Role of CCK and potential utility of CCK1 receptor antagonism in the treatment of pancreatitis induced by biliary tract obstruction von Barrett, T D, Yan, W, Freedman, J M, Lagaud, G J, Breitenbucher, J G, Shankley, N P

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Exploiting Subsite S1 of Trypsin-Like Serine Proteases for Selectivity:  Potent and Selective Inhibitors of Urokinase-Type Plasminogen Activator von Mackman, Richard L, Katz, Bradley A, Breitenbucher, J. Guy, Hui, Hon C, Verner, Erik, Luong, Christine, Liu, Liang, Sprengeler, Paul A

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Identification and Biological Evaluation of 4-(3-Trifluoromethylpyridin-2-yl)piperazine-1-carboxylic Acid (5-Trifluoromethylpyridin-2-yl)amide, a High Affinity TRPV1 (VR1) Vanilloi... von Swanson, Devin M, Dubin, Adrienne E, Shah, Chandra, Nasser, Nadia, Chang, Leon, Dax, Scott L, Jetter, Michele, Breitenbucher, J. Guy, Liu, Changlu, Mazur, Curt, Lord, Brian, Gonzales, Lisa, Hoey, Kenway, Rizzolio, Michele, Bogenstaetter, Michael, Codd, Ellen E, Lee, Doo H, Zhang, Sui-Po, Chaplan, Sandra R, Carruthers, Nicholas I

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Checkpoint Kinase Inhibitors:  SAR and Radioprotective Properties of a Series of 2-Arylbenzimidazoles von Arienti, Kristen L, Brunmark, Anders, Axe, Frank U, McClure, Kelly, Lee, Alice, Blevitt, Jon, Neff, Danielle K, Huang, Liming, Crawford, Shelby, Pandit, Chennagiri R, Karlsson, Lars, Breitenbucher, J. Guy

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Solid-phase synthesis of 4-aryl-1,4-dihydropyridines via the Hantzsch three component condensation von Breitenbucher, J.Guy, Figliozzi, Gina

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Characterization of 2-(2,6-dichloro-benzyl)-thiazolo[5,4- d]pyrimidin-7-yl]-(4-trifluoromethyl-phenyl)-amine (JNJ-39729209) as a novel TRPV1 antagonist von Maher, Michael P., Bhattacharya, Anindya, Ao, Hong, Swanson, Nadia, Wu, Nyan-Tsz, Freedman, Jamie, Kansagara, Mena, Scott, Brian, Li, Dong H., Eckert, William A., Liu, Yi, Sepassi, Kia, Rizzolio, Michele, Fitzgerald, Anne, Liu, Jing, Branstetter, Bryan J., Rech, Jason C., Lebsack, Alec D., Breitenbucher, J. Guy, Wickenden, Alan D., Chaplan, Sandra R.

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A general route for the synthesis of enantiopure indolizidine alkaloids from α-amino acids. Total synthesis of (+)-Monomorine von Angle, Steven R., Breitenbucher, J.Guy

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Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrimido-[4,5-d]azepines as novel TRPV1 antagonists von HAWRYLUK, Natalie A, MERIT, Jeffrey E, FREEDMAN, Jamie M, SCOTT, Brian P, WICKENDEN, Alan D, CHAPLAN, Sandra R, BREITENBUCHER, J. Guy, LEBSACK, Alec D, BRANSTETTER, Bryan J, HACK, Michael D, SWANSON, Nadia, HONG AO, MAHER, Michael P, BHATTACHARYA, Anindya, QI WANG

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Non-imidazole heterocyclic histamine H 3 receptor antagonists von Chai, Wenying, Breitenbucher, J.Guy, Kwok, Annette, Li, Xiaobing, Wong, Victoria, Carruthers, Nicholas I., Lovenberg, Timothy W., Mazur, Curt, Wilson, Sandy J., Axe, Frank U., Jones, Todd K.

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Novel non-benzimidazole chk2 kinase inhibitors von McClure, Kelly J., Huang, Liming, Arienti, Kristen L., Axe, Frank U., Brunmark, Anders, Blevitt, Jon, Guy Breitenbucher, J.

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Pyrazole CCK1 receptor antagonists. Part 2: SAR studies by solid-phase library synthesis and determination of Free-Wilson additivity von SEHON, Clark, MCCLURE, Kelly, HACK, Michael, MORTON, Magda, GOMEZ, Laurent, LI, Lina, BARRETT, Terrance D, SHANKLEY, Nigel, BREITENBUCHER, J. Guy

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Allylic coupling between electrophilic molybdenum and nucleophilic iron allyl complexes von Berryhill, S.R., Breitenbucher, J.G.

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Pyrazole CCK1 receptor antagonists. Part 1: Solution-phase library synthesis and determination of Free-Wilson additivity von MCCLURE, Kelly, HACK, Michael, LIMING HUANG, SEHON, Clark, MORTON, Magda, LINA LI, BARRETT, Terrance D, SHANKLEY, Nigel, BREITENBUCHER, J. Guy

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2-(2-Hydroxy-3-alkoxyphenyl)-1H-benzimidazole-5-carboxamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors von MACKMAN, Richard L, HUI, Hon C, SPRENGELER, Paul A, TARIO, James, VERNER, Erik, JING WANG, BREITENBUCHER, J. Guy, KATZ, Bradley A, LUONG, Christine, MARTELLI, Arnold, MCGEE, Danny, RADIKA, Kesavan, SENDZIK, Martin, SPENCER, Jeffrey R

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Novel human histamine H 3 receptor antagonists von Shah, Chandra, McAtee, Laura, Breitenbucher, J.Guy, Rudolph, Dale, Li, Xiaobing, Lovenberg, Timothy W, Mazur, Curt, Wilson, Sandy J, Carruthers, Nicholas I

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Inhibition of fatty acid amide hydrolase produces analgesia by multiple mechanisms von Chang, Leon, Luo, Lin, Palmer, James A, Sutton, Steven, Wilson, Sandy J, Barbier, Ann J, Breitenbucher, James Guy, Chaplan, Sandra R, Webb, Michael

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Titanium mediated reductive amination on solid support: Extending the utility of the 4-hydroxy-thiophenol linker von Breitenbucher, J.Guy, Hui, Hon C

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Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets von Katz, Bradley A, Sprengeler, Paul A, Luong, Christine, Verner, Erik, Elrod, Kyle, Kirtley, Matt, Janc, James, Spencer, Jeffrey R, Breitenbucher, J.Guy, Hui, Hon, McGee, Danny, Allen, Darin, Martelli, Arnold, Mackman, Richard L

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Generation of a piperazine-2-carboxamide library: A practical application of the phenol-sulfide react and release linker von Guy Breitenbucher, J., Johnson, Charles R., Haight, Mathew, Christopher Phelan, J.

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An efficient stereoselective synthesis of Δ4,5-pipecolic esters von ANGLE, S. R, BREITENBUCHER, J. G, ARNAIZ, D. O

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