Structure-Based Design and Identification of FT-2102 (Olutasidenib), a Potent Mutant-Selective IDH1 Inhibitor von Caravella, Justin A, Lin, Jian, Diebold, R. Bruce, Campbell, Ann-Marie, Ericsson, Anna, Gustafson, Gary, Wang, Zhongguo, Castro, Jennifer, Clarke, Andrea, Gotur, Deepali, Josephine, Helen R, Katz, Marie, Kershaw, Mark, Yao, Lili, Toms, Angela V, Barr, Kenneth J, Dinsmore, Christopher J, Walker, Duncan, Ashwell, Susan, Lu, Wei

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AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-xL, Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia von Balachander, Srividya B., Criscione, Steven W., Byth, Kate F., Cidado, Justin, Adam, Ammar, Lewis, Paula, Macintyre, Terry, Wen, Shenghua, Lawson, Deborah, Burke, Kathleen, Lubinski, Tristan, Tyner, Jeffrey W., Kurtz, Stephen E., McWeeney, Shannon K., Varnes, Jeffrey, Diebold, R. Bruce, Gero, Thomas, Ioannidis, Stephanos, Hennessy, Edward J., McCoull, William, Saeh, Jamal C., Tabatabai, Areya, Tavana, Omid, Su, Nancy, Schuller, Alwin, Garnett, Mathew J., Jaaks, Patricia, Coker, Elizabeth A., Gregory, Gareth P., Newbold, Andrea, Johnstone, Ricky W., Gangl, Eric, Wild, Martin, Zinda, Michael, Secrist, J. Paul, Davies, Barry R., Fawell, Stephen E., Gibbons, Francis D.

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3-Amido-4-anilinocinnolines as a novel class of CSF-1R inhibitor von Scott, David A., Dakin, Les A., Del Valle, David J., Bruce Diebold, R., Drew, Lisa, Gero, Thomas W., Ogoe, Claude A., Omer, Charles A., Repik, Galina, Thakur, Kumar, Ye, Qing, Zheng, Xiaolan

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Towards the next generation of dual Bcl-2/Bcl-xL inhibitors von Varnes, Jeffrey G., Gero, Thomas, Huang, Shan, Diebold, R. Bruce, Ogoe, Claude, Grover, Paul T., Su, Mei, Mukherjee, Prasenjit, Saeh, Jamal Carlos, MacIntyre, Terry, Repik, Galina, Dillman, Keith, Byth, Kate, Russell, Daniel John, Ioannidis, Stephanos

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Discovery and Optimization of Quinolinone Derivatives as Potent, Selective, and Orally Bioavailable Mutant Isocitrate Dehydrogenase 1 (mIDH1) Inhibitors von Lin, Jian, Lu, Wei, Caravella, Justin A, Campbell, Ann Marie, Diebold, R. Bruce, Ericsson, Anna, Fritzen, Edward, Gustafson, Gary R, Lancia, David R, Shelekhin, Tatiana, Wang, Zhongguo, Castro, Jennifer, Clarke, Andrea, Gotur, Deepali, Josephine, Helen R, Katz, Marie, Diep, Hien, Kershaw, Mark, Yao, Lili, Kauffman, Goss, Hubbs, Stephen E, Luke, George P, Toms, Angela V, Wang, Liann, Bair, Kenneth W, Barr, Kenneth J, Dinsmore, Christopher, Walker, Duncan, Ashwell, Susan

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Mitigation of cardiovascular toxicity in a series of CSF-1R inhibitors, and the identification of AZD7507 von Scott, David A., Dakin, Les A., Daly, Kevin, Del Valle, David J., Diebold, R. Bruce, Drew, Lisa, Ezhuthachan, Jayachandran, Gero, Thomas W., Ogoe, Claude A., Omer, Charles A., Redmond, Sean P., Repik, Galina, Thakur, Kumar, Ye, Qing, Zheng, Xiaolan

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Syntheses of Potent, Selective, and Orally Bioavailable Indazole-Pyridine Series of Protein Kinase B/Akt Inhibitors with Reduced Hypotension von Zhu, Gui-Dong, Gandhi, Viraj B, Gong, Jianchun, Thomas, Sheela, Woods, Keith W, Song, Xiaohong, Li, Tongmei, Diebold, R. Bruce, Luo, Yan, Liu, Xuesong, Guan, Ran, Klinghofer, Vered, Johnson, Eric F, Bouska, Jennifer, Olson, Amanda, Marsh, Kennan C, Stoll, Vincent S, Mamo, Mulugeta, Polakowski, James, Campbell, Thomas J, Martin, Ruth L, Gintant, Gary A, Penning, Thomas D, Li, Qun, Rosenberg, Saul H, Giranda, Vincent L

