Posing the APC/C E3 Ubiquitin Ligase to Orchestrate Cell Division von Watson, Edmond R., Brown, Nicholas G., Peters, Jan-Michael, Stark, Holger, Schulman, Brenda A.

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biGBac enables rapid gene assembly for the expression of large multisubunit protein complexes von Weissmann, Florian, Petzold, Georg, VanderLinden, Ryan, Veld, Pim J. Huis in ’t, Brown, Nicholas G., Lampert, Fabienne, Westermann, Stefan, Stark, Holger, Schulman, Brenda A., Peters, Jan-Michael

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Quantifying the heterogeneity of macromolecular machines by mass photometry von Sonn-Segev, Adar, Belacic, Katarina, Bodrug, Tatyana, Young, Gavin, VanderLinden, Ryan T., Schulman, Brenda A., Schimpf, Johannes, Friedrich, Thorsten, Dip, Phat Vinh, Schwartz, Thomas U., Bauer, Benedikt, Peters, Jan-Michael, Struwe, Weston B., Benesch, Justin L. P., Brown, Nicholas G., Haselbach, David, Kukura, Philipp

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Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation von Yamaguchi, Masaya, VanderLinden, Ryan, Weissmann, Florian, Qiao, Renping, Dube, Prakash, Brown, Nicholas G., Haselbach, David, Zhang, Wei, Sidhu, Sachdev S., Peters, Jan-Michael, Stark, Holger, Schulman, Brenda A.

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Mechanism of Polyubiquitination by Human Anaphase-Promoting Complex: RING Repurposing for Ubiquitin Chain Assembly von Brown, Nicholas G., Watson, Edmond R., Weissmann, Florian, Jarvis, Marc A., VanderLinden, Ryan, Grace, Christy R.R., Frye, Jeremiah J., Qiao, Renping, Dube, Prakash, Petzold, Georg, Cho, Shein Ei, Alsharif, Omar, Bao, Ju, Davidson, Iain F., Zheng, Jie J., Nourse, Amanda, Kurinov, Igor, Peters, Jan-Michael, Stark, Holger, Schulman, Brenda A.

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RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex von Brown, Nicholas G., VanderLinden, Ryan, Watson, Edmond R., Qiao, Renping, Grace, Christy R. R., Yamaguchi, Masaya, Weissmann, Florian, Frye, Jeremiah J., Dube, Prakash, Cho, Shein Ei, Actis, Marcelo L., Rodrigues, Patrick, Fujii, Naoaki, Peters, Jan-Michael, Stark, Holger, Schulman, Brenda A.

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APC15 mediates CDC20 autoubiquitylation by APC/CMCC and disassembly of the mitotic checkpoint complex von Uzunova, Kristina, Dye, Billy T, Schutz, Hannelore, Ladurner, Rene, Petzold, Georg, Toyoda, Yusuke, Jarvis, Marc A, Brown, Nicholas G, Poser, Ina, Novatchkova, Maria, Mechtler, Karl, Hyman, Anthony A, Stark, Holger, Schulman, Brenda A, Peters, Jan-Michael

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Proteomic analysis reveals a PLK1-dependent G2/M degradation program and a role for AKAP2 in coordinating the mitotic cytoskeleton von Mouery, Ryan D., Lukasik, Kimberly, Hsu, Carolyn, Bonacci, Thomas, Bolhuis, Derek L., Wang, Xianxi, Mills, C. Allie, Toomer, E. Drew, Canterbury, Owen G., Robertson, Kevin C., Branigan, Timothy B., Brown, Nicholas G., Herring, Laura E., Gupton, Stephanie L., Emanuele, Michael J.

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A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins von Lu, Xiuxiu, Chandravanshi, Monika, Sabbasani, Venkata R., Gaikwad, Snehal, Hughitt, V. Keith, Gyabaah-Kessie, Nana, Scroggins, Bradley T., Das, Sudipto, Myint, Wazo, Clapp, Michelle E., Schwieters, Charles D., Dyba, Marzena A., Bolhuis, Derek L., Koscielniak, Janusz W., Andresson, Thorkell, Emanuele, Michael J., Brown, Nicholas G., Matsuo, Hiroshi, Chari, Raj, Citrin, Deborah E., Mock, Beverly A., Swenson, Rolf E., Walters, Kylie J.

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In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators von Franks, Jennifer L, Martinez-Chacin, Raquel C, Wang, Xianxi, Tiedemann, Rochelle L, Bonacci, Thomas, Choudhury, Rajarshi, Bolhuis, Derek L, Enrico, Taylor P, Mouery, Ryan D, Damrauer, Jeffrey S, Yan, Feng, Harrison, Joseph S, Major, M Ben, Hoadley, Katherine A, Suzuki, Aussie, Rothbart, Scott B, Brown, Nicholas G, Emanuele, Michael J

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Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2 von Enrico, Taylor P, Stallaert, Wayne, Wick, Elizaveta T, Ngoi, Peter, Wang, Xianxi, Rubin, Seth M, Brown, Nicholas G, Purvis, Jeremy E, Emanuele, Michael J

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Frozen in time: analyzing molecular dynamics with time-resolved cryo-EM von Amann, Sascha Josef, Keihsler, Demian, Bodrug, Tatyana, Brown, Nicholas G., Haselbach, David

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Intricate Regulatory Mechanisms of the Anaphase-Promoting Complex/Cyclosome and Its Role in Chromatin Regulation von Bodrug, Tatyana, Welsh, Kaeli A., Hinkle, Megan, Emanuele, Michael J., Brown, Nicholas G.

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Minor papilla endotherapy in patients with ventral duct obstruction: identification and management von Brown, Nicholas G., MD, Howell, Douglas A., MD, Brauer, Brian C., MD, Walker, John, DO, Wani, Sachin, MD, Shah, Raj J., MD

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Probing the sites of interactions of rotaviral proteins involved in replication von Viskovska, Maria, Anish, Ramakrishnan, Hu, Liya, Chow, Dar-Chone, Hurwitz, Amy M, Brown, Nicholas G, Palzkill, Timothy, Estes, Mary K, Prasad, B V Venkataram

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Analysis of the Functional Contributions of Asn233 in Metallo-β-Lactamase IMP-1 von BROWN, Nicholas G, HORTON, Lori B, WANZHI HUANG, VONGPUNSAWAD, Sompong, PALZKILL, Timothy

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BLIP-II Is a Highly Potent Inhibitor of Klebsiella pneumoniae Carbapenemase (KPC-2) von BROWN, Nicholas G, CHOW, Dar-Chone, PALZKILL, Timothy

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Cryo-EM structure of the plant 26S proteasome von Kandolf, Susanne, Grishkovskaya, Irina, Belačić, Katarina, Bolhuis, Derek L., Amann, Sascha, Foster, Brent, Imre, Richard, Mechtler, Karl, Schleiffer, Alexander, Tagare, Hemant D., Zhong, Ellen D., Meinhart, Anton, Brown, Nicholas G., Haselbach, David

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Immediate and durable therapeutic response after EUS-guided radiofrequency ablation of a pancreatic insulinoma von Brown, Nicholas G., Patel, Anish A., Gonda, Tamas A.

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Cezanne/OTUD7B is a cell cycle‐regulated deubiquitinase that antagonizes the degradation of APC/C substrates von Bonacci, Thomas, Suzuki, Aussie, Grant, Gavin D, Stanley, Natalie, Cook, Jeanette G, Brown, Nicholas G, Emanuele, Michael J

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