The Discovery of I‑BET726 (GSK1324726A), a Potent Tetrahydroquinoline ApoA1 Up-Regulator and Selective BET Bromodomain Inhibitor von Gosmini, Romain, Nguyen, Van Loc, Toum, Jérôme, Simon, Christophe, Brusq, Jean-Marie G, Krysa, Gael, Mirguet, Olivier, Riou-Eymard, Alizon M, Boursier, Eric V, Trottet, Lionel, Bamborough, Paul, Clark, Hugh, Chung, Chun-wa, Cutler, Leanne, Demont, Emmanuel H, Kaur, Rejbinder, Lewis, Antonia J, Schilling, Mark B, Soden, Peter E, Taylor, Simon, Walker, Ann L, Walker, Matthew D, Prinjha, Rab K, Nicodème, Edwige

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Discovery of Epigenetic Regulator I‑BET762: Lead Optimization to Afford a Clinical Candidate Inhibitor of the BET Bromodomains von Mirguet, Olivier, Gosmini, Romain, Toum, Jérôme, Clément, Catherine A, Barnathan, Mélanie, Brusq, Jean-Marie, Mordaunt, Jacqueline E, Grimes, Richard M, Crowe, Miriam, Pineau, Olivier, Ajakane, Myriam, Daugan, Alain, Jeffrey, Phillip, Cutler, Leanne, Haynes, Andrea C, Smithers, Nicholas N, Chung, Chun-wa, Bamborough, Paul, Uings, Iain J, Lewis, Antonia, Witherington, Jason, Parr, Nigel, Prinjha, Rab K, Nicodème, Edwige

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Development of a Topical Treatment for Psoriasis Targeting RORγ: From Bench to Skin von Smith, Susan H, Peredo, Carlos E, Takeda, Yukimasa, Bui, Thi, Neil, Jessica, Rickard, David, Millerman, Elizabeth, Therrien, Jean-Philippe, Nicodeme, Edwige, Brusq, Jean-Marie, Birault, Veronique, Viviani, Fabrice, Hofland, Hans, Jetten, Anton M, Cote-Sierra, Javier

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Inhibition of lipid synthesis through activation of AMP kinase: an additional mechanism for the hypolipidemic effects of berberine von Brusq, Jean-Marie, Ancellin, Nicolas, Grondin, Pascal, Guillard, Raphaelle, Martin, Sandrine, Saintillan, Yannick, Issandou, Marc

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Co-activation of AMPK and mTORC1 Induces Cytotoxicity in Acute Myeloid Leukemia von Sujobert, Pierre, Poulain, Laury, Paubelle, Etienne, Zylbersztejn, Florence, Grenier, Adrien, Lambert, Mireille, Townsend, Elizabeth C., Brusq, Jean-Marie, Nicodeme, Edwige, Decrooqc, Justine, Nepstad, Ina, Green, Alexa S., Mondesir, Johanna, Hospital, Marie-Anne, Jacque, Nathalie, Christodoulou, Alexandra, Desouza, Tiffany A., Hermine, Olivier, Foretz, Marc, Viollet, Benoit, Lacombe, Catherine, Mayeux, Patrick, Weinstock, David M., Moura, Ivan C., Bouscary, Didier, Tamburini, Jerome

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From ApoA1 upregulation to BET family bromodomain inhibition: Discovery of I-BET151 von Mirguet, Olivier, Lamotte, Yann, Donche, Frédéric, Toum, Jérôme, Gellibert, Françoise, Bouillot, Anne, Gosmini, Romain, Nguyen, Van-Loc, Delannée, Delphine, Seal, Jonathan, Blandel, Florence, Boullay, Anne-Bénédicte, Boursier, Eric, Martin, Sandrine, Brusq, Jean-Marie, Krysa, Gael, Riou, Alizon, Tellier, Rémi, Costaz, Agnès, Huet, Pascal, Dudit, Yann, Trottet, Lionel, Kirilovsky, Jorge, Nicodeme, Edwige

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Inhibition of TGF‐β signaling by an ALK5 inhibitor protects rats from dimethylnitrosamine‐induced liver fibrosis von Gouville, Anne‐Charlotte, Boullay, Valerie, Krysa, Gael, Pilot, Julia, Brusq, Jean‐Marie, Loriolle, Florence, Gauthier, Jean‐Michel, Papworth, Stephen A, Laroze, Alain, Gellibert, Françoise, Huet, Stephane

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Pharmacological inhibition of Stearoyl-CoA Desaturase 1 improves insulin sensitivity in insulin-resistant rat models von Issandou, Marc, Bouillot, Anne, Brusq, Jean-Marie, Forest, Marie-Claire, Grillot, Didier, Guillard, Raphaelle, Martin, Sandrine, Michiels, Christelle, Sulpice, Thierry, Daugan, Alain

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Discovery and Characterization of Small Molecule Inhibitors of the BET Family Bromodomains von Chung, Chun-wa, Coste, Hervé, White, Julia H, Mirguet, Olivier, Wilde, Jonathan, Gosmini, Romain L, Delves, Chris, Magny, Sylvie M, Woodward, Robert, Hughes, Stephen A, Boursier, Eric V, Flynn, Helen, Bouillot, Anne M, Bamborough, Paul, Brusq, Jean-Marie G, Gellibert, Françoise J, Jones, Emma J, Riou, Alizon M, Homes, Paul, Martin, Sandrine L, Uings, Iain J, Toum, Jérôme, Clément, Catherine A, Boullay, Anne-Bénédicte, Grimley, Rachel L, Blandel, Florence M, Prinjha, Rab K, Lee, Kevin, Kirilovsky, Jorge, Nicodeme, Edwige

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Identification of an antibody‐based immunoassay for measuring direct target binding of RIPK1 inhibitors in cells and tissues von Finger, Joshua N., Brusq, Jean‐Marie, Campobasso, Nino, Cook, Michael N., Deutsch, Jennifer, Haag, Heather, Harris, Philip A., Jenkins, Earl L., Joglekar, Devika, Lich, John D., Maguire, Sean, Nagilla, Rakesh, Rivera, Elizabeth J., Sun, Helen, Votta, Bartholomew J., Bertin, John, Gough, Peter J.

