Could AlphaFold revolutionize chemical therapeutics? von Tong, Alexander B., Burch, Jason D., McKay, Daniel, Bustamante, Carlos, Crackower, Michael A., Wu, Hao

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Aminoalkylation of [1.1.1]Propellane Enables Direct Access to High-Value 3‑Alkylbicyclo[1.1.1]pentan-1-amines von Hughes, Jonathan M. E, Scarlata, David A, Chen, Austin C.-Y, Burch, Jason D, Gleason, James L

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One-Pot Synthesis of Benzofurans via Palladium-Catalyzed Enolate Arylation with o-Bromophenols von Eidamshaus, Christian, Burch, Jason D

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Discovery of MK-1439, an orally bioavailable non-nucleoside reverse transcriptase inhibitor potent against a wide range of resistant mutant HIV viruses von Côté, Bernard, Burch, Jason D., Asante-Appiah, Ernest, Bayly, Chris, Bédard, Leanne, Blouin, Marc, Campeau, Louis-Charles, Cauchon, Elizabeth, Chan, Manuel, Chefson, Amandine, Coulombe, Nathalie, Cromlish, Wanda, Debnath, Smita, Deschênes, Denis, Dupont-Gaudet, Kristina, Falgueyret, Jean-Pierre, Forget, Robert, Gagné, Sébastien, Gauvreau, Danny, Girardin, Melina, Guiral, Sébastien, Langlois, Eric, Li, Chun Sing, Nguyen, Natalie, Papp, Rob, Plamondon, Serge, Roy, Amélie, Roy, Stéphanie, Seliniotakis, Ria, St-Onge, Miguel, Ouellet, Stéphane, Tawa, Paul, Truchon, Jean-François, Vacca, Joe, Wrona, Marc, Yan, Youwei, Ducharme, Yves

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The effect of NOD2 on the microbiota in Crohn's disease von Lauro, Mackenzie L, Burch, Jason M, Grimes, Catherine Leimkuhler

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Total Synthesis of Aflastatin A von Evans, David A., Beiger, Jason J., Burch, Jason D., Fuller, Peter H., Glorius, Frank, Kattnig, Egmont, Thaisrivongs, David A., Trenkle, William C., Young, Joseph M., Zhang, Jing

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Fragment Molecular Orbital Method Applied to Lead Optimization of Novel Interleukin‑2 Inducible T‑Cell Kinase (ITK) Inhibitors von Heifetz, Alexander, Trani, Giancarlo, Aldeghi, Matteo, MacKinnon, Colin H, McEwan, Paul A, Brookfield, Frederick A, Chudyk, Ewa I, Bodkin, Mike, Pei, Zhonghua, Burch, Jason D, Ortwine, Daniel F

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Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-κB Inducing Kinase von Blaquiere, Nicole, Castanedo, Georgette M, Burch, Jason D, Berezhkovskiy, Leonid M, Brightbill, Hans, Brown, Suzanne, Chan, Connie, Chiang, Po-Chang, Crawford, James J, Dong, Teresa, Fan, Peter, Feng, Jianwen, Ghilardi, Nico, Godemann, Robert, Gogol, Emily, Grabbe, Alice, Hole, Alison J, Hu, Baihua, Hymowitz, Sarah G, Alaoui Ismaili, Moulay Hicham, Le, Hoa, Lee, Patrick, Lee, Wyne, Lin, Xingyu, Liu, Ning, McEwan, Paul A, McKenzie, Brent, Silvestre, Hernani L, Suto, Eric, Sujatha-Bhaskar, Swathi, Wu, Guosheng, Wu, Lawren C, Zhang, Yamin, Zhong, Zoe, Staben, Steven T

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In Vitro Characterization of MK-1439, a Novel HIV-1 Nonnucleoside Reverse Transcriptase Inhibitor von LAI, Ming-Tain, MEIZHEN FENG, CAUCHON, Elizabeth, CAMPEAU, Louis-Charles, GROBLER, Jay, YOUWEI YAN, DUCHARME, Yves, COTE, Bernard, ASANTE-APPIAH, Ernest, HAZUDA, Daria J, MILLER, Michael D, FALGUEYRET, Jean-Pierre, TAWA, Paul, WITMER, Marc, DISTEFANO, Daniel, YUAN LI, BURCH, Jason, SACHS, Nancy, MEIQING LU

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Novel pyridone EP4 agonists featuring allylic alcohol ω-chains von Dorich, Stéphane, Cox, Jennifer H., Burch, Jason D., Chagnon, Félix, Chen, Bin, Léger, Serge, St-Onge, Miguel, Fader, Lee D.

