Genomic Approaches to Understanding Response and Resistance to Immunotherapy von Braun, David A, Burke, Kelly P, Van Allen, Eliezer M

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Cytokine Response Is Determined by Duration of Receptor and Signal Transducers and Activators of Transcription 3 (STAT3) Activation von Braun, David A., Fribourg, Miguel, Sealfon, Stuart C.

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Germline variants associated with toxicity to immune checkpoint blockade von Groha, Stefan, Alaiwi, Sarah Abou, Xu, Wenxin, Naranbhai, Vivek, Nassar, Amin H., Bakouny, Ziad, El Zarif, Talal, Saliby, Renee Maria, Wan, Guihong, Rajeh, Ahmad, Adib, Elio, Nuzzo, Pier V., Schmidt, Andrew L., Labaki, Chris, Ricciuti, Biagio, Alessi, Joao Victor, Braun, David A., Shukla, Sachet A., Keenan, Tanya E., Van Allen, Eliezer, Awad, Mark M., Manos, Michael, Rahma, Osama, Zubiri, Leyre, Villani, Alexandra-Chloe, Fairfax, Benjamin, Hammer, Christian, Khan, Zia, Reynolds, Kerry, Semenov, Yevgeniy, Schrag, Deborah, Kehl, Kenneth L., Freedman, Matthew L., Choueiri, Toni K., Gusev, Alexander

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irRECIST for the Evaluation of Candidate Biomarkers of Response to Nivolumab in Metastatic Clear Cell Renal Cell Carcinoma: Analysis of a Phase II Prospective Clinical Trial von Pignon, Jean-Christophe, Jegede, Opeyemi, Shukla, Sachet A, Braun, David A, Horak, Christine E, Wind-Rotolo, Megan, Ishii, Yuko, Catalano, Paul J, Grosha, Jonian, Flaifel, Abdallah, Novak, Jesse S, Mahoney, Kathleen M, Freeman, Gordon J, Sharpe, Arlene H, Hodi, F Stephen, Motzer, Robert J, Choueiri, Toni K, Wu, Catherine J, Atkins, Michael B, McDermott, David F, Signoretti, Sabina

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Activity of cabozantinib after immune checkpoint blockade in metastatic clear-cell renal cell carcinoma von McGregor, Bradley A., Lalani, Aly-Khan A., Xie, Wanling, Steinharter, John A., E. Bakouny, Ziad, Martini, Dylan J., Fleischer, Justin H., Abou-Alaiwi, Sarah, Nassar, Amin, Nuzzo, Pier V., Kaymakcalan, Marina D., Braun, David A., Wei, Xiao X., Harshman, Lauren C., Bilen, Mehmet A., Choueiri, Toni K.

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PAK4-targeted PROTACs in clear cell renal cell carcinoma: a two-for-one targeted and immune therapy? von Bakouny, Ziad, Braun, David A., Reznik, Ed, Hakimi, A. Ari

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The Transcriptional Activator Krüppel-like Factor-6 Is Required for CNS Myelination von Laitman, Benjamin M, Asp, Linnéa, Mariani, John N, Zhang, Jingya, Liu, Jia, Sawai, Setsu, Chapouly, Candice, Horng, Sam, Kramer, Elisabeth G, Mitiku, Nesanet, Loo, Hannah, Burlant, Natalie, Pedre, Xiomara, Hara, Yuko, Nudelman, German, Zaslavsky, Elena, Lee, Young-Min, Braun, David A, Lu, Q Richard, Narla, Goutham, Raine, Cedric S, Friedman, Scott L, Casaccia, Patrizia, John, Gareth R

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Beyond conventional immune-checkpoint inhibition — novel immunotherapies for renal cell carcinoma von Braun, David A., Bakouny, Ziad, Hirsch, Laure, Flippot, Ronan, Van Allen, Eliezer M., Wu, Catherine J., Choueiri, Toni K.

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Applying high-dimensional single-cell technologies to the analysis of cancer immunotherapy von Gohil, Satyen H., Iorgulescu, J. Bryan, Braun, David A., Keskin, Derin B., Livak, Kenneth J.

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Immune dysfunction revealed by digital spatial profiling of immuno-oncology markers in progressive stages of renal cell carcinoma and in brain metastases von Schoenfeld, David A, Moutafi, Myrto, Martinez, Sandra, Djureinovic, Dijana, Merkin, Ross D, Adeniran, Adebowale, Braun, David A, Signoretti, Sabina, Choueiri, Toni K, Parisi, Fabio, Hurwitz, Michael, Rimm, David L, Wei, Wei, Jilaveanu, Lucia, Kluger, Harriet M

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Leveraging immune resistance archetypes in solid cancer to inform next-generation anticancer therapies von Anderson, Kristin G, Braun, David A, Buqué, Aitziber, Gitto, Sarah B, Guerriero, Jennifer L, Horton, Brendan, Keenan, Bridget P, Kim, Teresa S, Overacre-Delgoffe, Abigail, Ruella, Marco, Triplett, Todd A, Veeranki, Omkara, Verma, Vivek, Zhang, Fan

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Immune-restoring CAR-T cells display antitumor activity and reverse immunosuppressive TME in a humanized ccRCC mouse model von Wang, Yufei, Cho, Jae-Won, Kastrunes, Gabriella, Buck, Alicia, Razimbaud, Cecile, Culhane, Aedin C., Sun, Jiusong, Braun, David A., Choueiri, Toni K., Wu, Catherine J., Jones, Kristen, Nguyen, Quang-De, Zhu, Zhu, Wei, Kevin, Zhu, Quan, Signoretti, Sabina, Freeman, Gordon J., Hemberg, Martin, Marasco, Wayne A.

