Randomised clinical trial: a phase 1b study of GB004, an oral HIF‐1α stabiliser, for treatment of ulcerative colitis von Danese, Silvio, Levesque, Barrett G., Feagan, Brian G., Jucov, Alina, Bhandari, Bal Raj, Pai, Rish K., Taylor Meadows, Kristen, Kirby, Brian J., Bruey, Jean‐Marie, Olson, Allan, Osterhout, Robin, Van Biene, Courtney, Ford, Julia, Aranda, Richard, Raghupathi, Kartik, Sandborn, William J.

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Differential regulation of HSP27 oligomerization in tumor cells grown in vitro and in vivo von BRUEY, Jean-Marie, PAUL, Catherine, FROMENTIN, Annie, HILPERT, Sophie, ARRIGO, André-Patrick, SOLARY, Eric, GARRIDO, Carmen

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Reconstituted NALP1 Inflammasome Reveals Two-Step Mechanism of Caspase-1 Activation von Faustin, Benjamin, Lartigue, Lydia, Bruey, Jean-Marie, Luciano, Frederic, Sergienko, Eduard, Bailly-Maitre, Beatrice, Volkmann, Niels, Hanein, Dorit, Rouiller, Isabelle, Reed, John C.

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Editorial: protecting hypoxia‐inducible factor 1a and gut integrity with GB004—a promising therapeutic approach for ulcerative colitis? Authors' reply von Danese, Silvio, Levesque, Barrett G., Feagan, Brian G., Jucov, Alina, Bhandari, B. R., Pai, Rish K., Meadows, Kristen Taylor, Kirby, Brian J., Bruey, Jean‐Marie, Olson, Allan, Osterhout, Robin, Van Biene, Courtney, Ford, Julia, Aranda, Richard, Raghupathi, Kartik, Sandborn, William J.

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TORREY, a Phase 2 study to evaluate the efficacy and safety of inhaled seralutinib for the treatment of pulmonary arterial hypertension von Frantz, Robert P., Benza, Raymond L., Channick, Richard N., Chin, Kelly, Howard, Luke S., McLaughlin, Vallerie V., Sitbon, Olivier, Zamanian, Roham T., Hemnes, Anna R., Cravets, Matt, Bruey, Jean-Marie, Roscigno, Robert, Mottola, David, Elman, Erin, Zisman, Lawrence S., Ghofrani, Hossein-Ardeschir

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HGF/MET-directed therapeutics in gastroesophageal cancer: a review of clinical and biomarker development von Hack, Stephen P, Bruey, Jean-Marie, Koeppen, Hartmut

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HSP27 inhibits cytochrome c‐dependent activation of procaspase‐9 von Garrido, Carmen, Bruey, Jean‐Marie, Fromentin, Annie, Hammann, Arlette, Patrick Arrigo, André, Solary, Eric

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Nur77 converts phenotype of Bcl-B, an antiapoptotic protein expressed in plasma cells and myeloma von Luciano, Frederic, Krajewska, Maryla, Ortiz-Rubio, Paulina, Krajewski, Stan, Zhai, Dayong, Faustin, Benjamin, Bruey, Jean-Marie, Bailly-Maitre, Beatrice, Lichtenstein, Alan, Kolluri, Siva Kumar, Satterthwait, Arnold C., Zhang, Xiao-Kun, Reed, John C.

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Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity von Liu, Xiuting, Hogg, Graham D., Zuo, Chong, Borcherding, Nicholas C., Baer, John M., Lander, Varintra E., Kang, Liang-I, Knolhoff, Brett L., Ahmad, Faiz, Osterhout, Robin E., Galkin, Anna V., Bruey, Jean-Marie, Carter, Laura L., Mpoy, Cedric, Vij, Kiran R., Fields, Ryan C., Schwarz, Julie K., Park, Haeseong, Gupta, Vineet, DeNardo, David G.