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Effects of C‐type natriuretic peptide on rat cardiac contractility von Brusq, Jean‐Marie, Mayoux, Eric, Guigui, Laurent, Kirilovsky, Jorge

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Discovery of Pyridones As Oral AMPK Direct Activators von Mirguet, Olivier, Sautet, Stéphane, Clément, Catherine-Anne, Toum, Jérôme, Donche, Frédéric, Marques, Celine, Rondet, Emilie, Pizzonero, Mathieu, Beaufils, Benjamin, Dudit, Yann, Huet, Pascal, Trottet, Lionel, Grondin, Pascal, Brusq, Jean-Marie, Boursier, Eric, Saintillan, Yannick, Nicodeme, Edwige

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Selective CETP Inhibition and PPARα Agonism Increase HDL Cholesterol and Reduce LDL Cholesterol in Human ApoB100/Human CETP Transgenic Mice von Hansen, Michael K., McVey, Matthew J., White, Ray F., Legos, Jeffrey J., Brusq, Jean-Marie, Grillot, Didier A., Issandou, Marc, Barone, Frank C.

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Identification of an antibody‐based immunoassay for measuring direct target binding of RIPK 1 inhibitors in cells and tissues von Finger, Joshua N., Brusq, Jean‐Marie, Campobasso, Nino, Cook, Michael N., Deutsch, Jennifer, Haag, Heather, Harris, Philip A., Jenkins, Earl L., Joglekar, Devika, Lich, John D., Maguire, Sean, Nagilla, Rakesh, Rivera, Elizabeth J., Sun, Helen, Votta, Bartholomew J., Bertin, John, Gough, Peter J.

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Co-Activation of AMPK and mTORC1 Is Synthetically Lethal in Acute Myeloid Leukemia von Sujobert, Pierre, Paubelle, Etienne, Grenier, Adrien, Zylbersztejn, Florence, Lambert, Mireille, Poulain, Laury, Townsend, Elizabeth, Brusq, Jean-Marie, Nicodeme, Edwige, Decrooqc, Justine, Nepstad, Ina, Green, Alexa, Hospital, Marie-Anne, Jacque, Nathalie, Hermine, Olivier, Foretz, Marc, Viollet, Benoit, Lacombe, Catherine, Weinstock, David M., Mayeux, Patrick, Moura, Ivan C, Bouscary, Didier, Tamburini, Jerome

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Co-activation of AMPK and mTORC1 Induce Cytotoxicity in Acute Myeloid Leukemia von Sujobert, Pierre, Poulain, Laury, Paubelle, Etienne, Zylbersztejn, Florence, Grenier, Adrien, Lambert, Mireille, Townsend, Elizabeth  C, Brusq, Jean-Marie, Nicodeme, Edwige, Decrooqc, Justine, Nepstad, Ina, Green, Alexa S, Mondesir, Johanna, Hospital, Marie-Anne, Jacque, Nathalie, Christodoulou, Alexandra, Desouza, Tiffany A, Hermine, Olivier, Foretz, Marc, Viollet, Benoit, Lacombe, Catherine, Mayeux, Patrick, Weinstock, David m., Moura, Ivan C, Bouscary, Didier, Tamburini, Jerome

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Development of a Topical Treatment for Psoriasis Targeting ROR?: From Bench to Skin: e0147979 von Smith, Susan H, Peredo, Carlos E, Takeda, Yukimasa, Bui, Thi, Neil, Jessica, Rickard, David, Millerman, Elizabeth, Therrien, Jean-Philippe, Nicodeme, Edwige, Brusq, Jean-Marie

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Selective CETP Inhibition and PPARa Agonism Increase HDL Cholesterol and Reduce LDL Cholesterol in Human ApoB100/Human CETP Transgenic Mice von Hansen, Michael K, McVey, Matthew J, White, Ray F, Legos, Jeffrey J, Brusq, Jean-Marie, Grillot, Didier A, Issandou, Marc, Barone, Frank C

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Inhibition of TGF-[beta] signaling by an ALK5 inhibitor protects rats from dimethylnitrosamine-induced liver fibrosis von Anne-Charlotte de Gouville, Boullay, Valerie, Krysa, Gael, Pilot, Julia, Jean-Marie Brusq, Loriolle, Florence, Gauthier, Jean-Michel, Papworth, Stephen A, Laroze, Alain, Gellibert, Françoise, Huet, Stephane

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Selective CETP inhibition and PPARalpha agonism increase HDL cholesterol and reduce LDL cholesterol in human ApoB100/human CETP transgenic mice von Hansen, Michael K, McVey, Matthew J, White, Ray F, Legos, Jeffrey J, Brusq, Jean-Marie, Grillot, Didier A, Issandou, Marc, Barone, Frank C

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