Application of MetMax™ pooled donor human hepatocytes in a higher throughput assay for human hepatic metabolic stability screening von Brown, Karin D., Hingorani, Gary P., Li, Albert P.

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Identification of the Clinical Development Candidate MRTX849 , a Covalent KRAS G12C Inhibitor for the Treatment of Cancer von Fell, Jay B, Fischer, John P, Baer, Brian R, Blake, James F, Bouhana, Karyn, Briere, David M, Brown, Karin D, Burgess, Laurence E, Burns, Aaron C, Burkard, Michael R, Chiang, Harrah, Chicarelli, Mark J, Cook, Adam W, Gaudino, John J, Hallin, Jill, Hanson, Lauren, Hartley, Dylan P, Hicken, Erik J, Hingorani, Gary P, Hinklin, Ronald J, Mejia, Macedonio J, Olson, Peter, Otten, Jennifer N, Rhodes, Susan P, Rodriguez, Martha E, Savechenkov, Pavel, Smith, Darin J, Sudhakar, Niranjan, Sullivan, Francis X, Tang, Tony P, Vigers, Guy P, Wollenberg, Lance, Christensen, James G, Marx, Matthew A

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Discovery of 7‑Tetrahydropyran-2-yl Chromans: β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors That Reduce Amyloid β‑Protein (Aβ) in the Central Nervous System... von Thomas, Allen A, Hunt, Kevin W, Volgraf, Matthew, Watts, Ryan J, Liu, Xingrong, Vigers, Guy, Smith, Darin, Sammond, Douglas, Tang, Tony P, Rhodes, Susan P, Metcalf, Andrew T, Brown, Karin D, Otten, Jennifer N, Burkard, Michael, Cox, April A, Do, Mary K. Geck, Dutcher, Darrin, Rana, Sumeet, DeLisle, Robert K, Regal, Kelly, Wright, Albion D, Groneberg, Robert, Scearce-Levie, Kimberly, Siu, Michael, Purkey, Hans E, Lyssikatos, Joseph P, Gunawardana, Indrani W

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8‑Tetrahydropyran-2-yl Chromans: Highly Selective Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors von Thomas, Allen A, Hunt, Kevin W, Newhouse, Brad, Watts, Ryan J, Liu, Xingrong, Vigers, Guy, Smith, Darin, Rhodes, Susan P, Brown, Karin D, Otten, Jennifer N, Burkard, Michael, Cox, April A, Geck Do, Mary K, Dutcher, Darrin, Rana, Sumeet, DeLisle, Robert K, Regal, Kelly, Wright, Albion D, Groneberg, Robert, Liao, Jiangpeng, Scearce-Levie, Kimberly, Siu, Michael, Purkey, Hans E, Lyssikatos, Joseph P

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Identification of the Clinical Development Candidate MRTX849, a Covalent KRASG12C Inhibitor for the Treatment of Cancer von Fell, Jay B, Fischer, John P, Baer, Brian R, Blake, James F, Bouhana, Karyn, Briere, David M, Brown, Karin D, Burgess, Laurence E, Burns, Aaron C, Burkard, Michael R, Chiang, Harrah, Chicarelli, Mark J, Cook, Adam W, Gaudino, John J, Hallin, Jill, Hanson, Lauren, Hartley, Dylan P, Hicken, Erik J, Hingorani, Gary P, Hinklin, Ronald J, Mejia, Macedonio J, Olson, Peter, Otten, Jennifer N, Rhodes, Susan P, Rodriguez, Martha E, Savechenkov, Pavel, Smith, Darin J, Sudhakar, Niranjan, Sullivan, Francis X, Tang, Tony P, Vigers, Guy P, Wollenberg, Lance, Christensen, James G, Marx, Matthew A

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The Impact of Delirium After Cardiac Surgical Procedures on Postoperative Resource Use von Brown, Charles H., MD, MHS, Laflam, Andrew, BS, Max, Laura, BA, Lymar, Daria, MD, Neufeld, Karin J., MD, MPH, Tian, Jing, MS, Shah, Ashish S., MD, Whitman, Glenn J., MD, Hogue, Charles W., MD

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Delirium After Spine Surgery in Older Adults: Incidence, Risk Factors, and Outcomes von Brown IV, Charles H., LaFlam, Andrew, Max, Laura, Wyrobek, Julie, Neufeld, Karin J., Kebaish, Khaled M., Cohen, David B., Walston, Jeremy D., Hogue, Charles W., Riley, Lee H.

