Signaling and Functions of Angiopoietin-1 in Vascular Protection von Brindle, Nicholas P.J, Saharinen, Pipsa, Alitalo, Kari

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Carotid plaque instability and ischemic symptoms are linked to immaturity of microvessels within plaques von Dunmore, Benjamin J., PhD, McCarthy, Mark J., PhD, FRCS, Naylor, A. Ross, MD, FRCS, Brindle, Nicholas P.J., PhD

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Regulated Proteolytic Processing of Tie1 Modulates Ligand Responsiveness of the Receptor-tyrosine Kinase Tie2 von Marron, Marie B., Singh, Harprit, Tahir, Tariq A., Kavumkal, Jais, Kim, Hak-Zoo, Koh, Gou Young, Brindle, Nicholas P.J.

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Effects of angiopoietins-1 and -2 on the receptor tyrosine kinase Tie2 are differentially regulated at the endothelial cell surface von Hansen, Tania M., Singh, Harprit, Tahir, Tariq A., Brindle, Nicholas P.J.

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Directed Evolution of an Angiopoietin-2 Ligand Trap by Somatic Hypermutation and Cell Surface Display von Brindle, Nicholas P.J., Sale, Julian E., Arakawa, Hiroshi, Buerstedde, Jean-Marie, Nuamchit, Teonchit, Sharma, Shikha, Steele, Kathryn H.

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Vascular endothelial growth factor activates the Tie family of receptor tyrosine kinases von Singh, Harprit, Milner, Christopher S., Aguilar Hernandez, Maria M., Patel, Nisha, Brindle, Nicholas P.J.

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The Antiinflammatory Endothelial Tyrosine Kinase Tie2 Interacts With a Novel Nuclear Factor-κB Inhibitor ABIN-2 von Hughes, David P, Marron, Marie B, Brindle, Nicholas P.J

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High glucose and elevated fatty acids suppress signaling by the endothelium protective ligand angiopoietin-1 von Singh, Harprit, Brindle, Nicholas P.J., Zammit, Victor A.

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Angiogenesis and the atherosclerotic carotid plaque: An association between symptomatology and plaque morphology von McCarthy, Mark J., Loftus, Ian M., Thompson, Matt M., Jones, Louise, London, Nicholas J.M., Bell, Peter R.F., Naylor, A.Ross, Brindle, Nicholas P.J.

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Intrinsic differences in the mechanisms of Tie2 binding to angiopoietins exploited by directed evolution to create an Ang2-selective ligand trap von Bate, Neil, Lodge, James, Brindle, Nicholas P.J.

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The endothelial receptor tyrosine kinase tie-1 is upregulated by hypoxia and vascular endothelial growth factor von McCarthy, Mark J, Crowther, Matthew, R.F. Bell, Peter, Brindle, Nicholas P.J

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In vitro evolution predicts emerging SARS-CoV-2 mutations with high affinity for ACE2 and cross-species binding von Bate, Neil, Savva, Christos G, Moody, Peter C E, Brown, Edward A, Evans, Sian E, Ball, Jonathan K, Schwabe, John W R, Sale, Julian E, Brindle, Nicholas P J

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Evidence for Heterotypic Interaction between the Receptor Tyrosine Kinases TIE-1 and TIE-2 von Marron, Marie B., Hughes, David P., Edge, Michael D., Forder, Cheryl L., Brindle, Nicholas P.J.

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Noninvasive augmentation of microvessel number in patients with peripheral vascular disease von Clover, Anthony J, McCarthy, Mark J, Hodgkinson, Kaniz, Bell, Peter R.F, Brindle, Nicholas P.J

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The molecular balance between receptor tyrosine kinases Tie1 and Tie2 is dynamically controlled by VEGF and TNFα and regulates angiopoietin signalling von Singh, Harprit, Hansen, Tania M, Patel, Nisha, Brindle, Nicholas P J

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Regulation of Angiopoietin Signalling by Soluble Tie2 Ectodomain and Engineered Ligand Trap von Alawo, Deborah O. A., Tahir, Tariq A., Fischer, Marlies, Bates, Declan G., Amirova, Svetlana R., Brindle, Nicholas P. J.

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Vascular Endothelial Growth Factor Modulates the TIE-2:TIE-1 Receptor Complex von Tsiamis, Achilleas C., Morris, Paul N., Marron, Marie B., Brindle, Nicholas P.J.

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Development of an Orthogonal Tie2 Ligand Resistant to Inhibition by Ang2 von Issa, Eyad, Moss, Andrew J, Fischer, Marlies, Kang, Mandeep, Ahmed, Sultan, Farah, Hussein, Bate, Neil, Giakomidi, Despoina, Brindle, Nicholas PJ

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Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1 von Kopp, Petra M., Bate, Neil, Hansen, Tania M., Brindle, Nicholas P.J., Praekelt, Uta, Debrand, Emmanuel, Coleman, Stacey, Mazzeo, Daniela, Goult, Benjamin T., Gingras, Alexandre R., Pritchard, Catrin A., Critchley, David R., Monkley, Susan J.

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The RNA binding protein hnRNP-K mediates post-transcriptional regulation of uncoupling protein-2 by angiopoietin-1 von Tahir, Tariq A., Singh, Harprit, Brindle, Nicholas P.J.

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