The novel AKT inhibitor afuresertib shows favorable safety, pharmacokinetics, and clinical activity in multiple myeloma von Spencer, Andrew, Yoon, Sung-Soo, Harrison, Simon J., Morris, Shannon R., Smith, Deborah A., Brigandi, Richard A., Gauvin, Jennifer, Kumar, Rakesh, Opalinska, Joanna B., Chen, Christine

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A Novel Hypoxia-Inducible Factor−Prolyl Hydroxylase Inhibitor (GSK1278863) for Anemia in CKD: A 28-Day, Phase 2A Randomized Trial von Brigandi, Richard A., MD, PhD, Johnson, Brendan, PhD, Oei, Coreen, PhD, Westerman, Mark, PhD, Olbina, Gordana, PhD, de Zoysa, Janak, MBChB, Roger, Simon D., MD, Sahay, Manisha, MD, DNB, Cross, Nicholas, MBChB, MM, PhD, McMahon, Lawrence, MD, Guptha, Veerabhadra, MD, Smolyarchuk, Elena A., MD, Singh, Narinder, MD, Russ, Steven F., MPH, Kumar, Sanjay, PhD

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A population analysis of the DGAT1 inhibitor GSK3008356 and its effect on endogenous and meal‐induced triglyceride turnover in healthy subjects von Okour, Malek, Brigandi, Richard A., Tenero, David

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A Phase 1 Randomized, Placebo‐Controlled Trial With a Topical Inhibitor of Stearoyl‐Coenzyme A Desaturase 1 Under Occluded and Nonoccluded Conditions von Brigandi, Richard A., Zhu, John, Murnane, Amy A., Reedy, Beth Ann, Shakib, Sepehr

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First‐in‐Human Pharmacokinetics and Safety Study of GSK3008356, a Selective DGAT1 Inhibitor, in Healthy Volunteers von Okour, Malek, Gress, Angela, Zhu, Xinyi, Rieman, David, Lickliter, Jason D., Brigandi, Richard A.

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Candidate Selection and Preclinical Evaluation of N-tert-Butyl Isoquine (GSK369796), An Affordable and Effective 4-Aminoquinoline Antimalarial for the 21st Century von O’Neill, Paul M, Park, B. Kevin, Shone, Alison E, Maggs, James L, Roberts, Phillip, Stocks, Paul A, Biagini, Giancarlo A, Bray, Patrick G, Gibbons, Peter, Berry, Neil, Winstanley, Peter A, Mukhtar, Amira, Bonar-Law, Richard, Hindley, Stephen, Bambal, Ramesh B, Davis, Charles B, Bates, Martin, Hart, Timothy K, Gresham, Stephanie L, Lawrence, Ron M, Brigandi, Richard A, Gomez-delas-Heras, Federico M, Gargallo, Domingo V, Ward, Stephen A

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Synthesis, Antimalarial Activity, and Preclinical Pharmacology of a Novel Series of 4′-Fluoro and 4′-Chloro Analogues of Amodiaquine. Identification of a Suitable “Back-Up” Compoun... von O’Neill, Paul M, Shone, Alison E, Stanford, Deborah, Nixon, Gemma, Asadollahy, Eghbaleh, Park, B. Kevin, Maggs, James L, Roberts, Phil, Stocks, Paul A, Biagini, Giancarlo, Bray, Patrick G, Davies, Jill, Berry, Neil, Hall, Charlotte, Rimmer, Karen, Winstanley, Peter A, Hindley, Stephen, Bambal, Ramesh B, Davis, Charles B, Bates, Martin, Gresham, Stephanie L, Brigandi, Richard A, Gomez-de-las-Heras, Federico M, Gargallo, Domingo V, Parapini, Silvia, Vivas, Livia, Lander, Hollie, Taramelli, Donatella, Ward, Stephen A

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Intravenous pharmacokinetics, local tolerability, and hemolysis of an SBE7-β-cyclodextrin formulation of the neurokinin-1 receptor antagonist vestipitant von Brigandi, Richard A., Russ, Steven F., Petit, Chantal, Johnson, Brendan, Croy, Scott, Hodsman, Peter, Muller, Fran

