Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19 von Eastman, Richard T, Roth, Jacob S, Brimacombe, Kyle R, Simeonov, Anton, Shen, Min, Patnaik, Samarjit, Hall, Matthew D

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Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors von Singh, Anju, Venkannagari, Sreedhar, Oh, Kyu H, Zhang, Ya-Qin, Rohde, Jason M, Liu, Li, Nimmagadda, Sridhar, Sudini, Kuladeep, Brimacombe, Kyle R, Gajghate, Sachin, Ma, Jinfang, Wang, Amy, Xu, Xin, Shahane, Sampada A, Xia, Menghang, Woo, Juhyung, Mensah, George A, Wang, Zhibin, Ferrer, Marc, Gabrielson, Edward, Li, Zhuyin, Rastinejad, Fraydoon, Shen, Min, Boxer, Matthew B, Biswal, Shyam

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A high-content imaging-based screening pipeline for the systematic identification of anti-progeroid compounds von Kubben, Nard, Brimacombe, Kyle R., Donegan, Megan, Li, Zhuyin, Misteli, Tom

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Effective transvascular delivery of nanoparticles across the blood-brain tumor barrier into malignant glioma cells von Sarin, Hemant, Kanevsky, Ariel S, Wu, Haitao, Brimacombe, Kyle R, Fung, Steve H, Sousa, Alioscka A, Auh, Sungyoung, Wilson, Colin M, Sharma, Kamal, Aronova, Maria A, Leapman, Richard D, Griffiths, Gary L, Hall, Matthew D

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A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate von Pacold, Michael E, Brimacombe, Kyle R, Chan, Sze Ham, Rohde, Jason M, Lewis, Caroline A, Swier, Lotteke J Y M, Possemato, Richard, Chen, Walter W, Sullivan, Lucas B, Fiske, Brian P, Cho, Steve, Freinkman, Elizaveta, Birsoy, Kıvanç, Abu-Remaileh, Monther, Shaul, Yoav D, Liu, Chieh Min, Zhou, Minerva, Koh, Min Jung, Chung, Haeyoon, Davidson, Shawn M, Luengo, Alba, Wang, Amy Q, Xu, Xin, Yasgar, Adam, Liu, Li, Rai, Ganesha, Westover, Kenneth D, Vander Heiden, Matthew G, Shen, Min, Gray, Nathanael S, Boxer, Matthew B, Sabatini, David M

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Archie Brain: celebrating 30 years of development in laryngeal mask airways von van Zundert, T. C. R. V., Brimacombe, J. R., Ferson, D. Z., Bacon, D. R., Wilkinson, D. J.

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PKM2 activation sensitizes cancer cells to growth inhibition by 2-deoxy-D-glucose von Tee, Sui Seng, Park, Jae Mo, Hurd, Ralph E, Brimacombe, Kyle R, Boxer, Matthew B, Massoud, Tarik F, Rutt, Brian K, Spielman, Daniel M

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Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH) von Rai, Ganesha, Brimacombe, Kyle R, Mott, Bryan T, Urban, Daniel J, Hu, Xin, Yang, Shyh-Ming, Lee, Tobie D, Cheff, Dorian M, Kouznetsova, Jennifer, Benavides, Gloria A, Pohida, Katie, Kuenstner, Eric J, Luci, Diane K, Lukacs, Christine M, Davies, Douglas R, Dranow, David M, Zhu, Hu, Sulikowski, Gary, Moore, William J, Stott, Gordon M, Flint, Andrew J, Hall, Matthew D, Darley-Usmar, Victor M, Neckers, Leonard M, Dang, Chi V, Waterson, Alex G, Simeonov, Anton, Jadhav, Ajit, Maloney, David J

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Lysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal amplification in PET von Kannan, Pavitra, Brimacombe, Kyle R, Kreisl, William C, Liow, Jeih-San, Zoghbi, Sami S, Telu, Sanjay, Zhang, Yi, Pike, Victor W, Halldin, Christer, Gottesman, Michael M, Innis, Robert B, Hall, Matthew D

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Comparison of four methods for assessing airway sealing pressure with the laryngeal mask airway in adult patients von Keller, C, Brimacombe, J R, Keller, K, Morris, R

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Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo von Najm, Fadi J., Madhavan, Mayur, Zaremba, Anita, Shick, Elizabeth, Karl, Robert T., Factor, Daniel C., Miller, Tyler E., Nevin, Zachary S., Kantor, Christopher, Sargent, Alex, Quick, Kevin L., Schlatzer, Daniela M., Tang, Hong, Papoian, Ruben, Brimacombe, Kyle R., Shen, Min, Boxer, Matthew B., Jadhav, Ajit, Robinson, Andrew P., Podojil, Joseph R., Miller, Stephen D., Miller, Robert H., Tesar, Paul J.

