C–H Methylation of Heteroarenes Inspired by Radical SAM Methyl Transferase von Gui, Jinghan, Zhou, Qianghui, Pan, Chung-Mao, Yabe, Yuki, Burns, Aaron C, Collins, Michael R, Ornelas, Martha A, Ishihara, Yoshihiro, Baran, Phil S

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Simple Sulfinate Synthesis Enables CH Trifluoromethylcyclopropanation von Gianatassio, Ryan, Kawamura, Shuhei, Eprile, Cecil L, Foo, Klement, Ge, Jason, Burns, Aaron C., Collins, Michael R., Baran, Phil S.

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Estimating the potential for optimized curb management to reduce delivery vehicle double parking, traffic congestion and energy consumption von Burns, Aaron J., Michalek, Jeremy J., Samaras, Constantine

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Activity of Adagrasib (MRTX849) in Brain Metastases: Preclinical Models and Clinical Data from Patients with KRASG12C-Mutant Non-Small Cell Lung Cancer von Sabari, Joshua K, Velcheti, Vamsidhar, Shimizu, Kazuhide, Strickland, Matthew R, Heist, Rebecca S, Singh, Mohini, Nayyar, Naema, Giobbie-Hurder, Anita, Digumarthy, Subba R, Gainor, Justin F, Rajan, Anant P, Nieblas-Bedolla, Edwin, Burns, Aaron C, Hallin, Jill, Olson, Peter, Christensen, James G, Kurz, Sylvia C, Brastianos, Priscilla K, Wakimoto, Hiroaki

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Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of MTAP-Deleted Cancers von Smith, Christopher R, Aranda, Ruth, Bobinski, Thomas P, Briere, David M, Burns, Aaron C, Christensen, James G, Clarine, Jeffery, Engstrom, Lars D, Gunn, Robin J, Ivetac, Anthony, Jean-Baptiste, Ronald, Ketcham, John M, Kobayashi, Masakazu, Kuehler, Jon, Kulyk, Svitlana, Lawson, J. David, Moya, Krystal, Olson, Peter, Rahbaek, Lisa, Thomas, Nicole C, Wang, Xiaolun, Waters, Laura M, Marx, Matthew A

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Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein–Protein Interaction von Ketcham, John M., Haling, Jacob, Khare, Shilpi, Bowcut, Vickie, Briere, David M., Burns, Aaron C., Gunn, Robin J., Ivetac, Anthony, Kuehler, Jon, Kulyk, Svitlana, Laguer, Jade, Lawson, J. David, Moya, Krystal, Nguyen, Natalie, Rahbaek, Lisa, Saechao, Barbara, Smith, Christopher R., Sudhakar, Niranjan, Thomas, Nicole C., Vegar, Laura, Vanderpool, Darin, Wang, Xiaolun, Yan, Larry, Olson, Peter, Christensen, James G., Marx, Matthew A.

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Thionium Ion Initiated Medium-Sized Ring Formation: The Total Synthesis of Asteriscunolide D von Trost, Barry M, Burns, Aaron C, Bartlett, Mark J, Tautz, Thomas, Weiss, Andrew H

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Total Synthesis of (−)-Salvinorin A von Line, Nathan J., Burns, Aaron C., Butler, Sean C., Casbohm, Jerry, Forsyth, Craig J.

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Palladium-Catalyzed Asymmetric Allylic Alkylation of 3-Aryloxindoles with Allylidene Dipivalate: A Useful Enol Pivalate Product von Trost, Barry M., Masters, James T., Burns, Aaron C.

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Solvent-Controlled, Site-Selective N‑Alkylation Reactions of Azolo-Fused Ring Heterocycles at N1‑, N2‑, and N3-Positions, Including Pyrazolo[3,4‑d]pyrimidines, Purines, [1,2,3]Tria... von Bookser, Brett C, Weinhouse, Michael I, Burns, Aaron C, Valiere, Andrew N, Valdez, Lino J, Stanczak, Pawel, Na, Jim, Rheingold, Arnold L, Moore, Curtis E, Dyck, Brian

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Readily Accessible Chiral Diene Ligands for Rh-Catalyzed Enantioselective Conjugate Additions of Boronic Acids von Trost, Barry M, Burns, Aaron C, Tautz, Thomas

