Human immunocompetent Organ-on-Chip platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies von Kerns, S. Jordan, Belgur, Chaitra, Petropolis, Debora, Kanellias, Marianne, Barrile, Riccardo, Sam, Johannes, Weinzierl, Tina, Fauti, Tanja, Freimoser-Grundschober, Anne, Eckmann, Jan, Hage, Carina, Geiger, Martina, Ng, Patrick Ray, Tien-Street, William, Manatakis, Dimitris, Micallef, Virginie, Gerard, Regine, Bscheider, Michael, Breous-Nystrom, Ekaterina, Schneider, Anneliese, Giusti, Anna Maria, Bertinetti-Lapatki, Cristina, Grant, Heather Shannon, Roth, Adrian B., Hamilton, Geraldine A., Singer, Thomas, Karalis, Katia, Moisan, Annie, Bruenker, Peter, Klein, Christian, Bacac, Marina, Gjorevski, Nikolce, Cabon, Lauriane

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A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors von Bacac, Marina, Fauti, Tanja, Sam, Johannes, Colombetti, Sara, Weinzierl, Tina, Ouaret, Djamila, Bodmer, Walter, Lehmann, Steffi, Hofer, Thomas, Hosse, Ralf J, Moessner, Ekkehard, Ast, Oliver, Bruenker, Peter, Grau-Richards, Sandra, Schaller, Teilo, Seidl, Annette, Gerdes, Christian, Perro, Mario, Nicolini, Valeria, Steinhoff, Nathalie, Dudal, Sherri, Neumann, Sebastian, von Hirschheydt, Thomas, Jaeger, Christiane, Saro, Jose, Karanikas, Vaios, Klein, Christian, Umaña, Pablo

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Unique carbohydrate–carbohydrate interactions are required for high affinity binding between FcγRIII and antibodies lacking core fucose von Ferrara, Claudia, Grau, Sandra, Jäger, Christiane, Sondermann, Peter, Brünker, Peter, Waldhauer, Inja, Hennig, Michael, Ruf, Armin, Rufer, Arne Christian, Stihle, Martine, Umaña, Pablo, Benz, Jörg

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Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell–mediated B-cell cytotoxic... von Mössner, Ekkehard, Brünker, Peter, Moser, Samuel, Püntener, Ursula, Schmidt, Carla, Herter, Sylvia, Grau, Roger, Gerdes, Christian, Nopora, Adam, van Puijenbroek, Erwin, Ferrara, Claudia, Sondermann, Peter, Jäger, Christiane, Strein, Pamela, Fertig, Georg, Friess, Thomas, Schüll, Christine, Bauer, Sabine, Dal Porto, Joseph, Del Nagro, Christopher, Dabbagh, Karim, Dyer, Martin J.S., Poppema, Sibrand, Klein, Christian, Umaña, Pablo

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Adaptor Anti-P329G CAR T Cells for Modular Targeting of AML von Stock, Sophia, Strzalkowski, Thaddaeus, Gottschlich, Adrian, Rohrbacher, Lisa, Fertig, Luisa, Menkhoff, Vivien D., Surowka, Marlena, Bruenker, Peter, Darowski, Diana, Endres, Stefan, von Bergwelt-Baildon, Michael, Subklewe, Marion, Klein, Christian, Kobold, Sebastian

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Fibroblast Activation Protein α-Targeted CD40 Agonism Abrogates Systemic Toxicity and Enables Administration of High Doses to Induce Effective Antitumor Immunity von Sum, Eva, Rapp, Moritz, Froebel, Philipp, Le Clech, Marine, Durr, Harald, Giusti, Anna Maria, Perro, Mario, Speziale, Dario, Kunz, Leo, Menietti, Elena, Bruenker, Peter, Hopfer, Ulrike, Lechmann, Martin, Sobieniecki, Andrzej, Appelt, Birte, Adelfio, Roberto, Nicolini, Valeria, Freimoser-Grundschober, Anne, Jordaan, Whitney, Labiano, Sara, Weber, Felix, Emrich, Thomas, Christen, Francois, Essig, Birgit, Romero, Pedro, Trumpfheller, Christine, Umana, Pablo

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The Carbohydrate at Fc gamma RIIIa Asn-162: An element required for high affinity binding to non-fucosylated IgG glycoforms von Ferrara, Claudia, Stuart, Fiona, Sondermann, Peter, Bruenker, Peter, Umana, Pablo

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Protease-activation using anti-idiotypic masks enables tumor specificity of a folate receptor 1-T cell bispecific antibody von Geiger, Martina, Stubenrauch, Kay-Gunnar, Sam, Johannes, Richter, Wolfgang F., Jordan, Gregor, Eckmann, Jan, Hage, Carina, Nicolini, Valeria, Freimoser-Grundschober, Anne, Ritter, Mirko, Lauer, Matthias E., Stahlberg, Henning, Ringler, Philippe, Patel, Jigar, Sullivan, Eric, Grau-Richards, Sandra, Endres, Stefan, Kobold, Sebastian, Umaña, Pablo, Brünker, Peter, Klein, Christian

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First Infusion Reactions are Mediated by FcγRIIIb and Neutrophils von Weber, Felix, Breustedt, Daniel, Schlicht, Sonja, Meyer, Claas A., Niewoehner, Jens, Ebeling, Martin, Freskgard, Per-Ola, Bruenker, Peter, Singer, Thomas, Reth, Michael, Iglesias, Antonio

