Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens von Meermeier, Erin W., Laugel, Bruno F., Sewell, Andrew K., Corbett, Alexandra J., Rossjohn, Jamie, McCluskey, James, Harriff, Melanie J., Franks, Tamera, Gold, Marielle C., Lewinsohn, David M.

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In silico and pharmacological evaluation of GPR65 as a cancer immunotherapy target regulating T-cell functions von Li, Shamin, Melchiore, Fabien, Kantari-Mimoun, Chahrazade, Mouton, Aurore, Knockaert, Samantha, Philippon, Wendy, Chanrion, Benjamin, Bourgeois, Christophe, Lefebvre, Céline, Elhmouzi-Younes, Jamila, Blanc, Véronique, Ramon Olayo, Fernando, Laugel, Bruno

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Investigating and harnessing T-cell functions with engineered immune receptors and their ligands von Bruno Laugel

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Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor von Jakobsen, Bent K, Riley, James L, Varela-Rohena, Angel, Molloy, Peter E, Dunn, Steven M, Li, Yi, Suhoski, Megan M, Carroll, Richard G, Milicic, Anita, Mahon, Tara, Sutton, Deborah H, Laugel, Bruno, Moysey, Ruth, Cameron, Brian J, Vuidepot, Annelise, Purbhoo, Marco A, Cole, David K, Phillips, Rodney E, June, Carl H, Sewell, Andrew K

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Different T Cell Receptor Affinity Thresholds and CD8 Coreceptor Dependence Govern Cytotoxic T Lymphocyte Activation and Tetramer Binding Properties von Laugel, Bruno, van den Berg, Hugo A., Gostick, Emma, Cole, David K., Wooldridge, Linda, Boulter, Jonathan, Milicic, Anita, Price, David A., Sewell, Andrew K.

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The molecular determinants of CD8 co‐receptor function von Cole, David K., Laugel, Bruno, Clement, Mathew, Price, David A., Wooldridge, Linda, Sewell, Andrew K.

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RcsCDB His‐Asp phosphorelay system negatively regulates the flhDC operon in Escherichia coli von Francez‐Charlot, Anne, Laugel, Bruno, Van Gemert, Alice, Dubarry, Nelly, Wiorowski, Florent, Castanié‐Cornet, Marie‐Pierre, Gutierrez, Claude, Cam, Kaymeuang

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Interaction between the CD8 Coreceptor and Major Histocompatibility Complex Class I Stabilizes T Cell Receptor-Antigen Complexes at the Cell Surface von Wooldridge, Linda, van den Berg, Hugo A., Glick, Meir, Gostick, Emma, Laugel, Bruno, Hutchinson, Sarah L., Milicic, Anita, Brenchley, Jason M., Douek, Daniel C., Price, David A., Sewell, Andrew K.

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The multiple roles of the CD8 coreceptor in T cell biology: opportunities for the selective modulation of self-reactive cytotoxic T cells von Laugel, Bruno, Cole, David K., Clement, Mathew, Wooldridge, Linda, Price, David A., Sewell, Andrew K.

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Abstract LB220: S095029: a novel clinical-stage Fc-silenced NKG2A-blocking antibody with best-in-class potential von Melander, Maria, Laugel, Bruno

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Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region von Wooldridge, Linda, Lissina, Anna, Vernazza, Jonathan, Gostick, Emma, Laugel, Bruno, Hutchinson, Sarah L., Mirza, Fareed, Dunbar, P. Rod, Boulter, Jonathan M., Glick, Meir, Cerundolo, Vincenzo, van den Berg, Hugo A., Price, David A., Sewell, Andrew K.

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Design of Soluble Recombinant T Cell Receptors for Antigen Targeting and T Cell Inhibition von Laugel, Bruno, Boulter, Jonathan M., Lissin, Nikolai, Vuidepot, Annelise, Li, Yi, Gostick, Emma, Crotty, Laura E., Douek, Daniel C., Hemelaar, Joris, Price, David A., Jakobsen, Bent K., Sewell, Andrew K.

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The CD8 T Cell Coreceptor Exhibits Disproportionate Biological Activity at Extremely Low Binding Affinities von Hutchinson, Sarah L, Wooldridge, Linda, Tafuro, Sabrina, Laugel, Bruno, Glick, Meir, Boulter, Jonathan M, Jakobsen, Bent K, Price, David A, Sewell, Andrew K

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The HLA A0201–restricted hTERT540–548 peptide is not detected on tumor cells by a CTL clone or a high-affinity T-cell receptor von Purbhoo, Marco A., Li, Yi, Sutton, Deborah H., Brewer, Joanna E., Gostick, Emma, Bossi, Giovanna, Laugel, Bruno, Moysey, Ruth, Baston, Emma, Liddy, Nathaniel, Cameron, Brian, Bennett, Alan D., Ashfield, Rebecca, Milicic, Anita, Price, David A., Classon, Brendan J., Sewell, Andrew K., Jakobsen, Bent K.

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Adenosine and cAMP signalling skew human dendritic cell differentiation towards a tolerogenic phenotype with defective CD8+ T‐cell priming capacity von Challier, John, Bruniquel, Denis, Sewell, Andrew K., Laugel, Bruno

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Time to evolve: predicting engineered T cell-associated toxicity with next-generation models von Donnadieu, Emmanuel, Luu, Maik, Alb, Miriam, Anliker, Brigitte, Arcangeli, Silvia, Bonini, Chiara, De Angelis, Biagio, Choudhary, Rashmi, Espie, David, Galy, Anne, Holland, Cam, Ivics, Zoltán, Kantari-Mimoun, Chahrazade, Kersten, Marie Jose, Köhl, Ulrike, Kuhn, Chantal, Laugel, Bruno, Locatelli, Franco, Marchiq, Ibtissam, Markman, Janet, Moresco, Marta Angiola, Morris, Emma, Negre, Helene, Quintarelli, Concetta, Rade, Michael, Reiche, Kristin, Renner, Matthias, Ruggiero, Eliana, Sanges, Carmen, Stauss, Hans, Themeli, Maria, Van den Brulle, Jan, Hudecek, Michael, Casucci, Monica

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Bench, bedside, toolbox: T-cells deliver on every level von Laugel, Bruno

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CD8 controls T cell cross-reactivity von Wooldridge, Linda, Laugel, Bruno, Ekeruche, Julia, Clement, Mathew, van den Berg, Hugo A, Price, David A, Sewell, Andrew K

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Abstract 2281: DNA methyl transferase inhibitors (DNMTis) upregulate NY-ESO expression in several human primary cells: implications for co-therapy with engineered adoptive T-cell t... von Laugel, Bruno, Sevko, Alexandra, Howe, Karen, Ferjentsik, Zoltan, Ferronha, Tiago, Maroto, Miguel, Brewer, Joanna, Jakobsen, Bent, Binder-Scholl, Gwendolyn

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Engineering of Isogenic Cells Deficient for MR1 with a CRISPR/Cas9 Lentiviral System: Tools To Study Microbial Antigen Processing and Presentation to Human MR1-Restricted T Cells von Laugel, Bruno, Lloyd, Angharad, Meermeier, Erin W, Crowther, Michael D, Connor, Thomas R, Dolton, Garry, Miles, John J, Burrows, Scott R, Gold, Marielle C, Lewinsohn, David M, Sewell, Andrew K

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