Molecular characterization of common fragile sites as a strategy to discover cancer susceptibility genes von Savelyeva, Larissa, Brueckner, Lena M

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HD-MB03 is a novel Group 3 medulloblastoma model demonstrating sensitivity to histone deacetylase inhibitor treatment von Milde, Till, Lodrini, Marco, Savelyeva, Larissa, Korshunov, Andrey, Kool, Marcel, Brueckner, Lena M., Antunes, André S. L. M., Oehme, Ina, Pekrun, Arnulf, Pfister, Stefan M., Kulozik, Andreas E., Witt, Olaf, Deubzer, Hedwig E.

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The FRA14B common fragile site maps to a region prone to somatic and germline rearrangements within the large GPHN gene von Zheglo, Diana, Brueckner, Lena M., Sepman, Olga, Wecht, Elisa M., Kuligina, Ekaterina, Suspitsin, Evgenij, Imyanitov, Evgenij, Savelyeva, Larissa

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CDK4 inhibition restores G(1)-S arrest in MYCN-amplified neuroblastoma cells in the context of doxorubicin-induced DNA damage von Gogolin, Sina, Ehemann, Volker, Becker, Gabriele, Brueckner, Lena M, Dreidax, Daniel, Bannert, Steffen, Nolte, Ingo, Savelyeva, Larissa, Bell, Emma, Westermann, Frank

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The FRA2C common fragile site maps to the borders of MYCN amplicons in neuroblastoma and is associated with gross chromosomal rearrangements in different cancers von BLUMRICH, Anne, ZAPATKA, Marc, BRUECKNER, Lena M, ZHEGLO, Diana, SCHWAB, Manfred, SAVELYEVA, Larissa

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Instability at the FRA8I common fragile site disrupts the genomic integrity of the KIAA0146 , CEBPD and PRKDC genes in colorectal cancer von Brueckner, Lena M, Hess, Elisa M, Schwab, Manfred, Savelyeva, Larissa

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Genomic rearrangements at the FRA2H common fragile site frequently involve non-homologous recombination events across LTR and L1(LINE) repeats von Brueckner, Lena M., Sagulenko, Evgeny, Hess, Elisa M., Zheglo, Diana, Blumrich, Anne, Schwab, Manfred, Savelyeva, Larissa

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MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis von Alborzinia, Hamed, Flórez, Andrés F, Kreth, Sina, Brückner, Lena M, Yildiz, Umut, Gartlgruber, Moritz, Odoni, Dorett I, Poschet, Gernot, Garbowicz, Karolina, Shao, Chunxuan, Klein, Corinna, Meier, Jasmin, Zeisberger, Petra, Nadler-Holly, Michal, Ziehm, Matthias, Paul, Franziska, Burhenne, Jürgen, Bell, Emma, Shaikhkarami, Marjan, Würth, Roberto, Stainczyk, Sabine A, Wecht, Elisa M, Kreth, Jochen, Büttner, Michael, Ishaque, Naveed, Schlesner, Matthias, Nicke, Barbara, Stresemann, Carlo, Llamazares-Prada, María, Reiling, Jan H, Fischer, Matthias, Amit, Ido, Selbach, Matthias, Herrmann, Carl, Wölfl, Stefan, Henrich, Kai-Oliver, Höfer, Thomas, Trumpp, Andreas, Westermann, Frank

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CDK4 inhibition restores G₁-S arrest in MYCN-amplified neuroblastoma cells in the context of doxorubicin-induced DNA damage von Gogolin, Sina, Ehemann, Volker, Becker, Gabriele, Brueckner, Lena M., Dreidax, Daniel, Bannert, Steffen, Nolte, Ingo, Savelyeva, Larissa, Bell, Emma, Westermann, Frank

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Instability at theFRA8Icommon fragile site disrupts the genomic integrity of theKIAA0146,CEBPDandPRKDCgenes in colorectal cancer von Brueckner, Lena M, Hess, Elisa M, Schwab, Manfred, Savelyeva, Larissa

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