P04.04.A A comprehensive genomic study of 390 H3F3A-mutant pediatric-type diffuse high-grade gliomas WHO CNS grade 4 von Willimas, E A, Brastianos, P K, Wakimoto, H, Santagata, S, Cahill, D P, Juratli, T A

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Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S von Sevenich, Lisa, Bowman, Robert L., Mason, Steven D., Quail, Daniela F., Rapaport, Franck, Elie, Benelita T., Brogi, Edi, Brastianos, Priscilla K., Hahn, William C., Holsinger, Leslie J., Massagué, Joan, Leslie, Christina S., Joyce, Johanna A.

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318PAssociation between PIK3CA mutation status and development of brain metastases in HR+/HER2- metastatic breast cancer von Fitzgerald, D M, Muzikansky, A, Pinto, C, Henderson, L, Walmsley, C, Allen, R, Ferraro, G B, Isakoff, S, Moy, B, Oh, K, Shih, H A, Dias-Santagata, D, Iafrate, A J, Bardia, A, Brastianos, P K, Juric, D

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OS06.4 Identification of novel NTRK fusion in glioneuronal tumors and radiographic response following therapy with an NTRK inhibitor von Brastianos, P. K., Alvarez-Breckenridge, C., Miller, J. J., Nayyar, N., Gill, C., Dias-Santagata, D., Santagata, S., Multani, P., Yip, S., Cahill, D., Iafrate, A. J., Batchelor, T.

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Abstract P1-01-01: The blood-Tumor barrier as a therapeutic target to improve therapy of brain metastases of breast cancer von Steeg, PS, Lyle, TR, Paranjapee, A, Lockman, PR, Duchnowska, R, Brastianos, PK, Peer, C, Figg, WD, Pauly, GT, Schneider, JP, Smith, QR, Gril, B

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Abstract P1-12-03: Association between tumor genotype and development of brain metastases in patients with hormone receptor positive (HR+)/HER2- metastatic breast cancer von Fitzgerald, DM, Henderson, LE, Isakoff, SJ, Moy, B, Oh, K, Shih, HA, Dias-Santagata, D, Borger, DR, Iafrate, AJ, Brastianos, PK, Bardia, A, Juric, D

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Pervasive chromosomal instability and karyotype order in tumour evolution von Watkins, TBK, Lim, EL, Petkovic, M, Elizalde, S, Birkbak, NJ, Wilson, GA, Moore, DA, Grönroos, E, Rowan, A, Dewhurst, SM, Demeulemeester, J, Dentro, SC, Horswell, S, Au, L, Haase, K, Escudero, M, Rosenthal, R, Bakir, MA, Xu, H, Litchfield, K, Lu, WT, Mourikis, TP, Dietzen, M, Spain, L, Cresswell, GD, Biswas, D, Lamy, P, Nordentoft, I, Harbst, K, Castro-Giner, F, Yates, LR, Caramia, F, Jaulin, F, Vicier, C, Tomlinson, IPM, Brastianos, PK, Cho, RJ, Bastian, BC, Dyrskjøt, L, Jönsson, GB, Savas, P, Loi, S, Campbell, PJ, Andre, F, Luscombe, NM, Steeghs, N, Tjan-Heijnen, VCG, Szallasi, Z, Turajlic, S, Jamal-Hanjani, M, Van Loo, P, Bakhoum, SF, Schwarz, RF, McGranahan, N, Swanton, C

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Longitudinal Molecular Trajectories of Diffuse Glioma in Adults von Barthel, FP, Johnson, KC, Varn, FS, Moskalik, AD, Tanner, G, Kocakavuk, E, Anderson, KJ, Abiola, O, Aldape, K, Alfaro, KD, Alpar, D, Amin, SB, Ashley, DM, Bandopadhayay, P, Barnholtz-Sloan, JS, Beroukhim, R, Bock, C, Brastianos, PK, Brat, DJ, Brodbelt, AR, Bruns, A, Bulsara, KR, Chakrabarty, A, Chakravarti, A, Chuang, JH, Claus, EB, Cochran, EJ, Connelly, J, Costello, JF, Finocchiaro, G, Fletcher, MN, French, PJ, Gan, HK, Gilbert, MR, Gould, PV, Grimmer, MR, Iavarone, A, Ismail, A, Jenkinson, MD, Khasraw, M, Kim, H, Kouwenhoven, MCM, LaViolette, PS, Li, M, Lichter, P, Ligon, KL, Lowman, AK, Malta, TM, Mazor, T, McDonald, KL, Molinaro, AM, Nam, DH, Nayyar, N, Ng, HK, Ngan, CY, Niclou, SP, Niers, JM, Nouchmehr, H, Noorbakhsh, J, Ormond, DR, Park, CK, Poisson, LM, Rabadan, R, Radlwimmer, B, Rao, G, Reifenberger, G, Sa, JK, Schuster, M, Shaw, BL, Short, SC, Sillevis Smitt, PA, Sloan, AE, Smits, M, Suzuki, H, Tabatabai, G, Van Meir, EG, Watts, C, Weller, M, Wesseling, P, Westerman, BA, Widhalm, G, Woehrer, A, Alfred Yung, WK, Zadeh, G, Huse, JT, de Groot, JF, Stead, LF, Verhaak, RGW, GLASS Consortium