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Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3Kα Mutant Protein von Ketcham, John M., Harwood, Stephen J., Aranda, Ruth, Aloiau, Athenea N., Bobek, Briana M., Briere, David M., Burns, Aaron C., Caddell Haatveit, Kersti, Calinisan, Andrew, Clarine, Jeffery, Elliott, Adam, Engstrom, Lars D., Gunn, Robin J., Ivetac, Anthony, Jones, Benjamin, Kuehler, Jon, Lawson, J. David, Nguyen, Natalie, Parker, Cody, Pearson, Kelly E., Rahbaek, Lisa, Saechao, Barbara, Wang, Xiaolun, Waters, Anna, Waters, Laura, Watkins, Ashlee H., Olson, Peter, Smith, Christopher R., Christensen, James G., Marx, Matthew A.

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A Simple Litmus Test for Aldehyde Oxidase Metabolism of Heteroarenes von O’Hara, Fionn, Burns, Aaron C, Collins, Michael R, Dalvie, Deepak, Ornelas, Martha A, Vaz, Alfin D. N, Fujiwara, Yuta, Baran, Phil S

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Access to Functionalized Steroid Side Chains via Modified Julia Olefination von Izgu, Enver Cagri, Burns, Aaron C, Hoye, Thomas R

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Identification of the Clinical Development Candidate MRTX849 , a Covalent KRAS G12C Inhibitor for the Treatment of Cancer von Fell, Jay B, Fischer, John P, Baer, Brian R, Blake, James F, Bouhana, Karyn, Briere, David M, Brown, Karin D, Burgess, Laurence E, Burns, Aaron C, Burkard, Michael R, Chiang, Harrah, Chicarelli, Mark J, Cook, Adam W, Gaudino, John J, Hallin, Jill, Hanson, Lauren, Hartley, Dylan P, Hicken, Erik J, Hingorani, Gary P, Hinklin, Ronald J, Mejia, Macedonio J, Olson, Peter, Otten, Jennifer N, Rhodes, Susan P, Rodriguez, Martha E, Savechenkov, Pavel, Smith, Darin J, Sudhakar, Niranjan, Sullivan, Francis X, Tang, Tony P, Vigers, Guy P, Wollenberg, Lance, Christensen, James G, Marx, Matthew A

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Intramolecular Diels−Alder/Tsuji Allylation Assembly of the Functionalized trans-Decalin of Salvinorin A von Burns, Aaron C, Forsyth, Craig J

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Synthesis and olfactory activity of unnatural, sulfated 5β-bile acid derivatives in the sea lamprey ( Petromyzon marinus) von Burns, Aaron C., Sorensen, Peter W., Hoye, Thomas R.

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Identification of the Clinical Development Candidate MRTX849, a Covalent KRASG12C Inhibitor for the Treatment of Cancer von Fell, Jay B, Fischer, John P, Baer, Brian R, Blake, James F, Bouhana, Karyn, Briere, David M, Brown, Karin D, Burgess, Laurence E, Burns, Aaron C, Burkard, Michael R, Chiang, Harrah, Chicarelli, Mark J, Cook, Adam W, Gaudino, John J, Hallin, Jill, Hanson, Lauren, Hartley, Dylan P, Hicken, Erik J, Hingorani, Gary P, Hinklin, Ronald J, Mejia, Macedonio J, Olson, Peter, Otten, Jennifer N, Rhodes, Susan P, Rodriguez, Martha E, Savechenkov, Pavel, Smith, Darin J, Sudhakar, Niranjan, Sullivan, Francis X, Tang, Tony P, Vigers, Guy P, Wollenberg, Lance, Christensen, James G, Marx, Matthew A

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Simple Sulfinate Synthesis Enables CH Trifluoromethylcyclopropanation von Gianatassio, Ryan, Kawamura, Shuhei, Eprile, Cecil L, Foo, Klement, Ge, Jason, Burns, Aaron C., Collins, Michael R., Baran, Phil S.

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Palladium-Catalyzed Asymmetric Allylic Alkylation of 3-Aryloxindoles with Allylidene Dipivalate: A Useful Enol Pivalate Product von Trost, Barry M., Masters, James T., Burns, Aaron C.

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