MLL partial tandem duplication leukemia cells are sensitive to small molecule DOT1L inhibition von Kühn, Michael W M, Hadler, Michael J, Daigle, Scott R, Koche, Richard P, Krivtsov, Andrei V, Olhava, Edward J, Caligiuri, Michael A, Huang, Gang, Bradner, James E, Pollock, Roy M, Armstrong, Scott A

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Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers von Lovén, Jakob, Hoke, Heather A., Lin, Charles Y., Lau, Ashley, Orlando, David A., Vakoc, Christopher R., Bradner, James E., Lee, Tong Ihn, Young, Richard A.

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Transcriptional Amplification in Tumor Cells with Elevated c-Myc von Lin, Charles Y., Lovén, Jakob, Rahl, Peter B., Paranal, Ronald M., Burge, Christopher B., Bradner, James E., Lee, Tong Ihn, Young, Richard A.

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Convergence of Developmental and Oncogenic Signaling Pathways at Transcriptional Super-Enhancers von Hnisz, Denes, Schuijers, Jurian, Lin, Charles Y., Weintraub, Abraham S., Abraham, Brian J., Lee, Tong Ihn, Bradner, James E., Young, Richard A.

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RNA Exosome-Regulated Long Non-Coding RNA Transcription Controls Super-Enhancer Activity von Pefanis, Evangelos, Wang, Jiguang, Rothschild, Gerson, Lim, Junghyun, Kazadi, David, Sun, Jianbo, Federation, Alexander, Chao, Jaime, Elliott, Oliver, Liu, Zhi-Ping, Economides, Aris N., Bradner, James E., Rabadan, Raul, Basu, Uttiya

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Phthalimide conjugation as a strategy for in vivo target protein degradation von Winter, Georg E., Buckley, Dennis L., Paulk, Joshiawa, Roberts, Justin M., Souza, Amanda, Dhe-Paganon, Sirano, Bradner, James E.

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Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance von Marcotte, Richard, Sayad, Azin, Brown, Kevin R., Sanchez-Garcia, Felix, Reimand, Jüri, Haider, Maliha, Virtanen, Carl, Bradner, James E., Bader, Gary D., Mills, Gordon B., Pe’er, Dana, Moffat, Jason, Neel, Benjamin G.

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Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins von Lockwood, William W., Zejnullahu, Kreshnik, Bradner, James E., Varmus, Harold

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BET Bromodomain Inhibition Promotes Anti-tumor Immunity by Suppressing PD-L1 Expression von Zhu, Hengrui, Bengsch, Fee, Svoronos, Nikolaos, Rutkowski, Melanie R., Bitler, Benjamin G., Allegrezza, Michael J., Yokoyama, Yuhki, Kossenkov, Andrew V., Bradner, James E., Conejo-Garcia, Jose R., Zhang, Rugang

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Discovery and Characterization of Super-Enhancer-Associated Dependencies in Diffuse Large B Cell Lymphoma von Chapuy, Bjoern, McKeown, Michael R., Lin, Charles Y., Monti, Stefano, Roemer, Margaretha G.M., Qi, Jun, Rahl, Peter B., Sun, Heather H., Yeda, Kelly T., Doench, John G., Reichert, Elaine, Kung, Andrew L., Rodig, Scott J., Young, Richard A., Shipp, Margaret A., Bradner, James E.

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A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader von Huang, Hai-Tsang, Dobrovolsky, Dennis, Paulk, Joshiawa, Yang, Guang, Weisberg, Ellen L., Doctor, Zainab M., Buckley, Dennis L., Cho, Joong-Heui, Ko, Eunhwa, Jang, Jaebong, Shi, Kun, Choi, Hwan Geun, Griffin, James D., Li, Ying, Treon, Steven P., Fischer, Eric S., Bradner, James E., Tan, Li, Gray, Nathanael S.

