Methylation of p53 by Set7/9 Mediates p53 Acetylation and Activity In Vivo von Kurash, Julia K., Lei, Hong, Shen, Qiong, Marston, Wendy L., Granda, Brian W., Fan, Hong, Wall, Daniel, Li, En, Gaudet, François

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PAX8 lineage-driven T cell engaging antibody for the treatment of high-grade serous ovarian cancer von Lee, Emily, Szvetecz, Sarah, Polli, Ryan, Grauel, Angelo, Chen, Jayson, Judge, Joyce, Jaiswal, Smita, Maeda, Rie, Schwartz, Stephanie, Voedisch, Bernd, Piksa, Mateusz, Japutra, Chietara, Sadhasivam, Lingheswar, Wang, Yiqin, Carrion, Ana, Isim, Sinan, Liang, Jinsheng, Nicholson, Thomas, Lei, Hong, Fang, Qing, Steinkrauss, Michelle, Walker, Dana, Wagner, Joel, Cremasco, Viviana, Wang, Hui Qin, Galli, Giorgio G., Granda, Brian, Mansfield, Keith, Simmons, Quincey, Nguyen, Andrew Anh, Vincent Jordan, Nicole

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A CRISPR Screen Reveals Resistance Mechanisms to CD3-Bispecific Antibody Therapy von Liu, Si-Qi, Grantham, Alyssa, Landry, Casey, Granda, Brian, Chopra, Rajiv, Chakravarthy, Srinivas, Deutsch, Sabine, Vogel, Markus, Russo, Katie, Seiss, Katherine, Tschantz, William R, Rejtar, Tomas, Ruddy, David A, Hu, Tiancen, Aardalen, Kimberly, Wagner, Joel P, Dranoff, Glenn, D'Alessio, Joseph A

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Biophysical Investigation of the Mode of Inhibition of Tetramic Acids, the Allosteric Inhibitors of Undecaprenyl Pyrophosphate Synthase von Lee, Lac V, Granda, Brian, Dean, Karl, Tao, Jianshi, Liu, Eugene, Zhang, Rui, Peukert, Stefan, Wattanasin, Sompong, Xie, Xiaoling, Ryder, Neil S, Tommasi, Ruben, Deng, Gejing

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Relative contributions of CYP2C9 and 2C19 to phenytoin 4-hydroxylation in vitro : inhibition by sulfaphenazole, omeprazole, and ticlopidine von GIANCARLO, Gina M, VENKATAKRISHNAN, Karthik, GRANDA, Brian W, VON MOLTKE, Lisa L, GREENBLATT, David J

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Zolpidem metabolism in vitro: responsible cytochromes, chemical inhibitors, and in vivo correlations von Von Moltke, Lisa L., Greenblatt, David J., Granda, Brian W., Duan, Su Xiang, Grassi, Jeffrey M., Venkatakrishnan, Karthik, Harmatz, Jerold S., Shader, Richard I.

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Affinity-Tuned ErbB2 or EGFR Chimeric Antigen Receptor T Cells Exhibit an Increased Therapeutic Index against Tumors in Mice von Liu, Xiaojun, Jiang, Shuguang, Fang, Chongyun, Yang, Shiyu, Olalere, Devvora, Pequignot, Edward C, Cogdill, Alexandria P, Li, Na, Ramones, Melissa, Granda, Brian, Zhou, Li, Loew, Andreas, Young, Regina M, June, Carl H, Zhao, Yangbing

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Inhibition of Human Cytochrome P450 Isoforms by Nonnucleoside Reverse Transcriptase Inhibitors von von Moltke, Lisa L., Greenblatt, David J., Granda, Brian W., Giancarlo, Gina M., Duan, Su Xiang, Daily, Johanna P., Harmatz, Jerold S., Shader, Richard I.

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Antigen-independent activation enhances the efficacy of 4-1BB-costimulated CD22 CAR T cells von Singh, Nathan, Frey, Noelle V., Engels, Boris, Barrett, David M., Shestova, Olga, Ravikumar, Pranali, Cummins, Katherine D., Lee, Yong Gu, Pajarillo, Raymone, Chun, Inkook, Shyu, Amy, Highfill, Steven L., Price, Andrew, Zhao, Linlin, Peng, Liaomin, Granda, Brian, Ramones, Melissa, Lu, Xueqing Maggie, Christian, David A., Perazzelli, Jessica, Lacey, Simon F., Roy, Nathan H., Burkhardt, Janis K., Colomb, Florent, Damra, Mohammad, Abdel-Mohsen, Mohamed, Liu, Ting, Liu, Dongfang, Standley, Daron M., Young, Regina M., Brogdon, Jennifer L., Grupp, Stephan A., June, Carl H., Maude, Shannon L., Gill, Saar, Ruella, Marco

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Multiple Human Cytochromes Contribute to Biotransformation of Dextromethorphan In-vitro: Role of CYP2C9, CYP2C19, CYP2D6, and CYP3A von Von Moltke, Lisa L., Greenblatt, David J., Grassi, Jeffrey M., Granda, Brian W., Venkatakrishnan, Karthik, Schmider, JÜRgen, Harmatz, Jerold S., Shader, Richard I.

