific genetic associations with oesophageal squamous cell carcinoma in South Africa von Bye, Hannah, Prescott, Natalie J., Matejcic, Marco, Rose, Elizabeth, Lewis, Cathryn M., Parker, M.Iqbal, Mathew, Christopher G.

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