Evolving SAXS versatility: solution X-ray scattering for macromolecular architecture, functional landscapes, and integrative structural biology von Brosey, Chris A, Tainer, John A

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Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death von Houl, Jerry H., Ye, Zu, Brosey, Chris A., Balapiti-Modarage, Lakshitha P. F., Namjoshi, Sarita, Bacolla, Albino, Laverty, Daniel, Walker, Brian L., Pourfarjam, Yasin, Warden, Leslie S., Babu Chinnam, Naga, Moiani, Davide, Stegeman, Roderick A., Chen, Mei-Kuang, Hung, Mien-Chie, Nagel, Zachary D., Ellenberger, Tom, Kim, In-Kwon, Jones, Darin E., Ahmed, Zamal, Tainer, John A.

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A Quantitative Assay Reveals Ligand Specificity of the DNA Scaffold Repair Protein XRCC1 and Efficient Disassembly of Complexes of XRCC1 and the Poly(ADP-ribose) Polymerase 1 by Po... von Kim, In-Kwon, Stegeman, Roderick A., Brosey, Chris A., Ellenberger, Tom

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Defining NADH-Driven Allostery Regulating Apoptosis-Inducing Factor von Brosey, Chris A., Ho, Chris, Long, Winnie Z., Singh, Sukrit, Burnett, Kathryn, Hura, Greg L., Nix, Jay C., Bowman, Gregory R., Ellenberger, Tom, Tainer, John A.

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Functional Dynamics in Replication Protein A DNA Binding and Protein Recruitment Domains von Brosey, Chris A., Soss, Sarah E., Brooks, Sonja, Yan, Chunli, Ivanov, Ivaylo, Dorai, Kavita, Chazin, Walter J.

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Visualizing and accessing correlated SAXS data sets with Similarity Maps and Simple Scattering web resources von Murray, Daniel T, Shin, David S, Classen, Scott, Brosey, Chris A, Hura, Greg L

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Chemical screening by time-resolved X-ray scattering to discover allosteric probes von Brosey, Chris A., Link, Todd M., Shen, Runze, Moiani, Davide, Burnett, Kathryn, Hura, Greg L., Jones, Darin E., Tainer, John A.

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Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors von Brosey, Chris A., Houl, Jerry H., Katsonis, Panagiotis, Balapiti-Modarage, Lakshitha P.F., Bommagani, Shobanbabu, Arvai, Andy, Moiani, Davide, Bacolla, Albino, Link, Todd, Warden, Leslie S., Lichtarge, Olivier, Jones, Darin E., Ahmed, Zamal, Tainer, John A.

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Applying HT-SAXS to chemical ligand screening von Brosey, Chris A, Shen, Runze, Moiani, Davide, Jones, Darin E, Burnett, Kathryn, Hura, Greg L, Tainer, John A

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A new structural framework for integrating replication protein A into DNA processing machinery von Brosey, Chris A, Yan, Chunli, Tsutakawa, Susan E, Heller, William T, Rambo, Robert P, Tainer, John A, Ivanov, Ivaylo, Chazin, Walter J

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Targeting Allostery with Avatars to Design Inhibitors Assessed by Cell Activity: Dissecting MRE11 Endo- and Exonuclease Activities von Moiani, Davide, Ronato, Daryl A, Brosey, Chris A, Arvai, Andrew S, Syed, Aleem, Masson, Jean-Yves, Petricci, Elena, Tainer, John A

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An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2 von Moiani, Davide, Link, Todd M, Brosey, Chris A, Katsonis, Panagiotis, Lichtarge, Olivier, Kim, Youngchang, Joachimiak, Andrzej, Ma, Zhijun, Kim, In-Kwon, Ahmed, Zamal, Jones, Darin E, Tsutakawa, Susan E, Tainer, John A

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What Combined Measurements From Structures and Imaging Tell Us About DNA Damage Responses von Brosey, Chris A, Ahmed, Zamal, Lees-Miller, Susan P, Tainer, John A

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Structural Dynamics and Single-Stranded DNA Binding Activity of the Three N-Terminal Domains of the Large Subunit of Replication Protein A from Small Angle X-ray Scattering von Pretto, Dalyir I, Tsutakawa, Susan, Brosey, Chris A, Castillo, Amalchi, Chagot, Marie-Eve, Smith, Jarrod A, Tainer, John A, Chazin, Walter J

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NMR Analysis of the Architecture and Functional Remodeling of a Modular Multidomain Protein, RPA von Brosey, Chris A, Chagot, Marie-Eve, Ehrhardt, Mark, Pretto, Dalyir I, Weiner, Brian E, Chazin, Walter J

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Time-resolved HT-SAXS discovers allosteric chemotypes for redox target AIF

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Sample Preparation Methods to Analyze DNA-Induced Structural Changes in Replication Protein A von Brosey, Chris A., Tsutakawa, Susan E., Chazin, Walter J.

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Human Deafness Mutation E385D Disrupts the Mechanochemical Coupling and Subcellular Targeting of Myosin-1a von Yengo, Christopher M., Ananthanarayanan, Shobana K., Brosey, Chris A., Mao, Suli, Tyska, Matthew J.

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Preparation of the Modular Multi-Domain Protein RPA for Study by NMR Spectroscopy von Brosey, Chris A., Chagot, Marie-Eve, Chazin, Walter J.

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Apoptosis-inducing factor: mechanistic insights and therapeutic opportunities from a metabolic allosteric switch von Brosey, Chris A., Shen, Runze, Burnett, Kathryn, Hura, Greg, Tainer, John A.

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