The Regulatory Role of MicroRNAs in Breast Cancer von Loh, Hui-Yi, Norman, Brendan P, Lai, Kok-Song, Rahman, Nik Mohd Afizan Nik Abd, Alitheen, Noorjahan Banu Mohamed, Osman, Mohd Azuraidi

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Metabolomic studies in the inborn error of metabolism alkaptonuria reveal new biotransformations in tyrosine metabolism von Norman, Brendan P., Davison, Andrew S., Hughes, Juliette H., Sutherland, Hazel, Wilson, Peter JM, Berry, Neil G., Hughes, Andrew T., Milan, Anna M., Jarvis, Jonathan C., Roberts, Norman B., Ranganath, Lakshminarayan R., Bou-Gharios, George, Gallagher, James A.

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Comprehensive Biotransformation Analysis of Phenylalanine-Tyrosine Metabolism Reveals Alternative Routes of Metabolite Clearance in Nitisinone-Treated Alkaptonuria von Norman, Brendan P, Davison, Andrew S, Hickton, Bryony, Ross, Gordon A, Milan, Anna M, Hughes, Andrew T, Wilson, Peter J. M, Sutherland, Hazel, Hughes, Juliette H, Roberts, Norman B, Bou-Gharios, George, Gallagher, James A, Ranganath, Lakshminarayan R

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Impact of Nitisinone on the Cerebrospinal Fluid Metabolome of a Murine Model of Alkaptonuria von Davison, Andrew S, Norman, Brendan P, Sutherland, Hazel, Milan, Anna M, Gallagher, James A, Jarvis, Jonathan C, Ranganath, Lakshminarayan R

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Short-term nitisinone discontinuation of hereditary tyrosinemia type 1 mice causes metabolic alterations in glutathione metabolism/biosynthesis and multiple amino acid degradation... von Haaike, Colemonts-Vroninks, Brendan, Norman P., Sven, Van Laere, Andrew, Davison S., Lionel, Marcélis, Georges, Casimir, Philippe, Goyens, Paul, Claes, Dimitri, De Bundel, Geert, Martens, Rao, Ranganath Lakshminarayan, Tamara, Vanhaecke, James A, Gallagher, Joery, De Kock

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Comparing the Phenylalanine/Tyrosine Pathway and Related Factors between Keratopathy and No-Keratopathy Groups as Well as between Genders in Alkaptonuria during Nitisinone Treatmen... von Ranganath, Lakshminarayan R, Milan, Anna M, Hughes, Andrew T, Davison, Andrew S, Khedr, Milad, Imrich, Richard, Rudebeck, Mattias, Olsson, Birgitta, Norman, Brendan P, Bou-Gharios, George, Gallagher, James A

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Increased prevalence of Parkinson's disease in alkaptonuria von Ranganath, Lakshminarayan, Khedr, Milad, Milan, Anna M., Davison, Andrew S., Norman, Brendan P., Janssen, Mirian C. H., Lock, Edward, Bou‐Gharios, George, Gallagher, James A.

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Revisiting Quantification of Phenylalanine/Tyrosine Flux in the Ochronotic Pathway during Long-Term Nitisinone Treatment of Alkaptonuria von Ranganath, Lakshminarayan R, Hughes, Andrew T, Davison, Andrew S, Khedr, Milad, Imrich, Richard, Rudebeck, Mattias, Olsson, Birgitta, Norman, Brendan P, Bou-Gharios, George, Gallagher, James A, Milan, Anna M

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Comparing nitisinone 2 mg and 10 mg in the treatment of alkaptonuria—An approach using statistical modelling von Ranganath, Lakshminarayan R., Milan, Anna M., Hughes, Andrew T., Khedr, Milad, Norman, Brendan P., Alsbou, Mohammed, Imrich, Richard, Gornall, Matthew, Sireau, Nicolas, Gallagher, James A., Jackson, Richard

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Early Onset Parkinson's Disease in a family of Moroccan origin caused by a p.A217D mutation in PINK1: a case report von Norman, Brendan P, Lubbe, Steven J, Tan, Manuela, Warren, Naomi, Morris, Huw R

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Ochronotic pigmentation is caused by homogentisic acid and is the key event in alkaptonuria leading to the destructive consequences of the disease—A review von Ranganath, Lakshminarayan R., Norman, Brendan P., Gallagher, James A.

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Pigmentation Chemistry and Radical‐Based Collagen Degradation in Alkaptonuria and Osteoarthritic Cartilage von Chow, Wing Ying, Norman, Brendan P., Roberts, Norman B., Ranganath, Lakshminarayan R., Teutloff, Christian, Bittl, Robert, Duer, Melinda J., Gallagher, James A., Oschkinat, Hartmut

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Evaluation of the serum metabolome of patients with alkaptonuria before and after two years of treatment with nitisinone using LC‐QTOF‐MS von Davison, Andrew S., Norman, Brendan P., Ross, Gordon A., Hughes, Andrew T., Khedr, Milad, Milan, Anna M., Gallagher, James A., Ranganath, Lakshminarayan R.

