PhenoScanner V2: an expanded tool for searching human genotype–phenotype associations von Kamat, Mihir A, Blackshaw, James A, Young, Robin, Surendran, Praveen, Burgess, Stephen, Danesh, John, Butterworth, Adam S, Staley, James R

Volltext

PhenoScanner: a database of human genotype-phenotype associations von Staley, James R, Blackshaw, James, Kamat, Mihir A, Ellis, Steve, Surendran, Praveen, Sun, Benjamin B, Paul, Dirk S, Freitag, Daniel, Burgess, Stephen, Danesh, John, Young, Robin, Butterworth, Adam S

Volltext

Mendelian Randomization Study of ACLY and Cardiovascular Disease von Ference, Brian A, Ray, Kausik K, Catapano, Alberico L, Ference, Thatcher B, Burgess, Stephen, Neff, David R, Oliver-Williams, Clare, Wood, Angela M, Butterworth, Adam S, Di Angelantonio, Emanuele, Danesh, John, Kastelein, John J.P, Nicholls, Stephen J

Volltext

Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke von Abraham, Gad, Malik, Rainer, Yonova-Doing, Ekaterina, Salim, Agus, Wang, Tingting, Danesh, John, Butterworth, Adam S., Howson, Joanna M. M., Inouye, Michael, Dichgans, Martin

Volltext

Genome‐wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease von Yao, Chen, Chen, George, Song, Ci, Keefe, Joshua, Mendelson, Michael, Huan, Tianxiao, Sun, Benjamin B., Laser, Annika, Maranville, Joseph C., Wu, Hongsheng, Ho, Jennifer E., Courchesne, Paul, Lyass, Asya, Larson, Martin G., Gieger, Christian, Graumann, Johannes, Johnson, Andrew D., Danesh, John, Runz, Heiko, Hwang, Shih-Jen, Liu, Chunyu, Butterworth, Adam S., Suhre, Karsten, Levy, Daniel

Volltext

ProGeM: a framework for the prioritization of candidate causal genes at molecular quantitative trait loci von Stacey, David, Fauman, Eric B, Ziemek, Daniel, Sun, Benjamin B, Harshfield, Eric L, Wood, Angela M, Butterworth, Adam S, Suhre, Karsten, Paul, Dirk S

Volltext

Leucocyte telomere length and risk of type 2 diabetes mellitus: new prospective cohort study and literature-based meta-analysis von Willeit, Peter, Raschenberger, Julia, Heydon, Emma E, Tsimikas, Sotirios, Haun, Margot, Mayr, Agnes, Weger, Siegfried, Witztum, Joseph L, Butterworth, Adam S, Willeit, Johann, Kronenberg, Florian, Kiechl, Stefan

Volltext

Polygenic risk scores in cardiovascular risk prediction: A cohort study and modelling analyses von Sun, Luanluan, Pennells, Lisa, Kaptoge, Stephen, Nelson, Christopher P., Ritchie, Scott C., Abraham, Gad, Arnold, Matthew, Bell, Steven, Bolton, Thomas, Burgess, Stephen, Dudbridge, Frank, Guo, Qi, Sofianopoulou, Eleni, Stevens, David, Thompson, John R., Butterworth, Adam S., Wood, Angela, Danesh, John, Samani, Nilesh J., Inouye, Michael, Di Angelantonio, Emanuele

Volltext

Genome-wide analysis identifies molecular systems and 149 genetic loci associated with income von Hill, W. David, Davies, Neil M., Ritchie, Stuart J., Skene, Nathan G., Bryois, Julien, Bell, Steven, Di Angelantonio, Emanuele, Roberts, David J., Xueyi, Shen, Davies, Gail, Liewald, David C. M., Porteous, David J., Hayward, Caroline, Butterworth, Adam S., McIntosh, Andrew M., Gale, Catharine R., Deary, Ian J.

Volltext

Systematic Mendelian randomization using the human plasma proteome to discover potential therapeutic targets for stroke von Chen, Lingyan, Peters, James E., Prins, Bram, Persyn, Elodie, Traylor, Matthew, Surendran, Praveen, Karthikeyan, Savita, Yonova-Doing, Ekaterina, Di Angelantonio, Emanuele, Roberts, David J., Watkins, Nicholas A., Ouwehand, Willem H., Danesh, John, Lewis, Cathryn M., Bronson, Paola G., Markus, Hugh S., Burgess, Stephen, Butterworth, Adam S., Howson, Joanna M. M.

