Discovery of CP-690,550: A Potent and Selective Janus Kinase (JAK) Inhibitor for the Treatment of Autoimmune Diseases and Organ Transplant Rejection von Flanagan, Mark E, Blumenkopf, Todd A, Brissette, William H, Brown, Matthew F, Casavant, Jeffrey M, Shang-Poa, Chang, Doty, Jonathan L, Elliott, Eileen A, Fisher, Michael B, Hines, Michael, Kent, Craig, Kudlacz, Elizabeth M, Lillie, Brett M, Magnuson, Kelly S, McCurdy, Sandra P, Munchhof, Michael J, Perry, Bret D, Sawyer, Perry S, Strelevitz, Timothy J, Subramanyam, Chakrapani, Sun, Jianmin, Whipple, David A, Changelian, Paul S

Volltext

Thrombopoietin receptor activation: transmembrane helix dimerization, rotation, and allosteric modulation von Matthews, Erin E., Thévenin, Damien, Rogers, Julia M., Gotow, Lisa, Lira, Paul D., Reiter, Lawrence A., Brissette, William H., Engelman, Donald M.

Volltext

Absence of the P2X7 Receptor Alters Leukocyte Function and Attenuates an Inflammatory Response von Labasi, Jeffrey M, Petrushova, Nina, Donovan, Carol, McCurdy, Sandra, Lira, Paul, Payette, Mary M, Brissette, William, Wicks, Joan R, Audoly, Laurent, Gabel, Christopher A

Volltext

Destabilizing Role of Cathepsin S in Murine Atherosclerotic Plaques von Rodgers, Kenneth J, Watkins, Deborah J, Miller, Alastair L, Chan, Peter Y, Karanam, Sharada, Brissette, William H, Long, Clive J, Jackson, Christopher L

Volltext

Immunosuppression by the JAK3 inhibitor CP-690,550 delays rejection and significantly prolongs kidney allograft survival in nonhuman primates von BORIC, Dominic C, CHANGELIAN, Paul S, FLORES, Mono G, ROUSVOAL, Geraldine, HAWKINS, Jennifer, BALL, Douglas A, KUDLACZ, Elizabeth M, BRISSETTE, William H, ELLIOTT, Eileen A, REITZ, Bruce A, MORRIS, Randall E, LARSON, Michael J, SI, Ming-Sing, PANIAGUA, Ricardo, HIGGINS, John P, HOLM, Bari, CAMPBELL, Andrew, LAU, Macy, ZHANG, Sally

Volltext

Impaired Invariant Chain Degradation and Antigen Presentation and Diminished Collagen-Induced Arthritis in Cathepsin S Null Mice von Nakagawa, Terry Y, Brissette, William H, Lira, Paul D, Griffiths, Richard J, Petrushova, Nina, Stock, Jeffrey, McNeish, John D, Eastman, Susan E, Howard, Edward D, Clarke, Sally R.M, Rosloniec, Edward F, Elliott, Eileen A, Rudensky, Alexander Y

Volltext

CP-481,715, a Potent and Selective CCR1 Antagonist with Potential Therapeutic Implications for Inflammatory Diseases von Gladue, Ronald P., Tylaska, Laurie A., Brissette, William H., Lira, Paul D., Kath, John C., Poss, Christopher S., Brown, Matthew F., Paradis, Timothy J., Conklyn, Maryrose J., Ogborne, Kevin T., McGlynn, Molly A., Lillie, Brett M., DiRico, Amy P., Mairs, Erin N., McElroy, Eric B., Martin, William H., Stock, Ingrid A., Shepard, Richard M., Showell, Henry J., Neote, Kuldeep

Volltext

Combined use of the JAK3 inhibitor CP-690,550 with mycophenolate mofetil to prevent kidney allograft rejection in nonhuman primates von BORIE, Dominic C, LARSON, Michael J, ELLIOTT, Eileen A, REITZ, Bruce A, CHANGELIAN, Paul S, FLORES, Mona G, CAMPBELL, Andrew, ROUSVOAL, Geraldine, ZHANG, Sally, HIGGINS, John P, BALL, Douglas J, KUDLACZ, Elizabeth M, BRISSETTE, William H

Volltext

Analysis of the role of the HIF hydroxylase family members in erythropoiesis von Fisher, Timothy S., Lira, Paul D., Stock, Jeffrey L., Perregaux, David G., Brissette, William H., Ozolinš, Terence R.S., Li, Baiyong

Volltext

Defects in embryonic development of EGLN1/PHD2 knockdown transgenic mice are associated with induction of Igfbp in the placenta von Ozolinš, Terence R.S., Fisher, Timothy S., Nadeau, Diane M., Stock, Jeffrey L., Klein, Anne S., Milici, Anthony J., Morton, Daniel, Wilhelms, Margaret B., Brissette, William H., Li, Baiyong

Volltext

Structure–activity relationships and hepatic safety risks of thiazole agonists of the thrombopoietin receptor von Antipas, Amy S., Blumberg, Laura C., Brissette, William H., Brown, Matthew F., Casavant, Jeffrey M., Doty, Jonathan L., Driscoll, James, Harris, Thomas M., Jones, Christopher S., McCurdy, Sandra P., McElroy, Eric, Mitton-Fry, Mark, Munchhof, Michael J., Reim, David A., Reiter, Lawrence A., Ripp, Sharon L., Shavnya, Andrei, Smeets, Marc I., Trevena, Kristen A.

