Genotoxic mode of action predictions from a multiplexed flow cytometric assay and a machine learning approach von Bryce, Steven M., Bernacki, Derek T., Bemis, Jeffrey C., Dertinger, Stephen D.

Volltext

When pigs fly: Immunomagnetic separation facilitates rapid determination of Pig-a mutant frequency by flow cytometric analysis von Dertinger, Stephen D., Bryce, Steven M., Phonethepswath, Souk, Avlasevich, Svetlana L.

Volltext

Application of the adverse outcome pathway framework to genotoxic modes of action von Sasaki, Jennifer C., Allemang, Ashley, Bryce, Steven M., Custer, Laura, Dearfield, Kerry L., Dietz, Yasmin, Elhajouji, Azeddine, Escobar, Patricia A., Fornace, Albert J., Froetschl, Roland, Galloway, Sheila, Hemmann, Ulrike, Hendriks, Giel, Li, Heng‐Hong, Luijten, Mirjam, Ouedraogo, Gladys, Peel, Lauren, Pfuhler, Stefan, Roberts, Daniel J., Thybaud, Véronique, Benthem, Jan, Yauk, Carole L., Schuler, Maik

Volltext

Comparative Genotoxicity of TEMPO and 3 of Its Derivatives in Mouse Lymphoma Cells von Guo, Xiaoqing, Seo, Ji-Eun, Bryce, Steven M, Tan, Jenna A, Wu, Qiangen, Dial, Stacey L, Moore, Martha M, Mei, Nan

Volltext

Efficient monitoring of in vivo pig-a gene mutation and chromosomal damage: summary of 7 published studies and results from 11 new reference compounds von Dertinger, Stephen D, Phonethepswath, Souk, Avlasevich, Svetlana L, Torous, Dorothea K, Mereness, Jared, Bryce, Steven M, Bemis, Jeffrey C, Bell, Sara, Weller, Pamela, Macgregor, James T

Volltext

Interlaboratory evaluation of a multiplexed high information content in vitro genotoxicity assay von Bryce, Steven M., Bernacki, Derek T., Bemis, Jeffrey C., Spellman, Richard A., Engel, Maria E., Schuler, Maik, Lorge, Elisabeth, Heikkinen, Pekka T., Hemmann, Ulrike, Thybaud, Véronique, Wilde, Sabrina, Queisser, Nina, Sutter, Andreas, Zeller, Andreas, Guérard, Melanie, Kirkland, David, Dertinger, Stephen D.

Volltext

In vivo mutation assay based on the endogenous Pig-a locus von Bryce, Steven M, Bemis, Jeffrey C, Dertinger, Stephen D

Volltext

In vitro micronucleus assay scored by flow cytometry provides a comprehensive evaluation of cytogenetic damage and cytotoxicity von Bryce, Steven M., Bemis, Jeffrey C., Avlasevich, Svetlana L., Dertinger, Stephen D.

Volltext

Flow cytometric evaluation of the contribution of ionic silver to genotoxic potential of nanosilver in human liver HepG2 and colon Caco2 cells von Sahu, Saura C., Njoroge, Joyce, Bryce, Steven M., Zheng, Jiwen, Ihrie, John

Volltext

Pig-a Mutation: Kinetics in Rat Erythrocytes Following Exposure to Five Prototypical Mutagens von Phonethepswath, Souk, Franklin, Dean, Torous, Dorothea K., Bryce, Steven M., Bemis, Jeffrey C., Raja, Sarojini, Avlasevich, Svetlana, Weller, Pamela, Hyrien, Ollivier, Palis, James, MacGregor, James T., Dertinger, Stephen D.

Volltext

In vitro micronucleus scoring by flow cytometry: Differential staining of micronuclei versus apoptotic and necrotic chromatin enhances assay reliability von Avlasevich, Svetlana L., Bryce, Steven M., Cairns, Siân E., Dertinger, Stephen D.

Volltext

Miniaturized flow cytometry-based CHO-K1 micronucleus assay discriminates aneugenic and clastogenic modes of action von Bryce, Steven M., Avlasevich, Svetlana L., Bemis, Jeffrey C., Dertinger, Stephen D.

Volltext

Interlaboratory evaluation of a flow cytometric, high content in vitro micronucleus assay von Bryce, Steven M., Avlasevich, Svetlana L., Bemis, Jeffrey C., Lukamowicz, Magdalena, Elhajouji, Azeddine, Van Goethem, Freddy, De Boeck, Marlies, Beerens, Dominiek, Aerts, Hilde, Van Gompel, Jacky, Collins, Joanne E., Ellis, Patricia C., White, Angela T., Lynch, Anthony M., Dertinger, Stephen D.

Volltext

Investigating the Generalizability of the MultiFlow ® DNA Damage Assay and Several Companion Machine Learning Models With a Set of 103 Diverse Test Chemicals von Bryce, Steven M, Bernacki, Derek T, Smith-Roe, Stephanie L, Witt, Kristine L, Bemis, Jeffrey C, Dertinger, Stephen D

Volltext

Aneugen Molecular Mechanism Assay: Proof-of-Concept With 27 Reference Chemicals von Bernacki, Derek T, Bryce, Steven M, Bemis, Jeffrey C, Dertinger, Stephen D

Volltext

Visualization strategies to aid interpretation of high‐dimensional genotoxicity data von Dertinger, Stephen D., Briggs, Erica, Hussien, Yusuf, Bryce, Steven M., Avlasevich, Svetlana L., Conrad, Adam, Johnson, George E., Williams, Andrew, Bemis, Jeffrey C.

Volltext

Kinetics of γH2AX and phospho-histone H3 following pulse treatment of TK6 cells provides insights into clastogenic activity von Bryce, Steven M, Dertinger, Stephen D, Bemis, Jeffrey C

Volltext

In vivo flow cytometric Pig-a and micronucleus assays: Highly sensitive discrimination of the carcinogen/noncarcinogen pair benzo(a)pyrene and pyrene using acute and repeated-dose... von Torous, Dorothea K., Phonethepswath, Souk, Avlasevich, Svetlana L., Mereness, Jared, Bryce, Steven M., Bemis, Jeffrey C., Weller, Pamela, Bell, Sara, Gleason, Carol, Custer, Laura L., MacGregor, James T., Dertinger, Stephen D.

Volltext

In vitro human cell‐based aneugen molecular mechanism assay von Hall, Nikki E., Tichenor, Kyle, Bryce, Steven M., Bemis, Jeffrey C., Dertinger, Stephen D.

Volltext

Predictions of genotoxic potential, mode of action, molecular targets, and potency via a tiered multiflow® assay data analysis strategy von Dertinger, Stephen D., Kraynak, Andrew R., Wheeldon, Ryan P., Bernacki, Derek T., Bryce, Steven M., Hall, Nikki, Bemis, Jeffrey C., Galloway, Sheila M., Escobar, Patricia A., Johnson, George E.

Volltext