CD19-directed CAR T-cell therapy for treatment of primary CNS lymphoma von Siddiqi, Tanya, Wang, Xiuli, Blanchard, M. Suzette, Wagner, Jamie R., Popplewell, Leslie L., Budde, L. Elizabeth, Stiller, Tracey L., Clark, Mary C., Lim, Laura, Vyas, Vibhuti, Brown, Christine E., Forman, Stephen J.

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Pembrolizumab plus vorinostat induces responses in patients with Hodgkin lymphoma refractory to prior PD-1 blockade von Mei, Matthew, Chen, Lu, Godfrey, James, Song, Joo, Egelston, Colt, Puverel, Sandrine, Budde, L. Elizabeth, Armenian, Saro, Nikolaenko, Liana, Nwangwu, Mary, Guo, Weihua, Gao, Lei, Lee, Peter, Chen, Robert, Daniels, Shari, Kennedy, Neena, Peters, Lacolle, Zain, Jasmine, Rosen, Steven, Forman, Stephen, Popplewell, Leslie, Kwak, Larry, Herrera, Alex F.

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T cells expressing CD123-specific chimeric antigen receptors exhibit specific cytolytic effector functions and antitumor effects against human acute myeloid leukemia von Mardiros, Armen, Dos Santos, Cedric, McDonald, Tinisha, Brown, Christine E., Wang, Xiuli, Budde, L. Elizabeth, Hoffman, Lauren, Aguilar, Brenda, Chang, Wen-Chung, Bretzlaff, William, Chang, Brenda, Jonnalagadda, Mahesh, Starr, Renate, Ostberg, Julie R., Jensen, Michael C., Bhatia, Ravi, Forman, Stephen J.

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Interferon-γ blockade in CAR T-cell therapy–associated macrophage activation syndrome/hemophagocytic lymphohistiocytosis von Rainone, Michael, Ngo, Dat, Baird, John H., Budde, L. Elizabeth, Htut, Myo, Aldoss, Ibrahim, Pullarkat, Vinod

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Clonal Hematopoiesis is Associated With Severe Cytokine Release Syndrome in Patients Treated With Chimeric Antigen Receptor T-Cell (CART) Therapy von Goldsmith, Scott R., Shouse, Geoffrey, Wong, F. Lennie, Bosworth, Alysia, Iukuridze, Aleksi, Chen, Sitong, Rhee, June-Wha, Mei, Matthew, Htut, Myo, Janakiram, Murali, Forman, Stephen J., Pillai, Raju, Budde, L Elizabeth, Armenian, Saro H.

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Analysis of polyfunctionality for enhanced BAFF-R CAR T-cell therapy for hematologic malignancies von Dong, Zhengyuan, Budde, L. Elizabeth, Oh, Elizabeth, Szymura, Szymon, Anderson, Aaron, Del Real, Marissa, Cha, Soung-chul, Forman, Stephen J., Kwak, Larry W., Wang, Xiuli

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IBCL-249 Mosunetuzumab Monotherapy Is an Effective and Well-Tolerated Treatment Option for Patients With Relapsed/Refractory (R/R) Follicular Lymphoma (FL) Who Have Received ≥2 Pri... von Budde, Elizabeth L, Sehn, Laurie H, Matasar, Matthew, Schuster, Stephen J, Assouline, Sarit, Giri, Pratyush, Kuruvilla, John, Canales, Miguel, Dietrich, Sascha, Fay, Keith, Ku, Matthew, Nastoupil, Loretta, Wei, Michael C, Yin, Shen, Doral, Michelle Y, Li, Chi-Chung, Huang, Huang, Negricea, Raluca, Penuel, Elicia, O'Hear, Carol, Bartlett, Nancy L

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S220: REAL‐WORLD OUTCOMES OF BREXUCABTAGENE AUTOLEUCEL (BREXU‐CEL) FOR RELAPSED OR REFRACTORY MANTLE CELL LYMPHOMA: A CIBMTR SUBGROUP ANALYSIS BY PRIOR TREATMENT von Ahmed, Nausheen, Kambhampati, Swetha, Hamadani, Mehdi, Grover, Natalie, Shadman, Mazyar, Locke, Frederick, Gerson, James, Frank, Matthew J., Budde, L. Elizabeth, Wang, Michael, Hu, Zhen‐Huan, Nunes, Ana, Dalton, David, Kloos, Ioana, Lee, Daniel, Xu, Hairong, Pasquini, Marcelo, Herrera, Alex F.

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P1078: MOSUNETUZUMAB DEMONSTRATES DURABLE RESPONSES IN PATIENTS WITH RELAPSED AND/OR REFRACTORY FOLLICULAR LYMPHOMA WHO HAVE RECEIVED ≥2 PRIOR THERAPIES: UPDATED ANALYSIS OF A PIVO... von Sehn, Laurie H., Bartlett, Nancy L., Matasar, Matthew, Schuster, Stephen J., Assouline, Sarit, Kuruvilla, John, Shadman, Mazyar, Cheah, Chan, Fay, Keith, Ku, Matthew, Nastoupil, Loretta J., Wei, Michael, Yin, Shen, To, Iris, Hu, Nan, Min, Juliana, Penuel, Elicia, Belousov, Anton, Coimbra, Alexandre, Jemaa, Skander, Bender, Brendan, Turner, David, Elizabeth Budde, L.