Volltext

Molecular features crucial to the activity of pyrimidine benzamide-based thrombopoietin receptor agonists von Reiter, Lawrence A., Jones, Christopher S., Brissette, William H., McCurdy, Sandra P., Abramov, Yuriy A., Bordner, Jon, DiCapua, Frank M., Munchhof, Michael J., Rescek, Diane M., Samardjiev, Ivan J., Withka, Jane M.

Volltext

The identification of orally bioavailable thrombopoietin agonists von Munchhof, Michael J., Antipas, Amy S., Blumberg, Laura C., Brissette, William H., Brown, Matthew F., Casavant, Jeffrey M., Doty, Jonathan L., Driscoll, James, Harris, Thomas M., Wolf-Gouveia, Lilli A., Jones, Christopher S., Li, Qifang, Linde, Robert G., Lira, Paul D., Marfat, Anthony, McElroy, Eric, Mitton-Fry, Mark, McCurdy, Sandra P., Reiter, Lawrence A., Ripp, Sharon L., Shavnya, Andrei, Thomasco, Lisa M., Trevena, Kristen A.

Volltext

Pyrimidine benzamide-based thrombopoietin receptor agonists von Reiter, Lawrence A., Subramanyam, Chakrapani, Mangual, Emilio J., Jones, Christopher S., Smeets, Marc I., Brissette, William H., McCurdy, Sandra P., Lira, Paul D., Linde, Robert G., Li, Qifang, Zhang, Fangning, Antipas, Amy S., Blumberg, Laura C., Doty, Jonathan L., Driscoll, James P., Munchhof, Michael J., Ripp, Sharon L., Shavnya, Andrei, Shepard, Richard M., Sperger, Diana, Thomasco, Lisa M., Trevena, Kristen A., Wolf-Gouveia, Lilli A., Zhang, Liling

Volltext

Novel CCR1 antagonists with improved metabolic stability von BROWN, Matthew F, AVERY, Mike, LIRA, Paul D, LILLIE, Brett M, LUNDQUIST, Greg D, MAIRS, Erin N, MCELROY, Eric B, MCGLYNN, Molly A, PARADIS, Timothy J, POSS, Christopher S, ROSSULEK, Michelle I, SHEPARD, Richard M, BRISSETTE, William H, SIMS, Jeff, STRELEVITZ, Timothy J, TRUESDELL, Susan, TYLASKA, Laurie A, YOON, Kwansik, DEYE ZHENG, CHANG, J. H, COLIZZA, Kevin, CONKLYN, Maryrose, DIRICO, Amy P, GLADUE, Ronald P, KATH, John C, KRUEGER, Suzanne S

Volltext

Genomic Organization of the CC Chemokine MIP-3α/CCL20/LARC/EXODUS/SCYA20, Showing Gene Structure, Splice Variants, and Chromosome Localization von Nelson, Robin T., Boyd, James, Gladue, Ronald P., Paradis, Timothy, Thomas, Ranjeny, Cunningham, Ann C., Lira, Paul, Brissette, William H., Hayes, Lisa, Hames, Lynn M., Neote, Kuldeep S., McColl, Shaun R.

Volltext

Potent small molecule CCR1 antagonists von KATH, John C, BRISSETTE, William H, MARTIN, William H, MCELROY, Eric B, MCGLYNN, Molly A, PARADIS, Timothy J, POSS, Christopher S, STOCK, Ingrid A, TYLASKA, Laurie A, DEYE ZHENG, BROWN, Matthew F, CONKLYN, Maryrose, DIRICO, Amy P, DORFF, Peter, GLADUE, Ronald P, LILLIE, Brett M, LIRA, Paul D, MAIRS, Erin N

Volltext

Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation von Hanke, J H, Gardner, J P, Dow, R L, Changelian, P S, Brissette, W H, Weringer, E J, Pollok, B A, Connelly, P A

Volltext

The Novel JAK‐3 Inhibitor CP‐690550 Is a Potent Immunosuppressive Agent in Various Murine Models von Kudlacz, Elizabeth, Perry, Bret, Sawyer, Perry, Conklyn, Maryrose, McCurdy, Sandra, Brissette, William, Flanagan and, Mark, Changelian, Paul

Volltext

Piperazinyl CCR1 antagonists—optimization of human liver microsome stability von Brown, Matthew F., Bahnck, Kevin B., Blumberg, Laura C., Brissette, William H., Burrell, Sara A., Driscoll, James P., Fedeles, Flavia, Fisher, Michael B., Foti, Robert S., Gladue, Ronald P., Guzman-Martinez, Aikomari, Hayward, Matthew M., Lira, Paul D., Lillie, Brett M., Lu, Yi, Lundquist, Greg D., McElroy, Eric B., McGlynn, Molly A., Paradis, Timothy J., Poss, Christopher S., Roache, James H., Shavnya, Andrei, Shepard, Richard M., Trevena, Kristen A., Tylaska, Laurie A.

Volltext