Crystallographic structure of a small molecule SIRT1 activator-enzyme complex von Dai, Han, Case, April W., Riera, Thomas V., Considine, Thomas, Lee, Jessica E., Hamuro, Yoshitomo, Zhao, Huizhen, Jiang, Yong, Sweitzer, Sharon M., Pietrak, Beth, Schwartz, Benjamin, Blum, Charles A., Disch, Jeremy S., Caldwell, Richard, Szczepankiewicz, Bruce, Oalmann, Christopher, Yee Ng, Pui, White, Brian H., Casaubon, Rebecca, Narayan, Radha, Koppetsch, Karsten, Bourbonais, Francis, Wu, Bo, Wang, Junfeng, Qian, Dongming, Jiang, Fan, Mao, Cheney, Wang, Minghui, Hu, Erding, Wu, Joe C., Perni, Robert B., Vlasuk, George P., Ellis, James L.

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Synthesis of Carba-NAD and the Structures of Its Ternary Complexes with SIRT3 and SIRT5 von Szczepankiewicz, Bruce G, Dai, Han, Koppetsch, Karsten J, Qian, Dongming, Jiang, Fan, Mao, Cheney, Perni, Robert B

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Discovery of a Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Using a Linked-Fragment Strategy von Szczepankiewicz, Bruce G, Liu, Gang, Hajduk, Philip J, Abad-Zapatero, Cele, Pei, Zhonghua, Xin, Zhili, Lubben, Thomas H, Trevillyan, James M, Stashko, Michael A, Ballaron, Stephen J, Liang, Heng, Huang, Flora, Hutchins, Charles W, Fesik, Stephen W, Jirousek, Michael R

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Inhibition of MptpB phosphatase from Mycobacterium tuberculosis impairs mycobacterial survival in macrophages von Beresford, Nicola J., Mulhearn, Debbie, Szczepankiewicz, Bruce, Liu, Gang, Johnson, Michael E., Fordham-Skelton, Anthony, Abad-Zapatero, Cele, Cavet, Jennifer S., Tabernero, Lydia

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Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors von Xin, Zhili, Zhao, Hongyu, Serby, Michael D., Liu, Bo, Liu, Mei, Szczepankiewicz, Bruce G., Nelson, Lissa T.J., Smith, Harriet T., Suhar, Tom S., Janis, Rich S., Cao, Ning, Camp, Heidi S., Collins, Christine A., Sham, Hing L., Surowy, Teresa K., Liu, Gang

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Aminopyridine-Based c-Jun N-Terminal Kinase Inhibitors with Cellular Activity and Minimal Cross-Kinase Activity von Szczepankiewicz, Bruce G, Kosogof, Christi, Nelson, Lissa T. J, Liu, Gang, Liu, Bo, Zhao, Hongyu, Serby, Michael D, Xin, Zhili, Liu, Mei, Gum, Rebecca J, Haasch, Deanna L, Wang, Sanyi, Clampit, Jill E, Johnson, Eric F, Lubben, Thomas H, Stashko, Michael A, Olejniczak, Edward T, Sun, Chaohong, Dorwin, Sarah A, Haskins, Kristi, Abad-Zapatero, Cele, Fry, Elizabeth H, Hutchins, Charles W, Sham, Hing L, Rondinone, Cristina M, Trevillyan, James M

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Synthesis of Purines and Other Fused Imidazoles from Acyclic Amidines and Guanidines von Szczepankiewicz, Bruce G, Rohde, Jeffrey J, Kurukulasuriya, Ravi

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One-Step, Nonenzymatic Synthesis of O-Acetyl-ADP-ribose and Analogues from NAD and Carboxylates von Szczepankiewicz, Bruce G, Koppetsch, Karsten J, Perni, Robert B

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Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide c-Jun NH2-Terminal Kinase Inhibitors von Zhao, Hongyu, Serby, Michael D, Xin, Zhili, Szczepankiewicz, Bruce G, Liu, Mei, Kosogof, Christi, Liu, Bo, Nelson, Lissa T. J, Johnson, Eric F, Wang, Sanyi, Pederson, Terry, Gum, Rebecca J, Clampit, Jill E, Haasch, Deanna L, Abad-Zapatero, Cele, Fry, Elizabeth H, Rondinone, Cristina, Trevillyan, James M, Sham, Hing L, Liu, Gang

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Selective Protein Tyrosine Phosphatase 1B Inhibitors:  Targeting the Second Phosphotyrosine Binding Site with Non-Carboxylic Acid-Containing Ligands von Liu, Gang, Xin, Zhili, Liang, Heng, Abad-Zapatero, Cele, Hajduk, Philip J, Janowick, David A, Szczepankiewicz, Bruce G, Pei, Zhonghua, Hutchins, Charles W, Ballaron, Stephen J, Stashko, Michael A, Lubben, Thomas H, Berg, Cathy E, Rondinone, Cristina M, Trevillyan, James M, Jirousek, Michael R

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The Synthesis of Bromomethyltrifluoroborates through Continuous Flow Chemistry von Broom, Toby, Hughes, Mark, Szczepankiewicz, Bruce G., Ace, Karl, Hagger, Ben, Lacking, Gary, Chima, Ranjit, Marchbank, Graeme, Alford, Gareth, Evans, Paul, Cunningham, Christopher, Roberts, John C., Perni, Robert B., Berry, Malcolm, Rutter, Andrew, Watson, Simon A.