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An Ice Age JWST inventory of dense molecular cloud ices von McClure, M. K., Rocha, W. R. M., Pontoppidan, K. M., Crouzet, N., Chu, L. E. U., Dartois, E., Lamberts, T., Noble, J. A., Pendleton, Y. J., Perotti, G., Qasim, D., Rachid, M. G., Smith, Z. L., Sun, Fengwu, Beck, Tracy L., Boogert, A. C. A., Brown, W. A., Caselli, P., Charnley, S. B., Cuppen, Herma M., Dickinson, H., Drozdovskaya, M. N., Egami, E., Erkal, J., Fraser, H., Garrod, R. T., Harsono, D., Ioppolo, S., Jiménez-Serra, I., Jin, M., Jørgensen, J. K., Kristensen, L. E., Lis, D. C., McCoustra, M. R. S., McGuire, Brett A., Melnick, G. J., Öberg, Karin I., Palumbo, M. E., Shimonishi, T., Sturm, J. A., van Dishoeck, E. F., Linnartz, H.

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Bifidobacteria-mediated immune system imprinting early in life von Henrick, Bethany M., Rodriguez, Lucie, Lakshmikanth, Tadepally, Pou, Christian, Henckel, Ewa, Arzoomand, Aron, Olin, Axel, Wang, Jun, Mikes, Jaromir, Tan, Ziyang, Chen, Yang, Ehrlich, Amy M., Bernhardsson, Anna Karin, Mugabo, Constantin Habimana, Ambrosiani, Ylva, Gustafsson, Anna, Chew, Stephanie, Brown, Heather K., Prambs, Johann, Bohlin, Kajsa, Mitchell, Ryan D., Underwood, Mark A., Smilowitz, Jennifer T., German, J. Bruce, Frese, Steven A., Brodin, Petter

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Review, Evaluation, and Discussion of the Challenges of Missing Value Imputation for Mass Spectrometry-Based Label-Free Global Proteomics von Webb-Robertson, Bobbie-Jo M, Wiberg, Holli K, Matzke, Melissa M, Brown, Joseph N, Wang, Jing, McDermott, Jason E, Smith, Richard D, Rodland, Karin D, Metz, Thomas O, Pounds, Joel G, Waters, Katrina M

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Deferoxamine mesylate in patients with intracerebral haemorrhage (i-DEF): a multicentre, randomised, placebo-controlled, double-blind phase 2 trial von Selim, Magdy, Foster, Lydia D, Moy, Claudia S, Xi, Guohua, Hill, Michael D, Morgenstern, Lewis B, Greenberg, Steven M, James, Michael L, Singh, Vineeta, Clark, Wayne M, Norton, Casey, Palesch, Yuko Y, Yeatts, Sharon D, Dolan, Monica, Yeh, Erlinda, Sheth, Kevin, Kunze, Kimberly, Muehlschlegel, Susanne, Nieto, Iryna, Claassen, Jan, Falo, Cristina, Huang, David, Beckwith, Anne, Messe, Steven, Yates, Melissa, O'Phelan, Kristine, Escobar, Andrea, Becker, Kyra, Tanzi, Patricia, Gonzales, Nicole, Tremont, Chad, Venkatasubramanian, Chitra, Thiessen, Rosita, Save, Supriya, Verrault, Steven, Collard, Karin, DeGeorgia, Michael, Cwiklinski, Valerie, Thompson, Bradford, Wasilewski, Lesley, Andrews, Charles, Burfeind, Robert, Torbey, Michel, Hamed, Mohammad, Butcher, Kenneth, Sivakumar, Leka, Varelas, Nicolaou, Mays-Wilson, Kathleen, Leira, Enrique, Olalde, Heena, Silliman, Scott, Calhoun, Rhonda, Dangayach, Neha, Renvill, Ricardo, Malhotra, Rishi, Kordesch, Kristina, Lord, Aaron, Calahan, Thomas, Geocadin, Romergryko, Parish, Michelle, Frey, James, Harrigan, Mary, Leifer, Dana, Mathias, Ryna, Schneck, Michael, Bernier, Tara, Gonzales-Arias, Sergio, Elysee, Josette, Lopez, George, Volgi, Josephine, Brown, Robert, Jasak, Sara, Phillips, Stephen, Jarrett, Judith, Gomes, Joao, McBride, Moneen, Aldrich, Francois, Aldrich, Charlene, Kornbluth, Joshua, Bettle, Michelle, Goldstein, Joshua, Tirrell, Gregory, Shaw, Qaisar, Jonczak, Karin

