Specific Inhibition of Hepatic Lactate Dehydrogenase Reduces Oxalate Production in Mouse Models of Primary Hyperoxaluria von Lai, Chengjung, Pursell, Natalie, Gierut, Jessica, Saxena, Utsav, Zhou, Wei, Dills, Michael, Diwanji, Rohan, Dutta, Chaitali, Koser, Martin, Nazef, Naim, Storr, Rachel, Kim, Boyoung, Martin-Higueras, Cristina, Salido, Eduardo, Wang, Weimin, Abrams, Marc, Dudek, Henryk, Brown, Bob D.

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Hepatic Lactate Dehydrogenase A: An RNA Interference Target for the Treatment of All Known Types of Primary Hyperoxaluria von Ariceta, Gema, Barrios, Kelly, Brown, Bob D., Hoppe, Bernd, Rosskamp, Ralf, Langman, Craig B.

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RNAi-Mediated β-Catenin Inhibition Promotes T Cell Infiltration and Antitumor Activity in Combination with Immune Checkpoint Blockade von Ganesh, Shanthi, Shui, Xue, Craig, Kevin P., Park, Jihye, Wang, Weimin, Brown, Bob D., Abrams, Marc T.

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Therapeutic RNA interference: A novel approach to the treatment of primary hyperoxaluria von Forbes, Thomas A., Brown, Bob D., Lai, Chengjung

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Bcl-2 and Glutathione Depletion Sensitizes B16 Melanoma to Combination Therapy and Eliminates Metastatic Disease von MENA, Salvador, BENLLOCH, Maria, ORTEGA, Angel, CARRETERO, Julian, OBRADOR, Elena, ASENSI, Miguel, PETSCHEN, Ignacio, BROWN, Bob D, ESTRELA, José M

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bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice von Jansen, Burkhard, Schlagbauer-Wadl, Hermine, Brown, Bob D, Bryan, Robert N, Van Elsas, Andrea, Müller, Markus, Wolff, Klaus, Eichler, Hans-Georg, Pehamberger, Hubert

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Knock-down of Bcl-2 by antisense oligodeoxynucleotides induces radiosensitization and inhibition of angiogenesis in human PC-3 prostate tumor xenografts von Anai, Satoshi, Goodison, Steve, Shiverick, Kathleen, Hirao, Yoshihiko, Brown, Bob D, Rosser, Charles J

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First-in-human randomized study of RNAi therapeutic RG6346 for chronic hepatitis B virus infection von Gane, Edward J., Kim, Won, Lim, Tien Huey, Tangkijvanich, Pisit, Yoon, Jung-Hwan, Sievert, William, Sukeepaisarnjaroen, Wattana, Thompson, Alexander J., Pavlovic, Vedran, Surujbally, Bernadette, Wat, Cynthia, Brown, Bob D., Achneck, Hardean E., Yuen, Man-Fung

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RNAi mediated silencing of STAT3/PD-L1 in tumor-associated immune cells induces robust anti-tumor effects in immunotherapy resistant tumors von Ganesh, Shanthi, Kim, Min Ju, Lee, Jenny, Feng, Xudong, Ule, Krisjanis, Mahan, Amy, Krishnan, Harini Sivagurunatha, Wang, Zhe, Anzahaee, Maryam Yahyaee, Singhal, Garima, Korboukh, Ilia, Lockridge, Jennifer A., Sanftner, Laura, Rijnbrand, Rene, Abrams, Marc, Brown, Bob D.

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Inhibition of Glycolate Oxidase With Dicer-substrate siRNA Reduces Calcium Oxalate Deposition in a Mouse Model of Primary Hyperoxaluria Type 1 von Dutta, Chaitali, Avitahl-Curtis, Nicole, Pursell, Natalie, Larsson Cohen, Marita, Holmes, Benjamin, Diwanji, Rohan, Zhou, Wei, Apponi, Luciano, Koser, Martin, Ying, Bo, Chen, Dongyu, Shui, Xue, Saxena, Utsav, Cyr, Wendy A, Shah, Anee, Nazef, Naim, Wang, Weimin, Abrams, Marc, Dudek, Henryk, Salido, Eduardo, Brown, Bob D, Lai, Chengjung