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Back Pocket Flexibility Provides Group II p21-Activated Kinase (PAK) Selectivity for Type I 1/2 Kinase Inhibitors von Staben, Steven T, Feng, Jianwen A, Lyle, Karen, Belvin, Marcia, Boggs, Jason, Burch, Jason D, Chua, Ching-ching, Cui, Haifeng, DiPasquale, Antonio G, Friedman, Lori S, Heise, Christopher, Koeppen, Hartmut, Kotey, Adrian, Mintzer, Robert, Oh, Angela, Roberts, David Allen, Rouge, Lionel, Rudolph, Joachim, Tam, Christine, Wang, Weiru, Xiao, Yisong, Young, Amy, Zhang, Yamin, Hoeflich, Klaus P

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Tetrahydroindazoles as Interleukin‑2 Inducible T‑Cell Kinase Inhibitors. Part II. Second-Generation Analogues with Enhanced Potency, Selectivity, and Pharmacodynamic Modulation in... von Burch, Jason D, Barrett, Kathy, Chen, Yuan, DeVoss, Jason, Eigenbrot, Charles, Goldsmith, Richard, Ismaili, M. Hicham A, Lau, Kevin, Lin, Zhonghua, Ortwine, Daniel F, Zarrin, Ali A, McEwan, Paul A, Barker, John J, Ellebrandt, Claire, Kordt, Daniel, Stein, Daniel B, Wang, Xiaolu, Chen, Yong, Hu, Baihua, Xu, Xiaofeng, Yuen, Po-Wai, Zhang, Yamin, Pei, Zhonghua

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Enantioselective total synthesis of callipeltoside A: two approaches to the macrolactone fragment von Evans, David A., Burch, Jason D., Hu, Essa, Jaeschke, Georg

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Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response von Sun, Yonglian, Peng, Ivan, Webster, Joshua D, Suto, Eric, Lesch, Justin, Wu, Xiumin, Senger, Kate, Francis, George, Barrett, Kathy, Collier, Jenna L, Burch, Jason D, Zhou, Meijuan, Chen, Yuan, Chan, Connie, Eastham-Anderson, Jeff, Ngu, Hai, Li, Olga, Staton, Tracy, Havnar, Charles, Jaochico, Allan, Jackman, Janet, Jeet, Surinder, Riol-Blanco, Lorena, Wu, Lawren C, Choy, David F, Arron, Joseph R, McKenzie, Brent S, Ghilardi, Nico, Ismaili, Moulay Hicham Alaoui, Pei, Zhonghua, DeVoss, Jason, Austin, Cary D, Lee, Wyne P, Zarrin, Ali A

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Crohn’s Disease Variants of Nod2 Are Stabilized by the Critical Contact Region of Hsp70 von Schaefer, Amy K, Wastyk, Hannah C, Mohanan, Vishnu, Hou, Ching-Wen, Lauro, Mackenzie L, Melnyk, James E, Burch, Jason M, Grimes, Catherine L

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Property- and Structure-Guided Discovery of a Tetrahydroindazole Series of Interleukin‑2 Inducible T‑Cell Kinase Inhibitors von Burch, Jason D, Lau, Kevin, Barker, John J, Brookfield, Fred, Chen, Yong, Chen, Yuan, Eigenbrot, Charles, Ellebrandt, Claire, Ismaili, M. Hicham A, Johnson, Adam, Kordt, Daniel, MacKinnon, Colin H, McEwan, Paul A, Ortwine, Daniel F, Stein, Daniel B, Wang, Xiaolu, Winkler, Dirk, Yuen, Po-Wai, Zhang, Yamin, Zarrin, Ali A, Pei, Zhonghua

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Bacterial Derived Carbohydrates Bind Cyr1 and Trigger Hyphal Growth in Candida albicans von Burch, Jason M, Mashayekh, Siavash, Wykoff, Dennis D, Grimes, Catherine L

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Discovery and optimization of indazoles as potent and selective interleukin-2 inducible T cell kinase (ITK) inhibitors von Pastor, Richard M., Burch, Jason D., Magnuson, Steven, Ortwine, Daniel F., Chen, Yuan, De La Torre, Kelly, Ding, Xiao, Eigenbrot, Charles, Johnson, Adam, Liimatta, Marya, Liu, Yichin, Shia, Steven, Wang, Xiaolu, Wu, Lawren C., Pei, Zhonghua

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1,4-Induction in aldol reactions of (tertiary α′-alkoxy)methyl ketones: synthesis of the C8–C11 stereotriad of ent-fostriecin von Cowper, Nicholas, Azzi, Soula, Dupont-Gaudet, Kristina, Burch, Jason D.

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Enantioselective Total Synthesis of Callipeltoside A von Evans, David A, Hu, Essa, Burch, Jason D, Jaeschke, Georg

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