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The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins von Lu, Gang, Middleton, Richard E., Sun, Huahang, Naniong, MarkVic, Ott, Christopher J., Mitsiades, Constantine S., Wong, Kwok-Kin, Bradner, James E., Kaelin, William G.

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Plasticity in binding confers selectivity in ligand-induced protein degradation von Nowak, Radosław P., DeAngelo, Stephen L., Buckley, Dennis, He, Zhixiang, Donovan, Katherine A., An, Jian, Safaee, Nozhat, Jedrychowski, Mark P., Ponthier, Charles M., Ishoey, Mette, Zhang, Tinghu, Mancias, Joseph D., Gray, Nathanael S., Bradner, James E., Fischer, Eric S.

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Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation von Olson, Calla M, Jiang, Baishan, Erb, Michael A, Liang, Yanke, Doctor, Zainab M, Zhang, Zinan, Zhang, Tinghu, Kwiatkowski, Nicholas, Boukhali, Myriam, Green, Jennifer L, Haas, Wilhelm, Nomanbhoy, Tyzoon, Fischer, Eric S, Young, Richard A, Bradner, James E, Winter, Georg E, Gray, Nathanael S

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BET Bromodomains Mediate Transcriptional Pause Release in Heart Failure von Anand, Priti, Brown, Jonathan D., Lin, Charles Y., Qi, Jun, Zhang, Rongli, Artero, Pedro Calderon, Alaiti, M. Amer, Bullard, Jace, Alazem, Kareem, Margulies, Kenneth B., Cappola, Thomas P., Lemieux, Madeleine, Plutzky, Jorge, Bradner, James E., Haldar, Saptarsi M.

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YY1 Is a Structural Regulator of Enhancer-Promoter Loops von Weintraub, Abraham S., Li, Charles H., Zamudio, Alicia V., Sigova, Alla A., Hannett, Nancy M., Day, Daniel S., Abraham, Brian J., Cohen, Malkiel A., Nabet, Behnam, Buckley, Dennis L., Guo, Yang Eric, Hnisz, Denes, Jaenisch, Rudolf, Bradner, James E., Gray, Nathanael S., Young, Richard A.

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Quantitative ChIP-Seq Normalization Reveals Global Modulation of the Epigenome von Orlando, David A., Chen, Mei Wei, Brown, Victoria E., Solanki, Snehakumari, Choi, Yoon J., Olson, Eric R., Fritz, Christian C., Bradner, James E., Guenther, Matthew G.

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A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemia von Gröschel, Stefan, Sanders, Mathijs A, Hoogenboezem, Remco, de Wit, Elzo, Bouwman, Britta A M, Erpelinck, Claudia, van der Velden, Vincent H J, Havermans, Marije, Avellino, Roberto, van Lom, Kirsten, Rombouts, Elwin J, van Duin, Mark, Döhner, Konstanze, Beverloo, H Berna, Bradner, James E, Döhner, Hartmut, Löwenberg, Bob, Valk, Peter J M, Bindels, Eric M J, de Laat, Wouter, Delwel, Ruud

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Small-Molecule Inhibition of BRDT for Male Contraception von Matzuk, Martin M., McKeown, Michael R., Filippakopoulos, Panagis, Li, Qinglei, Ma, Lang, Agno, Julio E., Lemieux, Madeleine E., Picaud, Sarah, Yu, Richard N., Qi, Jun, Knapp, Stefan, Bradner, James E.

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NF-κB Directs Dynamic Super Enhancer Formation in Inflammation and Atherogenesis von Brown, Jonathan D., Lin, Charles Y., Duan, Qiong, Griffin, Gabriel, Federation, Alexander J., Paranal, Ronald M., Bair, Steven, Newton, Gail, Lichtman, Andrew H., Kung, Andrew L., Yang, Tianlun, Wang, Hong, Luscinskas, Francis W., Croce, Kevin J., Bradner, James E., Plutzky, Jorge

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