Discovery and Process Synthesis of Novel 2,7-Pyrrolo[2,1-f][1,2,4]triazines von Thieu, Tho, Sclafani, Joseph A, Levy, Daniel V, McLean, Andrew, Breslin, Henry J, Ott, Gregory R, Bakale, Roger P, Dorsey, Bruce D

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Strategies to Mitigate the Bioactivation of 2-Anilino-7-Aryl-Pyrrolo[2,1-f][1,2,4]triazines: Identification of Orally Bioavailable, Efficacious ALK Inhibitors von Mesaros, Eugen F, Thieu, Tho V, Wells, Gregory J, Zificsak, Craig A, Wagner, Jason C, Breslin, Henry J, Tripathy, Rabindranath, Diebold, James L, McHugh, Robert J, Wohler, Ashley T, Quail, Matthew R, Wan, Weihua, Lu, Lihui, Huang, Zeqi, Albom, Mark S, Angeles, Thelma S, Wells-Knecht, Kevin J, Aimone, Lisa D, Cheng, Mangeng, Ator, Mark A, Ott, Gregory R, Dorsey, Bruce D

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Identification of a dual δ OR antagonist/μ OR agonist as a potential therapeutic for diarrhea-predominant Irritable Bowel Syndrome (IBS-d) von Breslin, Henry J., Diamond, Craig J., Kavash, Robert W., Cai, Chaozhong, Dyatkin, Alexey B., Miskowski, Tamara A., Zhang, Sui-Po, Wade, Paul R., Hornby, Pamela J., He, Wei

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Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives von Pauwels, Rudi, Andries, Koen, Desmyter, Jan, Schols, Dominique, Kukla, Michael J, Breslin, Henry J, Raeymaeckers, Alfons, Gelder, Jozef Van, Woestenborghs, Robert, Heykants, Jozef, Schellekens, Karel, Janssen, Marcel A. C, Clercq, Erik De, Janssen, Paul A. J

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Design, Synthesis, and Anaplastic Lymphoma Kinase (ALK) Inhibitory Activity for a Novel Series of 2,4,8,22-Tetraazatetracyclo[14.3.1.13,7.19,13]docosa-1(20),3(22),4,6,9(21),10,12,1... von Breslin, Henry J, Lane, Brandon M, Ott, Gregory R, Ghose, Arup K, Angeles, Thelma S, Albom, Mark S, Cheng, Mangeng, Wan, Weihua, Haltiwanger, R. Curtis, Wells-Knecht, Kevin J, Dorsey, Bruce D

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2,7-Pyrrolo[2,1- f][1,2,4]triazines as JAK2 inhibitors: Modification of target structure to minimize reactive metabolite formation von Weinberg, Linda R., Albom, Mark S., Angeles, Thelma S., Breslin, Henry J., Gingrich, Diane E., Huang, Zeqi, Lisko, Joseph G., Mason, Jennifer L., Milkiewicz, Karen L., Thieu, Tho V., Underiner, Ted L., Wells, Gregory J., Wells-Knecht, Kevin J., Dorsey, Bruce D.

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2,7-Disubstituted-Pyrrolotriazine Kinase Inhibitors with an Unusually High Degree of Reactive Metabolite Formation von Wells-Knecht, Kevin J, Ott, Gregory R, Cheng, Mangeng, Wells, Gregory J, Breslin, Henry J, Gingrich, Diane E, Weinberg, Linda, Mesaros, Eugen F, Huang, Zeqi, Yazdanian, Mehran, Ator, Mark A, Aimone, Lisa D, Zeigler, Kelli, Dorsey, Bruce D

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Optimization of a novel kinase inhibitor scaffold for the dual inhibition of JAK2 and FAK kinases von Zificsak, Craig A., Gingrich, Diane E., Breslin, Henry J., Dunn, Derek D., Milkiewicz, Karen L., Theroff, Jay P., Thieu, Tho V., Underiner, Ted L., Weinberg, Linda R., Aimone, Lisa D., Albom, Mark S., Mason, Jennifer L., Saville, Lisa, Husten, Jean, Angeles, Thelma S., Finn, James P., Jan, Mahfuza, O’Kane, Teresa M., Dobrzanski, Pawel, Dorsey, Bruce D.