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Addition of docetaxel, zoledronic acid, or both to first-line long-term hormone therapy in prostate cancer (STAMPEDE): survival results from an adaptive, multiarm, multistage, plat... von James, Nicholas D, Prof, Sydes, Matthew R, MSc, Clarke, Noel W, Prof, Mason, Malcolm D, Prof, Dearnaley, David P, Prof, Spears, Melissa R, MSc, Ritchie, Alastair W S, MD, Parker, Christopher C, MD, Russell, J Martin, FRCR, Attard, Gerhardt, MD PhD, de Bono, Johann, Prof, Cross, William, PhD, Jones, Rob J, Prof, Thalmann, George, Prof, Amos, Claire, PhD, Matheson, David, PhD, Millman, Robin, Alzouebi, Mymoona, FRCR, Beesley, Sharon, FRCR, Birtle, Alison J, MD, Brock, Susannah, FRCR, Cathomas, Richard, MD, Chakraborti, Prabir, FRCR, Chowdhury, Simon, MD, Cook, Audrey, FRCR, Elliott, Tony, PhD, Gale, Joanna, DM, Gibbs, Stephanie, FRCR, Graham, John D, FRCP, Hetherington, John, FRCS[Eng], Hughes, Robert, FRCR, Laing, Robert, FRCR, McKinna, Fiona, FRCR, McLaren, Duncan B, FRCR, FRCP[Ed], O'Sullivan, Joe M, Prof, Parikh, Omi, FRCR, Peedell, Clive, FRCR, Protheroe, Andrew, PhD, Robinson, Angus J, FRCR, Srihari, Narayanan, MD, Srinivasan, Rajaguru, FRCR, Staffurth, John, MD, Sundar, Santhanam, FRCR, Tolan, Shaun, MD, Tsang, David, MCRP, Wagstaff, John, Prof, Parmar, Mahesh K B, Prof

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Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites von Wiemann, Philipp, Sieber, Christian M K, von Bargen, Katharina W, Studt, Lena, Niehaus, Eva-Maria, Espino, Jose J, Huß, Kathleen, Michielse, Caroline B, Albermann, Sabine, Wagner, Dominik, Bergner, Sonja V, Connolly, Lanelle R, Fischer, Andreas, Reuter, Gunter, Kleigrewe, Karin, Bald, Till, Wingfield, Brenda D, Ophir, Ron, Freeman, Stanley, Hippler, Michael, Smith, Kristina M, Brown, Daren W, Proctor, Robert H, Münsterkötter, Martin, Freitag, Michael, Humpf, Hans-Ulrich, Güldener, Ulrich, Tudzynski, Bettina

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Innate defense regulator peptide 1018 protects against perinatal brain injury von Bolouri, Hayde, Sävman, Karin, Wang, Wei, Thomas, Anitha, Maurer, Norbert, Dullaghan, Edie, Fjell, Christopher D., Ek, C. Joakim, Hagberg, Henrik, Hancock, Robert E. W., Brown, Kelly L., Mallard, Carina

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The incremental burden and healthcare resource utilization among people with migraine in Europe: Insights from the 2020 European National Health and Wellness Survey von Gendolla, Astrid, Brown, Joshua D., Mercadante, Amanda R., Drakeley, Sheila, Sternbach, Nikoletta, Jenkins, Aaron, Hygge Blakeman, Karin, Coppola, Gianluca

