Targeting transcription factors in cancer — from undruggable to reality von Bushweller, John H.

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Degree of Recruitment of DOT1L to MLL-AF9 Defines Level of H3K79 Di- and Tri-methylation on Target Genes and Transformation Potential von Kuntimaddi, Aravinda, Achille, Nicholas J., Thorpe, Jeremy, Lokken, Alyson A., Singh, Ritambhara, Hemenway, Charles S., Adli, Mazhar, Zeleznik-Le, Nancy J., Bushweller, John H.

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RUNX proteins desensitize multiple myeloma to lenalidomide via protecting IKZFs from degradation von Zhou, Nan, Gutierrez-Uzquiza, Alvaro, Zheng, Xiang Yu, Chang, Renxu, Vogl, Dan T., Garfall, Alfred L., Bernabei, Luca, Saraf, Anita, Florens, Laurence, Washburn, Michael P., Illendula, Anuradha, Bushweller, John H., Busino, Luca

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RUNX1-targeted therapy for AML expressing somatic or germline mutation in RUNX1 von Mill, Christopher P., Fiskus, Warren, DiNardo, Courtney D., Qian, Yimin, Raina, Kanak, Rajapakshe, Kimal, Perera, Dimuthu, Coarfa, Cristian, Kadia, Tapan M., Khoury, Joseph D., Saenz, Dyana T., Saenz, David N., Illendula, Anuradha, Takahashi, Koichi, Kornblau, Steven M., Green, Michael R., Futreal, Andrew P., Bushweller, John H., Crews, Craig M., Bhalla, Kapil N.

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Leukemia Fusion Target AF9 Is an Intrinsically Disordered Transcriptional Regulator that Recruits Multiple Partners via Coupled Folding and Binding von Leach, Benjamin I., Kuntimaddi, Aravinda, Schmidt, Charles R., Cierpicki, Tomasz, Johnson, Stephanie A., Bushweller, John H.

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Protein Disulfide Exchange by the Intramembrane Enzymes DsbB, DsbD, and CcdA von Bushweller, John H.

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An erythroid-to-myeloid cell fate conversion is elicited by LSD1 inactivation von Yu, Lei, Myers, Greggory, Ku, Chia-Jui, Schneider, Emily, Wang, Yu, Singh, Sharon A., Jearawiriyapaisarn, Natee, White, Andrew, Moriguchi, Takashi, Khoriaty, Rami, Yamamoto, Masayuki, Rosenfeld, Michael G., Pedron, Julien, Bushweller, John H., Lim, Kim-Chew, Engel, James Douglas

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Regulome analysis in B-acute lymphoblastic leukemia exposes Core Binding Factor addiction as a therapeutic vulnerability von Wray, Jason P., Deltcheva, Elitza M., Boiers, Charlotta, Richardson, Simon Е, Chhetri, Jyoti Bikram, Brown, John, Gagrica, Sladjana, Guo, Yanping, Illendula, Anuradha, Martens, Joost H. A., Stunnenberg, Hendrik G., Bushweller, John H., Nimmo, Rachael, Enver, Tariq

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Structure of the MLL CXXC domain-DNA complex and its functional role in MLL-AF9 leukemia von Grembecka, Jolanta, Bushweller, John H, Risner, Laurie E, Lukasik, Stephen M, Cierpicki, Tomasz, Shultis, David D, Zeleznik-Le, Nancy J, Popovic, Relja, Omonkowska, Monika

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Tom1 Modulates Binding of Tollip to Phosphatidylinositol 3-Phosphate via a Coupled Folding and Binding Mechanism von Xiao, Shuyan, Brannon, Mary K., Zhao, Xiaolin, Fread, Kristen I., Ellena, Jeffrey F., Bushweller, John H., Finkielstein, Carla V., Armstrong, Geoffrey S., Capelluto, Daniel G.S.

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Site-Directed Parallel Spin-Labeling and Paramagnetic Relaxation Enhancement in Structure Determination of Membrane Proteins by Solution NMR Spectroscopy von Liang, Binyong, Bushweller, John H, Tamm, Lukas K

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Membrane structure and fusion-triggering conformational change of the fusion domain from influenza hemagglutinin von Tamm, Lukas K, Han, Xing, Bushweller, John H, Cafiso, David S

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Structural and dynamic studies of the transcription factor ERG reveal DNA binding is allosterically autoinhibited von Regan, Michael C., Horanyi, Peter S., Pryor, Edward E., Sarver, Jessica L., Cafiso, David S., Bushweller, John H.

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Structure of outer membrane protein A transmembrane domain by NMR spectroscopy von Tamm, Lukas K, Arora, Ashish, Abildgaard, Frits, Bushweller, John H

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Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers von Illendula, Anuradha, Gilmour, Jane, Grembecka, Jolanta, Tirumala, Venkata Sesha Srimath, Boulton, Adam, Kuntimaddi, Aravinda, Schmidt, Charles, Wang, Lixin, Pulikkan, John A., Zong, Hongliang, Parlak, Mahmut, Kuscu, Cem, Pickin, Anna, Zhou, Yunpeng, Gao, Yan, Mishra, Lauren, Adli, Mazhar, Castilla, Lucio H., Rajewski, Roger A., Janes, Kevin A., Guzman, Monica L., Bonifer, Constanze, Bushweller, John H.

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Solution structure and elevator mechanism of the membrane electron transporter CcdA von Zhou, Yunpeng, Bushweller, John H.

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Functional Specificity of CpG DNA-binding CXXC Domains in Mixed Lineage Leukemia von Risner, Laurie E., Kuntimaddi, Aravinda, Lokken, Alyson A., Achille, Nicholas J., Birch, Noah W., Schoenfelt, Kelly, Bushweller, John H., Zeleznik-Le, Nancy J.

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Structural Basis for Recognition of SMRT/N-CoR by the MYND Domain and Its Contribution to AML1/ETO's Activity von Liu, Yizhou, Chen, Wei, Gaudet, Justin, Cheney, Matthew D., Roudaia, Liya, Cierpicki, Tomasz, Klet, Rachel C., Hartman, Kari, Laue, Thomas M., Speck, Nancy A., Bushweller, John H.

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MLL Protects CpG Clusters from Methylation within the Hoxa9 Gene, Maintaining Transcript Expression von Erfurth, Frank E., Popovic, Relja, Grembecka, Jolanta, Cierpicki, Tomasz, Theisler, Catherine, Xia, Zhen-Biao, Stuart, Tara, Diaz, Manuel O., Bushweller, John H., Zeleznik-Le, Nancy J.

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The interaction between RUNX2 and core binding factor beta as a potential therapeutic target in canine osteosarcoma von Alegre, Fernando, Ormonde, Amanda R., Godinez, Dayn R., Illendula, Anuradha, Bushweller, John H., Wittenburg, Luke A.

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