P418: DELE1 LOSS AND DYSFUNCTIONAL INTEGRATED STRESS SIGNALING IN TP53 MUTATED AML IS A NOVEL PATHWAY FOR VENETOCLAX RESISTANCE von Sharon, David, Jung, Paul, Sun, Yan, Feng, Weiguo, Yang, Ziping, Robinson, Valerie, Mitra, Diya, Liu, Wei, Zheng, Pingping, Uziel, Tami, Lam, Lloyd, Minden, Mark, Ross, Jeremy, Mendes, Wellington, Potluri, Jalaja, Wei, Andrew, Konopleva, Marina, Dail, Monique, Chyla, Brenda, Epling‐Burnette, Pk

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Icariin and its derivative, ICT, exert anti-inflammatory, anti-tumor effects, and modulate myeloid derived suppressive cells (MDSCs) functions von Zhou, Junmin, Wu, Jinfeng, Chen, Xianghong, Fortenbery, Nicole, Eksioglu, Erika, Kodumudi, Krithika N., PK, Epling-Burnette, Dong, Jingcheng, Djeu, Julie Y., Wei, Sheng

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Clonal expansion of T NK-cells during tyrosine kinase inhibitor dasatinib therapy von Mustjoki, S, Ekblom, M, Arstila, T P, Dybedal, I, Epling-Burnette, P K, Guilhot, F, Hjorth-Hansen, H, Höglund, M, Kovanen, P, Laurinolli, T, Liesveld, J, Paquette, R, Pinilla-Ibarz, J, Rauhala, A, Shah, N, Simonsson, B, Sinisalo, M, Steegmann, J L, Stenke, L, Porkka, K

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Inhibition of Bcr-Abl kinase activity by PD180970 blocks constitutive activation of Stat5 and growth of CML cells von MEI HUANG, DORSEY, Jay F, HUA YU, MOSCINSKI, Lynn, SHENG WEI, DJEU, Julie, DALTON, William S, BHALLA, Kapil, LOUGHRAN, Thomas P, JIE WU, JOVE, Richard, EPLING-BURNETTE, P. K, NIMMANAPALLI, Ramadevi, LANDOWSKI, Terry H, MORA, Linda B, NIU, Guilian, SINIBALDI, Dominic, FANQI BAI, KRAKER, Alan

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Bivalent BCMA Binding and Low Affinity CD3 T-Cell Engagement By Abbv-383 Drives Sustained Activation with Reduced T-Cell Exhaustion in Preclinical Models of Multiple Myeloma von Sharon, David, Robinson, Valerie, Hecquet, Claudie, Calabrese, Kelly, Cosgrove, Cormac, Mantis, Christine, Bueno, Orlando, Ahsan, Aarif, Chervin, Adam, Epling-Burnette, PK, Ross, Jeremy A

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SHP2 Inhibition Enhances JAK2 Inhibitor Therapy in Preclinical Models of Myeloproliferative Neoplasms von Pandey, Garima, Mazzacurati, Lucia, Horvat, Nathan P., Rowsell, Tegan, Amin, Narmin E., Zhang, Guolin, Akuffo, Afua Adutwumwa, Colin-Leitzinger, Christelle M., Haura, Eric B., Kuykendall, Andrew T., Epling-Burnette, PK, Reuther, Gary W.

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Evaluation of Epcoritamab and Rituximab Combination in Preclinical Models of B-Cell Non-Hodgkin's Lymphoma (NHL) von Epling-Burnette, PK, Dandamudi, Durga B, Konieczna, Iwona M, Calabrese, Kelly M, Wielgos-Bonvallet, Monica, Kweekel, Christiaan, Gresnigt - van den Heuvel, Elke, Parikh, Apurvasena, Li, Tommy, Chiu, Christopher W, Chervin, Adam, Reilly, Edward B, Szafer-Glusman, Edith

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Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression von Epling-Burnette, P K, Liu, J H, Catlett-Falcone, R, Turkson, J, Oshiro, M, Kothapalli, R, Li, Y, Wang, J M, Yang-Yen, H F, Karras, J, Jove, R, Loughran, Jr, T P

