P040 Prediction of endoscopic features of disease from single-cell RNA sequencing data in sigmoid colon of patients with ulcerative colitis von Riva, A, Primas, C, Wiekowski, M, Badalamenti, S, Reinisch, W, Busslinger, G

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GLP-2 Improves Hepatic Inflammation and Fibrosis in Mdr2-/- Mice Via Activation of NR4a1/Nur77 in Hepatic Stellate Cells and Intestinal FXR Signaling von Fuchs, Claudia D., Claudel, Thierry, Mlitz, Veronika, Riva, Alessandra, Menz, Moritz, Brusilovskaya, Ksenia, Haller, Felix, Baumgartner, Maximilian, Königshofer, Philipp, Unger, Lukas W., Sjöland, Wilhelm, Scharnagl, Hubert, Stojakovic, Tatjana, Busslinger, Georg, Reiberger, Thomas, Marschall, Hanns-Ulrich, Trauner, Michael

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Virulence monitoring and the structure of powdery mildew populations between 2003 and 2010 von Mascher, F, Matasci, C, Kellenberger, St., Forschungsanstalt Agroscope Changins-Waedenswil ACW, Nyon (Switzerland), Beuret, B, Beuret, M, Busslinger, G, Doernte, J, Gygax, M, Hecker, A, Heinzer, L, Hochstrasser, M, Horner, M, Kunz, P, Merz, U

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SARS-CoV-2 infection and replication in human gastric organoids von Giobbe, G, Bonfante, F, Jones, B, Gagliano, O, Luni, C, Zambaiti, E, Perin, S, Laterza, C, Busslinger, G, Stuart, H, Pagliari, M, Bortolami, A, Mazzetto, E, Manfredi, A, Colantuono, C, Di Filippo, L, Pellegata, A, Panzarin, V, Thapar, N, Li, V, Eaton, S, Cacchiarelli, D, Clevers, H, Elvassore, N, De Coppi, P

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Cryptic activation of an Irf8 enhancer governs cDC1 fate specification von Durai, Vivek, Bagadia, Prachi, Granja, Jeffrey M., Satpathy, Ansuman T., Kulkarni, Devesha H., Davidson, Jesse T., Wu, Renee, Patel, Swapneel J., Iwata, Arifumi, Liu, Tian-Tian, Huang, Xiao, Briseño, Carlos G., Grajales-Reyes, Gary E., Wöhner, Miriam, Tagoh, Hiromi, Kee, Barbara L., Newberry, Rodney D., Busslinger, Meinrad, Chang, Howard Y., Murphy, Theresa L., Murphy, Kenneth M.

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Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages von Klose, Christoph S N, Flach, Melanie, Möhle, Luisa, Rogell, Leif, Hoyler, Thomas, Ebert, Karolina, Fabiunke, Carola, Pfeifer, Dietmar, Sexl, Veronika, Fonseca-Pereira, Diogo, Domingues, Rita G, Veiga-Fernandes, Henrique, Arnold, Sebastian J, Busslinger, Meinrad, Dunay, Ildiko R, Tanriver, Yakup, Diefenbach, Andreas

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Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes von Mackay, Laura K., Minnich, Martina, Kragten, Natasja A. M., Liao, Yang, Nota, Benjamin, Seillet, Cyril, Zaid, Ali, Man, Kevin, Preston, Simon, Freestone, David, Braun, Asolina, Wynne-Jones, Erica, Behr, Felix M., Stark, Regina, Pellicci, Daniel G., Godfrey, Dale I., Belz, Gabrielle T., Pellegrini, Marc, Gebhardt, Thomas, Busslinger, Meinrad, Shi, Wei, Carbone, Francis R., van Lier, René A. W., Kallies, Axel, van Gisbergen, Klaas P. J. M.

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Commitment to the B-lymphoid lineage depends on the transcription factor Pax5 von Busslinger, Meinrad, Nutt, Stephen L, Heavey, Barry, Rolink, Antonius G

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PU.1 cooperates with IRF4 and IRF8 to suppress pre-B-cell leukemia von Pang, S H M, Minnich, M, Gangatirkar, P, Zheng, Z, Ebert, A, Song, G, Dickins, R A, Corcoran, L M, Mullighan, C G, Busslinger, M, Huntington, N D, Nutt, S L, Carotta, S

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The metabolite BH4 controls T cell proliferation in autoimmunity and cancer von Cronin, Shane J. F., Seehus, Corey, Weidinger, Adelheid, Talbot, Sebastien, Reissig, Sonja, Seifert, Markus, Pierson, Yann, McNeill, Eileen, Longhi, Maria Serena, Turnes, Bruna Lenfers, Kreslavsky, Taras, Kogler, Melanie, Hoffmann, David, Ticevic, Melita, da Luz Scheffer, Débora, Tortola, Luigi, Cikes, Domagoj, Jais, Alexander, Rangachari, Manu, Rao, Shuan, Paolino, Magdalena, Novatchkova, Maria, Aichinger, Martin, Barrett, Lee, Latremoliere, Alban, Wirnsberger, Gerald, Lametschwandtner, Guenther, Busslinger, Meinrad, Zicha, Stephen, Latini, Alexandra, Robson, Simon C., Waisman, Ari, Andrews, Nick, Costigan, Michael, Channon, Keith M., Weiss, Guenter, Kozlov, Andrey V., Tebbe, Mark, Johnsson, Kai, Woolf, Clifford J., Penninger, Josef M.

