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    Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing von Ahmad, Shahzad, Vardarajan, Badri N., Hoffmann, Per, Garnier, Jean-Guillaume, Harold, Denise, Fitzpatrick, Annette L., Valladares, Otto, Smith, Albert V., Qu, Liming, Zhao, Yi, Del Zompo, Maria, Uphill, James, Cantwell, Laura B., Garzia, Fabienne, Fin, Bertrand, Barber, Robert C., Mayhaus, Manuel, Hartmann, Annette M., Lovestone, Simon, Garcia, Melissa E., Fairchild, Thomas J., Karamujić-Čomić, Hata, Frosch, Matthew P., Maier, Wolfgang, Li, Shuo, Huebinger, Ryan M., Kamboh, M. Ilyas, Yang, Qiong, Haapasalo, Annakaisa, Lawlor, Brian, Solfrizzi, Vincenzo, Frisardi, Vincenza, Alvarez, Ignacio, Salani, Francesca, Fievet, Nathalie, Maletta, Raffaele Giovanni, Tsuang, Debby W., Soininen, Hilkka, Avramidou, Despoina, Panza, Francesco, Frölich, Lutz, Passmore, Peter, Schott, Jonathan M., Powell, John F., Burns, Jeffrey M., Hardy, John, Carrasquillo, Minerva M., Crocco, Elizabeth A., Faber, Kelley M., Scherer, Martin, Ferris, Steven, Galasko, Douglas R., Geschwind, Daniel H., Honig, Lawrence S., Cushion, Thomas D., Hollingworth, Paul, Hulette, Christine M., Jessen, Frank, Lah, James J., Leverenz, James B., Morgan, Kevin, Mash, Deborah C., McCurry, Susan M., Miller, Carol A., Shaw, Christopher E., Myers, Amanda J., Paulson, Henry L., Peskind, Elaine, Cribbs, David H., Rossor, Martin, Pierce, Aimee, Potter, Huntington, Sorbi, Sandro, Reitz, Christiane, Ringman, John M., Rosen, Howard J., Mecocci, Patrizia, Slifer, Susan, Spina, Salvatore, Vinters, Harry V., Weintraub, Sandra, Welsh-Bohmer, Kathleen A., Crane, Paul K., Bennett, David, Boccardi, Virginia, Lopez, Oscar L., Deloukas, Panagiotis, Cruchaga, Carlos, Berr, Claudine, Younkin, Steven G., Clarimon, Jordi, Schmidt, Reinhold, Farrer, Lindsay A., Van Broeckhoven, Christine, C. O’Donovan, Michael, Haines, Jonathan L., Gudnason, Vilmundur, Mayeux, Richard, Seshadri, Sudha, Williams, Julie

    Veröffentlicht in Nature genetics

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    New insights into the genetic etiology of Alzheimer’s disease and related dementias von Holmans, Peter A., de Rojas, Itziar, Bis, Joshua C., Alarcón-Martín, Emilio, Alcolea, Daniel, Alegret, Montserrat, Alvarez, Ignacio, Álvarez, Victoria, Antúnez, Carmen, Arosio, Beatrice, Athanasiu, Lavinia, Banaj, Nerisa, Below, Jennifer E., Benussi, Luisa, Bossù, Paola, Burholt, Vanessa, Calero, Miguel, Cervera-Carles, Laura, Chen, Hung-Hsin, Custodero, Carlo, de Paiva Lopes, Katia, DeStefano, Anita, Dichgans, Martin, Diehl-Schmid, Janine, Duron, Emmanuelle, Dufouil, Carole, Espinosa, Ana, Nielsen, Sune Fallgaard, Fenoglio, Chiara, Ferrari, Raffaele, Fox, Nick C., Frank-García, Ana, Galimberti, Daniela, Grande, Giulia, Green, Emma, Grünblatt, Edna, Grunin, Michelle, Gudnason, Vilmundur, Hampel, Harald, Hausner, Lucrezia, Hulsman, Marc, Kivipelto, Miia, Kornhuber, Johannes, Kuzma, Amanda B., Launer, Lenore, Ma, Yiyi, Maier, Wolfgang, Montes, Angel Martín, Masullo, Carlo, Mendoza, Silvia, Moebus, Susanne, Morgan, Kevin, Muchnik, Carolina, Mukherjee, Shubhabrata, Nacmias, Benedetta, Ngandu, Tiia, Nicolas, Gael, Nordestgaard, Børge G., Ortega, Gemma, Paolo, Caffarra, Papenberg, Goran, Peloso, Gina, Pérez-Cordón, Alba, Pérez-Tur, Jordi, Pineda, Juan A., Pisanu, Claudia, Polak, Thomas, Quintela, Inés, Rábano, Alberto, Reinders, Marcel J. T., Riedel-Heller, Steffi, Rubino, Elisa, Rujescu, Dan, Sanabria, Ángela, Sánchez-Valle, Raquel, Satizabal, Claudia L., Scarpini, Elio, Scheltens, Philip, Schmid, Matthias, Schneider, Anja, Serrano, Manuel, Solomon, Alina, Song, Yeunjoo, Spalletta, Gianfranco, Squassina, Alessio, Stordal, Eystein, Tartan, Juan Pablo, Tárraga, Lluís, Thomas, Tegos, Tosto, Giuseppe, Wallon, David, Wang, Li-San, Weinhold, Leonie, Wiltfang, Jens, Zare, Habil, Farrer, Lindsay A., Psaty, Bruce M., Williams, Julie, Frikke-Schmidt, Ruth, Deleuze, Jean-François

