Type I interferon gene signature test–low and –high patients with systemic lupus erythematosus have distinct gene expression signatures von Brohawn, PZ, Streicher, K, Higgs, B W, Morehouse, C, Liu, H, Illei, G, Ranade, K

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PO.5.97 The renal activity index for lupus (RAIL) identifies active renal disease in SLE patients and its longitudinal score associates with renal responses in lupus nephritis von Lindholm, C, Brunner, HI, Cody, E, Devarajan, P, Huang, B, Sinibaldi, D, Ramaswamy, M, Knagenhjelm, J, Qiu, T, Jones, F, Brohawn, PZ, Tummala, R, White, WI

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High tumor mutational burden (TMB) and PD-L1 have similar predictive utility in 2L+ NSCLC patients (pts) treated with anti-PD-L1 and anti-CTLA-4 von Higgs, B.W., Morehouse, C.A., Brohawn, P.Z., Sridhar, S., Raja, R., Gao, G., Englert, J., Ranade, K.

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Trial of Anifrolumab in Active Systemic Lupus Erythematosus von Morand, Eric F, Furie, Richard, Tanaka, Yoshiya, Bruce, Ian N, Askanase, Anca D, Richez, Christophe, Bae, Sang-Cheol, Brohawn, Philip Z, Pineda, Lilia, Berglind, Anna, Tummala, Raj

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OP0255 Inhibition of the Plasma Cell Signature Correlates with Reduced Collagen Expression in Systemic Sclerosis von Streicher, K., Morehouse, C., Groves, C., Rajan, B., Pilataxi, F., Lehmann, K., Brohawn, P. Z., Higgs, B. W., McKeever, K., Richman, L., Jallal, B., Herbst, R., Yao, Y., Ranade, K.

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THU0005 Investigating the Plasma Cell Signature in Autoimmune Disease von Streicher, K., Morehouse, C., Groves, C., Rajan, B., Pilataxi, F., Lehmann, K., Brohawn, P. Z., Higgs, B. W., McKeever, K., Greenberg, S. A., Fiorentino, D., Richman, L., Jallal, B., Herbst, R., Yao, Y., Ranade, K.

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65PDHigh tumor mutational burden (TMB) and PD-L1 have similar predictive utility in 2L+ NSCLC patients (pts) treated with anti-PD-L1 and anti-CTLA-4 von Higgs, B W, Morehouse, C A, Brohawn, P Z, Sridhar, S, Raja, R, Gao, G, Englert, J, Ranade, K

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528PDImpact of clonality and DNA repair mutations on plasma tumour mutation burden (pTMB) and immunotherapy efficacy in microsatellite stable (MSS) metastatic colorectal cancer (mC... von Loree, J M, Jonker, D J, Feilotter, H, Kennecke, H F, Brohawn, P Z, Banks, K, Quinn, K, Tu, D, O’Callaghan, C, Chen, E X

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A novel oncogenic role for the miRNA-506-514 cluster in initiating melanocyte transformation and promoting melanoma growth von Streicher, K L, Zhu, W, Lehmann, K P, Georgantas, R W, Morehouse, C A, Brohawn, P, Carrasco, R A, Xiao, Z, Tice, D A, Higgs, B W, Richman, L, Jallal, B, Ranade, K, Yao, Y

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Patients with systemic lupus erythematosus, myositis, rheumatoid arthritis and scleroderma share activation of a common type I interferon pathway von Higgs, Brandon W, Liu, Zheng, White, Barbara, Zhu, Wei, White, Wendy I, Morehouse, Chris, Brohawn, Philip, Kiener, Peter A, Richman, Laura, Fiorentino, David, Greenberg, Steven A, Jallal, Bahija, Yao, Yihong

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Publisher Correction: Interferon subverts an AHR–JUN axis to promote CXCL13+ T cells in lupus von Law, Calvin, Wacleche, Vanessa Sue, Cao, Ye, Pillai, Arundhati, Sowerby, John, Hancock, Brandon, Horisberger, Alice, Bracero, Sabrina, Skidanova, Viktoriya, Li, Zhihan, Adejoorin, Ifeoluwakiisi, Dillon, Eilish, Benque, Isaac J., Nunez, Diana Pena, Simmons, Daimon P., Keegan, Joshua, Chen, Lin, Baker, Tina, Brohawn, Phillip Z., Al-Mossawi, Hussein, Hao, Ling-Yang, Jones, Brian, Rao, Navin, Qu, Yujie, Alves, Stephen E., Jonsson, A. Helena, Shaw, Katharina S., Vleugels, Ruth Ann, Massarotti, Elena, Costenbader, Karen H., Brenner, Michael B., Lederer, James A., Hultquist, Judd F., Choi, Jaehyuk, Rao, Deepak A.