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Survey of Laryngeal Mask Airway Usage in 11,910 Patients: Safety and Efficacy for Conventional and Nonconventional Usage von Verghese, Chandi, Brimacombe, Joseph R.

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Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis von Anastasiou, Dimitrios, Yu, Yimin, Israelsen, William J, Jiang, Jian-Kang, Boxer, Matthew B, Hong, Bum Soo, Tempel, Wolfram, Dimov, Svetoslav, Shen, Min, Jha, Abhishek, Yang, Hua, Mattaini, Katherine R, Metallo, Christian M, Fiske, Brian P, Courtney, Kevin D, Malstrom, Scott, Khan, Tahsin M, Kung, Charles, Skoumbourdis, Amanda P, Veith, Henrike, Southall, Noel, Walsh, Martin J, Brimacombe, Kyle R, Leister, William, Lunt, Sophia Y, Johnson, Zachary R, Yen, Katharine E, Kunii, Kaiko, Davidson, Shawn M, Christofk, Heather R, Austin, Christopher P, Inglese, James, Harris, Marian H, Asara, John M, Stephanopoulos, Gregory, Salituro, Francesco G, Jin, Shengfang, Dang, Lenny, Auld, Douglas S, Park, Hee-Won, Cantley, Lewis C, Thomas, Craig J, Vander Heiden, Matthew G

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The ProSeal laryngeal mask airway in prone patients : a retrospective audit of 245 patients von BRIMACOMBE, J. R, WENZEL, V, KELLER, C

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Structure–Activity Relationship of Imidazopyridinium Analogues as Antagonists of Neuropeptide S Receptor von Patnaik, Samarjit, Marugan, Juan J, Liu, Ke, Zheng, Wei, Southall, Noel, Dehdashti, Seameen J, Thorsell, Annika, Heilig, Markus, Bell, Lauren, Zook, Michelle, Eskay, Bob, Brimacombe, Kyle R, Austin, Christopher P

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Correction to Remdesivir: A Review of Its Discovery and Development Leading to Human Clinical Trials for Treatment of COVID-19 von Eastman, Richard T, Roth, Jacob S, Brimacombe, Kyle R, Simeonov, Anton, Shen, Min, Patnaik, Samarjit, Hall, Matthew D

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High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2 von Coussens, Nathan P., Kales, Stephen C., Henderson, Mark J., Lee, Olivia W., Horiuchi, Kurumi Y., Wang, Yuren, Chen, Qing, Kuznetsova, Ekaterina, Wu, Jianghong, Chakka, Sirisha, Cheff, Dorian M., Cheng, Ken Chih-Chien, Shinn, Paul, Brimacombe, Kyle R., Shen, Min, Simeonov, Anton, Lal-Nag, Madhu, Ma, Haiching, Jadhav, Ajit, Hall, Matthew D.

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A dual-fluorescence high-throughput cell line system for probing multidrug resistance von Brimacombe, Kyle R, Hall, Matthew D, Auld, Douglas S, Inglese, James, Austin, Christopher P, Gottesman, Michael M, Fung, King-Leung

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Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis von Anastasiou, Dimitrios, Yu, Yimin, Israelsen, William J, Jiang, Jian-Kang, Boxer, Matthew B, Hong, Bum Soo, Tempel, Wolfram, Dimov, Svetoslav, Shen, Min, Jha, Abhishek, Yang, Hua, Mattaini, Katherine R, Metallo, Christian M, Fiske, Brian P, Courtney, Kevin D, Malstrom, Scott, Khan, Tahsin M, Kung, Charles, Skoumbourdis, Amanda P, Veith, Henrike, Southall, Noel, Walsh, Martin J, Brimacombe, Kyle R, Leister, William, Lunt, Sophia Y, Johnson, Zachary R, Yen, Katharine E, Kunii, Kaiko, Davidson, Shawn M, Christofk, Heather R, Austin, Christopher P, Inglese, James, Harris, Marian H, Asara, John M, Stephanopoulos, Gregory, Salituro, Francesco G, Jin, Shengfang, Dang, Lenny, Auld, Douglas S, Park, Hee-Won, Cantley, Lewis C, Thomas, Craig J, Vander Heiden, Matthew G

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Do mask aperture bars of extraglottic airway devices prevent prolapse of epiglottis causing airway obstruction? A randomized crossover trial in anesthetized adult patients von Van Zundert, Tom C.R.V., MD, PhD, EDRA, Hendrickx, Jan F.A., MD, PhD, De Witte, Jan L., MD, Wong, David T., MD, Cattano, Davide, MD, PhD, Brimacombe, Joseph R., MD, PhD, FANZCA

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