Zygotic Genome Activation Triggers Chromosome Damage and Checkpoint Signaling in C. elegans Primordial Germ Cells von Butuči, Melina, Williams, Ashley B., Wong, Matthew M., Kramer, Brendan, Michael, W. Matthew

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Mast Cell and Eosinophil Activation Are Associated With COVID-19 and TLR-Mediated Viral Inflammation: Implications for an Anti-Siglec-8 Antibody von Gebremeskel, Simon, Schanin, Julia, Coyle, Krysta M, Butuci, Melina, Luu, Thuy, Brock, Emily C, Xu, Alan, Wong, Alan, Leung, John, Korver, Wouter, Morin, Ryan D, Schleimer, Robert P, Bochner, Bruce S, Youngblood, Bradford A

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A monoclonal antibody to Siglec-8 suppresses non-allergic airway inflammation and inhibits IgE-independent mast cell activation von Schanin, Julia, Gebremeskel, Simon, Korver, Wouter, Falahati, Rustom, Butuci, Melina, Haw, Tatt Jhong, Nair, Prema M., Liu, Gang, Hansbro, Nicole G., Hansbro, Philip M., Evensen, Erik, Brock, Emily C., Xu, Alan, Wong, Alan, Leung, John, Bebbington, Christopher, Tomasevic, Nenad, Youngblood, Bradford A.

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Mast cell activation is associated with post‐acute COVID‐19 syndrome von Wechsler, Joshua B., Butuci, Melina, Wong, Alan, Kamboj, Amol P., Youngblood, Bradford A.

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Trouble in transitioning: activation of zygotic transcription can lead to DNA breakage and genome instability von Butuči, Melina, Wong, Matthew M, Michael, W Matthew

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Mast Cells are Locally Activated and Respond to MRGPRX2 Stimulation in Atopic Dermatitis Ex Vivo Skin Biopsies von Butuci, Melina, Benet, Zachary, Wong, Alan, Schanin, Julia, Xu, Alan, Kamboj, Amol, Youngblood, Brad

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EoE Biopsies have Elevated and Activated Mast Cells that Produce Cytokines and Chemokines that Drive Disease Pathogenesis von Butuci, Melina, Brock, Emily, Schanin, Julia, Rasmussen, Henrik, Singh, Bhupinder, Drake, Richard, Peterson, Kathryn, Youngblood, Brad

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Fr178 ACTIVATED MAST CELLS AND EOSINOPHILS ARE ASSOCIATED WITH INCREASED INFLAMMATORY MEDIATORS IN MUCOSAL BIOPSIES FROM PATIENTS WITH CHRONIC GASTROINTESTINAL SYMPTOMS von Butuci, Melina, Gebremeskel, Simon, Peterson, Kathryn A., Wong, Alan, Schanin, Julia, Rasmussen, Henrik S., Singh, Bhupinder, Kamboj, Amol P., Youngblood, Bradford

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867 EGID BIOPSIES HAVE FUNCTIONALLY DISTINCT AND ACTIVATED MAST CELLS THAT CONTRIBUTE TO DISEASE PATHOGENESIS AND ARE INHIBITED BY AN ANTI-SIGLEC-8 ANTIBODY, ANTOLIMAB (AK002) von Butuci, Melina, Schanin, Julia, Brock, Emily C., Rasmussen, Henrik S., Singh, Bhupinder, Kamboj, Amol P., Drake, Richard, Peterson, Kathryn A., Youngblood, Bradford

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P159 PHENOTYPIC CHARACTERIZATION OF INFLAMMATORY BOWEL DISEASE BIOPSIES REVEAL THAT MAST CELLS ARE SIGNIFICANTLY ELEVATED AND ACTIVATED IN PATIENTS WITH ULCERATIVE COLITIS von Youngblood, Bradford, Davis, Tina, Schanin, Julia, Butuci, Melina, Brock, Emily, Singh, Bhupinder, Rasmussen, Henrik, Holman, Amy, Drake, Richard, Peterson, Kathryn, Flynn, Ann

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P159 PHENOTYPIC CHARACTERIZATION OF INFLAMMATORY BOWEL DISEASE BIOPSIES REVEAL THAT MAST CELLS ARE SIGNIFICANTLY ELEVATED AND ACTIVATED IN PATIENTS WITH ULCERATIVE COLITIS von Youngblood, Bradford, Davis, Tina, Schanin, Julia, Butuci, Melina, Brock, Emily, Singh, Bhupinder, Rasmussen, Henrik, Holman, Amy, Drake, Richard, Peterson, Kathryn, Flynn, Ann

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Tu1251 MAST CELLS ARE SIGNIFICANTLY ACTIVATED IN PATIENTS WITH ULCERATIVE COLITIS AND ARE INHIBITED BY AN ANTI-SIGLEC-8 ANTIBODY, ANTOLIMAB (AK002) von Youngblood, Bradford, Davis, Tina, Schanin, Julia, Butuci, Melina, Brock, Emily C., Singh, Bhupinder, Rasmussen, Henrik S., Kamboj, Amol P., Holman, Amy, Drake, Richard, Peterson, Kathryn A., Flynn, Ann D.

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