Optknock: A bilevel programming framework for identifying gene knockout strategies for microbial strain optimization von Burgard, Anthony P., Pharkya, Priti, Maranas, Costas D.

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In silico design and adaptive evolution of Escherichia coli for production of lactic acid von Fong, Stephen S., Burgard, Anthony P., Herring, Christopher D., Knight, Eric M., Blattner, Frederick R., Maranas, Costas D., Palsson, Bernhard O.

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Optimization-based framework for inferring and testing hypothesized metabolic objective functions von Burgard, Anthony P., Maranas, Costas D.

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Exploring the overproduction of amino acids using the bilevel optimization framework OptKnock von Pharkya, Priti, Burgard, Anthony P., Maranas, Costas D.

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Minimal Reaction Sets for Escherichia coli Metabolism under Different Growth Requirements and Uptake Environments von Burgard, Anthony P., Vaidyaraman, Shankar, Maranas, Costas D.

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Probing the performance limits of the Escherichia coli metabolic network subject to gene additions or deletions von Burgard, Anthony P., Maranas, Costas D.

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