Harnessing the anti-cancer natural product nimbolide for targeted protein degradation von Spradlin, Jessica N., Hu, Xirui, Ward, Carl C., Brittain, Scott M., Jones, Michael D., Ou, Lisha, To, Milton, Proudfoot, Andrew, Ornelas, Elizabeth, Woldegiorgis, Mikias, Olzmann, James A., Bussiere, Dirksen E., Thomas, Jason R., Tallarico, John A., McKenna, Jeffrey M., Schirle, Markus, Maimone, Thomas J., Nomura, Daniel K.

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Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex von Bussiere, Dirksen E., Xie, Lili, Srinivas, Honnappa, Shu, Wei, Burke, Ashley, Be, Celine, Zhao, Junping, Godbole, Adarsh, King, Dan, Karki, Rajeshri G., Hornak, Viktor, Xu, Fangmin, Cobb, Jennifer, Carte, Nathalie, Frank, Andreas O., Frommlet, Alexandra, Graff, Patrick, Knapp, Mark, Fazal, Aleem, Okram, Barun, Jiang, Songchun, Michellys, Pierre-Yves, Beckwith, Rohan, Voshol, Hans, Wiesmann, Christian, Solomon, Jonathan M., Paulk, Joshiawa

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High-Confidence Protein–Ligand Complex Modeling by NMR-Guided Docking Enables Early Hit Optimization von Proudfoot, Andrew, Bussiere, Dirksen E, Lingel, Andreas

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Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED von Li, Ling, Zhang, Hailong, Zhang, Man, Zhao, Mengxi, Feng, Lijian, Luo, Xiao, Gao, Zhenting, Huang, Ying, Ardayfio, Ophelia, Zhang, Ji-Hu, Lin, Ying, Fan, Hong, Mi, Yuan, Li, Guobin, Liu, Lei, Feng, Leying, Luo, Fangjun, Teng, Lin, Qi, Wei, Ottl, Johannes, Lingel, Andreas, Bussiere, Dirksen E, Yu, Zhengtian, Atadja, Peter, Lu, Chris, Li, En, Gu, Justin, Zhao, Kehao

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Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo von Dowdle, William E., Nyfeler, Beat, Nagel, Jane, Elling, Robert A., Liu, Shanming, Triantafellow, Ellen, Menon, Suchithra, Wang, Zuncai, Honda, Ayako, Pardee, Gwynn, Cantwell, John, Luu, Catherine, Cornella-Taracido, Ivan, Harrington, Edmund, Fekkes, Peter, Lei, Hong, Fang, Qing, Digan, Mary Ellen, Burdick, Debra, Powers, Andrew F., Helliwell, Stephen B., D’Aquin, Simon, Bastien, Julie, Wang, Henry, Wiederschain, Dmitri, Kuerth, Jenny, Bergman, Philip, Schwalb, David, Thomas, Jason, Ugwonali, Savuth, Harbinski, Fred, Tallarico, John, Wilson, Christopher J., Myer, Vic E., Porter, Jeffery A., Bussiere, Dirksen E., Finan, Peter M., Labow, Mark A., Mao, Xiaohong, Hamann, Lawrence G., Manning, Brendan D., Valdez, Reginald A., Nicholson, Thomas, Schirle, Markus, Knapp, Mark S., Keaney, Erin P., Murphy, Leon O.

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Discovery of 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), A Potent and Selective Inhibitor of the... von Guagnano, Vito, Furet, Pascal, Spanka, Carsten, Bordas, Vincent, Le Douget, Mickaël, Stamm, Christelle, Brueggen, Josef, Jensen, Michael R, Schnell, Christian, Schmid, Herbert, Wartmann, Markus, Berghausen, Joerg, Drueckes, Peter, Zimmerlin, Alfred, Bussiere, Dirksen, Murray, Jeremy, Graus Porta, Diana

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Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase von Lingel, Andreas, Sendzik, Martin, Huang, Ying, Shultz, Michael D, Cantwell, John, Dillon, Michael P, Fu, Xingnian, Fuller, John, Gabriel, Tobias, Gu, Justin, Jiang, Xiangqing, Li, Ling, Liang, Fang, McKenna, Maureen, Qi, Wei, Rao, Weijun, Sheng, Xijun, Shu, Wei, Sutton, James, Taft, Benjamin, Wang, Long, Zeng, Jue, Zhang, Hailong, Zhang, Maya, Zhao, Kehao, Lindvall, Mika, Bussiere, Dirksen E

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Synthesis, Binding Mode, and Antihyperglycemic Activity of Potent and Selective (5-Imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine Inhibitors of Glycogen Syntha... von Wagman, Allan S, Boyce, Rustum S, Brown, Sean P, Fang, Eric, Goff, Dane, Jansen, Johanna M, Le, Vincent P, Levine, Barry H, Ng, Simon C, Ni, Zhi-Jie, Nuss, John M, Pfister, Keith B, Ramurthy, Savithri, Renhowe, Paul A, Ring, David B, Shu, Wei, Subramanian, Sharadha, Zhou, Xiaohui A, Shafer, Cynthia M, Harrison, Stephen D, Johnson, Kirk W, Bussiere, Dirksen E

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Structural basis for therapeutic inhibition of influenza A polymerase PB2 subunit von Ma, Xiaolei, Xie, Lili, Wartchow, Charles, Warne, Robert, Xu, Yongjin, Rivkin, Alexey, Tully, David, Shia, Steven, Uehara, Kyoko, Baldwin, Dianna M., Muiru, Gladys, Zhong, Weidong, Zaror, Isabel, Bussiere, Dirksen E., Leonard, Vincent H. J.

