Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines von Cano-Gamez, Eddie, Soskic, Blagoje, Roumeliotis, Theodoros I., So, Ernest, Smyth, Deborah J., Baldrighi, Marta, Willé, David, Nakic, Nikolina, Esparza-Gordillo, Jorge, Larminie, Christopher G. C., Bronson, Paola G., Tough, David F., Rowan, Wendy C., Choudhary, Jyoti S., Trynka, Gosia

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Systematic Mendelian randomization using the human plasma proteome to discover potential therapeutic targets for stroke von Chen, Lingyan, Peters, James E., Prins, Bram, Persyn, Elodie, Traylor, Matthew, Surendran, Praveen, Karthikeyan, Savita, Yonova-Doing, Ekaterina, Di Angelantonio, Emanuele, Roberts, David J., Watkins, Nicholas A., Ouwehand, Willem H., Danesh, John, Lewis, Cathryn M., Bronson, Paola G., Markus, Hugh S., Burgess, Stephen, Butterworth, Adam S., Howson, Joanna M. M.

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Immune disease risk variants regulate gene expression dynamics during CD4+ T cell activation von Soskic, Blagoje, Cano-Gamez, Eddie, Smyth, Deborah J., Ambridge, Kirsty, Ke, Ziying, Matte, Julie C., Bossini-Castillo, Lara, Kaplanis, Joanna, Ramirez-Navarro, Lucia, Lorenc, Anna, Nakic, Nikolina, Esparza-Gordillo, Jorge, Rowan, Wendy, Wille, David, Tough, David F., Bronson, Paola G., Trynka, Gosia

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Chromatin activity at GWAS loci identifies T cell states driving complex immune diseases von Soskic, Blagoje, Cano-Gamez, Eddie, Smyth, Deborah J., Rowan, Wendy C., Nakic, Nikolina, Esparza-Gordillo, Jorge, Bossini-Castillo, Lara, Tough, David F., Larminie, Christopher G. C., Bronson, Paola G., Willé, David, Trynka, Gosia

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Neurology-related protein biomarkers are associated with cognitive ability and brain volume in older age von Harris, Sarah E., Cox, Simon R., Bell, Steven, Marioni, Riccardo E., Prins, Bram P., Pattie, Alison, Corley, Janie, Muñoz Maniega, Susana, Valdés Hernández, Maria, Morris, Zoe, John, Sally, Bronson, Paola G., Tucker-Drob, Elliot M., Starr, John M., Bastin, Mark E., Wardlaw, Joanna M., Butterworth, Adam S., Deary, Ian J.

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The genetics of type I interferon in systemic lupus erythematosus von Bronson, Paola G, Chaivorapol, Christina, Ortmann, Ward, Behrens, Timothy W, Graham, Robert R

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A higher burden of multiple sclerosis genetic risk confers an earlier onset von Misicka, Elina, Davis, Mary F, Kim, Woori, Brugger, Steven W, Beales, Jeremy, Loomis, Stephanie, Bronson, Paola G, Briggs, Farren BS

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Genome-wide study of longitudinal brain imaging measures of multiple sclerosis progression across six clinical trials von Loomis, Stephanie J., Sadhu, Nilanjana, Fisher, Elizabeth, Gafson, Arie R., Huang, Yunfeng, Yang, Chengran, Hughes, Emily E., Marshall, Eric, Herman, Ann, John, Sally, Runz, Heiko, Jia, Xiaoming, Bhangale, Tushar, Bronson, Paola G.

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A whole-genome sequence study identifies genetic risk factors for neuromyelitis optica von Estrada, Karol, Whelan, Christopher W., Zhao, Fengmei, Bronson, Paola, Handsaker, Robert E., Sun, Chao, Carulli, John P., Harris, Tim, Ransohoff, Richard M., McCarroll, Steven A., Day-Williams, Aaron G., Greenberg, Benjamin M., MacArthur, Daniel G.

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Increased DNA methylation of SLFN12 in CD4+ and CD8+ T cells from multiple sclerosis patients von Rhead, Brooke, Brorson, Ina S, Berge, Tone, Adams, Cameron, Quach, Hong, Moen, Stine Marit, Berg-Hansen, Pål, Celius, Elisabeth Gulowsen, Sangurdekar, Dipen P, Bronson, Paola G, Lea, Rodney A, Burnard, Sean, Maltby, Vicki E, Scott, Rodney J, Lechner-Scott, Jeannette, Harbo, Hanne F, Bos, Steffan D, Barcellos, Lisa F

