Deep learning-based models for preimplantation mouse and human embryos based on single-cell RNA sequencing von Proks, Martin, Salehin, Nazmus, Brickman, Joshua M.

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Common modes of ERK induction resolve into context specific signalling via emergent networks and cell type specific transcriptional repression von Perera, Marta, Brickman, Joshua M

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In vitro models of human hypoblast and mouse primitive endoderm von Perera, Marta, Brickman, Joshua M

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Functional heterogeneity of embryonic stem cells revealed through translational amplification of an early endodermal transcript von Canham, Maurice A, Sharov, Alexei A, Ko, Minoru S H, Brickman, Joshua M

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Enhancers are activated by p300/CBP activity-dependent PIC assembly, RNAPII recruitment, and pause release von Narita, Takeo, Ito, Shinsuke, Higashijima, Yoshiki, Chu, Wai Kit, Neumann, Katrin, Walter, Jonas, Satpathy, Shankha, Liebner, Tim, Hamilton, William B., Maskey, Elina, Prus, Gabriela, Shibata, Marika, Iesmantavicius, Vytautas, Brickman, Joshua M., Anastassiadis, Konstantinos, Koseki, Haruhiko, Choudhary, Chunaram

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Cell-state transitions and collective cell movement generate an endoderm-like region in gastruloids von Hashmi, Ali, Tlili, Sham, Perrin, Pierre, Lowndes, Molly, Peradziryi, Hanna, Brickman, Joshua M, Martínez Arias, Alfonso, Lenne, Pierre-François

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Naïve human pluripotent stem cells respond to Wnt, Nodal and LIF signalling to produce expandable naïve extra-embryonic endoderm von Linneberg-Agerholm, Madeleine, Wong, Yan Fung, Romero Herrera, Jose Alejandro, Monteiro, Rita S, Anderson, Kathryn G V, Brickman, Joshua M

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Totipotent Embryonic Stem Cells Arise in Ground-State Culture Conditions von Morgani, Sophie M., Canham, Maurice A., Nichols, Jennifer, Sharov, Alexei A., Migueles, Rosa Portero, Ko, Minoru S.H., Brickman, Joshua M.

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LIF supports primitive endoderm expansion during pre-implantation development von Morgani, Sophie M, Brickman, Joshua M

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Four simple rules that are sufficient to generate the mammalian blastocyst von Nissen, Silas Boye, Perera, Marta, Gonzalez, Javier Martin, Morgani, Sophie M, Jensen, Mogens H, Sneppen, Kim, Brickman, Joshua M, Trusina, Ala

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Evolutionary origin of vertebrate OCT4/POU5 functions in supporting pluripotency von Sukparangsi, Woranop, Morganti, Elena, Lowndes, Molly, Mayeur, Hélène, Weisser, Melanie, Hammachi, Fella, Peradziryi, Hanna, Roske, Fabian, Hölzenspies, Jurriaan, Livigni, Alessandra, Godard, Benoit Gilbert, Sugahara, Fumiaki, Kuratani, Shigeru, Montoya, Guillermo, Frankenberg, Stephen R., Mazan, Sylvie, Brickman, Joshua M.

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Symmetric inheritance of parental histones governs epigenome maintenance and embryonic stem cell identity von Wenger, Alice, Biran, Alva, Alcaraz, Nicolas, Redó-Riveiro, Alba, Sell, Annika Charlotte, Krautz, Robert, Flury, Valentin, Reverón-Gómez, Nazaret, Solis-Mezarino, Victor, Völker-Albert, Moritz, Imhof, Axel, Andersson, Robin, Brickman, Joshua M., Groth, Anja

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HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development von Gauvrit, Sébastien, Villasenor, Alethia, Strilic, Boris, Kitchen, Philip, Collins, Michelle M., Marín-Juez, Rubén, Guenther, Stefan, Maischein, Hans-Martin, Fukuda, Nana, Canham, Maurice A., Brickman, Joshua M., Bogue, Clifford W., Jayaraman, Padma-Sheela, Stainier, Didier Y. R.

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Gene expression heterogeneities in embryonic stem cell populations: origin and function von Martinez Arias, Alfonso, Brickman, Joshua M

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Insulin fine-tunes self-renewal pathways governing naive pluripotency and extra-embryonic endoderm von Anderson, Kathryn G. V., Hamilton, William B., Roske, Fabian V., Azad, Ajuna, Knudsen, Teresa E., Canham, Maurice A., Forrester, Lesley M., Brickman, Joshua M.

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A Conserved Oct4/POUV-Dependent Network Links Adhesion and Migration to Progenitor Maintenance von Livigni, Alessandra, Peradziryi, Hanna, Sharov, Alexei A., Chia, Gloryn, Hammachi, Fella, Migueles, Rosa Portero, Sukparangsi, Woranop, Pernagallo, Salvatore, Bradley, Mark, Nichols, Jennifer, Ko, Minoru S.H., Brickman, Joshua M.

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Transcriptional heterogeneity and cell cycle regulation as central determinants of Primitive Endoderm priming von Perera, Marta, Nissen, Silas Boye, Proks, Martin, Pozzi, Sara, Monteiro, Rita S, Trusina, Ala, Brickman, Joshua M

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The primitive endoderm supports lineage plasticity to enable regulative development von Linneberg-Agerholm, Madeleine, Sell, Annika Charlotte, Redó-Riveiro, Alba, Perera, Marta, Proks, Martin, Knudsen, Teresa E., Barral, Antonio, Manzanares, Miguel, Brickman, Joshua M.

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The molecular underpinnings of totipotency von Morgani, Sophie M., Brickman, Joshua M.

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Dynamic lineage priming is driven via direct enhancer regulation by ERK von Hamilton, William B., Mosesson, Yaron, Monteiro, Rita S., Emdal, Kristina B., Knudsen, Teresa E., Francavilla, Chiara, Barkai, Naama, Olsen, Jesper V., Brickman, Joshua M.

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