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A polyomavirus peptide binds to the capsid VP1 pore and has potent antiviral activity against BK and JC polyomaviruses von Kane, Joshua R., Fong, Susan, Shaul, Jacob, Frommlet, Alexandra, Frank, Andreas O., Knapp, Mark, Bussiere, Dirksen E., Kim, Peter, Ornelas, Elizabeth, Cuellar, Carlos, Hyrina, Anastasia, Abend, Johanna R., Wartchow, Charles A.

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Author Correction: Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex von Bussiere, Dirksen E., Xie, Lili, Srinivas, Honnappa, Shu, Wei, Burke, Ashley, Be, Celine, Zhao, Junping, Godbole, Adarsh, King, Dan, Karki, Rajeshri G., Hornak, Viktor, Xu, Fangmin, Cobb, Jennifer, Carte, Nathalie, Frank, Andreas O., Frommlet, Alexandra, Graff, Patrick, Knapp, Mark, Fazal, Aleem, Okram, Barun, Jiang, Songchun, Michellys, Pierre-Yves, Beckwith, Rohan, Voshol, Hans, Wiesmann, Christian, Solomon, Jonathan M., Paulk, Joshiawa

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Discovery and optimization of novel pyridines as highly potent and selective glycogen synthase kinase 3 inhibitors von Ramurthy, Savithri, Pfister, Keith B., Boyce, Rustum S., Brown, Sean P., Costales, Abran Q., Desai, Manoj C., Fang, Eric, Levine, Barry H., Ng, Simon C., Nuss, John M., Ring, David B., Shafer, Cynthia M., Shu, Wei, Subramanian, Sharadha, Wagman, Allan S., Wang, Haixia, Bussiere, Dirksen E.

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Molecular Basis of mRNA Cap Recognition by Influenza B Polymerase PB2 Subunit von Xie, Lili, Wartchow, Charles, Shia, Steven, Uehara, Kyoko, Steffek, Micah, Warne, Robert, Sutton, James, Muiru, Gladys T., Leonard, Vincent H.J., Bussiere, Dirksen E., Ma, Xiaolei

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Identification of NVP-BKM120 as a Potent, Selective, Orally Bioavailable Class I PI3 Kinase Inhibitor for Treating Cancer von Burger, Matthew T, Pecchi, Sabina, Wagman, Allan, Ni, Zhi-Jie, Knapp, Mark, Hendrickson, Thomas, Atallah, Gordana, Pfister, Keith, Zhang, Yanchen, Bartulis, Sarah, Frazier, Kelly, Ng, Simon, Smith, Aaron, Verhagen, Joelle, Haznedar, Joshua, Huh, Kay, Iwanowicz, Ed, Xin, Xiaohua, Menezes, Daniel, Merritt, Hanne, Lee, Isabelle, Wiesmann, Marion, Kaufman, Susan, Crawford, Kenneth, Chin, Michael, Bussiere, Dirksen, Shoemaker, Kevin, Zaror, Isabel, Maira, Sauveur-Michel, Voliva, Charles F

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Targeting the Purinome von Murray, Jeremy M., Bussiere, Dirksen E.

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Novel Ecdysteroids from Serratula wolffii von Ványolós, Attila, Béni, Zoltán, Dékány, Miklós, Simon, András, Báthori, Mária

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4-(Aminoalkylamino)-3-benzimidazole-quinolinones as potent CHK-1 inhibitors von Ni, Zhi-Jie, Barsanti, Paul, Brammeier, Nathan, Diebes, Anthony, Poon, Daniel J., Ng, Simon, Pecchi, Sabina, Pfister, Keith, Renhowe, Paul A., Ramurthy, Savithri, Wagman, Allan S., Bussiere, Dirksen E., Le, Vincent, Zhou, Yasheen, Jansen, Johanna M., Ma, Sylvia, Gesner, Thomas G.

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Termination of DNA replication of bacterial and plasmid chromosomes von Bussiere, Dirksen E., Bastia, Deepak

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First Crystal Structure of a Nonstructural Hepatitis E Viral Protein Identifies a Putative Novel Zinc-Binding Protein von Proudfoot, Andrew, Hyrina, Anastasia, Holdorf, Meghan, Frank, Andreas O, Bussiere, Dirksen

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Crystal structure of VC0702 at 2.0 Å: Conserved hypothetical protein from Vibrio cholerae von Ni, Shuisong, Forouhar, Farhad, Bussiere, Dirksen E., Robinson, Howard, Kennedy, Michael A.

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