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Emerging therapeutic targets in psoriasis von Bayliffe, Andrew I, Brigandi, Richard A, Wilkins, H Jeffrey, Levick, Mark P

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Strongyloides stercoralis:Eosinophil-Dependent Immune-Mediated Killing of Third Stage Larvae in BALB/cByJ Mice von Rotman, Harris L., Yutanawiboonchai, Wiboonchai, Brigandi, Richard A., Leon, Ofra, Gleich, Gerald J., Nolan, Thomas J., Schad, Gerhard A., Abraham, David

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Strongyloides stercoralis:Role of Antibody and Complement in Immunity to the Third Stage Larvae in BALB/cByJ Mice von Brigandi, Richard A., Rotman, Harris L., Yutanawiboonchai, Wiboonchai, Leon, Ofra, Nolan, Thomas J., Schad, Gerhard A., Abraham, David

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Chronicity in Strongyloides stercoralis Infections: Dichotomy of the Protective Immune Response to Infective and Autoinfective Larvae in a Mouse Model von Brigandi, Richard A, Rotman, Harris L, Nolan, Thomas J, Schad, Gerhard A, Abraham, David

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Strongyloides stercoralis Host-Adapted Third-Stage Larvae Are the Target of Eosinophil-Associated Immune-Mediated Killing in Mice von BRIGANDI, R. A, ROTMAN, H. L, LEON, O, NOLAN, T. J, SCHAD, G. A, ABRAHAM, D

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Intravenous pharmacokinetics, local tolerability, and hemolysis of an SBE7-[beta]-cyclodextrin formulation of the neurokinin-1 receptor antagonist vestipitant von Brigandi, Richard A, Russ, Steven F, Petit, Chantal, Johnson, Brendan, Croy, Scott, Hodsman, Peter, Muller, Fran

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Strongyloides stercoralis: Protective Immunity to Third-Stage Larvae in BALB/cByJ Mice von Abraham, D., Rotman, H.L., Haberstroh, H.F., Yutanawiboonchai, W., Brigandi, R.A., Leon, O., Nolan, T.J., Schad, G.A.

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Strongyloides stercoralis: Complete Life Cycle in SCID Mice von Rotman, H.L., Yutanawiboonchai, W., Brigandi, R.A., Leon, O., Nolan, T.J., Schad, G.A., Abraham, D.

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Intradermal substance P as a challenge agent in healthy individuals von Ten Voorde, Wouter, Akinseye, Chika, Abdisalaam, Ismahaan, Wind, Selinde, Klarenbeek, Naomi, Bergmans, Menthe, van Doorn, Martijn, Rissmann, Robert, Kaur, Rejbinder, Hotee, Sarah, Foster, Katie, Nair, Arati, Fortunato, Lea, Macphee, Colin, Mole, Sarah, Baumann, Katrine, Brigandi, Richard

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Farglitazar Lacks Antifibrotic Activity in Patients With Chronic Hepatitis C Infection von McHutchison, John, Goodman, Zachary, Patel, Keyur, Makhlouf, Hala, Rodriguez–Torres, Maribel, Shiffman, Mitchell, Rockey, Don, Husa, Petr, Chuang, Wan–Long, Levine, Robert, Jonas, Mark, Theodore, Dickens, Brigandi, Richard, Webster, Alison, Schultz, Margaret, Watson, Helen, Stancil, Britt, Gardner, Stephen

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Novel AKT Inhibitor GSK2110183 Shows Favorable Safety, Pharmacokinetics, and Clinical Activity in Multiple Myeloma. Preliminary Results From a Phase I First-Time-In-Human Study von Spencer, Andrew, Yoon, Sung-Soo, Harrison, Simon J., Morris, Shannon, Smith, Deborah, Freedman, Steven J., Brigandi, Richard, Oliff, Allen, Opalinska, Joanna B., Chen, Christine

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Treatment of ocular neovascular disorders such as macular degeneration, angiod streaks, uveitis and macular edema von MILLER WILLIAM HENRY, LEVICK MARK, BRIGANDI RICHARD ANTHONY

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