Wza the translocon for E. coli capsular polysaccharides defines a new class of membrane protein von Naismith, James H, Dong, Changjiang, Beis, Konstantinos, Nesper, Jutta, Brunkan-LaMontagne, Anne L, Clarke, Bradley R, Whitfield, Chris

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Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Aβ 42/40 ratios von Walker, Emily S., Martinez, Maribel, Brunkan, Anne L., Goate, Alison

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A Presenilin Dimer at the Core of the γ-Secretase Enzyme: Insights from Parallel Analysis of Notch 1 and APP Proteolysis von Schroeter, Eric H., Ma. Xenia G. Ilagan, Brunkan, Anne L., Hecimovic, Silva, Li, Yue-ming, Xu, Min, Lewis, Huw D., Saxena, Meera T., De Strooper, Bart, Coonrod, Archie, Tomita, Taisuke, Iwatsubo, Takeshi, Moore, Chad L., Goate, Alison, Wolfe, Michael S., Shearman, Mark, Kopan, Raphael

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Conserved “PAL” sequence in presenilins is essential for γ-secretase activity, but not required for formation or stabilization of γ-secretase complexes von Wang, Jun, Brunkan, Anne L, Hecimovic, Silva, Walker, Emily, Goate, Alison

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Presenilin endoproteolysis is an intramolecular cleavage von Brunkan, Anne L., Martinez, Maribel, Walker, Emily S., Goate, Alison M.

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Presenilin-1 Protects against Neuronal Apoptosis Caused by Its Interacting Protein PAG von Zhou, Yan, Zhang, Wanjiang, Easton, Rachael, Ray, James W., Lampe, Patricia, Jiang, Zhihong, Brunkan, Anne L., Goate, Alison, Johnson, Eugene M., Wu, Jane Y.

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Structure–function relationships of the outer membrane translocon Wza investigated by cryo-electron microscopy and mutagenesis von Ford, Robert C., Brunkan-LaMontagne, Anne L., Collins, Richard F., Clarke, Bradley R., Harris, Robert, Naismith, James H., Whitfield, Chris

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Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios von Walker, Emily S, Martinez, Maribel, Brunkan, Anne L, Goate, Alison

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The structure of Wza, the translocon for group 1 capsular polysaccharides in Escherichia coli, identifies a new class of outer membrane protein von Dong, Changjiang, Beis, Konstantinos, Nesper, Jutta, Brunkan, Anne L., Clarke, Bradley R., Whitfield, Chris, Naismith, James H.

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P4-283 Endoproteolysis of presenilin-1 is an intramolecular autocatalytic event von Brunkan, Anne L., Martinez, Maribel, Goate, Alison M.

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P4-309 Presenilin 2 familial Alzheimer's disease mutation decrease Aβ and CTFγ while differentially affecting NICD production von Walker, Emily S., Martinez, Maribel, Brunkan, Anne, Hecimovic, Silva, Wang, Jun, Goate, Alison

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Conserved 'PAL'sequence in presenilins is essential for gamma -secretase activity, but not required for formation or stabilization of gamma -secretase complexes von Wang, Jun, Brunkan, Anne L, Hecimovic, Silva, Walker, Emily, Goate, Alison

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The stability and endoproteolysis of endogenous presenilin-1 von Brunkan, Anne, Ray, William J., Goate, Alison M.

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APP and notch proteolysis by γ-secretase requires that these substrates complex with PS1 von Ray, William J., Brunkan, Anne, Schroeter, Eric H., Kopan, Raphael, Goate, Alison M.

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