Volltext

Assessing the causal association of glycine with risk of cardio-metabolic diseases von Wittemans, Laura B. L., Lotta, Luca A., Oliver-Williams, Clare, Stewart, Isobel D., Surendran, Praveen, Karthikeyan, Savita, Day, Felix R., Koulman, Albert, Imamura, Fumiaki, Zeng, Lingyao, Erdmann, Jeanette, Schunkert, Heribert, Khaw, Kay-Tee, Griffin, Julian L., Forouhi, Nita G., Scott, Robert A., Wood, Angela M., Burgess, Stephen, Howson, Joanna M. M., Danesh, John, Wareham, Nicholas J., Butterworth, Adam S., Langenberg, Claudia

Volltext

Quality control and removal of technical variation of NMR metabolic biomarker data in ~120,000 UK Biobank participants von Ritchie, Scott C., Surendran, Praveen, Karthikeyan, Savita, Lambert, Samuel A., Bolton, Thomas, Pennells, Lisa, Danesh, John, Di Angelantonio, Emanuele, Butterworth, Adam S., Inouye, Michael

Volltext

Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases von Ferreira, Ricardo C, Freitag, Daniel F, Cutler, Antony J, Howson, Joanna M M, Rainbow, Daniel B, Smyth, Deborah J, Kaptoge, Stephen, Clarke, Pamela, Boreham, Charlotte, Coulson, Richard M, Pekalski, Marcin L, Chen, Wei-Min, Onengut-Gumuscu, Suna, Rich, Stephen S, Butterworth, Adam S, Malarstig, Anders, Danesh, John, Todd, John A

Volltext

Neurology-related protein biomarkers are associated with cognitive ability and brain volume in older age von Harris, Sarah E., Cox, Simon R., Bell, Steven, Marioni, Riccardo E., Prins, Bram P., Pattie, Alison, Corley, Janie, Muñoz Maniega, Susana, Valdés Hernández, Maria, Morris, Zoe, John, Sally, Bronson, Paola G., Tucker-Drob, Elliot M., Starr, John M., Bastin, Mark E., Wardlaw, Joanna M., Butterworth, Adam S., Deary, Ian J.

Volltext

Genetically personalised organ-specific metabolic models in health and disease von Foguet, Carles, Xu, Yu, Ritchie, Scott C., Lambert, Samuel A., Persyn, Elodie, Nath, Artika P., Davenport, Emma E., Roberts, David J., Paul, Dirk S., Di Angelantonio, Emanuele, Danesh, John, Butterworth, Adam S., Yau, Christopher, Inouye, Michael

Volltext

Lipoprotein signatures of cholesteryl ester transfer protein and HMG-CoA reductase inhibition von Kettunen, Johannes, Holmes, Michael V, Allara, Elias, Anufrieva, Olga, Ohukainen, Pauli, Oliver-Williams, Clare, Wang, Qin, Tillin, Therese, Hughes, Alun D, Kähönen, Mika, Lehtimäki, Terho, Viikari, Jorma, Raitakari, Olli T, Salomaa, Veikko, Järvelin, Marjo-Riitta, Perola, Markus, Davey Smith, George, Chaturvedi, Nish, Danesh, John, Di Angelantonio, Emanuele, Butterworth, Adam S, Ala-Korpela, Mika

Volltext

Genome-wide analysis of blood lipid metabolites in over 5000 South Asians reveals biological insights at cardiometabolic disease loci von Harshfield, Eric L., Fauman, Eric B., Stacey, David, Paul, Dirk S., Ziemek, Daniel, Ong, Rachel M. Y., Danesh, John, Butterworth, Adam S., Rasheed, Asif, Sattar, Taniya, Zameer-ul-Asar, Saleem, Imran, Hina, Zoubia, Ishtiaq, Unzila, Qamar, Nadeem, Mallick, Nadeem Hayat, Yaqub, Zia, Saghir, Tahir, Rizvi, Syed Nadeem Hasan, Memon, Anis, Ishaq, Mohammad, Rasheed, Syed Zahed, Memon, Fazal-ur-Rehman, Jalal, Anjum, Abbas, Shahid, Frossard, Philippe, Saleheen, Danish, Wood, Angela M., Griffin, Julian L., Koulman, Albert

Volltext

Mendelian randomization for cardiovascular diseases: principles and applications von Larsson, Susanna C., Butterworth, Adam S., Burgess, Stephen

Volltext

The influence of rare variants in circulating metabolic biomarkers von Riveros-Mckay, Fernando, Oliver-Williams, Clare, Karthikeyan, Savita, Walter, Klaudia, Kundu, Kousik, Ouwehand, Willem H., Roberts, David, Di Angelantonio, Emanuele, Soranzo, Nicole, Danesh, John, Wheeler, Eleanor, Zeggini, Eleftheria, Butterworth, Adam S., Barroso, Ines

Volltext

Shorter leukocyte telomere length is associated with adverse COVID-19 outcomes: A cohort study in UK Biobank von Wang, Qingning, Codd, Veryan, Raisi-Estabragh, Zahra, Musicha, Crispin, Bountziouka, Vasiliki, Kaptoge, Stephen, Allara, Elias, Di Angelantonio, Emanuele, Butterworth, Adam S., Wood, Angela M., Thompson, John R., Petersen, Steffen E, Harvey, Nicholas C., Danesh, John N., Samani, Nilesh J., Nelson, Christopher P.

Volltext