Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases von Pinkas, Daniel M, Sanvitale, Caroline E, Bufton, Joshua C, Sorrell, Fiona J, Solcan, Nicolae, Chalk, Rod, Doutch, James, Bullock, Alex N

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The DUF1669 domain of FAM83 family proteins anchor casein kinase 1 isoforms von Fulcher, Luke J, Bozatzi, Polyxeni, Tachie-Menson, Theresa, Wu, Kevin Z L, Cummins, Timothy D, Bufton, Joshua C, Pinkas, Daniel M, Dunbar, Karen, Shrestha, Sabin, Wood, Nicola T, Weidlich, Simone, Macartney, Thomas J, Varghese, Joby, Gourlay, Robert, Campbell, David G, Dingwell, Kevin S, Smith, James C, Bullock, Alex N, Sapkota, Gopal P

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Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNA von Powers, Kyle T, Stevenson-Jones, Flint, Yadav, Sathish K N, Amthor, Beate, Bufton, Joshua C, Borucu, Ufuk, Shen, Dakang, Becker, Jonas P, Lavysh, Daria, Hentze, Matthias W, Kulozik, Andreas E, Neu-Yilik, Gabriele, Schaffitzel, Christiane

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Receptor-interacting protein kinase 2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling inhibitors based on a 3,5-diphenyl-2-aminopyridine scaffold von Suebsuwong, Chalada, Dai, Bing, Pinkas, Daniel M., Duddupudi, Anantha Lakshmi, Li, Li, Bufton, Joshua C., Schlicher, Lisa, Gyrd-Hansen, Mads, Hu, Ming, Bullock, Alex N., Degterev, Alexei, Cuny, Gregory D.

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A BTB extension and ion-binding domain contribute to the pentameric structure and TFAP2A binding of KCTD1 von Pinkas, Daniel M., Bufton, Joshua C., Hunt, Alice E., Manning, Charlotte E., Richardson, William, Bullock, Alex N.

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Structures of nonsense-mediated mRNA decay factors UPF3B and UPF3A in complex with UPF2 reveal molecular basis for competitive binding and for neurodevelopmental disorder-causing m... von Bufton, Joshua C, Powers, Kyle T, Szeto, Jenn-Yeu A, Toelzer, Christine, Berger, Imre, Schaffitzel, Christiane

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Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling von Hrdinka, Matous, Schlicher, Lisa, Dai, Bing, Pinkas, Daniel M, Bufton, Joshua C, Picaud, Sarah, Ward, Jennifer A, Rogers, Catherine, Suebsuwong, Chalada, Nikhar, Sameer, Cuny, Gregory D, Huber, Kilian VM, Filippakopoulos, Panagis, Bullock, Alex N, Degterev, Alexei, Gyrd‐Hansen, Mads

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Engineering the ADDobody protein scaffold for generation of high-avidity ADDomer super-binders von Buzas, Dora, Sun, Huan, Toelzer, Christine, Yadav, Sathish K.N., Borucu, Ufuk, Gautam, Gunjan, Gupta, Kapil, Bufton, Joshua C., Capin, Julien, Sessions, Richard B., Garzoni, Frederic, Berger, Imre, Schaffitzel, Christiane

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Sample Preparation for Electron Cryo-Microscopy of Macromolecular Machines von Deniaud, Aurélien, Kabasakal, Burak V., Bufton, Joshua C., Schaffitzel, Christiane

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Development of a Selective Dual Discoidin Domain Receptor (DDR)/p38 Kinase Chemical Probe von Röhm, Sandra, Berger, Benedict-Tilman, Schröder, Martin, Chatterjee, Deep, Mathea, Sebastian, Joerger, Andreas C, Pinkas, Daniel M, Bufton, Joshua C, Tjaden, Amelie, Kovooru, Lohitesh, Kudolo, Mark, Pohl, Christian, Bullock, Alex N, Müller, Susanne, Laufer, Stefan, Knapp, Stefan

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Activation loop targeting strategy for design of receptor-interacting protein kinase 2 (RIPK2) inhibitors von Suebsuwong, Chalada, Pinkas, Daniel M., Ray, Soumya S., Bufton, Joshua C., Dai, Bing, Bullock, Alex N., Degterev, Alexei, Cuny, Gregory D.