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Intrapatient functional clonality deconvoluted by coupling intracellular flow cytometry and next-generation sequencing in human leukemia von Zhang, Q, Ball, M C, Zhao, Y, Balasis, M, Letson, C, Vedder, A, List, A F, Epling-Burnette, P K, Komrokji, R S, Padron, E

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Abstract 540: c-MET mutations sensitize to antibody-drug conjugate telisotuzumab vedotin through efficient internalization and rapid intracellular drug delivery von Batth, Izhar S., Jaiswal, Bijay S., Maji, Dolonchampa, Sparks, Robert, Glauser, William, Uziel, Tamar, Camidge, D. Ross, Vasilopoulos, Athan, Ansell, Peter, Epling-Burnette, PK

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Altered naive and memory CD4+ T-cell homeostasis and immunosenescence characterize younger patients with myelodysplastic syndrome von Zou, J X, Rollison, D E, Boulware, D, Chen, D-T, Sloand, E M, Pfannes, L V, Goronzy, J J, Bai, F, Painter, J S, Wei, S, Cosgrove, D, List, A F, Epling-Burnette, P K

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Reversal of T-cell tolerance in myelodysplastic syndrome through lenalidomide immune modulation von McDaniel, J M, Zou, J X, Fulp, W, Chen, D-T, List, A F, Epling-Burnette, P K

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Abstract 2530: DELE1 loss and dysfunctional integrated stress signaling in TP53 mutated AML is a novel pathway for venetoclax resistance von Sharon, David, Jung, Paul, Sun, Yan, Feng, Weiguo, Yang, Ziping, Robinson, Valerie, Mitra, Diya, Liu, Wei, Zheng, Pingping, Uziel, Tamar, Lam, Lloyd, Minden, Mark D., Ross, Jeremy, Mendes, Wellington, Potluri, Jalaja, Wei, Andrew H., Konopleva, Marina, Dail, Monique, Chyla, Brenda, Epling-Burnette, PK

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Blockade of Fas-dependent apoptosis by soluble Fas in LGL leukemia von Liu, Jin Hong, Wei, Sheng, Lamy, Thierry, Li, Yongxiang, Epling-Burnette, P.K., Djeu, Julie Y., Loughran, Thomas P.

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Cooperative Regulation of Mcl-1 by Janus Kinase/STAT and Phosphatidylinositol 3-Kinase Contribute to Granulocyte-Macrophage Colony-Stimulating Factor-Delayed Apoptosis in Human Neu... von Epling-Burnette, P. K, Zhong, Bin, Bai, Fanqi, Jiang, Kun, Bailey, Ratna D, Garcia, Roy, Jove, Richard, Djeu, Julie Y, Loughran, Thomas P., Jr, Wei, Sheng

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Dysregulated NK receptor expression in patients with lymphoproliferative disease of granular lymphocytes von Epling-Burnette, Pearlie Kay, Painter, Jeffrey S., Chaurasia, Pratima, Bai, Fanqi, Wei, Sheng, Djeu, Julie Y., Loughran, Thomas P.

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Chronic neutropenia mediated by Fas ligand von JINHONG LIU, SHENG WEI, LAMY, T, EPLING-BURNETTE, P. K, STARKEBAUM, G, DJEU, J. Y, LOUGHRAN, T. P

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Cross‐sectional associations between cutaneous viral infections and regulatory T lymphocytes in circulation von Hampras, S.S., Tommasino, M., Zhao, Y., Messina, J.L., Giuliano, A.R., Fenske, N.A., Cherpelis, B., Hesterberg, R.S., Akuffo, A.A., Amorrortu, R.P., Balliu, J., Vijayan, L., Gheit, T., Epling‐Burnette, P.K., Rollison, D.E.

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Roscovitine inhibits STAT5 activity and induces apoptosis in the human leukemia virus type 1-transformed cell line MT-2 von MOHAPATRA, Subhra, CHU, Baoky, SHENG WEI, DJEU, Julie, EPLING-BURNETTE, P. K, LOUGHRAN, Thomas, JOVE, Richard, PLEDGER, W. Jackson

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Survival signals in leukemic large granular lymphocytes von Epling-Burnette, P.K., Loughran, Thomas P.

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