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Filaggrin-stratified transcriptomic analysis of pediatric skin identifies mechanistic pathways in patients with atopic dermatitis von Cole, Christian, PhD, Kroboth, Karin, MSc, Schurch, Nicholas J., PhD, Sandilands, Aileen, PhD, Sherstnev, Alexander, PhD, O'Regan, Grainne M., MRCPI, Watson, Rosemarie M., MD, Irwin McLean, W.H., DSc, Barton, Geoffrey J., PhD, Irvine, Alan D., MD, Brown, Sara J., MD

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The Association of Brain MRI Characteristics and Postoperative Delirium in Cardiac Surgery Patients von Brown, Charles H., MD, MHS, Faigle, Roland, MD, PhD, MHS, Klinker, Lauren, BA, Bahouth, Mona, MD, Max, Laura, BA, LaFlam, Andrew, BS, Neufeld, Karin J., MD, MPH, Mandal, Kaushik, MD, MBBS, Gottesman, Rebecca F., MD, PhD, Hogue, Charles W., MD

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COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort study von Lee, Lennard YW, Cazier, Jean-Baptiste, Angelis, Vasileios, Arnold, Roland, Bisht, Vartika, Campton, Naomi A, Chackathayil, Julia, Cheng, Vinton WT, Curley, Helen M, Fittall, Matthew W, Freeman-Mills, Luke, Gennatas, Spyridon, Goel, Anshita, Hartley, Simon, Hughes, Daniel J, Kerr, David, Lee, Alvin JX, Lee, Rebecca J, McGrath, Sophie E, Middleton, Christopher P, Murugaesu, Nirupa, Newsom-Davis, Thomas, Okines, Alicia FC, Olsson-Brown, Anna C, Palles, Claire, Pan, Yi, Pettengell, Ruth, Powles, Thomas, Protheroe, Emily A, Purshouse, Karin, Sharma-Oates, Archana, Sivakumar, Shivan, Smith, Ashley J, Starkey, Thomas, Turnbull, Chris D, Várnai, Csilla, Yousaf, Nadia, Kerr, Rachel, Middleton, Gary

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Validation of High-Sensitivity Troponin I in a 2-Hour Diagnostic Strategy to Assess 30-Day Outcomes in Emergency Department Patients With Possible Acute Coronary Syndrome von Cullen, Louise, MB, BS, Mueller, Christian, MD, Parsonage, William A., DM, Wildi, Karin, MD, Greenslade, Jaimi H., PhD, Twerenbold, Raphael, MD, Aldous, Sally, MB, ChB, MD, Meller, Bernadette, MD, Tate, Jillian R., MSc, Reichlin, Tobias, MD, Hammett, Christopher J., MB, ChB, MD, Zellweger, Christa, MD, Ungerer, Jacobus P.J., MMed, MB, ChB, Rubini Gimenez, Maria, MD, Troughton, Richard, MB, ChB, PhD, Murray, Karsten, MD, Brown, Anthony F.T., MB, ChB, Mueller, Mira, MD, George, Peter, MB, BS, Mosimann, Tamina, MD, Flaws, Dylan F., BA, MSc, Reiter, Miriam, MD, Lamanna, Arvin, MB, BS, Haaf, Philip, MD, Pemberton, Christopher J., PhD, Richards, A. Mark, PhD, MD, Chu, Kevin, MB, BS, MS, Reid, Christopher M., PhD, Peacock, William Frank, MD, Jaffe, Allan S., MD, Florkowski, Christopher, MB, BS, Deely, Joanne M., PhD, Than, Martin, MB, BS

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Cryptic extinction risk in a western Pacific lizard radiation von McDonald, Peter J., Brown, Rafe M., Kraus, Fred, Bowles, Philip, Arifin, Umilaela, Eliades, Samuel J., Fisher, Robert N., Gaulke, Maren, Grismer, L. Lee, Ineich, Ivan, Karin, Benjamin R., Meneses, Camila G., Richards, Stephen J., Sanguila, Marites B., Siler, Cameron D., Oliver, Paul M.

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