E2 enzymes： more than just middle men von Stewart, Mikaela D, Ritterhoff, Tobias, Klevit, Rachel E, Brzovic, Peter S

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Structure of an E3:E2∼Ub Complex Reveals an Allosteric Mechanism Shared among RING/U-box Ligases von Pruneda, Jonathan N., Littlefield, Peter J., Soss, Sarah E., Nordquist, Kyle A., Chazin, Walter J., Brzovic, Peter S., Klevit, Rachel E.

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The Acidic Transcription Activator Gcn4 Binds the Mediator Subunit Gal11/Med15 Using a Simple Protein Interface Forming a Fuzzy Complex von Brzovic, Peter S., Heikaus, Clemens C., Kisselev, Leonid, Vernon, Robert, Herbig, Eric, Pacheco, Derek, Warfield, Linda, Littlefield, Peter, Baker, David, Klevit, Rachel E., Hahn, Steven

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E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages von Klevit, Rachel E, Christensen, Devin E, Brzovic, Peter S

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Regulating the Regulators: Recent Revelations in the Control of E3 Ubiquitin Ligases von Vittal, Vinayak, Stewart, Mikaela D., Brzovic, Peter S., Klevit, Rachel E.

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Mechanism of phosphoribosyl-ubiquitination mediated by a single Legionella effector von Akturk, Anil, Wasilko, David J., Wu, Xiaochun, Liu, Yao, Zhang, Yong, Qiu, Jiazhang, Luo, Zhao-Qing, Reiter, Katherine H., Brzovic, Peter S., Klevit, Rachel E., Mao, Yuxin

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Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis von Starita, Lea M., Pruneda, Jonathan N., Lo, Russell S., Fowler, Douglas M., Kim, Helen J., Hiatt, Joseph B., Shendure, Jay, Brzovic, Peter S., Fields, Stanley, Klevit, Rachel E.

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Legionella effector MavC targets the Ube2N~Ub conjugate for noncanonical ubiquitination von Puvar, Kedar, Iyer, Shalini, Fu, Jiaqi, Kenny, Sebastian, Negrón Terón, Kristos I., Luo, Zhao-Qing, Brzovic, Peter S., Klevit, Rachel E., Das, Chittaranjan

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Salmonella Translocated Effectors Recruit OSBP1 to the Phagosome to Promote Vacuolar Membrane Integrity von Kolodziejek, Anna M., Altura, Melissa A., Fan, Junping, Petersen, Erik M., Cook, Matthew, Brzovic, Peter S., Miller, Samuel I.

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Ubiquitin in Motion: Structural Studies of the Ubiquitin-Conjugating Enzyme∼Ubiquitin Conjugate von Pruneda, Jonathan N, Stoll, Kate E, Bolton, Laura J, Brzovic, Peter S, Klevit, Rachel E

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Structural Mechanism for the Regulation of HCN Ion Channels by the Accessory Protein TRIP8b von DeBerg, Hannah A., Bankston, John R., Rosenbaum, Joel C., Brzovic, Peter S., Zagotta, William N., Stoll, Stefan

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Binding and Recognition in the Assembly of an Active BRCA1/BARD1 Ubiquitin-Ligase Complex von Brzovic, Peter S., Keeffe, Jennifer R., Nishikawa, Hiroyuki, Miyamoto, Keiko, Fox, David, Fukuda, Mamoru, Ohta, Tomohiko, Klevit, Rachel

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Structure of a BRCA1-BARD1 heterodimeric RING-RING complex von Klevit, Rachel E, Brzovic, Peter S, Rajagopal, Ponni, Hoyt, David W, King, Mary-Claire

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UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids von Wenzel, Dawn M., Lissounov, Alexei, Brzovic, Peter S., Klevit, Rachel E.

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Ubiquitin Transfer from the E2 Perspective: Why is UbcH5 So Promiscuous? von Brzovic, Peter S., Klevit, Rachel E.

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Identification of an unconventional E3 binding surface on the UbcH5 ~ Ub conjugate recognized by a pathogenic bacterial E3 ligase von Levin, Itay, Eakin, Catherine, Blanc, Marie-Pierre, Klevit, Rachel E, Miller, Samuel I, Brzovic, Peter S

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BRCA1/BARD1 is a nucleosome reader and writer von Witus, Samuel R., Zhao, Weixing, Brzovic, Peter S., Klevit, Rachel E.

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Bacterial ligases reveal fundamental principles of polyubiquitin specificity von Franklin, Tyler G, Brzovic, Peter S, Pruneda, Jonathan N

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BRCA1/BARD1 site-specific ubiquitylation of nucleosomal H2A is directed by BARD1 von Witus, Samuel R., Burrell, Anika L., Farrell, Daniel P., Kang, Jianming, Wang, Meiling, Hansen, Jesse M., Pravat, Alex, Tuttle, Lisa M., Stewart, Mikaela D., Brzovic, Peter S., Chatterjee, Champak, Zhao, Weixing, DiMaio, Frank, Kollman, Justin M., Klevit, Rachel E.

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BRCA1/BARD1 intrinsically disordered regions facilitate chromatin recruitment and ubiquitylation von Witus, Samuel R, Tuttle, Lisa M, Li, Wenjing, Zelter, Alex, Wang, Meiling, Kermoade, Klaiten E, Wilburn, Damien B, Davis, Trisha N, Brzovic, Peter S, Zhao, Weixing, Klevit, Rachel E

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