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Results of a Phase 2b Trial With GB001, a Prostaglandin D2 Receptor 2 Antagonist, in Moderate to Severe Eosinophilic Asthma von Moss, Mark H., Lugogo, Njira L., Castro, Mario, Hanania, Nicola A., Ludwig-Sengpiel, Andrea, Saralaya, Dinesh, Dobek, Rafal, Ojanguren, Iñigo, Vyshnyvetskyy, Ivan, Bruey, Jean-Marie, Osterhout, Robin, Tompkins, Cindy-ann, Dittrich, Karen, Raghupathi, Kartik, Ortega, Hector

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Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1 von Bruey, Jean-Marie, Bruey-Sedano, Nathalie, Luciano, Frederic, Zhai, Dayong, Balpai, Ruchi, Xu, Chunyan, Kress, Christina L, Bailly-Maitre, Beatrice, Li, Xiaoqing, Osterman, Andrei, Matsuzawa, Shu-ichi, Terskikh, Alexey V, Faustin, Benjamin, Reed, John C

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Selective depletion of inducible HSP70 enhances immunogenicity of rat colon cancer cells von GURBUXANI, Sandeep, BRUEY, Jean-Marie, FROMENTIN, Annie, LARMONIER, Nicolas, PARCELLIER, Arnaud, JÄÄTTELÄ, Marja, MARTIN, Francois, SOLARY, Eric, GARRIDO, Carmen

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Mitochondria-targeting drugs arsenic trioxide and lonidamine bypass the resistance of TPA-differentiated leukemic cells to apoptosis von Sordet, Olivier, Rébé, Cédric, Leroy, Ingrid, Bruey, Jean-Marie, Garrido, Carmen, Miguet, Carole, Lizard, Gérard, Plenchette, Stéphanie, Corcos, Laurent, Solary, Eric

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Hsp27 negatively regulates cell death by interacting with cytochrome c von Garrido, Carmen, Bruey, Jean-Marie, Ducasse, Cécile, Bonniaud, Philippe, Ravagnan, Luigi, Susin, Santos A, Diaz-Latoud, Chantal, Gurbuxani, Sandeep, Arrigo, André-Patrick, Kroemer, Guido, Solary, Eric

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ET-12 PHASE II STUDY OF ONARTUZUMAB PLUS BEVACIZUMAB VERSUS PLACEBO PLUS BEVACIZUMAB IN PATIENTS WITH RECURRENT GLIOBLASTOMA von Cloughesy, T., Finocchiaro, G., Belda-Iniesta, C., Recht, L., Brandes, A. A., Pineda, E., Mikkelsen, T., Chinot, O., Balana, C., Macdonald, D., Westphal, M., Hopkins, K., Weller, M., Bruey, J.-M., Liu, B., Verret, W.

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The PAAD/PYRIN-Family Protein ASC Is a Dual Regulator of a Conserved Step in Nuclear Factor κB Activation Pathways von Stehlik, Christian, Fiorentino, Loredana, Dorfleutner, Andrea, Bruey, Jean-Marie, Ariza, Eugenia M., Sagara, Junji, Reed, John C.

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Ubiquitin-conjugating enzyme Ubc13 is a critical component of TNF receptor-associated factor (TRAF)-mediated inflammatory responses von Fukushima, Toru, Matsuzawa, Shu-ichi, Kress, Christina L, Bruey, Jean Marie, Krajewska, Maryla, Lefebvre, Sophie, Zapata, Juan M, Ronai, Ze'ev, Reed, John C

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Protective role of Cop in Rip2/Caspase-1/Caspase-4-mediated HeLa cell death von Wang, Xin, Narayanan, Malini, Bruey, Jean-Marie, Rigamonti, Dorotea, Cattaneo, Elena, Reed, John C., Friedlander, Robert M.

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Exon scanning by reverse transcriptase–polymerase chain reaction for detection of known and novel EML4–ALK fusion variants in non–small cell lung cancer von Sanders, Heather R, Li, Hai-Rong, Bruey, Jean-Marie, Scheerle, Jay A, Meloni-Ehrig, Aurelia M, Kelly, JoAnn C, Novick, Constance, Albitar, Maher

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389 Combining transcriptomic- and tissue-based immune biomarkers to evaluate GB1275, a CD11b modulator, as a single agent or with pembrolizumab in patients with advanced solid tumo... von Messersmith, Wells, Rasco, Drew, Bono, Johann De, Wang-Gillam, Andrea, Park, Wungki, Nickle, David, Galkin, Anna, Ferguson, Beatrice, Carter, Laura, Zhou, Lei, Dupont, Jakob, Chaney, Marya, Bendell, Johanna, Bruey, Jean-Marie

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