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Acute myeloid leukemia therapeutics: CARs in the driver's seat von Mardiros, Armen, Brown, Christine E, Budde, L Elizabeth, Wang, Xiuli, Forman, Stephen J

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Acrue: A Phase 2, Open-Label Study of Acalabrutinib in Combination with Rituximab in Elderly and/or Frail Patients with Treatment-Naive Diffuse Large B-Cell Lymphoma von Perini, Guilherme F, Graff, Tara, Roos, Jack, Hermann, Richard, Lovenklev, Magnus, Shaw, Bob, Budde, L. Elizabeth

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A Phase 1b Dose Expansion Study Evaluating Safety, Preliminary Anti-Tumor Activity, and Accelerated T Cell Reconstitution with NT-I7 (Efineptakin Alfa), a Long-Acting Human IL-7, A... von Ghobadi, Armin, Budde, L. Elizabeth, Galal, Ahmed, Stermer, Kristina, Bierly, Allison, Ferrando-Martinez, Sara, Lee, Byung Ha, DiPersio, John F.

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Results from a phase I trial of pembrolizumab plus vorinostat in relapsed/refractory B-cell non-Hodgkin lymphoma von Godfrey, James, Mei, Matthew, Chen, Lu, Song, Joo Y, Bedell, Victoria, Budde, Elizabeth, Armenian, Saro, Puverel, Sandrine, Nikolaenko, Liana, Chen, Robert, Daniels, Shari, Kennedy, Neena, Peters, Lacolle, Rosen, Steven T, Forman, Stephen J, Popplewell, Leslie L, Kwak, Larry W, Herrera, Alex F

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Trial in progress: A phase 1b study evaluating the safety, tolerability, and preliminary anti-tumor activity of NT-I7 (efineptakin alfa), a long-acting human IL-7, post-tisagenlecl... von Ghobadi, Armin, Budde, L Elizabeth, Galal, Ahmed, Stermer, Kristina, Austin, TaShara Lynn, Fan, Jean, DiPersio, John F.

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The Combination of Nivolumab and CC-486 Is Active in Hodgkin Lymphoma Refractory to PD-1 Blockade von Mei, Matthew G., Chen, Lu, Puverel, Sandrine, Budde, L. Elizabeth, Kambhampati, Swetha, Daniels, Shari, Dunning, Bev, Banez, Melissa, Kwak, Larry W., Herrera, Alex F.

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Subcutaneous Mosunetuzumab Is Active and Has a Manageable Safety Profile in Patients with Previously Untreated, Low-Tumor Burden Follicular Lymphoma: Initial Results from the Phase... von Flinn, Ian W., Budde, L. Elizabeth, Tun, Aung M., Burke, John M., Anz, Bertrand, Peles, Shachar, Sharman, Jeff P., Tumula, Praveen K., Biondo, Juliana M. L., Jani, Prachi, Wu, Mei, Lin, Tony, Parmar, Neha, Mun, Yong, Yao, Nai-Shun, Liu, Steven

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CD19-Directed CAR T-Cells (CD19-CAR) Combined with Acalabrutinib Achieves Durable Remissions in Patients with Relapsed or Refractory (r/r) Mantle Cell Lymphoma (MCL) von Baird, John H., Del Real, Marissa Morales, Song, Joo Y., Shouse, Geoffrey P., Danilov, Alexey, Herrera, Alex F., Popplewell, Leslie L., Rosen, Steven T., Davis, Jennifer, Barva, Baishakhi, Chen, Lu, Kwak, Larry W., Forman, Stephen J., Budde, L. Elizabeth

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Fixed Duration Mosunetuzumab Plus Polatuzumab Vedotin Has Promising Efficacy and a Manageable Safety Profile in Patients with BTKi Relapsed/Refractory Mantle Cell Lymphoma: Initial... von Wang, Michael L., Assouline, Sarit, Kamdar, Manali, Ghosh, Nilanjan, Naik, Seema, Nakhoda, Shazia K., Chavez, Julio C., Jia, Ting, Pham, Song, Huw, Ling-Yuh, Jing, Jing, Ead, Wahib, To, Iris, Batlevi, Connie Lee, Wei, Michael C., Budde, L. Elizabeth

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Mosunetuzumab Monotherapy Demonstrates Activity and a Manageable Safety Profile in Patients with Relapsed or Refractory Richter's Transformation von Cheah, Chan Y., Assouline, Sarit, Baker, Ross, Bartlett, Nancy L., El-Sharkawi, Dima, Giri, Pratyush, Ku, Matthew, Schuster, Stephen J., Matasar, Matthew, Radford, John, Wei, Michael C., Yin, Shen, To, Iris, Huang, Jiangeng, Kwan, Antonia, Budde, L. Elizabeth

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Promising Safety and Anti-Lymphoma Efficacy of Autologous Pmb-CT01 (BAFFRCAR T Cell) Therapy in a First-in-Human Phase 1 Study von Budde, L. Elizabeth, Del Real, Marissa Morales, Baird, John H., Chen, Lu, Song, Joo Y., Kambhampati, Swetha, Macias, Alan, Kim, Teresa, Dulan, Sylvia, Barva, Baishakhi, Puverel, Sandrine, Tiemann, Katrin, Cheng, Hazel Ting-Ying, Forman, Stephen J., Kwak, Larry W.

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