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Novel triazole based inhibitors of Ras farnesyl transferase von Saha, Ashis K., Liu, Li, Simoneaux, Richard, DeCorte, Bart, Meyer, Christophe, Skrzat, Stacy, Breslin, Henry J., Kukla, Michael J., End, Dave W.

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Identification of potent phenyl imidazoles as opioid receptor agonists von Breslin, Henry J., Cai, Chaozhong, Miskowski, Tamara A., Coutinho, Santosh V., Zhang, Sui-Po, Hornby, Pamela, He, Wei

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Tripeptidyl-peptidase II (TPP II) inhibitory activity of (S)-2,3-dihydro-2-(1H-imidazol-2-yl)-1H-indoles, a systematic SAR evaluation. Part 2 von BRESLIN, Henry J, MISKOWSKI, Tamara A, KUKLA, Michael J, DE WINTER, Hans L, SOMERS, Maria V. F, ROEVENS, Peter W. M, KAVASH, Robert W

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Synthesis and Anti-HIV-1 Activity of 4,5,6,7-Tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one (TIBO) Derivatives. 3 von Breslin, Henry J, Kukla, Michael J, Ludovici, Donald W, Mohrbacher, Richard, Ho, Winston, Miranda, Milton, Rodgers, James D, Hitchens, T. Kevin, Leo, Gregory

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Rationale, Design, and Synthesis of Novel Phenyl Imidazoles as Opioid Receptor Agonists for Gastrointestinal Disorders von Breslin, Henry J, Miskowski, Tamara A, Rafferty, Bryan M, Coutinho, Santosh V, Palmer, Jeffrey M, Wallace, Nathaniel H, Schneider, Craig R, Kimball, Edward S, Zhang, Sui-Po, Li, Jian, Colburn, Raymond W, Stone, Dennis J, Martinez, Rebecca P, He, Wei

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Synthesis and Anti-HIV-1 Activity of 4,5,6,7-Tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one (TlBO) Derivatives. 4 von Ho, Winston, Kukla, Michael J, Breslin, Henry J, Ludovici, Donald W, Grous, Philip P, Diamond, Craig J, Miranda, Milton, Rodgers, James D, Ho, Chih Y

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Design, Synthesis, and Tripeptidyl Peptidase II Inhibitory Activity of a Novel Series of (S)-2,3-Dihydro-2-(4-alkyl-1H-imidazol-2-yl)-1H-indoles von Breslin, Henry J, Miskowski, Tamara A, Kukla, Michael J, Leister, William H, De Winter, Hans L, Gauthier, Diane A, Somers, Maria V. F, Peeters, Daniëlle C. G, Roevens, Peter W. M

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Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one (TIBO) derivatives von Kukla, Michael J, Breslin, Henry J, Pauwels, Rudi, Fedde, Cynthia L, Miranda, Milton, Scott, Malcolm K, Sherrill, Ronald G, Raeymaekers, Alfons, Van Gelder, Jozef

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Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one (TIBO) derivatives. 2 von Kukla, Michael J, Breslin, Henry J, Diamond, Craig J, Grous, Philip P, Ho, Chih Y, Miranda, Milton, Rodgers, James D, Sherrill, Ronald G, De Clercq, Erik, Pauwels, Rudi, Andries, Koen, Moens, Luc J, Janssen, Marcel A. C, Janssen, Paul A. J

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A convenient, large-scale synthesis of 4′-carboxamido N-Boc-2′,6′-dimethyl- l-phenylalanines von Cai, Chaozhong, Breslin, Henry J., He, Wei

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Polycyclic heterocycles from glutaraldehyde in one reaction von Kukla, Michael J, Breslin, Henry J

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Antihypertensive dihydropyridines with 1,4,4-trisubstitution von Kukla, Michael J, Breslin, Henry J, Gill, Alan

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