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Inhibition of homologous phosphorolytic ribonucleases by citrate may represent an evolutionarily conserved communicative link between RNA degradation and central metabolism von Stone, Carlanne M, Butt, Louise E, Bufton, Joshua C, Lourenco, Daniel C, Gowers, Darren M, Pickford, Andrew R, Cox, Paul A, Vincent, Helen A, Callaghan, Anastasia J

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Synthetic self-assembling ADDomer platform for highly efficient vaccination by genetically encoded multiepitope display von Vragniau, Charles, Bufton, Joshua C, Garzoni, Frédéric, Stermann, Emilie, Rabi, Fruzsina, Terrat, Céline, Guidetti, Mélanie, Josserand, Véronique, Williams, Matt, Woods, Christopher J, Viedma, Gerardo, Bates, Phil, Verrier, Bernard, Chaperot, Laurence, Schaffitzel, Christiane, Berger, Imre, Fender, Pascal

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In vitro generated antibodies guide thermostable ADDomer nanoparticle design for nasal vaccination and passive immunization against SARS-CoV-2 von Buzas, Dora, Bunzel, Adrian H, Staufer, Oskar, Milodowski, Emily J, Edmunds, Grace L, Bufton, Joshua C, Vidana Mateo, Beatriz V, Yadav, Sathish K N, Gupta, Kapil, Fletcher, Charlotte, Williamson, Maia K, Harrison, Alexandra, Borucu, Ufuk, Capin, Julien, Francis, Ore, Balchin, Georgia, Hall, Sophie, Vega, Mirella V, Durbesson, Fabien, Lingappa, Srikanth, Vincentelli, Renaud, Roe, Joe, Wooldridge, Linda, Burt, Rachel, Anderson, Ross J L, Mulholland, Adrian J, Bristol UNCOVER Group, Hare, Jonathan, Bailey, Mick, Davidson, Andrew D, Finn, Adam, Morgan, David, Mann, Jamie, Spatz, Joachim, Garzoni, Frederic, Schaffitzel, Christiane, Berger, Imre

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Target highlights in CASP13: Experimental target structures through the eyes of their authors von Lepore, Rosalba, Kryshtafovych, Andriy, Alahuhta, Markus, Veraszto, Harshul A., Bomble, Yannick J., Bufton, Joshua C., Bullock, Alex N., Caba, Cody, Cao, Hongnan, Davies, Owen R., Desfosses, Ambroise, Dunne, Matthew, Fidelis, Krzysztof, Goulding, Celia W., Gurusaran, Manickam, Gutsche, Irina, Harding, Christopher J., Hartmann, Marcus D., Hayes, Christopher S., Joachimiak, Andrzej, Leiman, Petr G., Loppnau, Peter, Lovering, Andrew L., Lunin, Vladimir V., Michalska, Karolina, Mir‐Sanchis, Ignacio, Mitra, AK, Moult, John, Phillips Jr, George N., Pinkas, Daniel M., Rice, Phoebe A., Tong, Yufeng, Topf, Maya, Walton, Jonathan D., Schwede, Torsten

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Small molecule inhibitors reveal an indispensable scaffolding role of RIPK 2 in NOD 2 signaling von Hrdinka, Matous, Schlicher, Lisa, Dai, Bing, Pinkas, Daniel M, Bufton, Joshua C, Picaud, Sarah, Ward, Jennifer A, Rogers, Catherine, Suebsuwong, Chalada, Nikhar, Sameer, Cuny, Gregory D, Huber, Kilian VM, Filippakopoulos, Panagis, Bullock, Alex N, Degterev, Alexei, Gyrd‐Hansen, Mads

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Human With No Lysine Kinase 3 (WNK3); A Target Enabling Package von Pinkas, Daniel M, Bufton, Joshua C, Bartual, Sergio G., Zhuoyao Chen, Daubner, Gerrit M., Frances-Rose Schumacher, Georghiou, George, Jinwei Zhang, Sorrell, Fiona J, Kurz, Thimo, Alessi, Dario R, Bullock, Alex N

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Human Family With Sequence Similarity 83 Member B (Fam83B); A Target Enabling Package von Pinkas, Daniel M., Bufton, Joshua C., Fox, Alice E., Ruda, Gian Filippo, Talon, Romain, Krojer, Tobias, Bradley, Anthony R., Delft, Frank Von, Brennan, Paul E., Fulcher, Luke J., Bozatzi, Polyxeni, Tachi-Menson, Theresa, Wu, Kevin Z. L., Cummins, Timothy D., Dunbar, Karen, Shrestha, Sabin, Wood, Nicola T., Weidlich, Simone, Macartney, Thomas J., Joby Varghese, Gourlay, Robert, Campbell, David G., Hutchinson, Luke D., Vogt, Janis, Cooper, Fay, Dingwell, Kevin S., Smith, James C., Sapkota, Gopal P., Bullock, Alex N.

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Human Receptor-Interacting Serine/Threonine-Protein Kinase 2 (RIPK2); A Target Enabling Package von Canning, Peter, Pinkas, Daniel M., Bufton, Joshua C., Picaud, Sarah, Ward, Jennifer A., Rogers, Catherine, Benedict-Tilman Berger, Matous Hrdinka, Ruan, Qui, Chalada Suebsuwong, Schlicher, Lisa, Dai, Bing, Maki, Jenny L., Soumya S. Ray, Danish Saleh, Nikhar, Sameer, Schwerd, Tobias, Uhlig, Holm H., Knapp, Stefan, Muller-Knapp, Susanne, Brennan, Paul E., Huber, Kilian V. M., Filippakopoulos, Panagis, Cuny, Gregory D., Degterev, Alexei, Gyrd-Hansen, Mads, Bullock, Alex N.

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