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AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-x L , Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia von Balachander, Srividya B, Criscione, Steven W, Byth, Kate F, Cidado, Justin, Adam, Ammar, Lewis, Paula, Macintyre, Terry, Wen, Shenghua, Lawson, Deborah, Burke, Kathleen, Lubinski, Tristan, Tyner, Jeffrey W, Kurtz, Stephen E, McWeeney, Shannon K, Varnes, Jeffrey, Diebold, R Bruce, Gero, Thomas, Ioannidis, Stephanos, Hennessy, Edward J, McCoull, William, Saeh, Jamal C, Tabatabai, Areya, Tavana, Omid, Su, Nancy, Schuller, Alwin, Garnett, Mathew J, Jaaks, Patricia, Coker, Elizabeth A, Gregory, Gareth P, Newbold, Andrea, Johnstone, Ricky W, Gangl, Eric, Wild, Martin, Zinda, Michael, Secrist, J Paul, Davies, Barry R, Fawell, Stephen E, Gibbons, Francis D

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SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND THEIR USES THEREOF von LEE, Wongil, SEUNG, Sang-Ae, DIEBOLD, R. Bruce, LIU, Yan, DEVINE, William G, HWANG, So Young, KOH, Jong Sung, CHOI, Yunggeun, YONG, Miyong, KIM, Sewon, LEE, Jaekyoo

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SELECTIVE INHIBITORS OF ROCK2 PROTEIN KINASES AND USES THEREOF von LEE, Wongil, SEUNG, Sang-Ae, DIEBOLD, R. Bruce, HWANG, So Young, DASHNAMOORTHY, Ravi, GUPTA, Anu, KOH, Jong Sung, DEVINE, William, YONG, Miyong, LEE, Jaekyoo

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BLOOD BRAIN BARRIER PENETRATING SELECTIVE INHIBITORS OF ROCK2 PROTEIN KINASES AND USES THEREOF von LEE, Wongil, SEUNG, Sang-Ae, DIEBOLD, R. Bruce, HWANG, So Young, GUPTA, Anu, KOH, Jong Sung, NG, Nicholas, SAGAR, Vinay, DEVINE, William, YONG, Miyong, LEE, Jaekyoo

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Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof von Lee, Jaekyoo, Koh, Jong Sung, Seung, Sang-Ae, Yong, Miyong, Lee, Wongil, Choi, Yunggeun, Hwang, So Young, Kim, Sewon, Liu, Yan, Devine, William G, Diebold, R. Bruce

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PYRIDIN-2(1H)-ONE QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS von Caravella, Justin Andrew, Gustafson, Gary, Lancia, JR., David R, Lu, Wei, Ashwell, Susan, Campbell, Ann-Marie, Lin, Jian, Ericsson, Anna, Wang, Zhongguo, Diebold, R. Bruce

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PYRIDIN-2(1H)-ONE QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS von LU, WEI, CARAVELLA, JUSTIN ANDREW, ERICSSON, ANNA, CAMPBELL, ANN-MARIE, LIN, JIAN, GUSTAFSON, GARY, WANG, ZHONGGUO, ASHWELL, SUSAN, LANCIA, DAVID R, DIEBOLD, R. BRUCE

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PYRIDIN-2(1H)-ONE QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS von LIN, Jian, CARAVELLA, Justin Andrew, DIEBOLD, R. Bruce, ERICSSON, Anna, LU, Wei, WANG, Zhongguo, GUSTAFSON, Gary, ASHWELL, Susan, LANCIA, David R. Jr, CAMPBELL, Ann-Marie

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Pyrrolo and pyrazolopyrimidines as ubiquitin-specific protease 7 inhibitors von Caravella, Justin Andrew, Talbot, Adam Charles, Campbell, Ann-Marie, Buckmelter, Alexandre Joseph, Guerin, David Joseph, Wang, Minghua, Lancia, Jr., David R, Ericsson, Anna, Follows, Bruce, Ioannidis, Stephanos, Schmidt, Darby Rye, Diebold, R. Bruce

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PYRIDIN-2(1H)-ONE QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS von LIN, Jian, CAMPBELL, Ann-marie, CARAVELLA, Justin Andrew, DIEBOLD, R. Bruce, ERICSSON, Anna, LU, Wei, WANG, Zhongguo, GUSTAFSON, Gary, ASHWELL, Susan, LANCIA, David R. Jr

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PYRIDIN-2(1H)-ONE QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS von JUSTIN A CARAVELLA, JIAN LIN, ANNA ERICSSON, R BRUCE DIEBOLD, SUSAN ASHWELL, WEI LU, ZHONGGUO WANG, GARY GUSTAFSON, ANN-MARIE CAMPBELL, DAVID R LANCIA JR

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Pyridin-2(1h)-one quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors von Caravella, Justin Andrew, Gustafson, Gary, Lu, Wei, Ashwell, Susan, Campbell, Ann-Marie, Lin, Jian, Ericsson, Anna, Lancia, Jr, Wang, Zhongguo, Diebold, R. Bruce

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Pyridin-2(1h)-one quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors von Caravella, Justin Andrew, Gustafson, Gary, Lu, Wei, Ashwell, Susan, Campbell, Ann-Marie, Lin, Jian, Ericsson, Anna, Lancia Jr., David R, Wang, Zhongguo, Diebold, R. Bruce

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