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The Plasma Cell Signature in Autoimmune Disease von Streicher, Katie, Morehouse, Christopher A., Groves, Christopher J., Rajan, Bhargavi, Pilataxi, Fernanda, Lehmann, Kim P., Brohawn, Philip Z., Higgs, Brandon W., McKeever, Kathleen, Greenberg, Steven A., Fiorentino, David, Richman, Laura K., Jallal, Bahija, Herbst, Ronald, Yao, Yihong, Ranade, Koustubh

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Interferon subverts an AHR–JUN axis to promote CXCL13+ T cells in lupus von Law, Calvin, Wacleche, Vanessa Sue, Cao, Ye, Pillai, Arundhati, Sowerby, John, Hancock, Brandon, Horisberger, Alice, Bracero, Sabrina, Skidanova, Viktoriya, Li, Zhihan, Adejoorin, Ifeoluwakiisi, Dillon, Eilish, Benque, Isaac J., Nunez, Diana Pena, Simmons, Daimon P., Keegan, Joshua, Chen, Lin, Baker, Tina, Brohawn, Phillip Z., Al-Mossawi, Hussein, Hao, Ling-Yang, Jones, Brian, Rao, Navin, Qu, Yujie, Alves, Stephen E., Jonsson, A. Helena, Shaw, Katharina S., Vleugels, Ruth Ann, Massarotti, Elena, Costenbader, Karen H., Brenner, Michael B., Lederer, James A., Hultquist, Judd F., Choi, Jaehyuk, Rao, Deepak A.

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Somatic mutations in BRCA2, NFE2L2, ARID1A and NOTCH1 sensitize to anti-PDL1 therapy in multiple tumor types von Kuziora, M., Si, H., Higgs, B., Brohawn, P., Streicher, K., Jure-Kunkel, M., Raja, R., Helman, E., Franovic, A., Cooper, Z., Shrestha, Y., Holoweckyj, N., Lee, Y., Achour, I., Ye, J., Mukhopadhyay, P., Dennis, P.A., Melillo, G., Abdullah, S.E., Ranade, K.

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2OSomatic mutations in BRCA2, NFE2L2, ARID1A and NOTCH1 sensitize to anti-PDL1 therapy in multiple tumor types von Kuziora, M, Si, H, Higgs, B, Brohawn, P, Streicher, K, Jure-Kunkel, M, Raja, R, Helman, E, Franovic, A, Cooper, Z, Shrestha, Y, Holoweckyj, N, Lee, Y, Achour, I, Ye, J, Mukhopadhyay, P, Dennis, P A, Melillo, G, Abdullah, S E, Ranade, K

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SAT0020 Molecular characterization of collagen in muscle of polymyositis and dermatomyositis von Liu, Z., Morehouse, C., Higgs, B.W., Czapiga, M., Rebelatto, M., Brohawn, P., Richman, L., Fiorentino, D., Jallal, B., Greenberg, S.A., Yao, Y.

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Functional characterization of an oncogenic role for the miRNA-506-514 cluster in initiating melanocyte transformation and promoting melanoma growth von Streicher, K., Zhu, W., Lehmann, K., Georgantas, R. W., Morehouse, C., Brohawn, P., Carrasco, R., Xiao, Z., Tice, D., Higgs, B. W., Richman, L., Jallal, B., Yao, Y.

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MicroRNA oncogenes and tumor suppressors controlling malignant melanoma cell growth, apoptosis, migration, and invasion von Georgantas, R. W., Streicher, K., Zhu, W., Carrasco, R., Xiao, Z., Liu, Z., Brohawn, P., Morehouse, C., Tice, D., Higgs, B. W., Richman, L., Kiener, P., Jallal, B., Yao, Y.

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