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Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq von Venteicher, Andrew S., Tirosh, Itay, Hebert, Christine, Yizhak, Keren, Neftel, Cyril, Filbin, Mariella G., Hovestadt, Volker, Escalante, Leah E., Shaw, McKenzie L., Rodman, Christopher, Gillespie, Shawn M., Dionne, Danielle, Luo, Christina C., Ravichandran, Hiranmayi, Mylvaganam, Ravindra, Mount, Christopher, Onozato, Maristela L., Nahed, Brian V., Wakimoto, Hiroaki, Curry, William T., Iafrate, A. John, Rivera, Miguel N., Frosch, Matthew P., Golub, Todd R., Brastianos, Priscilla K., Getz, Gad, Patel, Anoop P., Monje, Michelle, Cahill, Daniel P., Rozenblatt-Rosen, Orit, Louis, David N., Bernstein, Bradley E., Regev, Aviv, Suvà, Mario L.

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Consensus recommendations for a standardized brain tumor imaging protocol for clinical trials in brain metastases von Kaufmann, Timothy J, Smits, Marion, Boxerman, Jerrold, Huang, Raymond, Barboriak, Daniel P, Weller, Michael, Chung, Caroline, Tsien, Christina, Brown, Paul D, Shankar, Lalitha, Galanis, Evanthia, Gerstner, Elizabeth, van den Bent, Martin J, Burns, Terry C, Parney, Ian F, Dunn, Gavin, Brastianos, Priscilla K, Lin, Nancy U, Wen, Patrick Y, Ellingson, Benjamin M

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Dramatic Response of BRAF V600E Mutant Papillary Craniopharyngioma to Targeted Therapy von Brastianos, Priscilla K, Shankar, Ganesh M, Gill, Corey M, Taylor-Weiner, Amaro, Nayyar, Naema, Panka, David J, Sullivan, Ryan J, Frederick, Dennie T, Abedalthagafi, Malak, Jones, Pamela S, Dunn, Ian F, Nahed, Brian V, Romero, Javier M, Louis, David N, Getz, Gad, Cahill, Daniel P, Santagata, Sandro, Curry, Jr, William T, Barker, 2nd, Fred G

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An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma von Neftel, Cyril, Laffy, Julie, Filbin, Mariella G., Hara, Toshiro, Shore, Marni E., Rahme, Gilbert J., Richman, Alyssa R., Silverbush, Dana, Shaw, McKenzie L., Hebert, Christine M., Dewitt, John, Gritsch, Simon, Perez, Elizabeth M., Gonzalez Castro, L. Nicolas, Lan, Xiaoyang, Druck, Nicholas, Rodman, Christopher, Dionne, Danielle, Kaplan, Alexander, Bertalan, Mia S., Small, Julia, Pelton, Kristine, Becker, Sarah, Bonal, Dennis, Nguyen, Quang-De, Servis, Rachel L., Fung, Jeremy M., Mylvaganam, Ravindra, Mayr, Lisa, Gojo, Johannes, Haberler, Christine, Geyeregger, Rene, Czech, Thomas, Slavc, Irene, Nahed, Brian V., Curry, William T., Carter, Bob S., Wakimoto, Hiroaki, Brastianos, Priscilla K., Batchelor, Tracy T., Stemmer-Rachamimov, Anat, Martinez-Lage, Maria, Frosch, Matthew P., Stamenkovic, Ivan, Riggi, Nicolo, Rheinbay, Esther, Monje, Michelle, Rozenblatt-Rosen, Orit, Cahill, Daniel P., Patel, Anoop P., Hunter, Tony, Verma, Inder M., Ligon, Keith L., Louis, David N., Regev, Aviv, Bernstein, Bradley E., Tirosh, Itay, Suvà, Mario L.