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Efficacy and safety of once-daily nitisinone for patients with alkaptonuria (SONIA 2): an international, multicentre, open-label, randomised controlled trial von Ranganath, Lakshminarayan R, Psarelli, Eftychia Eirini, Arnoux, Jean-Baptiste, Braconi, Daniela, Briggs, Michael, Bröijersén, Anders, Loftus, Nadia, Bygott, Helen, Cox, Trevor F, Davison, Andrew S, Dillon, Jane P, Fisher, Michael, FitzGerald, Richard, Genovese, Federica, Glasova, Helena, Hall, Anthony K, Hughes, Andrew T, Hughes, Juliette H, Imrich, Richard, Jarvis, Jonathan C, Khedr, Milad, Laan, Dinny, Le Quan Sang, Kim-Hanh, Luangrath, Emily, Lukáčová, Ol'ga, Milan, Anna M, Mistry, Alpesh, Mlynáriková, Vanda, Norman, Brendan P, Olsson, Birgitta, Rhodes, Nicholas P, Rovenský, Jozef, Rudebeck, Mattias, Santucci, Annalisa, Shweihdi, Ella, Scott, Ciarán, Sedláková, Jana, Sireau, Nicolas, Stančík, Roman, Szamosi, Johan, Taylor, Sophie, van Kan, Christa, Vinjamuri, Sobhan, Vrtíková, Eva, Webb, Chris, West, Elizabeth, Záňová, Elizabeth, Zatkova, Andrea, Gallagher, James A

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A Comprehensive LC-QTOF-MS Metabolic Phenotyping Strategy: Application to Alkaptonuria von Norman, Brendan P, Davison, Andrew S, Ross, Gordon A, Milan, Anna M, Hughes, Andrew T, Sutherland, Hazel, Jarvis, Jonathan C, Roberts, Norman B, Gallagher, James A, Ranganath, Lakshminarayan R

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Post-Transcriptional Regulatory Crosstalk between MicroRNAs and Canonical TGF-β/BMP Signalling Cascades on Osteoblast Lineage: A Comprehensive Review von Loh, Hui-Yi, Norman, Brendan P, Lai, Kok-Song, Cheng, Wan-Hee, Nik Abd Rahman, Nik Mohd Afizan, Mohamed Alitheen, Noorjahan Banu, Osman, Mohd Azuraidi

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Conditional targeting in mice reveals that hepatic homogentisate 1,2-dioxygenase activity is essential in reducing circulating homogentisic acid and for effective therapy in the ge... von Hughes, Juliette H, Liu, Ke, Plagge, Antonius, Wilson, Peter J M, Sutherland, Hazel, Norman, Brendan P, Hughes, Andrew T, Keenan, Craig M, Milan, Anna M, Sakai, Takao, Ranganath, Lakshminarayan R, Gallagher, James A, Bou-Gharios, George

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Nitisinone causes acquired tyrosinosis in alkaptonuria von Khedr, Milad, Cooper, Maggie S., Hughes, Andrew T., Milan, Anna M., Davison, Andrew S., Norman, Brendan P., Sutherland, Hazel, Jarvis, Jonathan C., Fitzgerald, Richard, Markinson, Louise, Psarelli, Eftychia‐Eirini, Ghane, Parisa, Deutz, Nicolaas E. P., Gallagher, James A., Ranganath, Lakshminarayan R.

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Homogentisic acid is not only eliminated by glomerular filtration and tubular secretion but also produced in the kidney in alkaptonuria von Ranganath, Lakshminarayan R., Milan, Anna M., Hughes, Andrew T., Khedr, Milad, Davison, Andrew S., Shweihdi, Ella, Norman, Brendan P., Hughes, Juliette H., Bygott, Helen, Luangrath, Emily, Fitzgerald, Richard, Psarelli, Eftychia E., Kan, Christa, Laan, Dinny, Olsson, Birgitta, Rudebeck, Mattias, Mankowitz, Louise, Sireau, Nicolas, Arnoux, Jean‐Baptiste, Le Quan Sang, Kim‐Hanh, Jarvis, Jonathan C., Genovese, Federica, Braconi, Daniela, Santucci, Annalisa, Zatkova, Andrea, Glasova, Helena, Stančík, Roman, Imrich, Richard, Rhodes, Nicholas P., Gallagher, James A.

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Pigmentierungschemie und radikalbasierter Kollagenabbau bei Alkaptonurie und Arthrose von Chow, Wing Ying, Norman, Brendan P., Roberts, Norman B., Ranganath, Lakshminarayan R., Teutloff, Christian, Bittl, Robert, Duer, Melinda J., Gallagher, James A., Oschkinat, Hartmut

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