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Inhibition of Glycogen Synthase II with RNAi Prevents Liver Injury in Mouse Models of Glycogen Storage Diseases von Pursell, Natalie, Gierut, Jessica, Zhou, Wei, Dills, Michael, Diwanji, Rohan, Gjorgjieva, Monika, Saxena, Utsav, Yang, Jr-Shiuan, Shah, Anee, Venkat, Nandini, Storr, Rachel, Kim, Boyoung, Wang, Weimin, Abrams, Marc, Raffin, Margaux, Mithieux, Gilles, Rajas, Fabienne, Dudek, Henryk, Brown, Bob D., Lai, Chengjung

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Glutathione and Bcl-2 targeting facilitates elimination by chemoradiotherapy of human A375 melanoma xenografts overexpressing bcl-xl, bcl-2, and mcl-1 von Mena, Salvador, Rodriguez, María L, Ortega, Angel, Priego, Sonia, Obrador, Elena, Asensi, Miguel, Petschen, Ignacio, Cerdá, Miguel, Brown, Bob D, Estrela, José M

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Downregulation of BCL-2 Induces Downregulation of Carbonic Anhydrase IX, Vascular Endothelial Growth Factor, and pAkt and Induces Radiation Sensitization von Anai, Satoshi, Shiverick, Kathleen, Medrano, Theresa, Nakamura, Kogenta, Goodison, Steve, Brown, Bob D, Rosser, Charles J

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Direct Pharmacological Inhibition of β-Catenin by RNA Interference in Tumors of Diverse Origin von Ganesh, Shanthi, Koser, Martin L, Cyr, Wendy A, Chopda, Girish R, Tao, Junyan, Shui, Xue, Ying, Bo, Chen, Dongyu, Pandya, Purva, Chipumuro, Edmond, Siddiquee, Zakir, Craig, Kevin, Lai, Chengjung, Dudek, Henryk, Monga, Satdarshan P, Wang, Weimin, Brown, Bob D, Abrams, Marc T

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Direct Inhibition of β-catenin: A new strategy for colorectal cancer von Ganesh, Shanthi, Brown, Bob D, Abrams, Marc

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Quantitative analysis of dicer substrate oligonucleotides in mouse liver by ultra-high-performance liquid chromatography-electrospray ionization tandem mass spectrometry von Jiao, Kaisheng, Rashid, Aftab, Basu, Sujit K, Zhu, Shuhao, Brown, Bob D, Guerciolini, Roberto, Fambrough, Douglas M

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β-Catenin mRNA Silencing and MEK Inhibition Display Synergistic Efficacy in Preclinical Tumor Models von Ganesh, Shanthi, Shui, Xue, Craig, Kevin P, Koser, Martin L, Chopda, Girish R, Cyr, Wendy A, Lai, Chengjung, Dudek, Henryk, Wang, Weimin, Brown, Bob D, Abrams, Marc T

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Knockdown of β-catenin with Dicer-Substrate siRNAs Reduces Liver Tumor Burden In vivo von Dudek, Henryk, Wong, Darren H, Arvan, Rokhand, Shah, Anee, Wortham, Kathleen, Ying, Bo, Diwanji, Rohan, Zhou, Wei, Holmes, Benjamin, Yang, Hailin, Cyr, Wendy A, Zhou, Yi, Shah, Aalok, Farkiwala, Ruchir, Lee, Michael, Li, Yiting, Rettig, Garrett R, Collingwood, Michael A, Basu, Sujit K, Behlke, Mark A, Brown, Bob D

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Bcl-2 Protein in 518A2 Melanoma Cells In vivo and In vitro von BENIMETSKAYA, Luba, AYYANAR, Kanyalakshmi, MCMICKEN, Harilyn, YIN CHEN, STEIN, C. A, KORNBLUM, Noah, CASTANOTTO, Daniela, ROSSI, John, SIJIAN WU, LAI, Johnathan, BROWN, Bob D, POPOVA, Natalia, MILLER, Paul

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Irradiation of Human Prostate Cancer Cells Increases Uptake of Antisense Oligodeoxynucleotide von Anai, Satoshi, M.D, Brown, Bob D., M.D., Ph.D, Nakamura, Kogenta, M.D., Ph.D, Goodison, Steve, Ph.D, Hirao, Yoshihiko, M.D, Rosser, Charles J., M.D

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