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P329G-CAR-J: a novel Jurkat-NFAT-based CAR-T reporter system recognizing the P329G Fc mutation von Darowski, Diana, Jost, Christian, Stubenrauch, Kay, Wessels, Uwe, Benz, Jörg, Ehler, Andreas, Freimoser-Grundschober, Anne, Brünker, Peter, Mössner, Ekkehard, Umaña, Pablo, Kobold, Sebastian, Klein, Christian

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Abstract C125: Preclinical pharmacodynamic biomarker and combination strategy of RG7386, a novel FAP-DR5 bispecific antibody for targeting solid tumors von Friess, Thomas, Broeske, Ann-Marie, Lechner, Stefanie, Abraham, Esther, Hoelzlwimmer, Gabriele, Sade, Hadassa, Bruenker, Peter, Krieter, Oliver

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Abstract 952: Induction of avidity-driven hyperclustering of DR5 by a new FAP-DR5 bispecific antibody (RG7386) leads to strong anti-tumor efficacy von Friess, Thomas, Lechner, Stefanie, Abraham, Esther, Broeske, Ann-Marie, Bader, Sabine, Roller, Andreas, Majety, Meher, Wartha, Katharina, Vega-Harring, Suzana, Sade, Hadassah, Krieter, Oliver, Bruenker, Peter

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Abstract 4573: A novel bispecific Fap-Dr5 antibody inducing potent and tumor-specific death receptor 5 (Dr5) activation by fibroblast activation protein (Fap)-dependent crosslinkin... von Wartha, Katharina, Weiser, Barbara, Friess, Thomas, Majety, Meher, Runza, Valeria, Herting, Frank, Weber, Thomas, Scheuer, Werner, Harring, Suzana Vega, Sade, Hadassah, Niu, Huifeng, Bruenker, Peter

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Abstract 2481: CEA TCB, a novel T-cell bispecific antibody with potent in vitro and in vivo antitumor activity against solid tumors von Bacac, Marina, Fauti, Tanja, Colombetti, Sara, Sam, Johannes, Nicolini, Valeria, Steinhoff, Nathalie, Ast, Oliver, Bruenker, Peter, Hosse, Ralf, Hofer, Thomas, Moessner, Ekkehard, Jaeger, Christiane, Saro, Jose, Karanikas, Vaios, Klein, Christian, Umana, Pablo

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ITOC2 – 037. CEA TCB, A novel T-cell bispecific antibody with potent in vitro and in vivo antitumour activity against solid tumours von Bacac, Marina, Fauti, Tanja, Colombetti, Sara, Sam, Johannes, Nicolini, Valeria, Steinhoff, Nathalie, Ast, Oliver, Bruenker, Peter, Hosse, Ralf, Hofer, Thomas, Moessner, Ekkehard, Jaeger, Christiane, Saro, Jose, Karanikas, Vaios, Klein, Christian, Umaña, Pablo

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A New Class of T-Cell Bispecific Antibodies for the Treatment of Multiple Myeloma, Binding to B Cell Maturation Antigen and CD3 and Showing Potent, Specific Antitumor Activity in M... von Vu, Minh Diem, Moser, Samuel, Delon, Camille, Latzko, Melanie, Gianotti, Reto, Lüoend, Remo, Friang, Chloé, Murr, Ramona, Duerner, Lydia Jasmin, Weinzierl, Tina, Fauti, Tanja, Bacac, Marina, Ast, Oliver, Freimoser-Grundschober, Anne, Rodriguez Diaz, Tea, Zielonka, Jörg, van Puijenbroek, Erwin, Hosse, Ralf, Bruenker, Peter, Mössner, Ekkehard, Klein, Christian, Umaña, Pablo, Strein, Klaus

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Improved effector functions of a therapeutic monoclonal Lewis Y-specific antibody by glycoform engineering von SCHUSTER, Manfred, UMANA, Pablo, MUDDE, Geert C, FERRARA, Claudia, BRÜNKER, Peter, GERDES, Christian, WAXENECKER, Gunter, WIEDERKUM, Susanne, SCHWAGER, Cornelia, LOIBNER, Hans, HIMMLER, Gottfried

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Abstract 486: Tumor-targeted, engineered IL-2 variant (IL-2v)-based immunocytokines for the immunotherapy of cancer von Klein, Christian, Waldhauer, Inja, Nicolini, Valeria, Dunn, Claire, Freimoser-Grundschober, Anne, Herter, Sylvia, Geven, Edwin, Boerman, Otto, Nayak, Tapan, van Puijenbroek, Erwin, Wittig, David, Moser, Samuel, Ast, Oliver, Bruenker, Peter, Hosse, Ralf, Lang, Sabine, Neumann, Sebastian, Kettenberger, Hubert, Grossmann, Adelbert, Gorr, Ingo, Evers, Stefan, Pisa, Pavel, Fretland, Jennifer, Levitsky, Victor, Gerdes, Christian, Bacac, Marina, Moessner, Ekkehard, Umaña, Pablo

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ANTIBODIES BINDING TO CSF1R AND CD3 von KLEIN, Christian, BRUENKER, Peter, GOTTSCHLICH, Adrian, KOBOLD, Sebastian

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IMPROVED FOLR1 PROTEASE-ACTIVATABLE T CELL BISPECIFIC ANTIBODIES von GEIGER, Martina, KLEIN, Christian, UMAÑA, Pablo, BRUENKER, Peter

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