Mechanistic Insight into NMDA Receptor Dysregulation by Rare Variants in the GluN2A and GluN2B Agonist Binding Domains von Swanger, Sharon A., Chen, Wenjuan, Wells, Gordon, Burger, Pieter B., Tankovic, Anel, Bhattacharya, Subhrajit, Strong, Katie L., Hu, Chun, Kusumoto, Hirofumi, Zhang, Jing, Adams, David R., Millichap, John J., Petrovski, Slavé, Traynelis, Stephen F., Yuan, Hongjie

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Error Tolerance of Machine Learning Algorithms across Contemporary Biological Targets von Kaiser, Thomas M, Burger, Pieter B

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Mechanism for noncompetitive inhibition by novel GluN2C/D N-methyl-D-aspartate receptor subunit-selective modulators von Acker, Timothy M, Yuan, Hongjie, Hansen, Kasper B, Vance, Katie M, Ogden, Kevin K, Jensen, Henrik S, Burger, Pieter B, Mullasseril, Praseeda, Snyder, James P, Liotta, Dennis C, Traynelis, Stephen F

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Functional Evaluation of a De Novo GRIN2A Mutation Identified in a Patient with Profound Global Developmental Delay and Refractory Epilepsy von Chen, Wenjuan, Tankovic, Anel, Burger, Pieter B, Kusumoto, Hirofumi, Traynelis, Stephen F, Yuan, Hongjie

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FEP Augmentation as a Means to Solve Data Paucity Problems for Machine Learning in Chemical Biology von Burger, Pieter B., Hu, Xiaohu, Balabin, Ilya, Muller, Morné, Stanley, Megan, Joubert, Fourie, Kaiser, Thomas M.

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Exploring inhibition of Pdx1, a component of the PLP synthase complex of the human malaria parasite Plasmodium falciparum von Reeksting, Shaun B, Müller, Ingrid B, Burger, Pieter B, Burgos, Emmanuel S, Salmon, Laurent, Louw, Abraham I, Birkholtz, Lyn-Marie, Wrenger, Carsten

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NMDA receptor channel gating control by the pre-M1 helix von McDaniel, Miranda J., Ogden, Kevin K., Kell, Steven A., Burger, Pieter B., Liotta, Dennis C., Traynelis, Stephen F.

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A novel inhibitor of Plasmodium falciparum spermidine synthase: a twist in the tail von Burger, Pieter B, Williams, Marni, Sprenger, Janina, Reeksting, Shaun B, Botha, Mariëtte, Müller, Ingrid B, Joubert, Fourie, Birkholtz, Lyn-Marie, Louw, Abraham I

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Negative allosteric modulation of GluN1/GluN3 NMDA receptors von Zhu, Zongjian, Yi, Feng, Epplin, Matthew P., Liu, Ding, Summer, Samantha L., Mizu, Ruth, Shaulsky, Gil, XiangWei, Wenshu, Tang, Weiting, Burger, Pieter B., Menaldino, David S., Myers, Scott J., Liotta, Dennis C., Hansen, Kasper B., Yuan, Hongjie, Traynelis, Stephen F.

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Structural determinants and mechanism of action of a GluN2C-selective NMDA receptor positive allosteric modulator von Khatri, Alpa, Burger, Pieter B, Swanger, Sharon A, Hansen, Kasper B, Zimmerman, Sommer, Karakas, Erkan, Liotta, Dennis C, Furukawa, Hiro, Snyder, James P, Traynelis, Stephen F

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A Machine Learning Approach for Predicting HIV Reverse Transcriptase Mutation Susceptibility of Biologically Active Compounds von Kaiser, Thomas M, Burger, Pieter B, Butch, Christopher J, Pelly, Stephen C, Liotta, Dennis C

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Structural Determinants of D-Cycloserine Efficacy at the NR1/NR2C NMDA Receptors von Dravid, Shashank M, Burger, Pieter B, Prakash, Anand, Geballe, Matthew T, Yadav, Roopali, Le, Phuong, Vellano, Kimberly, Snyder, James P, Traynelis, Stephen F

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The Bioactive Protein-Ligand Conformation of GluN2C-Selective Positive Allosteric Modulators Bound to the NMDA Receptor von Kaiser, Thomas M, Kell, Steven A, Kusumoto, Hirofumi, Shaulsky, Gil, Bhattacharya, Subhrajit, Epplin, Matthew P, Strong, Katie L, Miller, Eric J, Cox, Bryan D, Menaldino, David S, Liotta, Dennis C, Traynelis, Stephen F, Burger, Pieter B

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Selective targeting of CD38 hydrolase and cyclase activity as an approach to immunostimulation von Benton, Thomas Z, Mills, Catherine M, Turner, Jonathan M, Francis, Megan J, Solomon, Dalan J, Burger, Pieter B, Peterson, Yuri K, Dolloff, Nathan G, Bachmann, André S, Woster, Patrick M

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The Structure–Activity Relationship of a Tetrahydroisoquinoline Class of N‑Methyl‑d‑Aspartate Receptor Modulators that Potentiates GluN2B-Containing N‑Methyl‑d‑Aspartate Receptors... von Strong, Katie L, Epplin, Matthew P, Bacsa, John, Butch, Christopher J, Burger, Pieter B, Menaldino, David S, Traynelis, Stephen F, Liotta, Dennis C

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Mapping the binding of GluN2B-selective N-methyl-D-aspartate receptor negative allosteric modulators von Burger, Pieter B, Yuan, Hongjie, Karakas, Erkan, Geballe, Matthew, Furukawa, Hiro, Liotta, Dennis C, Snyder, James P, Traynelis, Stephen F

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Distinct GluN1 and GluN2 Structural Determinants for Subunit-Selective Positive Allosteric Modulation of N-Methyl-D-aspartate Receptors von Strong, Katie L., Epplin, Matthew P., Ogden, Kevin K., Burger, Pieter B., Kaiser, Thomas M., Wilding, Timothy J., Kusumoto, Hiro, Camp, Chad R., Shaulsky, Gil, Bhattacharya, Subhrajit, Perszyk, Riley E., Menaldino, David S., McDaniel, Miranda J., Zhang, Jing, Phuong Le, Banke, Tue G., Hansen, Kasper B., Huettner, James E., Liotta, Dennis C., Traynelis, Stephen F.

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Accelerated Discovery of Potent Fusion Inhibitors for Respiratory Syncytial Virus von Pribut, Nicole, Kaiser, Thomas M, Wilson, Robert J, Jecs, Edgars, Dentmon, Zackery W, Pelly, Stephen C, Sharma, Savita, Bartsch, Perry W, Burger, Pieter B, Hwang, Soyon S, Le, Thalia, Sourimant, Julien, Yoon, Jeong-Joong, Plemper, Richard K, Liotta, Dennis C

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Discovery-2: an interactive resource for the rational selection and comparison of putative drug target proteins in malaria von Mpangase, Phelelani T, Szolkiewicz, Michal J, le Grange, Misha, Smit, Jeanré H, Burger, Pieter B, Joubert, Fourie

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Structural and mechanistic insights into the action of Plasmodium falciparum spermidine synthase von Burger, Pieter B., Birkholtz, Lyn-Marie, Joubert, Fourie, Haider, Nashya, Walter, Rolf D., Louw, Abraham I.

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