Discovery of ZN-c3, a Highly Potent and Selective Wee1 Inhibitor Undergoing Evaluation in Clinical Trials for the Treatment of Cancer von Huang, Peter Q, Boren, Brant C, Hegde, Sayee G, Liu, Hui, Unni, Aditya K, Abraham, Sunny, Hopkins, Chad D, Paliwal, Sunil, Samatar, Ahmed A, Li, Jiali, Bunker, Kevin D

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Scalable Synthesis of 1-Bicyclo[1.1.1]pentylamine via a Hydrohydrazination Reaction von Bunker, Kevin D, Sach, Neal W, Huang, Qinhua, Richardson, Paul F

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Acid-Induced Liberation of Polysubstituted Cyclopentadiene Ligands from Cyclopentadienyl Cobalt: A [2 + 2 + 1] Cycloaddition Route toward 1,2,4-Trisubstituted Cyclopentadienes von Qin, Pengjin, Holland, Ryan L, Bunker, Kevin D, O’Connor, Joseph M, Baldridge, Kim K, Rheingold, Arnold L

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Evaluation of KP‐1199: a novel acetaminophen analog for hemostatic function and antinociceptive effects von Reddoch‐Cardenas, Kristin M., Cheppudira, Bopaiah P., Garza, Thomas, Hopkins, Chad D., Bunker, Kevin D., Slee, Deborah H., Cap, Andrew P., Bynum, James A., Christy, Robert J.

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Structural Characterization of (C5H5)Co(PPh3)(η2‑alkyne) and (C5H5)Co(η2‑alkyne) Complexes of Highly Polarized Alkynes von Baldridge, Kim K, Bunker, Kevin D, Vélez, Carmen L, Holland, Ryan L, Rheingold, Arnold L, Moore, Curtis E, O’Connor, Joseph M

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An efficient synthesis of highly functionalized chiral lactams von Ornelas, Martha A., Gonzalez, Javier, Sach, Neal W., Richardson, Paul F., Bunker, Kevin D., Linton, Angelica, Kephart, Susan E., Pairish, Mason, Guo, Chuangxing

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Reactions of a Metallacyclobutene Complex with Alkenes von Holland, Ryan L, Bunker, Kevin D, Chen, Christopher H, DiPasquale, Antonio G, Rheingold, Arnold L, Baldridge, Kim K, O’Connor, Joseph M

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Abstract 1965: Discovery of ZN-c3, a potent Wee-1 inhibitor with a differentiated pharmacologic and kinase selectivity profile von Li, Jiali, Boren, Brant, Huang, Peter Q., Bunker, Kevin D., Doñate, Fernando, Samatar, Ahmed A.

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Sulfoxide Carbon−Sulfur Bond Activation von O'Connor, Joseph M, Bunker, Kevin D, Rheingold, Arnold L, Zakharov, Lev

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Abstract 2423: Discovery of ZN-e4, an irreversible EGFR-TKI with potent anti-tumor activity in EGFR mutant non-small-cell lung cancer von Li, Jiali, Abraham, Sunny, Ma, Jianhui, Huang, Peter Q., Bunker, Kevin D., Doñate, Fernando, Samatar, Ahmed A.

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Abstract 4373: Discovery of ZN-c5, a novel potent and oral selective estrogen receptor degrader von Samatar, Ahmed A., Li, Jiali, Hegde, Sayee, Huang, Peter, Ma, Jianhui, Bunker, Kevin, Winkler, Robert, Donate, Fernando, Sergeeva, Masha

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Thermolysis of [(η 5-C 5H 5)Co(PPh 3)(η 2-DMAD)], revisited: a solid state analysis reveals the true structure of the triphenylphosphine–alkyne coupling product von O'Connor, Joseph M, Bunker, Kevin D

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Design of Potent and Selective Inhibitors to Overcome Clinical Anaplastic Lymphoma Kinase Mutations Resistant to Crizotinib von Huang, Qinhua, Johnson, Ted W, Bailey, Simon, Brooun, Alexei, Bunker, Kevin D, Burke, Benjamin J, Collins, Michael R, Cook, Andrew S, Cui, J. Jean, Dack, Kevin N, Deal, Judith G, Deng, Ya-Li, Dinh, Dac, Engstrom, Lars D, He, Mingying, Hoffman, Jacqui, Hoffman, Robert L, Johnson, Patrick S, Kania, Robert S, Lam, Hieu, Lam, Justine L, Le, Phuong T, Li, Qiuhua, Lingardo, Laura, Liu, Wei, Lu, Melissa West, McTigue, Michele, Palmer, Cynthia L, Richardson, Paul F, Sach, Neal W, Shen, Hong, Smeal, Tod, Smith, Graham L, Stewart, Albert E, Timofeevski, Sergei, Tsaparikos, Konstantinos, Wang, Hui, Zhu, Huichun, Zhu, Jinjiang, Zou, Helen Y, Edwards, Martin P

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Conversion of (η5-C5H5)Co(PPh3)2 and Nitro Compounds to Mononuclear η1(N)-Nitrosoalkyl and Dinuclear μ-η1(N):η2(N,O)-Nitrosoaryl Complexes von O'Connor, Joseph M, Bunker, Kevin D

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Abstract 2591: Combination of the BCL-2 inhibitor ZN-d5 with the WEE1 inhibitor ZN-c3 shows additive or synergistic anti-tumor activity in acute myeloid leukemia (AML) models von Izadi, Hooman, Hoang, Tiffany, Ibrahim, Noah, Pinchman, Joseph, Boren, Brant C., Ma, Jianhui, de Jong, Petrus R., Li, Jiali, Bunker, Kevin D., Samatar, Ahmed A., Doñate, Fernando

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Abstract 2605: BH3 mimetics synergize with the Wee1 inhibitor ZN-c3 by activating caspases which induce DNA damage and degrade key proteins von Izadi, Hooman, Ibrahim, Noah, Hoang, Tiffany, Ma, Jianhui, de Jong, Petrus R., Pinchman, Joseph, Bunker, Kevin D., Samatar, Ahmed A., Doñate, Fernando

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Abstract 2153: Cyclin E1 protein overexpression sensitizes ovarian cancer cells to ZN-c3, a novel, selective and oral bioavailable inhibitor of Wee1 von Ma, Jianhui, Liu, Wen, Chung, Heekyung, Izadi, Hooman, DeJong, Petrus, Harismendy, Olivier, li, Jia, Doñate, Fernando, Samatar, Ahmed, Lackner, Mark, Escoubet, Laure, Bunker, Kevin, Kim, Daehwan, Jameson, Nathan, Ozmen, Tugba Yildiran, Jeong, Kangjin, Zhang, Dong, Pan, Wen-An, Mills, Gordon

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Synthesis of the cobalt–alkyne complex (η5-C5H5)(PPh3)Co{η2-(Me3Si)CC(CO2Et)} and structural characterization of trimethylsilyl substituted cobaltacyclopentadiene complexes derived... von Bunker, Kevin D., Rheingold, Arnold L., Moore, Curtis E., Aubrey, Marissa, O'Connor, Joseph M.

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Ring-strain effects on the oxidation potential of enediynes and enediyne complexes von Baldridge, Kim K, Donovan-Merkert, Bernadette T, O'Connor, Joseph M, Lee, Linda I, Closson, Adam, Fandrick, Daniel, Tran, Tuan, Bunker, Kevin D, Fouzi, Mouffouk, Gantzel, Peter

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3-Amino-5-bromo-2-iodopyridine von Bunker, Kevin D., Sach, Neal W., Nukui, Seiji, Rheingold, Arnold L., Yanovsky, Alex

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