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Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in advanced clear cell renal cell carcinoma von Braun, David A., Hou, Yue, Bakouny, Ziad, Ficial, Miriam, Sant’ Angelo, Miriam, Forman, Juliet, Ross-Macdonald, Petra, Berger, Ashton C., Jegede, Opeyemi A., Elagina, Liudmilla, Steinharter, John, Sun, Maxine, Wind-Rotolo, Megan, Pignon, Jean-Christophe, Cherniack, Andrew D., Lichtenstein, Lee, Neuberg, Donna, Catalano, Paul, Freeman, Gordon J., Sharpe, Arlene H., McDermott, David F., Van Allen, Eliezer M., Signoretti, Sabina, Wu, Catherine J., Shukla, Sachet A., Choueiri, Toni K.

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Tumor and immune reprogramming during immunotherapy in advanced renal cell carcinoma von Bi, Kevin, He, Meng Xiao, Bakouny, Ziad, Kanodia, Abhay, Napolitano, Sara, Wu, Jingyi, Grimaldi, Grace, Braun, David A., Cuoco, Michael S., Mayorga, Angie, DelloStritto, Laura, Bouchard, Gabrielle, Steinharter, John, Tewari, Alok K., Vokes, Natalie I., Shannon, Erin, Sun, Maxine, Park, Jihye, Chang, Steven L., McGregor, Bradley A., Haq, Rizwan, Denize, Thomas, Signoretti, Sabina, Guerriero, Jennifer L., Vigneau, Sébastien, Rozenblatt-Rosen, Orit, Rotem, Asaf, Regev, Aviv, Choueiri, Toni K., Van Allen, Eliezer M.

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Progressive immune dysfunction with advancing disease stage in renal cell carcinoma von Braun, David A., Street, Kelly, Burke, Kelly P., Cookmeyer, David L., Denize, Thomas, Pedersen, Christina B., Gohil, Satyen H., Schindler, Nicholas, Pomerance, Lucas, Hirsch, Laure, Bakouny, Ziad, Hou, Yue, Forman, Juliet, Huang, Teddy, Li, Shuqiang, Cui, Ang, Keskin, Derin B., Steinharter, John, Bouchard, Gabrielle, Sun, Maxine, Pimenta, Erica M., Xu, Wenxin, Mahoney, Kathleen M., McGregor, Bradley A., Hirsch, Michelle S., Chang, Steven L., Livak, Kenneth J., McDermott, David F., Shukla, Sachet A., Olsen, Lars R., Signoretti, Sabina, Sharpe, Arlene H., Irizarry, Rafael A., Choueiri, Toni K., Wu, Catherine J.

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Tumor-Infiltrating T Cells — A Portrait von Braun, David A., Wu, Catherine J.

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A large peptidome dataset improves HLA class I epitope prediction across most of the human population von Sarkizova, Siranush, Klaeger, Susan, Le, Phuong M., Li, Letitia W., Oliveira, Giacomo, Keshishian, Hasmik, Hartigan, Christina R., Zhang, Wandi, Braun, David A., Ligon, Keith L., Bachireddy, Pavan, Zervantonakis, Ioannis K., Rosenbluth, Jennifer M., Ouspenskaia, Tamara, Law, Travis, Justesen, Sune, Stevens, Jonathan, Lane, William J., Eisenhaure, Thomas, Lan Zhang, Guang, Clauser, Karl R., Hacohen, Nir, Carr, Steven A., Wu, Catherine J., Keskin, Derin B.

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Water availability and plant-herbivore interactions von Lin, Po-An, Kansman, Jessica, Chuang, Wen-Po, Robert, Christelle, Erb, Matthias, Felton, Gary W

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Optimized Management of Nivolumab and Ipilimumab in Advanced Renal Cell Carcinoma: A Response-Based Phase II Study (OMNIVORE) von McKay, Rana R, McGregor, Bradley A, Xie, Wanling, Braun, David A, Wei, Xiao, Kyriakopoulos, Christos E, Zakharia, Yousef, Maughan, Benjamin L, Rose, Tracy L, Stadler, Walter M, McDermott, David F, Harshman, Lauren C, Choueiri, Toni K

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HLA-A03 and response to immune checkpoint blockade in cancer: an epidemiological biomarker study von Naranbhai, Vivek, Viard, Mathias, Dean, Michael, Groha, Stefan, Braun, David A, Labaki, Chris, Shukla, Sachet A, Yuki, Yuko, Shah, Parantu, Chin, Kevin, Wind-Rotolo, Megan, Mu, Xinmeng Jasmine, Robbins, Paul B, Gusev, Alexander, Choueiri, Toni K, Gulley, James L, Carrington, Mary

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