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Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors von Zhao, Hongyu, Liu, Gang, Xin, Zhili, Serby, Michael D., Pei, Zhonghua, Szczepankiewicz, Bruce G., Hajduk, Philip J., Abad-Zapatero, Cele, Hutchins, Charles W., Lubben, Thomas H., Ballaron, Stephen J., Haasch, Deanna L., Kaszubska, Wiweka, Rondinone, Cristina M., Trevillyan, James M., Jirousek, Michael R.

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2,4-Diaminopyrimidine Derivatives as Potent Growth Hormone Secretagogue Receptor Antagonists von Serby, Michael D., Zhao, Hongyu, Szczepankiewicz, Bruce G., Kosogof, Christi, Xin, Zhili, Liu, Bo, Liu, Mei, Nelson, Lissa T. J., Kaszubska, Wiweka, Falls, H. Douglas, Schaefer, Verlyn, Bush, Eugene N., Shapiro, Robin, Droz, Brian A., Knourek-Segel, Victoria E., Fey, Thomas A., Brune, Michael E., Beno, David W. A., Turner, Theresa M., Collins, Christine A., Jacobson, Peer B., Sham, Hing L., Liu, Gang

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Identification of a monoacid-Based, cell permeable, selective inhibitor of protein tyrosine phosphatase 1B von Xin, Zhili, Liu, Gang, Abad-Zapatero, Cele, Pei, Zhonghua, Szczepankiewicz, Bruce G., Li, Xiaofeng, Zhang, Tianyuan, Hutchins, Charles W., Hajduk, Philip J., Ballaron, Stephen J., Stashko, Michael A., Lubben, Thomas H., Trevillyan, James M., Jirousek, Michael R.

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Discovery and Pharmacological Evaluation of Growth Hormone Secretagogue Receptor Antagonists von Xin, Zhili, Serby, Michael D, Zhao, Hongyu, Kosogof, Christi, Szczepankiewicz, Bruce G, Liu, Mei, Hutchins, Charles W, Sarris, Kathy A, Hoff, Ethan D, Falls, H. Douglas, Lin, Chun W, Ogiela, Christopher A, Collins, Christine A, Brune, Michael E, Bush, Eugene N, Droz, Brian A, Fey, Thomas A, Knourek-Segel, Victoria E, Shapiro, Robin, Jacobson, Peer B, Beno, David W. A, Turner, Teresa M, Sham, Hing L, Liu, Gang

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Discovery and Structure−Activity Relationship of Oxalylarylaminobenzoic Acids as Inhibitors of Protein Tyrosine Phosphatase 1B von Liu, Gang, Szczepankiewicz, Bruce G, Pei, Zhonghua, Janowick, David A, Xin, Zhili, Hajduk, Philip J, Abad-Zapatero, Cele, Liang, Heng, Hutchins, Charles W, Fesik, Stephen W, Ballaron, Steve J, Stashko, Mike A, Lubben, Tom, Mika, Amanda K, Zinker, Bradley A, Trevillyan, James M, Jirousek, Michael R

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Pyrrolidine-3-carboxylic Acids as Endothelin Antagonists. 4. Side Chain Conformational Restriction Leads to ETB Selectivity von von Geldern, Thomas W, Tasker, Andrew S, Sorensen, Bryan K, Winn, Martin, Szczepankiewicz, Bruce G, Dixon, Douglas B, Chiou, William J, Wang, Liming, Wessale, Jerry L, Adler, Andy, Marsh, Kennan C, Nguyen, Bach, Opgenorth, Terry J

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Xanthine mimetics as potent dipeptidyl peptidase IV inhibitors von Kurukulasuriya, Ravi, Rohde, Jeffrey J., Szczepankiewicz, Bruce G., Basha, Fatima, Lai, Chunqui, Jae, Hwan-Soo, Winn, Martin, Stewart, Kent D., Longenecker, Kenton L., Lubben, Thomas W., Ballaron, Stephen J., Sham, Hing L., von Geldern, Thomas W.

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Potent, selective inhibitors of protein tyrosine phosphatase 1B von Xin, Zhili, Oost, Thorsten K, Abad-Zapatero, Cele, Hajduk, Philip J, Pei, Zhonghua, Szczepankiewicz, Bruce G, Hutchins, Charles W, Ballaron, Steve J, Stashko, Mike A, Lubben, Tom, Trevillyan, James M, Jirousek, Mike R, Liu, Gang

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New Antimitotic Agents with Activity in Multi-Drug-Resistant Cell Lines and in Vivo Efficacy in Murine Tumor Models von Szczepankiewicz, Bruce G, Liu, Gang, Jae, Hwan-Soo, Tasker, Andrew S, Gunawardana, Indrani W, von Geldern, Thomas W, Gwaltney, Stephen L, Wu-Wong, J. Ruth, Gehrke, Laura, Chiou, William J, Credo, R. Bruce, Alder, Jeffery D, Nukkala, Michael A, Zielinski, Nicolette A, Jarvis, Ken, Mollison, Karl W, Frost, David J, Bauch, Joy L, Hui, Yu Hua, Claiborne, Akiyo K, Li, Qun, Rosenberg, Saul H

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