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The PAX5‐JAK2 translocation acts as dual‐hit mutation that promotes aggressive B‐cell leukemia via nuclear STAT5 activation von Jurado, Sabine, Fedl, Anna S, Jaritz, Markus, Kostanova‐Poliakova, Daniela, Malin, Stephen G, Mullighan, Charles G, Strehl, Sabine, Fischer, Maria, Busslinger, Meinrad

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Repression of the B cell identity factor Pax5 is not required for plasma cell development von Liu, Grace J, Jaritz, Markus, Wöhner, Miriam, Agerer, Benedikt, Bergthaler, Andreas, Malin, Stephen G, Busslinger, Meinrad

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The microbiota regulates type 2 immunity through RORγt+T cells von Ohnmacht, Caspar, Park, Joo-Hong, Cording, Sascha, Wing, James B., Atarashi, Koji, Obata, Yuuki, Gaboriau-Routhiau, Valérie, Marques, Rute, Dulauroy, Sophie, Fedoseeva, Maria, Busslinger, Meinrad, Cerf-Bensussan, Nadine, Boneca, Ivo G., Voehringer, David, Hase, Koji, Honda, Kenya, Sakaguchi, Shimon, Eberl, Gérard

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CXCR5+ follicular cytotoxic T cells control viral infection in B cell follicles von Leong, Yew Ann, Chen, Yaping, Ong, Hong Sheng, Wu, Di, Man, Kevin, Deleage, Claire, Minnich, Martina, Meckiff, Benjamin J, Wei, Yunbo, Hou, Zhaohua, Zotos, Dimitra, Fenix, Kevin A, Atnerkar, Anurag, Preston, Simon, Chipman, Jeffrey G, Beilman, Greg J, Allison, Cody C, Sun, Lei, Wang, Peng, Xu, Jiawei, Toe, Jesse G, Lu, Hao K, Tao, Yong, Palendira, Umaimainthan, Dent, Alexander L, Landay, Alan L, Pellegrini, Marc, Comerford, Iain, McColl, Shaun R, Schacker, Timothy W, Long, Heather M, Estes, Jacob D, Busslinger, Meinrad, Belz, Gabrielle T, Lewin, Sharon R, Kallies, Axel, Yu, Di

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Pax5 induces V-to-DJ rearrangements and locus contraction of the immunoglobulin heavy-chain gene von Fuxa, Martin, Skok, Jane, Souabni, Abdallah, Salvagiotto, Giorgia, Roldan, Esther, Busslinger, Meinrad

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The potential and challenges of patient-derived organoids in guiding the multimodality treatment of upper gastrointestinal malignancies von Busslinger, Georg A, Lissendorp, Fianne, Franken, Ingrid A, van Hillegersberg, Richard, Ruurda, Jelle P, Clevers, Hans, de Maat, Michiel F G

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A Kinase-Independent Function of CDK6 Links the Cell Cycle to Tumor Angiogenesis von Kollmann, Karoline, Heller, Gerwin, Schneckenleithner, Christine, Warsch, Wolfgang, Scheicher, Ruth, Ott, Rene G., Schäfer, Markus, Fajmann, Sabine, Schlederer, Michaela, Schiefer, Ana-Iris, Reichart, Ursula, Mayerhofer, Matthias, Hoeller, Christoph, Zöchbauer-Müller, Sabine, Kerjaschki, Dontscho, Bock, Christoph, Kenner, Lukas, Hoefler, Gerald, Freissmuth, Michael, Green, Anthony R., Moriggl, Richard, Busslinger, Meinrad, Malumbres, Marcos, Sexl, Veronika

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Pax5 regulates B cell immunity by promoting PI3K signaling via PTEN down-regulation von Calderon, L, Schindler, K, Malin, SG, Schebesta, A, Sun, Q, Schwickert, T, Alberti, C, Fischer, M, Jaritz, M, Tagoh, H, Ebert, A, Minnich, M, Liston, A, Cochella, L, Busslinger, M

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CTCF-binding elements mediate control of V(D)J recombination von Guo, Chunguang, Yoon, Hye Suk, Franklin, Andrew, Jain, Suvi, Ebert, Anja, Cheng, Hwei-Ling, Hansen, Erica, Despo, Orion, Bossen, Claudia, Vettermann, Christian, Bates, Jamie G., Richards, Nicholas, Myers, Darienne, Patel, Harin, Gallagher, Michael, Schlissel, Mark S., Murre, Cornelis, Busslinger, Meinrad, Giallourakis, Cosmas C., Alt, Frederick W.

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RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci von Marszalek, Katarzyna, Salvagiotto, Giorgia, Sleckman, Barry P, Schatz, David G, Farrar, Michael A, Ghysdael, Jacques, Skok, Jane A, Busslinger, Meinrad, Yin, Bu, Bassing, Craig H, Tenthorey, Jeannette, Ramsey, Laura B, Hewitt, Susannah L, Chaumeil, Julie, Steinel, Natalie, Ji, Yanhong

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