    Veröffentlicht in Nature genetics

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    Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease von Badarinarayan, Nandini, Bis, Joshua C, Heilmann-Heimbach, Stefanie, Sleegers, Kristel, Vronskaya, Maria, White, Charles C, Hamilton-Nelson, Kara L, Choi, Seung-Hoan, Forstner, Andreas J, Bacq, Delphine, Brody, Jennifer A, Wolters, Frank J, Fornage, Myriam, Majounie, Elisa, Wallon, David, Lupton, Michelle K, Jian, Xueqiu, Mukherjee, Shubhabrata, Solfrizzi, Vincenzo, Allen, Mariet, Cupples, L Adrienne, Giegling, Ina, Giedraitis, Vilmantas, Wang, Xue, Mecocci, Patrizia, Eiriksdottir, Gudny, Chen, Yuning, Frosch, Matthew P, Huebinger, Ryan M, Morris, John, Sotolongo-Grau, Oscar, Katz, Mindy J, Braddel, Amy, Chapman, Jade, Hill, Matt, Vellas, Bruno, Soininen, Hilkka, Hughes, Joseph T, Mayhaus, Manuel, Maletta, Raffaele Giovanni, Carrell, David, Pilotto, Alberto, Fox, Nick C, Arnold, Steven E, Becker, James T, Burke, James R, Carlsson, Cynthia M, Clark, David G, Cribbs, David H, Duara, Ranjan, Evans, Denis A, Fallon, Kenneth B, Farlow, Martin R, Foroud, Tatiana M, Galasko, Douglas R, Jin, Lee-Way, Lah, James J, Levey, Allan I, Lieberman, Andrew P, McKee, Ann C, Morris, John C, Paulson, Henry L, Peskind, Elaine, Quinn, Joseph F, Raskind, Murray, Spina, Salvatore, Swerdlow, Russell H, Van Eldik, Linda J, Vinters, Harry V, Vonsattel, Jean Paul, De Deyn, Peter P, Concari, Letizia, Brice, Alexis, Dubois, Bruno, Tschanz, JoAnn, Fitzpatrick, Annette L, Kukull, Walter A, Bullido, María J, Coto, Eliecer, Reiman, Eric M, Gallo, Maura, Scarpini, Elio, Tsuang, Debby W, Bonuccelli, Ubaldo, Rubinsztein, David C, Bras, Jose, Guerreiro, Rita, Lovestone, Simon, Owen, Michael J, Cruchaga, Carlos, Powell, John, De Jager, Philip L, Rujescu, Dan, Ortega-Cubero, Sara, Ikram, M Arfan, Mayeux, Richard, Deleuze, Jean-François, Amin, Najaf, Amouyel, Philippe, van Duijn, Cornelia M

    Veröffentlicht in Nature genetics

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    Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis von Kunkle, Brian W, Schmidt, Michael, Klein, Hans-Ulrich, Naj, Adam C, Hamilton-Nelson, Kara L, Larson, Eric B, Evans, Denis A, De Jager, Phil L, Crane, Paul K, Buxbaum, Joe D, Ertekin-Taner, Nilufer, Barnes, Lisa L, Fallin, M. Daniele, Manly, Jennifer J, Go, Rodney C. P, Obisesan, Thomas O, Kamboh, M. Ilyas, Bennett, David A, Hall, Kathleen S, Goate, Alison M, Foroud, Tatiana M, Martin, Eden R, Wang, Li-San, Byrd, Goldie S, Farrer, Lindsay A, Haines, Jonathan L, Schellenberg, Gerard D, Mayeux, Richard, Pericak-Vance, Margaret A, Reitz, Christiane, Graff-Radford, Neill R, Martinez, Izri, Ayodele, Temitope, Logue, Mark W, Cantwell, Laura B, Jean-Francois, Melissa, Kuzma, Amanda B, Adams, L.D, Vance, Jeffery M, Cuccaro, Michael L, Chung, Jaeyoon, Mez, Jesse, Lunetta, Kathryn L, Jun, Gyungah R, Lopez, Oscar L, Hendrie, Hugh C, Reiman, Eric M, Kowall, Neil W, Leverenz, James B, Small, Scott A, Levey, Allan I, Golde, Todd E, Saykin, Andrew J, Starks, Takiyah D, Albert, Marilyn S, Hyman, Bradley T, Petersen, Ronald C, Sano, Mary, Wisniewski, Thomas, Vassar, Robert, Kaye, Jeffrey A, Henderson, Victor W, DeCarli, Charles, LaFerla, Frank M, Brewer, James B, Miller, Bruce L, Swerdlow, Russell H, Van Eldik, Linda J, Paulson, Henry L, Trojanowski, John Q, Chui, Helena C, Rosenberg, Roger N, Craft, Suzanne, Grabowski, Thomas J, Asthana, Sanjay, Morris, John C, Strittmatter, Stephen M, Kukull, Walter A

    Veröffentlicht in JAMA neurology

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