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Nefazodone, meta-chlorophenylpiperazine, and their metabolites in vitro : cytochromes mediating transformation, and P450-3A4 inhibitory actions von VON MOLTKE, L. L, GREENBLATT, D. J, GRANDA, B. W, GRASSI, J. M, SCHMIDER, J, HARMATZ, J. S, SHADER, R. I

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PIT565, a First-in-Class Anti-CD19, Anti-CD3, Anti-CD2 Trispecific Antibody for the Treatment of B Cell Malignancies von Lu, Haihui, Oka, Adwait, Coulson, Michelle, Polli, Joseph Ryan, Aardalen, Kimberly, Ramones, Melissa, Walker, Dana B, Carrion, Ana, Alexander, Dylan, Klopfenstein, Matthieu, Akiyama, Masaki, Rucci, Francesca, Granda, Brian, Pastore, Alessandro

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Two cases of severe pulmonary toxicity from highly active mesothelin-directed CAR T cells von Haas, Andrew R., Golden, Ryan J., Litzky, Leslie A., Engels, Boris, Zhao, Linlin, Xu, Fangmin, Taraszka, John A., Ramones, Melissa, Granda, Brian, Chang, Wan-Jung, Jadlowsky, Julie, Shea, Kim-Marie, Runkle, Adam, Chew, Anne, Dowd, Emily, Gonzalez, Vanessa, Chen, Fang, Liu, Xiaojun, Fang, Chongyun, Jiang, Shuguang, Davis, Megan M., Sheppard, Neil C., Zhao, Yangbing, Fraietta, Joseph A., Lacey, Simon F., Plesa, Gabriela, Melenhorst, J. Joseph, Mansfield, Keith, Brogdon, Jennifer L., Young, Regina M., Albelda, Steven M., June, Carl H., Tanyi, Janos L.

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Short-Term Exposure to Low-Dose Ritonavir Impairs Clearance and Enhances Adverse Effects of Trazodone von Greenblatt, David J., von Moltke, Lisa L., Harmatz, Jerold S., Fogelman, Steven M., Chen, Gengsheng, Graf, Jennifer A., Mertzanis, Polyxane, Byron, Susan, Culm, Kerry E., Granda, Brian W., Daily, Johanna P., Shader, Richard I.

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Clearance of plasma PCSK9 via the asialoglycoprotein receptor mediated by heterobifunctional ligands von Bagdanoff, Jeffrey T., Smith, Thomas M., Allan, Martin, O’Donnell, Peter, Nguyen, Zachary, Moore, Elizabeth A., Baird, Jason, Wang, Shuangxi, Subramanian, Vanitha, Tigani, Bruno, Nettleton, David O., Monovich, Lauren G., Lewis, Ian, Flyer, Alec N., Granda, Brian, Blankenship, John W., Barnes-Seeman, David, Clairmont, Kevin B.

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Identification and Development of PHE885: A Novel and Highly Potent Fully Human Anti-BCMA CAR-T Manufactured with a Novel T-Charge TM Platform for the Treatment of Multiple Myeloma von Bu, Dexiu, Bennett, Paul, Barton, Nathaniel, Bradshaw, Laura, Pinon-Ortiz, Maria, Li, Xiangen, Vaidya, Poonam, Zhu, Xu, Mansfield, Keith, Granda, Brian, Guimaraes, Carla P, Treanor, Louise M, Brogdon, Jennifer L

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Preclinical discovery and initial clinical data of WVT078, a BCMA × CD3 bispecific antibody: MULTIPLE MYELOMA, GAMMOPATHIES von Raab, Marc S., Cohen, Yael C., Schjesvold, Fredrik, Aardalen, Kimberly, Oka, Adwait, Spencer, Andrew, Wermke, Martin, Souza, Anita D., Kaufman, Jonathan L., Cafro, Anna Maria, Ocio, Enrique M., Doki, Noriko, Henson, Kristin, Trabucco, Gina, Carrion, Ana, Bender, Florent C., Juif, Pierre-Eric, Fessehatsion, Adonai, Fan, Liqiong, Stonehouse, Jeffrey P., Blankenship, John W., Granda, Brian, De Vita, Serena, Lu, Haihui

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Preclinical discovery and initial clinical data of WVT078, a BCMA × CD3 bispecific antibody von Raab, Marc S, Cohen, Yael C, Schjesvold, Fredrik, Aardalen, Kimberly, Oka, Adwait, Spencer, Andrew, Wermke, Martin, Souza, Anita D, Kaufman, Jonathan L, Cafro, Anna Maria, Ocio, Enrique M, Doki, Noriko, Henson, Kristin, Trabucco, Gina, Carrion, Ana, Bender, Florent C, Juif, Pierre-Eric, Fessehatsion, Adonai, Fan, Liqiong, Stonehouse, Jeffrey P, Blankenship, John W, Granda, Brian, De Vita, Serena, Lu, Haihui

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Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondin von Xie, Yang, Zamponi, Raffaella, Charlat, Olga, Ramones, Melissa, Swalley, Susanne, Jiang, Xiaomo, Rivera, Daniel, Tschantz, William, Lu, Bo, Quinn, Lisa, Dimitri, Chris, Parker, Jefferson, Jeffery, Doug, Wilcox, Sheri K, Watrobka, Mike, LeMotte, Peter, Granda, Brian, Porter, Jeffrey A, Myer, Vic E, Loew, Andreas, Cong, Feng

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Pre-clinical validation of B cell maturation antigen (BCMA) as a target for T cell immunotherapy of multiple myeloma von Bu, De-Xiu, Singh, Reshma, Choi, Eugene E, Ruella, Marco, Nunez-Cruz, Selene, Mansfield, Keith G, Bennett, Paul, Barton, Nathanial, Wu, Qilong, Zhang, Jiquan, Wang, Yongqiang, Wei, Lai, Cogan, Shawn, Ezell, Tucker, Joshi, Shree, Latimer, Kellie J, Granda, Brian, Tschantz, William R, Young, Regina M, Huet, Heather A, Richardson, Celeste J, Milone, Michael C

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