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Systematic single-variant and gene-based association testing of thousands of phenotypes in 394,841 UK Biobank exomes von Karczewski, Konrad J., Solomonson, Matthew, Chao, Katherine R., Goodrich, Julia K., Tiao, Grace, Lu, Wenhan, Riley-Gillis, Bridget M., Tsai, Ellen A., Kim, Hye In, Zheng, Xiuwen, Rahimov, Fedik, Esmaeeli, Sahar, Grundstad, A. Jason, Reppell, Mark, Waring, Jeff, Jacob, Howard, Sexton, David, Bronson, Paola G., Chen, Xing, Hu, Xinli, Goldstein, Jacqueline I., King, Daniel, Vittal, Christopher, Poterba, Timothy, Palmer, Duncan S., Churchhouse, Claire, Howrigan, Daniel P., Zhou, Wei, Watts, Nicholas A., Nguyen, Kevin, Nguyen, Huy, Mason, Cara, Farnham, Christopher, Tolonen, Charlotte, Gauthier, Laura D., Gupta, Namrata, MacArthur, Daniel G., Rehm, Heidi L., Seed, Cotton, Philippakis, Anthony A., Daly, Mark J., Davis, J. Wade, Runz, Heiko, Miller, Melissa R., Neale, Benjamin M.

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Common variants at PVT1, ATG13–AMBRA1, AHI1 and CLEC16A are associated with selective IgA deficiency von Bronson, Paola G, Chang, Diana, Bhangale, Tushar, Seldin, Michael F, Ortmann, Ward, Ferreira, Ricardo C, Urcelay, Elena, Pereira, Luis Fernández, Martin, Javier, Plebani, Alessandro, Lougaris, Vassilios, Friman, Vanda, Freiberger, Tomáš, Litzman, Jiri, Thon, Vojtech, Pan-Hammarström, Qiang, Hammarström, Lennart, Graham, Robert R, Behrens, Timothy W

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STXBP6 and B3GNT6 Genes are Associated With Selective IgA Deficiency von Lim, Che Kang, Bronson, Paola G, Varade, Jezabel, Behrens, Timothy W, Hammarström, Lennart

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Genome-wide association study identifies kallikrein 5 in type 2 inflammation-low asthma von Jackman, Janet K., Stockwell, Amy, Choy, David F., Xie, Markus M., Lu, Peipei, Jia, Guiquan, Li, Hong, Abbas, Alexander R., Bronson, Paola G., Lin, Wei-Yu, Chiu, Cecilia P.C., Maun, Henry R., Roose-Girma, Merone, Tam, Lucinda, Zhang, Juan, Modrusan, Zora, Graham, Robert R., Behrens, Timothy W., White, Steven R., Naureckas, Ted, Ober, Carole, Ferreira, Manuel, Sedlacek, Radislav, Wu, Jiansheng, Lee, Wyne P., Lazarus, Robert A., Koerber, James T., Arron, Joseph R., Yaspan, Brian L., Yi, Tangsheng

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Adaptive and Innate Immunity Are Key Drivers of Age at Onset of Multiple Sclerosis von Misicka, Elina, Huang, Yunfeng, Loomis, Stephanie, Sadhu, Nilanjana, Fisher, Elizabeth, Gafson, Arie, Runz, Heiko, Tsai, Ellen, Jia, Xiaoming, Herman, Ann, Bronson, Paola G, Bhangale, Tushar, Briggs, Farren B

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Genetic Study of Severe Prolonged Lymphopenia in Multiple Sclerosis Patients Treated With Dimethyl Fumarate von Sangurdekar, Dipen, Sun, Chao, McLaughlin, Helen, Ayling-Rouse, Katherine, Allaire, Normand E., Penny, Michelle A., Bronson, Paola G.

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A sequence-based approach demonstrates that balancing selection in classical human leukocyte antigen (HLA) loci is asymmetric von Bronson, Paola G, Mack, Steven J, Erlich, Henry A, Slatkin, Montgomery

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CIITA variation in the presence of HLA-DRB11501 increases risk for multiple sclerosis von Bronson, Paola G., Caillier, Stacy, Ramsay, Patricia P., McCauley, Jacob L., Zuvich, Rebecca L., De Jager, Philip L., Rioux, John D., Ivinson, Adrian J., Compston, Alastair, Hafler, David A., Sawcer, Stephen J., Pericak-Vance, Margaret A., Haines, Jonathan L., Hauser, Stephen L., Oksenberg, Jorge R., Barcellos, Lisa F.

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Discovering Context-dependent Whole Blood Gene Expression Quantitative Trait Loci (eQTL) In Relapsing Remitting Multiple Sclerosis (P2.2-051) von Partha, Raghavendran, Bronson, Paola G., Sangurdekar, Dipen

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No Significant Genetic or Transcriptomic Predictors of Severe and Prolonged Lymphopenia in MS Cases Treated with Dimethyl Fumarate (P4.377) von Bronson, Paola, Sangurdekar, Dipen, Penny, Michelle

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