The aggrecanopathies; an evolving phenotypic spectrum of human genetic skeletal diseases von Gibson, Beth G, Briggs, Michael D

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CRELD2 is a novel modulator of calcium release and calcineurin-NFAT signalling during osteoclast differentiation von Duxfield, Adam, Munkley, Jennifer, Briggs, Michael D., Dennis, Ella P.

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Multiple epiphyseal dysplasia and related disorders: Molecular genetics, disease mechanisms, and therapeutic avenues von Dennis, Ella P., Greenhalgh‐Maychell, Phillippa L., Briggs, Michael D.

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Curcumin Reduces Pathological Endoplasmic Reticulum Stress through Increasing Proteolysis of Mutant Matrilin-3 von Dennis, Ella P, Watson, Robyn N, McPate, Florence, Briggs, Michael D

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unfolded protein response and its relevance to connective tissue diseases von Boot-Handford, Raymond P, Briggs, Michael D

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Increased intracellular proteolysis reduces disease severity in an ER stress-associated dwarfism von Mullan, Lorna A, Mularczyk, Ewa J, Kung, Louise H, Forouhan, Mitra, Wragg, Jordan Ma, Goodacre, Royston, Bateman, John F, Swanton, Eileithyia, Briggs, Michael D, Boot-Handford, Raymond P

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Cartilage endoplasmic reticulum stress may influence the onset but not the progression of experimental osteoarthritis von Kung, Louise H W, Mullan, Lorna, Soul, Jamie, Wang, Ping, Mori, Kazutoshi, Bateman, John F, Briggs, Michael D, Boot-Handford, Raymond P

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Increased classical endoplasmic reticulum stress is sufficient to reduce chondrocyte proliferation rate in the growth plate and decrease bone growth von Kung, Louise H W, Rajpar, M Helen, Preziosi, Richard, Briggs, Michael D, Boot-Handford, Raymond P

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Armet/Manf and Creld2 are components of a specialized ER stress response provoked by inappropriate formation of disulphide bonds: implications for genetic skeletal diseases von Hartley, Claire L, Edwards, Sarah, Mullan, Lorna, Bell, Peter A, Fresquet, Maryline, Boot-Handford, Raymond P, Briggs, Michael D

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Targeted induction of endoplasmic reticulum stress induces cartilage pathology von Rajpar, M Helen, McDermott, Ben, Kung, Louise, Eardley, Rachel, Knowles, Lynette, Heeran, Mel, Thornton, David J, Wilson, Richard, Bateman, John F, Poulsom, Richard, Arvan, Peter, Kadler, Karl E, Briggs, Michael D, Boot-Handford, Raymond P

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XBP1 signalling is essential for alleviating mutant protein aggregation in ER-stress related skeletal disease von Piróg, Katarzyna A, Dennis, Ella P, Hartley, Claire L, Jackson, Robert M, Soul, Jamie, Schwartz, Jean-Marc, Bateman, John F, Boot-Handford, Raymond P, Briggs, Michael D

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Genotype to phenotype correlations in cartilage oligomeric matrix protein associated chondrodysplasias von Briggs, Michael D, Brock, Joanne, Ramsden, Simon C, Bell, Peter A

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Increased hippocampal excitability in miR-324-null mice von Hayman, Dan J., Modebadze, Tamara, Charlton, Sarah, Cheung, Kat, Soul, Jamie, Lin, Hua, Hao, Yao, Miles, Colin G., Tsompani, Dimitra, Jackson, Robert M., Briggs, Michael D., Piróg, Katarzyna A., Clark, Ian M., Barter, Matt J., Clowry, Gavin J., LeBeau, Fiona E. N., Young, David A.

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Abnormal chondrocyte apoptosis in the cartilage growth plate is influenced by genetic background and deletion of CHOP in a targeted mouse model of pseudoachondroplasia von Piróg, Katarzyna A, Irman, Andreja, Young, Siobhan, Halai, Poonam, Bell, Peter A, Boot-Handford, Raymond P, Briggs, Michael D

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Collagen XXVII organises the pericellular matrix in the growth plate von Plumb, Darren A, Ferrara, Laila, Torbica, Tanja, Knowles, Lynnette, Mironov, Jr, Aleksandr, Kadler, Karl E, Briggs, Michael D, Boot-Handford, Raymond P

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New developments in chondrocyte ER stress and related diseases [version 1; peer review: 2 approved] von Briggs, Michael D., Dennis, Ella P., Dietmar, Helen F., Pirog, Katarzyna A.

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Mild myopathy is associated with COMP but not MATN3 mutations in mouse models of genetic skeletal diseases von Piróg, Katarzyna A, Katakura, Yoshihisa, Mironov, Aleksandr, Briggs, Michael D

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An unfolded protein response is the initial cellular response to the expression of mutant matrilin-3 in a mouse model of multiple epiphyseal dysplasia von Nundlall, Seema, Rajpar, M. Helen, Bell, Peter A., Clowes, Christopher, Zeeff, Leo A. H., Gardner, Benjamin, Thornton, David J., Boot-Handford, Raymond P., Briggs, Michael D.

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Decreased chondrocyte proliferation and dysregulated apoptosis in the cartilage growth plate are key features of a murine model of epiphyseal dysplasia caused by a matn3 mutation von Leighton, Matthew P., Nundlall, Seema, Starborg, Tobias, Meadows, Roger S., Suleman, Farhana, Knowles, Lynette, Wagener, Raimund, Thornton, David J., Kadler, Karl E., Boot-Handford, Raymond P., Briggs, Michael D.

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Collagen XXVII Is Developmentally Regulated and Forms Thin Fibrillar Structures Distinct from Those of Classical Vertebrate Fibrillar Collagens von Plumb, Darren A., Dhir, Vivek, Mironov, Aleksandr, Ferrara, Laila, Poulsom, Richard, Kadler, Karl E., Thornton, David J., Briggs, Michael D., Boot-Handford, Raymond P.

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