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Updates in prognostic markers for gliomas von Aquilanti, Elisa, Miller, Julie, Santagata, Sandro, Cahill, Daniel P, Brastianos, Priscilla K

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Phase 2 study of pembrolizumab in patients with recurrent and residual high-grade meningiomas von Brastianos, Priscilla K., Kim, Albert E., Giobbie-Hurder, Anita, Lee, Eudocia Quant, Wang, Nancy, Eichler, April F., Chukwueke, Ugonma, Forst, Deborah A., Arrillaga-Romany, Isabel C., Dietrich, Jorg, Corbin, Zachary, Moliterno, Jennifer, Baehring, Joachim, White, Michael, Lou, Kevin W., Larson, Juliana, de Sauvage, Magali A., Evancic, Kathryn, Mora, Joana, Nayyar, Naema, Loeffler, Jay, Oh, Kevin, Shih, Helen A., Curry, William T., Cahill, Daniel P., Barker, Fred G., Gerstner, Elizabeth R., Santagata, Sandro

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The Dual PI3K/mTOR Pathway Inhibitor GDC-0084 Achieves Antitumor Activity in PIK3CA -Mutant Breast Cancer Brain Metastases von Ippen, Franziska M, Alvarez-Breckenridge, Christopher A, Kuter, Benjamin M, Fink, Alexandria L, Bihun, Ivanna V, Lastrapes, Matthew, Penson, Tristan, Schmidt, Stephen P, Wojtkiewicz, Gregory R, Ning, Jianfang, Subramanian, Megha, Giobbie-Hurder, Anita, Martinez-Lage, Maria, Carter, Scott L, Cahill, Daniel P, Wakimoto, Hiroaki, Brastianos, Priscilla K

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Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis von Mathewson, Nathan D., Ashenberg, Orr, Tirosh, Itay, Gritsch, Simon, Perez, Elizabeth M., Marx, Sascha, Jerby-Arnon, Livnat, Chanoch-Myers, Rony, Hara, Toshiro, Richman, Alyssa R., Ito, Yoshinaga, Pyrdol, Jason, Friedrich, Mirco, Schumann, Kathrin, Poitras, Michael J., Gokhale, Prafulla C., Gonzalez Castro, L. Nicolas, Shore, Marni E., Hebert, Christine M., Shaw, Brian, Cahill, Heather L., Drummond, Matthew, Zhang, Wubing, Olawoyin, Olamide, Wakimoto, Hiroaki, Rozenblatt-Rosen, Orit, Brastianos, Priscilla K., Liu, X. Shirley, Jones, Pamela S., Cahill, Daniel P., Frosch, Matthew P., Louis, David N., Freeman, Gordon J., Ligon, Keith L., Marson, Alexander, Chiocca, E. Antonio, Reardon, David A., Regev, Aviv, Suvà, Mario L., Wucherpfennig, Kai W.

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Reactive astrocytic S1P3 signaling modulates the blood–tumor barrier in brain metastases von Gril, Brunilde, Paranjape, Anurag N., Woditschka, Stephan, Hua, Emily, Dolan, Emma L., Hanson, Jeffrey, Wu, Xiaolin, Kloc, Wojciech, Izycka-Swieszewska, Ewa, Duchnowska, Renata, Pęksa, Rafał, Biernat, Wojciech, Jassem, Jacek, Nayyar, Naema, Brastianos, Priscilla K., Hall, O. Morgan, Peer, Cody J., Figg, William D., Pauly, Gary T., Robinson, Christina, Difilippantonio, Simone, Bialecki, Emilie, Metellus, Philippe, Schneider, Joel P., Steeg, Patricia S.

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Thrombosis, brain metastasis formation, and the perivascular metastatic niche-Novel insights from the tumor microvascular circulation von Alvarez-Breckenridge, Christopher, Brastianos, Priscilla K, Cahill, Daniel P

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Systemic Therapy of Brain Metastases von Brastianos, Harry C., Cahill, Daniel P., Brastianos, Priscilla K.

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Genomic and transcriptomic correlates of immunotherapy response within the tumor microenvironment of leptomeningeal metastases von Prakadan, Sanjay M., Alvarez-Breckenridge, Christopher A., Markson, Samuel C., Kim, Albert E., Klein, Robert H., Nayyar, Naema, Navia, Andrew W., Kuter, Benjamin M., Kolb, Kellie E., Bihun, Ivanna, Mora, Joana L., Bertalan, Mia Solana, Shaw, Brian, White, Michael, Kaplan, Alexander, Stocking, Jackson H., Wadsworth, Marc H., Lee, Eudocia Q., Chukwueke, Ugonma, Wang, Nancy, Subramanian, Megha, Rotem, Denisse, Cahill, Daniel P., Adalsteinsson, Viktor A., Miller, Jeffrey W., Sullivan, Ryan J., Carter, Scott L., Brastianos, Priscilla K., Shalek, Alex K.

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